Faculty

Institution

Unit

Venue

Thomas E. Smithgall

William S McEllroy Professor and Chair

University of Pittsburgh

Affiliations

Kenneth P. Dietrich School of Arts and Sciences

Integrative Molecular Biology

Medicine

Interdisciplinary Biomedical Graduate Program

Microbiology and Molecular Genetics

Thomas E. Smithgall is currently serving as an Integrative Molecular Biology William S McEllroy Professor and Chair at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Thomas E. Smithgall

University of Pittsburgh

William S McEllroy Professor and Chair

You can click a keyword to filter the displayed items

molecular biology pharmacology immunology protein science biochemistry cell signaling hiv medicinal research gene expression virology enzyme inhibition enzymes tumor biology structural biology biological chemistry cancer biology general virology virus-host interactions viral genetics protein structure virus research molecular virology cancer genetics receptor tyrosine kinases leukemia molecular cancer protein function molecular regulation oncogenes antiviral research molecular physiology structural molecular biology cell regulation antiviral therapy molecular cell biology viral pathogenesis biomolecular interactions viral structural protein drug targeting signaling pathways redox biology protein expression viral replication enzyme specificity protein phosphorylation transcription regulation therapeutic efficacy infection control antiviral drug development protein chemistry vascular biology antiviral drugs host factors myeloid neoplasia c-fes protein-tyrosine kinase fes tyrosine kinase src-family kinases fibroblast growth factors gene function gene regulation human retrovirus pharmaceutical chemistry oncogenic agent src family kinases small molecule inhibitors myeloid differentiation myeloid leukemia cells tyrosine phosphorylation constitutive activation fibroblast transformation ras gtpase-activating protein hck tyrosine kinase c-fes tyrosine kinase src-family kinase hck kinase activation small-molecule inhibitors pathology signal transduction hiv nef cell biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Constitutive Activation of the Src-Family Kinases Fgr and Hck Enhances the Tumor Burden of Acute Myeloid Leukemia Cells in Immunocompromised Mice. Scientific Reports (2025)

Sherry T. ShuLi ChenGiancarlo Gonzalez-AreizagaThomas E. Smithgall

immune responsescancer cellscell biologyhematologyconstitutive activationcancer researchtumor biologyoncologycellular therapyimmunologycancer immunosurveillanceimmune checkpoint inhibitorshematological malignanciessrc-family kinases fgrimmunocompromised miceoncogenescancer discoveryleukemiamolecular biologytumor burdencellular immune responsesmyeloid neoplasia

Allosteric Restriction Enhances Sensitivity of the Aml-Associated Src-Family Kinase Fgr to Atp-Site Inhibitors. Biophysical Journal (2024)

Giancarlo Gonzalez-AreizagaJohn J. AlvaradoDu ShouchengThomas E. Smithgall

pharmacologybiophysical chemistrygene expressionbiophysicsenzyme inhibitionallosteric restrictionatp-site inhibitorsimmunologyexperimental biophysicsenzymesprotein sciencemolecular biophysics

An Sh3-Binding Allosteric Modulator Stabilizes the Global Conformation of the Aml-Associated Src-Family Kinase, Hck. Journal of Biological Chemistry (2024)

Ari M SelzerGabriella GerlachGiancarlo Gonzalez-AreizagaThomas E WalesStephanie Y CuiPrema IyerJohn R EngenCarlos CamachoRieko IshimaThomas E Smithgall

biochemistryprotein sciencebiomolecular structuremolecular cell biologygene expressionbiological chemistryprotein structureprotein assemblystructural molecular biologyprotein phosphorylationenzymesmolecular regulationprotein chemistryaml-associated src-family kinasebiophysicsprotein foldingmolecular biologycell signalingglobal conformation

Cocrystallization of the Src-Family Kinase Hck With the Atp-Site Inhibitor A-419259 Stabilizes an Extended Activation Loop Conformation. Biochemistry (2024)

Ari M. SelzerJohn J. AlvaradoThomas E. Smithgall

protein x-ray crystallographysrc-family kinase hcksignal transductionstructural biologyprotein foldingprotein structurebiochemistrymolecular biologystructural molecular biologyprotein phosphorylationatp-site inhibitorenzymesprotein sciencemolecular regulation

