Faculty

Institution

Unit

Venue

Thuc Le

Assistant Professor

University of California, Los Angeles

Affiliations

David Geffen School of Medicine

Molecular & Medical Pharmacology

Thuc Le is currently serving as a David Geffen School Of Medicine Assistant Professor at University of California, Los Angeles.

Honors

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Experiences

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Education

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Thuc Le

University of California, Los Angeles

Assistant Professor

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pharmacology cell biology oncology cancer research medicinal research tumor biology immunology cancer biology cancer genomics cancer treatment pancreatic cancer genetics molecular cancer gene expression clinical research cellular therapy drug discovery membrane biology cancer cells enzyme inhibition cancer genetics oncogenes tumor targeting anti-cancer agents cancer management medicinal chemistry stem cell research genome biology leukemia cancer imaging pharmacotherapy drug targeting nucleotide metabolism biomedical imaging mammalian biology mitochondrial function dna methylation nuclear medicine experimental medicine clinical investigation cell regulation positron emission tomography clinical immunology tissue imaging molecular regulation radiation therapy mouse model psychopharmacology molecular neurobiology neural science lifespan development epigenomics embryonic development skeletal muscle muscle function musculoskeletal science neurochemistry germ cells cell proliferation gene regulation optical engineering drug targets experimental biology basic function adult forebrain neurons synaptic function adult mammalian brain non-cpg methylation epigenomic profiling memory extinction combined deficiency postnatal development metabolic homeostasis skeletal muscle action estrogen receptor cocaine action

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract P012: Psma-Rlt and Targeting the Cgas-Sting Pathway as a Combination Approach for Prostate Cancer. Clinical Cancer Research (2025)

radiation oncologycancer cellscell biologymedicinal researchprostate cancerprostatic diseasetherapeutic targetsurologyoncology

Adipose Tissue Releases Nucleosides. American Journal of Physiology-Cell Physiology (2025)

metabolismphysiologycell biologymetabolic pathwayscell metabolismendocrinologyobesity medicine

Tailoring the Adjuvanticity of Lipid Nanoparticles by Peg Lipid Ratio and Phospholipid Modifications. Nature Nanotechnology (2025)

future medicinal chemistrylipidsnanomaterialsbiological engineeringdrug deliverybiomoleculesnanoparticlesnanomedicinepharmaceuticsbiopolymersmembrane biologymembrane sciencebiomedical engineeringbiomolecular engineeringnanoparticle researchbiomaterialscontrolled release

Targeting Orthotopic and Metastatic Pancreatic Cancer With Allogeneic Stem Cell–Engineered Mesothelin-Redirected Car-Nkt Cells. Proceedings of the National Academy of Sciences (2025)

oncogenesmetastasispathologytumor biologystem cell researchcancer immunotherapyimmunologycell transplantationstem cellsimmunotherapycellular therapymolecular cancercell biologycell engineeringcancer discoverycancer cellstumor microenvironment

Abstract A037: Enhanced Anti-Tumor Activity Through Targeted Immunotherapy Combined With Mutant Kras Inhibition in Pancreatic Cancer. Cancer Immunology Research (2024)

Amanda CreechHailey LeeKhalid RashidThuc LeAlykhan PremjiTony LuuAhmad KassemWeihang ZhaoLuyi LiNanping WuNorbert PardiJames WohlschlegelTimothy DonahueCaius Radu

cancer immunotherapyenhanced anti-tumor activityimmunologyimmunotherapymutant kras inhibitionpancreatic cancer

Abstract B059: Signaling Requirements for Enhanced Cd8+ T Cell Responses in Mrna Cancer Vaccine Immunotherapy. Cancer Immunology Research (2024)

Khalid RashidHailey R LeeAmanda L CreechTony LuuKatelyn NguyenPu Lin TengWeihang ZhaoAlykhan M PremjiEvan R. AbtThuc M LeTing-Ting WuNorbert PardiCaius G Radu

molecular immunologyvaccine designvaccinescancer immunotherapycell signalingimmunologyimmunotherapyimmune responsesadaptive immune systemsignaling requirements

Abstract Pr15: Adenosine Inhibits Sting Driven Anti-Tumor Immunity in Pancreatic Cancer. Cancer Research (2024)

Alykhan PremjiJason LinkTakanobu YamaoKhalid RashidEvan AbtAmanda LaboraCharlotte ChanThuc LeZev WainbergCaius RaduTimothy Donahue

cancer caretumor biologyanti-cancer agentscancer immunotherapyimmunologymedicinal researchimmunotherapyadenosine inhibitscancer researchpancreatic cancerpharmacologycancer managementcancer treatmenthealth sciencesoncologycancer biology

Author Response: Targeting Host Deoxycytidine Kinase Mitigates Staphylococcus Aureus Abscess Formation. (2024)

Volker WinstelEvan R AbtThuc M LeCaius G Radu

clinical microbiologyenzyme specificitypathologyinfectious diseaseshost deoxycytidine kinasepathogenic bacteriaantibiotic resistanceantimicrobial resistancemicrobiologydrug resistancepathogensapplied microbiologyinnate immune systeminfection controlmicrobial pathogenesis

Supplementary Fig. 2 From Mek Inhibition Sensitizes Pancreatic Cancer to Sting Agonism by Tumor-Cell Intrinsic Amplification of Type I Interferon Signaling. (2024)

