Faculty

Institution

Unit

Venue

Timothy O'Brien

Professor and Division Head Comparative Pathology Department of Veterinary Population Medicine

University of Minnesota

Affiliations

College of Veterinary Medicine

Veterinary Population Medicine Department

Timothy O'brien is currently serving as a College Of Veterinary Medicine Professor and Division Head Comparative Pathology Department of Veterinary Population Medicine at University of Minnesota.

Honors

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Experiences

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Education

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Timothy O'Brien

University of Minnesota

Professor and Division Head Comparative Pathology Department of Veterinary Population Medicine

You can click a keyword to filter the displayed items

veterinary medicine immunology veterinary science diabetes veterinary pathology pathology regenerative medicine pharmacology vascular biology hematology veterinary research biochemistry neurodegenerative diseases diabetes mellitus endocrinology inflammation medicinal research cell transplantation transplantation medicine islet amyloid polypeptide animal science peptides diabetes research stem cell research clinical transplantation insulin signaling diabetes therapies avian biology transplantation proceeding hepatology avian medicine mammalian biology kidney failure neuropeptides diabetes management tissue transplantation metabolic syndrome diabetic medicine veterinary diagnostics transplant surgery lymphoid neoplasia islet amyloidosis mesenchymal stem cells small animal internal medicine cell culture cancer treatment clinical immunology cell therapy insulin management adaptive immune system stem-cell therapy biochemical interaction pulmonary vascular disease islet amyloid normal cats aged dogs aa amyloidosis protein secretion inhibitory activity secondary metabolism diabetic neuropathy neuroendocrine disorders host factors key site companion animals stem cell transplantation pancreatic beta cells insulin secretion captive cheetahs intracellular amyloidogenesis enhanced differentiation adult cats pancreatic islets diagnostic tool bone marrow chronic renal failure neurology molecular neurodegeneration parkinson's disease brain organoids medicine

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Bioengineered Artificial Interstitium Supports Long-Term Islet Xenograft Survival in Nonhuman Primates Without Immunosuppression. Science Advances (2024)

Scott H. OpplerLaura L. Hocum StoneDavid J. LeishmanJody L. JanecekMeghan E. G. MooreParthasarathy RangarajanBradley J. WillenbergTimothy D. O’BrienJaime ModianoNatan PheilJordan DaltonMichael DaltonSabarinathan RamachandranMelanie L. Graham

bioengineered artificial interstitiumregenerative medicinescience advancenonhuman primatesimmunosuppressionbiological engineering

Targeted Mapping and Utilization of the Perihepatic Surface for Therapeutic Beta Cell Replacement and Retrieval in Diabetic Non-Human Primates. Frontiers in Transplantation (2024)

David J. LeishmanScott H. OpplerLaura L. Hocum StoneTimothy D. O’BrienSabarinathan RamachandranBradley J. WillenbergAndrew B. AdamsBernhard J. HeringMelanie L. Graham

perihepatic surfacetissue transplantationtransplantation proceedingtranslational medicinecell biologydiabetic non-human primatesstem cell transplantationdermatologyliver transplantationcell therapyregenerative medicinetherapeutic targetstransplantation medicinecell replacement therapiespharmacologyorgan transplantationtissue engineeringcellular therapycell transplantationclinical transplantation

Hypoxia Within Subcutaneously Implanted Macroencapsulation Devices Limits the Viability and Functionality of Densely Loaded Islets. Frontiers in Transplantation (2023)

Samuel A. EinsteinLeah V. SteynBradley P. WeegmanThomas M. SuszynskiAthanassios SambanisTimothy D. O’BrienEfstathios S. AvgoustiniatosMeri T. FirpoMelanie L. GrahamJody JanecekLynn E. EberlyMichael GarwoodCharles W. PutnamKlearchos K. Papas

transplant surgerytissue transplantationtransplantation proceedinghematologyvascular biologydermatologyliver transplantationregenerative medicinetransplantation medicineimmunologyorgan transplantationbiomedical engineeringtissue engineeringimplantable devicesoncologycell transplantationhypoxia (medicine)macroencapsulation devicesclinical transplantation

Clinically Available Immunosuppression Averts Rejection but Not Systemic Inflammation After Porcine Islet Xenotransplant in Cynomolgus Macaques. American Journal of Transplantation (2021)

