Faculty

Institution

Unit

Venue

Tim Heffernan

The University of Texas MD Anderson Cancer Center

Affiliations

Center Of Sheikh Ahmed Pancreatic Cancer Research

The University of Texas MD Anderson Cancer Center

NoneTim Heffernan is currently serving as a Center Of Sheikh Ahmed Pancreatic Cancer Research faculty at The University of Texas Md Anderson Cancer Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Tim Heffernan

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

oncology tumor biology medicinal research cancer biology cancer treatment pharmacology oncogenes therapeutic targets cancer genomics radiation oncology cancer immunotherapy molecular biology cancer cells tumor targeting brain tumor research metastasis enzyme inhibition cellular therapy cancer care pancreatic cancer cancer genetics medicine translational medicine experimental medicine cancer discovery anti-cancer agents drug targeting dna damage response parp inhibitor pharmacological research tumor suppressors host specificity cancer immunosurveillance tumor heterogeneity immune checkpoint inhibitors lung cancer carcinogenesis redox biology molecular cell biology thoracic oncology clinical investigation applied pharmacology future medicinal chemistry lymphoid neoplasia host factors clinical radiation oncology immunoediting host response clinical immunology gastrointestinal oncology immunomodulation mechanisms of action novel therapies mitochondrial function melanoma chromatin remodeling epigenomics epigenetic changes radiation effects radiation biology rna biology nucleic acid amplification mantle cell lymphoma oxidative phosphorylation promote metastasis e-cadherin internalization interferon response genes resistance mechanisms systems-level interrogation pooled shrna screens histone acetyltransferase synthetic cytotoxicity specific aml subsets pancreatic cancer aggressiveness abstract 3824 allelic imbalance

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 7813: Antitumor Activity of a B7-H3 Antibody-Drug Conjugate in Osteosarcoma Patient-Derived and Metastatic Models. Cancer Research (2026)

pharmacologytumor targetingcancer treatmentantitumor activityoncologycancer discoverymetastasisanti-cancer agentsabstract 7813immunologyb7-h3 antibody-drug conjugatecancer cells

Cell-Free Chromatin Epigenomic Profiling Enables Non-Invasive Pancreatic Cancer Cell-State Identification. medRxiv (2026)

cancer cellscancer researchchromatin remodelingcancer genomicsepigenomicsepigeneticscell biologyepigenetic changeschromatinpancreatic cancer

Abstract 3824: Investigating the Role of Allelic Imbalance in Pancreatic Cancer Aggressiveness, Survival, and Therapeutic Resistance. Cancer Research (2025)

pathologycancer biologymolecular cancercancer cellsoncogenesoncologypancreatic cancer aggressivenessabstract 3824cancer geneticstumor biologyallelic imbalancecell biologymolecular diagnosticspancreatic cancer

Abstract 447: Preclinical Development and Characterization of Iacs-16559, a Dual Bromodomain Inhibitor of Cbp/Ep300, and Its Potential in Aml Subtypes. Cancer Research (2025)

pharmacological researchpharmacologydrug discoverypreclinical developmentoncogenesmechanisms of actionaml subtypesenzyme inhibitionleukemiamolecular biologynovel therapiesabstract 447therapeutic targets

CORRECTION: Targeting of Epigenetic Co-Dependencies Enhances Anti-Aml Efficacy of Menin Inhibitor in Aml With Mll1-R or Mutant Npm1. Blood Cancer Journal (2025)

oncogenesmenin inhibitormolecular biologymutant npm1epigeneticscell biologytherapeutic targets

Trls-12 Pd-1 and Lag3 Combination Blockade Therapy Reduces Melanoma Brain Metastatic Tumor Growth in Preclinical Models and is Abrogated by Neutrophil Infiltration. Neuro-Oncology Advances (2025)

cancer immunotherapycancer treatmentcancer cellstumor microenvironmentbrain tumor researchmetastasiscellular therapyimmunologyimmune checkpoint inhibitorscell biology

Abstract 1494: Clonal Dominance Defines Metastatic Dissemination in Pancreatic Cancer. Cancer Research (2024)

gastrointestinal oncologypathologycancer biologyoncogenesoncologytumor heterogeneitymetastasistumor biologycell biologypancreatic cancer

Abstract 3229: Iacs-16559, a Cbp/P300 Bromodomain Inhibitor for the Treatment of Specific Aml Subsets. Cancer Research (2024)

Ciro ZancaMichael SothGuang GaoJason GayNingping FengChristopher BristowKang LeQuanyun XuPhuong NguyenYongying JiangTeresa PerryFaika MseehPaul LeonardJason CrossVirginia GiulianiJoe MarszalekPhilip JonesTim Heffernan

pharmacologymedicinal chemistrycancer biologycancer treatmentdrug discoverycancer researchoncologybiochemistrybiomolecular engineeringspecific aml subsetsmedicinal researchtherapeutic targets