Razmik GhukasyanKeke LiangKevin ChauLuyi LiCharlotte ChanEvan R. AbtThuc LeJoon Y. ParkNanping WuAlykhan PremjiRobert DamoiseauxTony LuuAmanda LaboraKhalid RashidJason M. LinkCaius G. RaduTimothy R. Donahue

mek inhibitioninhibitory activitytumor biologycell signalingimmunologytumor-cell intrinsic amplificationpancreatic cancercancer cellstumor microenvironment

Targeting Host Deoxycytidine Kinase Mitigates Staphylococcus Aureus Abscess Formation. eLife (2024)

Volker WinstelEvan R AbtThuc M LeCaius G Radu

clinical microbiologymedical microbiologyhost deoxycytidine kinaseimmunologyveterinary microbiologymedicinepharmacologymicrobial pathogenesis

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Thuc Le

Assistant Professor

University of California, Los Angeles

Affiliations

David Geffen School of Medicine

Molecular & Medical Pharmacology

Thuc Le is currently serving as a David Geffen School Of Medicine Assistant Professor at University of California, Los Angeles.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Thuc Le

University of California, Los Angeles

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract P012: Psma-Rlt and Targeting the Cgas-Sting Pathway as a Combination Approach for Prostate Cancer. Clinical Cancer Research (2025)

radiation oncologycancer cellscell biologymedicinal researchprostate cancerprostatic diseasetherapeutic targetsurologyoncology

Adipose Tissue Releases Nucleosides. American Journal of Physiology-Cell Physiology (2025)

metabolismphysiologycell biologymetabolic pathwayscell metabolismendocrinologyobesity medicine

Tailoring the Adjuvanticity of Lipid Nanoparticles by Peg Lipid Ratio and Phospholipid Modifications. Nature Nanotechnology (2025)

Targeting Orthotopic and Metastatic Pancreatic Cancer With Allogeneic Stem Cell–Engineered Mesothelin-Redirected Car-Nkt Cells. Proceedings of the National Academy of Sciences (2025)

Abstract A037: Enhanced Anti-Tumor Activity Through Targeted Immunotherapy Combined With Mutant Kras Inhibition in Pancreatic Cancer. Cancer Immunology Research (2024)

Amanda CreechHailey LeeKhalid RashidThuc LeAlykhan PremjiTony LuuAhmad KassemWeihang ZhaoLuyi LiNanping WuNorbert PardiJames WohlschlegelTimothy DonahueCaius Radu

cancer immunotherapyenhanced anti-tumor activityimmunologyimmunotherapymutant kras inhibitionpancreatic cancer

Abstract B059: Signaling Requirements for Enhanced Cd8+ T Cell Responses in Mrna Cancer Vaccine Immunotherapy. Cancer Immunology Research (2024)

Khalid RashidHailey R LeeAmanda L CreechTony LuuKatelyn NguyenPu Lin TengWeihang ZhaoAlykhan M PremjiEvan R. AbtThuc M LeTing-Ting WuNorbert PardiCaius G Radu

molecular immunologyvaccine designvaccinescancer immunotherapycell signalingimmunologyimmunotherapyimmune responsesadaptive immune systemsignaling requirements

Abstract Pr15: Adenosine Inhibits Sting Driven Anti-Tumor Immunity in Pancreatic Cancer. Cancer Research (2024)

Alykhan PremjiJason LinkTakanobu YamaoKhalid RashidEvan AbtAmanda LaboraCharlotte ChanThuc LeZev WainbergCaius RaduTimothy Donahue

Author Response: Targeting Host Deoxycytidine Kinase Mitigates Staphylococcus Aureus Abscess Formation. (2024)

Volker WinstelEvan R AbtThuc M LeCaius G Radu

Supplementary Fig. 2 From Mek Inhibition Sensitizes Pancreatic Cancer to Sting Agonism by Tumor-Cell Intrinsic Amplification of Type I Interferon Signaling. (2024)

mek inhibitioninhibitory activitytumor biologycell signalingimmunologytumor-cell intrinsic amplificationpancreatic cancercancer cellstumor microenvironment

Targeting Host Deoxycytidine Kinase Mitigates Staphylococcus Aureus Abscess Formation. eLife (2024)

Volker WinstelEvan R AbtThuc M LeCaius G Radu

clinical microbiologymedical microbiologyhost deoxycytidine kinaseimmunologyveterinary microbiologymedicinepharmacologymicrobial pathogenesis

1
2
3
4
5
6
7
10 / page

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Similar Faculty Members

Caius Gabriel Radu

Institution

University of California, Los Angeles

cancer imaging

molecular diagnostics

Dean W. Felsher

Institution

Stanford University

oncology

cancer research

Jun Yan

Institution

University of Louisville

immunology

oncology

Justin D. Lathia

Institution

Case Western Reserve University

oncology

brain tumor research

Gary Johnson

Institution

University of North Carolina at Chapel Hill

mapk kinase

apoptosis

Jeffrey C. Rathmell

Institution

Vanderbilt University

cellular therapy

immune response

Robert Anders

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cancer research

John Digiovanni

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cancer letter

molecular cancer

Amato J. Giaccia

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cancer biology

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health science

energy balance