Faculty

Institution

Unit

Venue

Thomas Kocarek

Professor

Wayne State University

Affiliations

School of Medicine

Pharmacology

Thomas Kocarek is currently serving as a Pharmacology Professor at Wayne State University.

Honors

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Experiences

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Education

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Thomas Kocarek

Wayne State University

Professor

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pharmacology liver physiology cell biology biochemistry gene expression hepatology drug metabolism membrane biology molecular pharmacology endocrinology pharmacological research mammalian biology pharmacokinetics molecular biology medicinal research enzyme inhibition cell metabolism molecular regulation clinical pharmacology transcription regulation medicinal chemistry metabolic regulation redox biology cell regulation drug development primary cultures steroid metabolism pharmacotherapy gene regulation regenerative medicine molecular physiology cellular biochemistry protein science experimental pharmacology translational pharmacology cancer biology molecular cell biology protein expression biochemical genetics transcriptional regulation avian medicine applied pharmacology avian biology redox signaling receptor (biochemistry) rat hepatocytes colorectal cancer lipoprotein metabolism adult rat hepatocytes gene transcription experimental medicine rna biology cancer genetics negative regulation human liver clinical toxicology biological inorganic chemistry cancer treatment breast oncology pharmacological studies developmental expression cytosolic sulfotransferases catalyst activation developmental endocrinology tumor targeting constitutive androstane receptor rat liver estrogenicity genes differential regulation protein levels hydroxysteroid sulfotransferases organ development functional regulation hyperlipidemia drug targeting peroxisome proliferator-activated receptor drug-induced liver injury hepatotoxicity toxicological mechanism toxicology metabolism molecular metabolism

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cytochrome P450 Induction Through the Efficient Photoinduced Release of a Pyridine-Substituted Agent From Ru(II). Journal of the American Chemical Society (2025)

pharmacologypyridine-substituted agentdrug metabolismredox biologymechanistic photochemistryphotochemistryphotomedicinephotocatalysisredox chemistrycytochrome p450 inductionphotoredox processefficient photoinduced releasebiochemistry

Metabolism Disrupting Effects in Human Pre-Adipocytes: Influence of Donor Sex and Body Composition. Toxicology and Applied Pharmacology (2025)

physiologyobesity medicineenergy homeostasishuman pre-adipocytesbody compositionmetabolic regulationmetabolic syndromemetabolic disordersobesityhuman biologymetabolic healthmetabolismhealth sciencesdonor sexcell metabolism

Mixed Ru(II)–Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme Cyp3a4. Inorganic Chemistry (2024)

Justin J. AhrensMadeline DenisonSantana GarciaSayak GuptaThomas A. KocarekIrina F. SevrioukovaClaudia TurroJeremy J. Kodanko

medicinal chemistrymajor human drugenzyme inhibitionpharmacologyphotoactive inhibitorscoordination chemistrycoordination complexdrug discoveryinorganic chemistrytransition metal chemistry

Nonylphenol and Cetyl Alcohol Polyethoxylates Disrupt Thyroid Hormone Receptor Signaling to Disrupt Metabolic Health. Endocrinology (2024)

Roxanne BérubéBrooklynn MurrayThomas A KocarekKatherine GurdzielChristopher D Kassotis

thyroidendocrinologythyroid hormonemetabolismbiochemistry

Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3a4. Inorganic Chemistry (2023)

Madeline DenisonJustin J. AhrensMarilyn N. DunbarHabon WarmahayeAliza MajeedClaudia TurroThomas A. KocarekIrina F. SevrioukovaJeremy J. Kodanko

medicinal chemistrypharmacologydrug metabolismphotochemistryphotomedicinecoordination chemistrybiomolecular engineeringbiological inorganic chemistrydrug discoveryinorganic chemistrytransition metal chemistrybiochemistry

Ir(III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy. Inorganic Chemistry (2022)

Madeline DenisonSean J. SteinkeAliza MajeedClaudia TurroThomas A. KocarekIrina F. SevrioukovaJeremy J. Kodanko

biological inorganic chemistryactive site occupancypharmacologyinorganic chemistry

Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins. Drug Metabolism and Disposition (2021)

Liberta CukoZofia Duniec-DmuchowskiElizabeth A. RondiniAsmita PantJohn K. FallonElizabeth M. WilsonNicholas J. PerainoJudy A. WestrickPhilip C. SmithThomas A. Kocarek

medicinal chemistrydrug metabolismclinical pharmacologyliver physiologymedicineclinical lipidologypharmacokineticsmetabolic regulationendocrinologymembrane biologysteroid metabolismmolecular metabolismhepatologycholesterol synthesis inhibitionpharmacological researchphysiologypharmacologylipoprotein metabolismnegative regulationmedicinal research

Developmental Expression of Sult1C4 Transcript Variants in Human Liver: Implications for Discordance Between Sult1C4 Mrna and Protein Levels. Drug Metabolism and Disposition (2020)

Sarah DubaisiHailin FangJoseph A. CarusoRoger GaedigkCarrie A. VyhlidalThomas A. KocarekMelissa Runge-Morris

medicinegene expressionvariant interpretationdrug metabolismgeneticsveterinary medicinedevelopmental geneticsdevelopmental expressionhepatologydevelopmental biologyprotein levelshuman geneticsliver physiologydrug developmenthuman liver