Mutagenesis of the Hiv-1 Nef Homodimerization Interface Suppresses Multiple Functions Without Altering the Core Fold. Biophysical Journal (2024)

Catherine E. ThomasFrank HeinrichJohn J. AlvaradoThomas E. Smithgall

mutagenesis (molecular biology technique)biophysical chemistrymutagenesisviral structural proteinvirologybiophysicscore foldvirus-host interactionsmultiple functionsvirus researchmolecular biologyimmunologyantiviral researchmolecular virologyviral geneticsgeneral virologyhivmolecular biophysics

Nef Defect Attenuates Hiv Viremia and Immune Dysregulation in the Bone Marrow-Liver-Thymus-Spleen (Blts) Humanized Mouse Model.. Virology (2024)

Shivkumar BiradarYash AgarwalAntu DasSherry T ShuJasmine SamalSara HoNickolas KellyDeepika MaheshShreya TeredesaiIsabella CastronovaLondon MussinaRobbie B MailliardThomas E SmithgallMoses T Bility

mouse modelhiv viremiavirologyimmune dysregulationnef defectimmunologyhiv

Protac-Mediated Degradation of Hiv-1 Nef Efficiently Restores Cell-Surface Cd4 and Mhc-I Expression and Blocks Hiv-1 Replication. Cell chemical biology (2024)

Lori A. Emert-SedlakColin M. TiceHaibin ShiJohn J. AlvaradoSherry T. ShuAllen B. ReitzThomas E. Smithgall

pharmacologyprotac-mediated degradationgene expressionvirologymhc-i expressionvirus researchviral replicationimmunologymedicinal researchantiviral researchcell biologymolecular virologyantiviral therapygeneral virologyhivclinical microbiology

Small-Molecule Allosteric Modulators of the Aml-Associated Src-Family Kinase, Hck. Biophysical Journal (2024)

Ari M. SelzerGabriella J. GerlachGiancarlo Gonzalez-AreizagaThomas E. WalesCarlos J. CamachoRieko IshimaJohn R. EngenThomas E. Smithgall

biophysical chemistrybiochemical sciencesmedical biophysicsbiochemistryprotein sciencemolecular physiologytumor biologymolecular biophysicssmall-molecule allosteric modulatorscancer geneticsimmunologyenzymesmolecular regulationaml-associated src-family kinasebiophysicsreceptor (biochemistry)cell signalingmedicinal researchexperimental biophysics

Abstract 2017: Conformation-Dependent Inhibition of the Aml-Associated Src-Family Kinase Fgr by Atp-Site Inhibitors. Journal of Biological Chemistry (2023)

Giancarlo Gonzalez-AreizagaShoucheng DuJohn AlvaradoThomas Smithgall

biological inorganic chemistrybiochemistrybiomolecular interactionsprotein sciencemembrane biologybiochemical geneticsatp-site inhibitorspharmacologymedicinal chemistrystructural biologybiological chemistrystructural molecular biologyprotein phosphorylationenzymesmolecular regulationconformation-dependent inhibitiondrug discoveryenzyme inhibitionmolecular biologymedicinal research

Membrane-Bound Merkel Cell Polyomavirus Middle T Protein Constitutively Activates Plcγ1 Signaling Through Src-Family Kinases. Proceedings of the National Academy of Sciences (2023)

Wen-Yu PengBizunesh AbereHaibin ShiSabrina TolandThomas E. SmithgallPatrick S. MooreYuan Chang

cancer biologygene expressionvirologyvirus-host interactionssrc-family kinasesvirus researchmolecular biologyprotein functioncell signalingimmunologymedicinal researchmolecular virologycell biologyviral geneticsgeneral virology

1
2
3
4
5
21
10 / page

Thomas E. Smithgall

William S McEllroy Professor and Chair

University of Pittsburgh

Affiliations

Kenneth P. Dietrich School of Arts and Sciences

Integrative Molecular Biology

Medicine

Interdisciplinary Biomedical Graduate Program

Microbiology and Molecular Genetics

Thomas E. Smithgall is currently serving as an Integrative Molecular Biology William S McEllroy Professor and Chair at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Thomas E. Smithgall