Melanie L. GrahamSabarinathan RamachandranAmar SinghMeghan E.G. MooreE. Brian FlanaganAgnes AzimzadehChristopher BurlakKate R. MuellerKyra MartinsTakayuki AnazawaBalamurugan N. AppakalaiPratima Bansal-PakalaMichael P. MurtaughTimothy D. O’BrienKlearchos K. PapasThomas SpizzoHenk-J. SchuurmanWayne W. HancockBernhard. J. Hering

transplant surgerysystemic inflammationtissue transplantationtransplantation proceedingtranslational medicinehematologyporcine islet xenotransplantimmunosuppressioninflammationdermatologyregenerative medicinexenotransplantationavian medicinetransplantation medicinecynomolgus macaquesimmunologyimmunosuppressive therapypharmacologyorgan transplantationmedicinal researchclinical transplantation

Development of an Exosomal Gene Signature to Detect Residual Disease in Dogs With Osteosarcoma Using a Novel Xenograft Platform and Machine Learning. Laboratory Investigation (2021)

Kelly M. MakielskiAlicia J. DonnellyAli KhammanivongMilcah C. ScottAndrea R. OrtizDana C. GalvanHirotaka TomiyasuClarissa AmayaKristin A. WardAlexa MontoyaJohn R. GarbeLauren J. MillsGary R. CutterJoelle M. FengerWilliam C. KisseberthTimothy D. O'BrienBrenda J. WeigelLogan G. SpectorBrad A. BryanSubbaya SubramanianJaime F. Modiano

genomicslaboratory animal caredermatologylaboratory investigationlaboratory medicineveterinary diagnosticsexosomal gene signatureepidemiologyveterinary medicinemammalian biologyresidual diseaseveterinary scienceclinical investigationlaboratory animal studieshealth sciencesbioinformatics

Self-Organized Emergence of Hyaline Cartilage in Hipsc-Derived Multi-Tissue Organoids. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Manci LiJuan E. AbrahanteAmanda VegoeYi Wen ChaiBeth LindborgFerenc TothPeter A. LarsenTimothy D. O’Brien

organ developmentbiomedical engineeringcartilageself-organized emergencehyaline cartilagehipsc-derived multi-tissue organoids

A Novel Mct1 and Mct4 Dual Inhibitor Reduces Mitochondrial Metabolism and Inhibits Tumour Growth of Feline Oral Squamous Cell Carcinoma. Veterinary and Comparative Oncology (2019)

Ali KhammanivongJhuma SahaAngela K. SpartzBrent S. SorensonAlexander G. BushDerek M. KorpelaRaj GopalakrishnanShirisha JonnalagaddaVenkatram R. MereddyTimothy D. O'BrienLester R. DrewesErin B. Dickerson

dermatologymedicinepharmacologyenzyme inhibitioncancer carecancer researchveterinary medicineveterinary researchanti-cancer agentsanimal scienceanimal biotechnologyoncologyveterinary sciencehepatologygenitourinary cancerscancer treatmentcancer biologytumor biology

Interspecies Organogenesis for Human Transplantation. Cell Transplantation (2019)

Andrew T. CraneRajagopal N. AravalliAtsushi AsakuraAndrew W. GrandeVenkatramana D. KrishnaDaniel F. CarlsonMaxim C.-J. CheeranGeorgette DanczykJames R. DuttonPerry B. HackettWei-Shou HuLing LiWei-Cheng LuZachary D. MillerTimothy D. O’BrienAngela Panoskaltsis-MortariAnn M. ParrClairice PearceMercedes Ruiz-EstevezMaple ShiaoChristopher J. SipeNikolas G. TomanJoseph VothHui XieClifford J. SteerWalter C. Low

interspecies organogenesisorgan transplantationbiomedical engineeringhuman transplantationcell transplantation

What is Your Diagnosis? Nasal Lesion in a Horse With Exophthalmos. Veterinary Clinical Pathology (2019)

Ashley E. ZiburaLeah K. ManningAngela GwynnLeslie SharkeyMichala de Linde HenriksenElizabeth CoppelmanTimothy D. O’Brien

nasal lesionophthalmologydiagnosisveterinary medicineveterinary pathologypathology