Wrad Core Perturbation Impairs Dna Replication Fidelity Promoting Immunoediting in Pancreatic Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Francesca CitronI-Lin HoChiara BalestrieriZhaoliang LiuEr-Yen YenLuca CecchettoLuigi PerelliLi ZhangLuis Castillo MontanezNicholas BlazaninCharles A. DykeRutvi ShahSergio AttanasioSanjana SrinivasanKo-Chien ChenZiheng ChenIolanda ScognamiglioNhung PhamHania KhanShan JiangJing PanBen VanderkrukCecilia S. LeungMahinur MattohtiKunal RaiYanshuo ChuLinghua WangSisi GaoAngela K. DeemAlessandro CarugoHuamin WangWantong YaoGiovanni TononYun XiongPhilip L. LorenziChiara BoniniM. Anna ZalBrad G. HoffmanTim HeffernanVirginia GiulianiCollene R. JeterYonathan LissanuGiannicola GenoveseMauro Di PilatoAndrea VialeGiulio F. Draetta

molecular biologyimmunoeditingpancreatic cancerdna replication

Abstract 312: The Atr Inhibitor Art0380 Shows Preclinical Efficacy in Monotherapy or in Combination With Gemcitabine, Apd1, Parp Inhibitors and Topoisomerase 1 Poisons. Cancer Research (2023)

pharmacological researchpharmacologyapplied pharmacologyfuture medicinal chemistrymedicinal chemistrydrug discoverymedicinecancer letteroncologyradiation oncologypharmacotherapytranslational medicinemedicinal researchmolecular pharmacologyjama oncologydrug metabolismtherapeutic targets

1
2
3
4
10 / page

Tim Heffernan

The University of Texas MD Anderson Cancer Center

Affiliations

Center Of Sheikh Ahmed Pancreatic Cancer Research

The University of Texas MD Anderson Cancer Center

NoneTim Heffernan is currently serving as a Center Of Sheikh Ahmed Pancreatic Cancer Research faculty at The University of Texas Md Anderson Cancer Center.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Tim Heffernan

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 7813: Antitumor Activity of a B7-H3 Antibody-Drug Conjugate in Osteosarcoma Patient-Derived and Metastatic Models. Cancer Research (2026)

pharmacologytumor targetingcancer treatmentantitumor activityoncologycancer discoverymetastasisanti-cancer agentsabstract 7813immunologyb7-h3 antibody-drug conjugatecancer cells

Cell-Free Chromatin Epigenomic Profiling Enables Non-Invasive Pancreatic Cancer Cell-State Identification. medRxiv (2026)

cancer cellscancer researchchromatin remodelingcancer genomicsepigenomicsepigeneticscell biologyepigenetic changeschromatinpancreatic cancer

Abstract 3824: Investigating the Role of Allelic Imbalance in Pancreatic Cancer Aggressiveness, Survival, and Therapeutic Resistance. Cancer Research (2025)

Abstract 447: Preclinical Development and Characterization of Iacs-16559, a Dual Bromodomain Inhibitor of Cbp/Ep300, and Its Potential in Aml Subtypes. Cancer Research (2025)

CORRECTION: Targeting of Epigenetic Co-Dependencies Enhances Anti-Aml Efficacy of Menin Inhibitor in Aml With Mll1-R or Mutant Npm1. Blood Cancer Journal (2025)

oncogenesmenin inhibitormolecular biologymutant npm1epigeneticscell biologytherapeutic targets

Trls-12 Pd-1 and Lag3 Combination Blockade Therapy Reduces Melanoma Brain Metastatic Tumor Growth in Preclinical Models and is Abrogated by Neutrophil Infiltration. Neuro-Oncology Advances (2025)

cancer immunotherapycancer treatmentcancer cellstumor microenvironmentbrain tumor researchmetastasiscellular therapyimmunologyimmune checkpoint inhibitorscell biology

Abstract 1494: Clonal Dominance Defines Metastatic Dissemination in Pancreatic Cancer. Cancer Research (2024)

gastrointestinal oncologypathologycancer biologyoncogenesoncologytumor heterogeneitymetastasistumor biologycell biologypancreatic cancer

Abstract 3229: Iacs-16559, a Cbp/P300 Bromodomain Inhibitor for the Treatment of Specific Aml Subsets. Cancer Research (2024)

pharmacologymedicinal chemistrycancer biologycancer treatmentdrug discoverycancer researchoncologybiochemistrybiomolecular engineeringspecific aml subsetsmedicinal researchtherapeutic targets

Wrad Core Perturbation Impairs Dna Replication Fidelity Promoting Immunoediting in Pancreatic Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2024)

molecular biologyimmunoeditingpancreatic cancerdna replication

Abstract 312: The Atr Inhibitor Art0380 Shows Preclinical Efficacy in Monotherapy or in Combination With Gemcitabine, Apd1, Parp Inhibitors and Topoisomerase 1 Poisons. Cancer Research (2023)

1
2
3
4
10 / page