Faculty

Institution

Unit

Venue

Bruce Trapp

Professor Department Chair The Morris R and Ruth V Graham Endowed Chair in Biomedical Research

Case Western Reserve University

Affiliations

School of Medicine

Molecular Medicine

Bruce Trapp is currently serving as a Molecular Medicine Professor Department Chair The Morris R and Ruth V Graham Endowed Chair in Biomedical Research at Case Western Reserve University.

Honors

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Experiences

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Education

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Bruce Trapp

Case Western Reserve University

Professor Department Chair The Morris R and Ruth V Graham Endowed Chair in Biomedical Research

You can click a keyword to filter the displayed items

neuroscience neurology multiple sclerosis cell biology immunology neuroanatomy neurophysiology systems neuroscience central nervous system neuropathology mammalian biology brain science neuroinflammation cellular neurobiology cognitive neuroscience clinical neurology neurochemistry myelin-associated glycoprotein membrane biology experimental neuropathology clinical neuroscience peripheral nervous system neuroprotection protein science brain imaging neural science brain function spinal cord medicinal research cellular biology molecular physiology cellular physiology molecular neurobiology brain-immune interaction schwann cells vascular biology peripheral nerve magnetic resonance imaging neuroradiology stem cell research neurotransmission protein expression immunocytochemical localization transgenic mice neurorehabilitation animal physiology cell death disease progression white matter mitochondrial function experimental medicine neuroregeneration gene function neurological disorders axonal degeneration demyelinated axons axonal loss gene regulation brain structure brain organization myelinated axons amyloid precursor protein cortical demyelination mouse model progressive multiple sclerosis multiple sclerosis lesions adult brain spinal cord medicine respiratory medicine brain tumor research carbohydrate-protein interactions transcription regulation relapse prevention cancer biology chronic lesions axonal pathology myelin formation molecular neurodegeneration neurological disorder glial cell development neurological progress developmental neurobiology molecular psychiatry

Notable Scholarly Works

Notable Federal Grants

Collaborators

Btk Regulates Microglial Function and Neuroinflammation in Human Stem Cell Models and Mouse Models of Multiple Sclerosis. Nature Communications (2024)

Ross C. GruberGregory S. WirakAnna S. BlazierLan LeeMichael R. DufaultNellwyn HaganNathalie ChretienMichael LaMorteTimothy R. HammondAgnes CheongSean K. RyanAndrew MacklinMindy ZhangNilesh PandeEvis HavariTimothy J. TurnerAnthony ChomykEmilie ChristieBruce D. TrappDimitry Ofengeim

neuroinflammationmultiple sclerosismicroglial functionneurosciencemouse models

Comparison of Postmortem in Situ 3T Mri and Ex Vivo Ultra-High-Resolution 7T Mri in Multiple Sclerosis Cortical Lesions. Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024)

Kunio NakamuraKen SakaieJacqueline ChenKedar MahajanBruce TrappMark LoweStephen JonesDaniel OntanedaEmmanuel Obusez

magnetic resonance imagingradiologymagnetic resonancemultiple sclerosisneuroimagingmedical imaging

Disability Independent of Cerebral White Matter Demyelination in Progressive Multiple Sclerosis. Acta Neuropathologica (2024)

Vikas SinghYufan ZhengDaniel OntanedaKedar R MahajanJameson HollomanRobert J FoxKunio NakamuraBruce D Trapp

neurologyneurological disordersmultiple sclerosiswhite matterneuropathologyclinical neurosciencecognitive impairmentprogressive multiple sclerosiscerebral blood flowclinical neurologydisabilityneuroscienceneurodegenerative diseases

Network Medicine Informed Multi-Omics Integration Identifies Drug Targets and Repurposable Medicines for Amyotrophic Lateral Sclerosis. Research Square (Research Square) (2024)

Feixiong ChengMucen YuJielin XuRanjan DuttaBruce TrappAndrew Pieper

neurologymedicinenetwork medicinerepurposable medicinesneuroscienceamyotrophic lateral sclerosis

Small-Molecule-Induced Epigenetic Rejuvenation Promotes Srebp Condensation and Overcomes Barriers to Cns Myelin Regeneration. Cell (2024)

Xuezhao LiuDazhuan Eric XinXiaowen ZhongChuntao ZhaoZhidan LiLiguo ZhangAdam J DoursonLindsay LeeShreya MishraArman E BayatEva NicholsonWilliam L SeibelBingfang YanJoel MasonBradley J TurnerDavid G GonsalvezWilliam OngSing Yian ChewBalaram GhoshSung Ok YoonMei XinZhigang HeJason TchieuMichael WegnerKlaus-Armin NaveRobin J M FranklinRanjan DuttaBruce D TrappMing HuMatthew A SmithMichael P JankowskiSamantha K BartonXuelian HeQ Richard Lu

epigeneticsmolecular biologyneurosciencecell biology

Transcript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis. Annals of Neurology (2024)

Anthony ChomykRikki KucinskiJihye KimEmilie ChristieKaitlyn CyncynatusZachary GossmanZhihong ChenBrian RichardsonMark CameronTim TurnerRanjan DuttaBruce Trapp

immunologyneurologyneuroinflammationmultiple sclerosisneuroimagingneuroimmunologychronic inflammationclinical neurosciencetranscript profilesimmune responsesmedicinal researchclinical neurologyneurosciencebrain-immune interactioninflammation

Ultra High Spatial Resolution Mri of Intact Ex Vivo Multiple Sclerosis Brain. Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2024)

Ken SakaieJagjit SidhuKedar MahajanKunio NakamuraDaniel OntanedaBruce TrappMark LoweStephen JonesEmmanuel Obusez

magnetic resonance imagingradiologymagnetic resonancemultiple sclerosisneuroimagingbrain imagingmultiple sclerosis brainmedical imaging