A Completely Biological “Off-The-Shelf” Arteriovenous Graft That Recellularizes in Baboons. Science Translational Medicine (2017)

Zeeshan H. SyedainMelanie L. GrahamTy B. DunnTimothy O’BrienSandra L. JohnsonRobert J. SchumacherRobert T. Tranquillo

dermatologymedicinelaboratory medicinebiomedical engineeringregenerative medicinevascular biologytransplantation medicineangiologyarteriovenous grafttranslational medicine

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Timothy O'Brien

Professor and Division Head Comparative Pathology Department of Veterinary Population Medicine

University of Minnesota

Affiliations

College of Veterinary Medicine

Veterinary Population Medicine Department

Timothy O'brien is currently serving as a College Of Veterinary Medicine Professor and Division Head Comparative Pathology Department of Veterinary Population Medicine at University of Minnesota.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Timothy O'Brien

University of Minnesota

Professor and Division Head Comparative Pathology Department of Veterinary Population Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Bioengineered Artificial Interstitium Supports Long-Term Islet Xenograft Survival in Nonhuman Primates Without Immunosuppression. Science Advances (2024)

bioengineered artificial interstitiumregenerative medicinescience advancenonhuman primatesimmunosuppressionbiological engineering

Targeted Mapping and Utilization of the Perihepatic Surface for Therapeutic Beta Cell Replacement and Retrieval in Diabetic Non-Human Primates. Frontiers in Transplantation (2024)

David J. LeishmanScott H. OpplerLaura L. Hocum StoneTimothy D. O’BrienSabarinathan RamachandranBradley J. WillenbergAndrew B. AdamsBernhard J. HeringMelanie L. Graham

Hypoxia Within Subcutaneously Implanted Macroencapsulation Devices Limits the Viability and Functionality of Densely Loaded Islets. Frontiers in Transplantation (2023)

Clinically Available Immunosuppression Averts Rejection but Not Systemic Inflammation After Porcine Islet Xenotransplant in Cynomolgus Macaques. American Journal of Transplantation (2021)

Development of an Exosomal Gene Signature to Detect Residual Disease in Dogs With Osteosarcoma Using a Novel Xenograft Platform and Machine Learning. Laboratory Investigation (2021)

Self-Organized Emergence of Hyaline Cartilage in Hipsc-Derived Multi-Tissue Organoids. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Manci LiJuan E. AbrahanteAmanda VegoeYi Wen ChaiBeth LindborgFerenc TothPeter A. LarsenTimothy D. O’Brien

organ developmentbiomedical engineeringcartilageself-organized emergencehyaline cartilagehipsc-derived multi-tissue organoids

A Novel Mct1 and Mct4 Dual Inhibitor Reduces Mitochondrial Metabolism and Inhibits Tumour Growth of Feline Oral Squamous Cell Carcinoma. Veterinary and Comparative Oncology (2019)

Interspecies Organogenesis for Human Transplantation. Cell Transplantation (2019)

interspecies organogenesisorgan transplantationbiomedical engineeringhuman transplantationcell transplantation

What is Your Diagnosis? Nasal Lesion in a Horse With Exophthalmos. Veterinary Clinical Pathology (2019)

Ashley E. ZiburaLeah K. ManningAngela GwynnLeslie SharkeyMichala de Linde HenriksenElizabeth CoppelmanTimothy D. O’Brien

nasal lesionophthalmologydiagnosisveterinary medicineveterinary pathologypathology

A Completely Biological “Off-The-Shelf” Arteriovenous Graft That Recellularizes in Baboons. Science Translational Medicine (2017)

Zeeshan H. SyedainMelanie L. GrahamTy B. DunnTimothy O’BrienSandra L. JohnsonRobert J. SchumacherRobert T. Tranquillo

dermatologymedicinelaboratory medicinebiomedical engineeringregenerative medicinevascular biologytransplantation medicineangiologyarteriovenous grafttranslational medicine

1
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5
15
10 / page

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stem-cell therapy

Richard L. Simmons

Institution

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immune mediator

cell research

Donna Stolz

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tissue (biology)

developmental biology

Angus Thomson

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graft rejection

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Anthony J. Demetris

Institution

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hepatology

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Angela Panoskaltsis-Mortari

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stem-cell therapy

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