Developmental Expression of the Cytosolic Sulfotransferases in Human Liver. Drug Metabolism and Disposition (2019)

Sarah DubaisiJoseph A. CarusoRoger GaedigkCarrie A. VyhlidalPhilip C. SmithRonald N. HinesThomas A. KocarekMelissa Runge-Morris

medicinepharmacologycytosolic sulfotransferasesdrug metabolismdevelopmental expressionhepatologydevelopmental biologydrug developmenthuman liver

Farnesol Induces Fatty Acid Oxidation and Decreases Triglyceride Accumulation in Steatotic Heparg Cells. Toxicology and Applied Pharmacology (2019)

Asmita PantElizabeth A. RondiniThomas A. Kocarek

neurologydermatologyenvironmental toxicologypharmacologyaquatic toxicologyrespiratory toxicologydrug metabolismpharmacotherapyapplied pharmacologyhepatotoxicitytoxicologyclinical toxicologysteatotic heparg cellsexperimental toxicologyliver physiologyregulatory toxicology

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Thomas Kocarek

Professor

Wayne State University

Affiliations

School of Medicine

Pharmacology

Thomas Kocarek is currently serving as a Pharmacology Professor at Wayne State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Thomas Kocarek

Wayne State University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cytochrome P450 Induction Through the Efficient Photoinduced Release of a Pyridine-Substituted Agent From Ru(II). Journal of the American Chemical Society (2025)

Metabolism Disrupting Effects in Human Pre-Adipocytes: Influence of Donor Sex and Body Composition. Toxicology and Applied Pharmacology (2025)

Mixed Ru(II)–Ir(III) Complexes as Photoactive Inhibitors of the Major Human Drug Metabolizing Enzyme Cyp3a4. Inorganic Chemistry (2024)

Justin J. AhrensMadeline DenisonSantana GarciaSayak GuptaThomas A. KocarekIrina F. SevrioukovaClaudia TurroJeremy J. Kodanko

medicinal chemistrymajor human drugenzyme inhibitionpharmacologyphotoactive inhibitorscoordination chemistrycoordination complexdrug discoveryinorganic chemistrytransition metal chemistry

Nonylphenol and Cetyl Alcohol Polyethoxylates Disrupt Thyroid Hormone Receptor Signaling to Disrupt Metabolic Health. Endocrinology (2024)

Roxanne BérubéBrooklynn MurrayThomas A KocarekKatherine GurdzielChristopher D Kassotis

thyroidendocrinologythyroid hormonemetabolismbiochemistry

Dynamic Ir(III) Photosensors for the Major Human Drug-Metabolizing Enzyme Cytochrome P450 3a4. Inorganic Chemistry (2023)

Madeline DenisonJustin J. AhrensMarilyn N. DunbarHabon WarmahayeAliza MajeedClaudia TurroThomas A. KocarekIrina F. SevrioukovaJeremy J. Kodanko

Ir(III)-Based Agents for Monitoring the Cytochrome P450 3A4 Active Site Occupancy. Inorganic Chemistry (2022)

Madeline DenisonSean J. SteinkeAliza MajeedClaudia TurroThomas A. KocarekIrina F. SevrioukovaJeremy J. Kodanko

biological inorganic chemistryactive site occupancypharmacologyinorganic chemistry

Negative Regulation of Human Hepatic Constitutive Androstane Receptor by Cholesterol Synthesis Inhibition: Role of Sterol Regulatory Element Binding Proteins. Drug Metabolism and Disposition (2021)

Liberta CukoZofia Duniec-DmuchowskiElizabeth A. RondiniAsmita PantJohn K. FallonElizabeth M. WilsonNicholas J. PerainoJudy A. WestrickPhilip C. SmithThomas A. Kocarek

Developmental Expression of Sult1C4 Transcript Variants in Human Liver: Implications for Discordance Between Sult1C4 Mrna and Protein Levels. Drug Metabolism and Disposition (2020)

Sarah DubaisiHailin FangJoseph A. CarusoRoger GaedigkCarrie A. VyhlidalThomas A. KocarekMelissa Runge-Morris

Developmental Expression of the Cytosolic Sulfotransferases in Human Liver. Drug Metabolism and Disposition (2019)

Sarah DubaisiJoseph A. CarusoRoger GaedigkCarrie A. VyhlidalPhilip C. SmithRonald N. HinesThomas A. KocarekMelissa Runge-Morris

medicinepharmacologycytosolic sulfotransferasesdrug metabolismdevelopmental expressionhepatologydevelopmental biologydrug developmenthuman liver

Farnesol Induces Fatty Acid Oxidation and Decreases Triglyceride Accumulation in Steatotic Heparg Cells. Toxicology and Applied Pharmacology (2019)

Asmita PantElizabeth A. RondiniThomas A. Kocarek

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biomedical informatics

biostatistics

Nathan J Cherrington

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organic anion transport

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University of Arizona

translational research

toxicological aspect

Donald McDonnell

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cell biology

Shantu Amin

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polycyclic aromatic hydrocarbon

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