Neuroprotection by Preconditioning in Mice is Dependent on Myd88-Mediated Cxcl10 Expression in Endothelial Cells. ASN NEURO (2023)

Zhihong ChenWeiwei HuMynor J. MendezZachary C. GossmanAnthony ChomykBrendan T. BoylanGrahame J. KiddTimothy W. PharesCornelia C. BergmannBruce D. Trapp

neuroprotectiongene expressionneuroscienceendothelial cells

P38γ Mapk Delays Myelination and Remyelination and is Abundant in Multiple Sclerosis Lesions. Brain (2023)

Leandro N MarzialiYoonchan HwangMarilena PalmisanoAna CuendaFraser J SimAlberto GonzalezChristina VolskoRanjan DuttaBruce D TrappLawrence WrabetzMaria L Feltri

cognitive neuroscienceneurologybrain scienceneuroinflammationmultiple sclerosis lesionsmultiple sclerosisnervous systembrain functioncentral nervous systemneuroscienceneuroanatomyhealth sciences

Physics-Constrained Neural Network for Synthesis of Mr Parameter Maps and Clinical Contrast. Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition (2023)

Gawon LeeJi Wan SonKen SaKaieKunio NakamuraYufan ZhengDaniel OntanedaBruce TrappMark LoweDong Hye YeSe-hong Oh

medicinemagnetic resonanceclinical contrastphysics-constrained neural networkcomputational neurosciencemr parameter mapsmachine learningneurosciencehealth sciences

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Bruce Trapp

Professor Department Chair The Morris R and Ruth V Graham Endowed Chair in Biomedical Research

Case Western Reserve University

Affiliations

School of Medicine

Molecular Medicine

Bruce Trapp is currently serving as a Molecular Medicine Professor Department Chair The Morris R and Ruth V Graham Endowed Chair in Biomedical Research at Case Western Reserve University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Bruce Trapp

Case Western Reserve University

Professor Department Chair The Morris R and Ruth V Graham Endowed Chair in Biomedical Research

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Btk Regulates Microglial Function and Neuroinflammation in Human Stem Cell Models and Mouse Models of Multiple Sclerosis. Nature Communications (2024)

neuroinflammationmultiple sclerosismicroglial functionneurosciencemouse models

Kunio NakamuraKen SakaieJacqueline ChenKedar MahajanBruce TrappMark LoweStephen JonesDaniel OntanedaEmmanuel Obusez

magnetic resonance imagingradiologymagnetic resonancemultiple sclerosisneuroimagingmedical imaging

Disability Independent of Cerebral White Matter Demyelination in Progressive Multiple Sclerosis. Acta Neuropathologica (2024)

Vikas SinghYufan ZhengDaniel OntanedaKedar R MahajanJameson HollomanRobert J FoxKunio NakamuraBruce D Trapp

Network Medicine Informed Multi-Omics Integration Identifies Drug Targets and Repurposable Medicines for Amyotrophic Lateral Sclerosis. Research Square (Research Square) (2024)

Feixiong ChengMucen YuJielin XuRanjan DuttaBruce TrappAndrew Pieper

neurologymedicinenetwork medicinerepurposable medicinesneuroscienceamyotrophic lateral sclerosis

Small-Molecule-Induced Epigenetic Rejuvenation Promotes Srebp Condensation and Overcomes Barriers to Cns Myelin Regeneration. Cell (2024)

epigeneticsmolecular biologyneurosciencecell biology

Transcript Profiles of Microglia/Macrophage Cells at the Borders of Chronic Active and Subpial Gray Matter Lesions in Multiple Sclerosis. Annals of Neurology (2024)

Anthony ChomykRikki KucinskiJihye KimEmilie ChristieKaitlyn CyncynatusZachary GossmanZhihong ChenBrian RichardsonMark CameronTim TurnerRanjan DuttaBruce Trapp

Ken SakaieJagjit SidhuKedar MahajanKunio NakamuraDaniel OntanedaBruce TrappMark LoweStephen JonesEmmanuel Obusez

magnetic resonance imagingradiologymagnetic resonancemultiple sclerosisneuroimagingbrain imagingmultiple sclerosis brainmedical imaging

Neuroprotection by Preconditioning in Mice is Dependent on Myd88-Mediated Cxcl10 Expression in Endothelial Cells. ASN NEURO (2023)

Zhihong ChenWeiwei HuMynor J. MendezZachary C. GossmanAnthony ChomykBrendan T. BoylanGrahame J. KiddTimothy W. PharesCornelia C. BergmannBruce D. Trapp

neuroprotectiongene expressionneuroscienceendothelial cells

P38γ Mapk Delays Myelination and Remyelination and is Abundant in Multiple Sclerosis Lesions. Brain (2023)

Leandro N MarzialiYoonchan HwangMarilena PalmisanoAna CuendaFraser J SimAlberto GonzalezChristina VolskoRanjan DuttaBruce D TrappLawrence WrabetzMaria L Feltri

cognitive neuroscienceneurologybrain scienceneuroinflammationmultiple sclerosis lesionsmultiple sclerosisnervous systembrain functioncentral nervous systemneuroscienceneuroanatomyhealth sciences

Gawon LeeJi Wan SonKen SaKaieKunio NakamuraYufan ZhengDaniel OntanedaBruce TrappMark LoweDong Hye YeSe-hong Oh

medicinemagnetic resonanceclinical contrastphysics-constrained neural networkcomputational neurosciencemr parameter mapsmachine learningneurosciencehealth sciences

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cerebrovascular disease

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