University of Pittsburgh

William S McEllroy Professor and Chair

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Constitutive Activation of the Src-Family Kinases Fgr and Hck Enhances the Tumor Burden of Acute Myeloid Leukemia Cells in Immunocompromised Mice. Scientific Reports (2025)

Sherry T. ShuLi ChenGiancarlo Gonzalez-AreizagaThomas E. Smithgall

Allosteric Restriction Enhances Sensitivity of the Aml-Associated Src-Family Kinase Fgr to Atp-Site Inhibitors. Biophysical Journal (2024)

Giancarlo Gonzalez-AreizagaJohn J. AlvaradoDu ShouchengThomas E. Smithgall

pharmacologybiophysical chemistrygene expressionbiophysicsenzyme inhibitionallosteric restrictionatp-site inhibitorsimmunologyexperimental biophysicsenzymesprotein sciencemolecular biophysics

An Sh3-Binding Allosteric Modulator Stabilizes the Global Conformation of the Aml-Associated Src-Family Kinase, Hck. Journal of Biological Chemistry (2024)

Ari M SelzerGabriella GerlachGiancarlo Gonzalez-AreizagaThomas E WalesStephanie Y CuiPrema IyerJohn R EngenCarlos CamachoRieko IshimaThomas E Smithgall

Cocrystallization of the Src-Family Kinase Hck With the Atp-Site Inhibitor A-419259 Stabilizes an Extended Activation Loop Conformation. Biochemistry (2024)

Ari M. SelzerJohn J. AlvaradoThomas E. Smithgall

Mutagenesis of the Hiv-1 Nef Homodimerization Interface Suppresses Multiple Functions Without Altering the Core Fold. Biophysical Journal (2024)

Catherine E. ThomasFrank HeinrichJohn J. AlvaradoThomas E. Smithgall

Nef Defect Attenuates Hiv Viremia and Immune Dysregulation in the Bone Marrow-Liver-Thymus-Spleen (Blts) Humanized Mouse Model.. Virology (2024)

Shivkumar BiradarYash AgarwalAntu DasSherry T ShuJasmine SamalSara HoNickolas KellyDeepika MaheshShreya TeredesaiIsabella CastronovaLondon MussinaRobbie B MailliardThomas E SmithgallMoses T Bility

mouse modelhiv viremiavirologyimmune dysregulationnef defectimmunologyhiv

Protac-Mediated Degradation of Hiv-1 Nef Efficiently Restores Cell-Surface Cd4 and Mhc-I Expression and Blocks Hiv-1 Replication. Cell chemical biology (2024)

Lori A. Emert-SedlakColin M. TiceHaibin ShiJohn J. AlvaradoSherry T. ShuAllen B. ReitzThomas E. Smithgall

Small-Molecule Allosteric Modulators of the Aml-Associated Src-Family Kinase, Hck. Biophysical Journal (2024)

Ari M. SelzerGabriella J. GerlachGiancarlo Gonzalez-AreizagaThomas E. WalesCarlos J. CamachoRieko IshimaJohn R. EngenThomas E. Smithgall

Abstract 2017: Conformation-Dependent Inhibition of the Aml-Associated Src-Family Kinase Fgr by Atp-Site Inhibitors. Journal of Biological Chemistry (2023)

Giancarlo Gonzalez-AreizagaShoucheng DuJohn AlvaradoThomas Smithgall

Membrane-Bound Merkel Cell Polyomavirus Middle T Protein Constitutively Activates Plcγ1 Signaling Through Src-Family Kinases. Proceedings of the National Academy of Sciences (2023)

Wen-Yu PengBizunesh AbereHaibin ShiSabrina TolandThomas E. SmithgallPatrick S. MooreYuan Chang

1
2
3
4
5
21
10 / page

Similar Faculty Members

Alan Wells

Institution

University of Pittsburgh

stem cell

stem-cell therapy

Donald McDonnell

Institution

Duke University

pharmacology

endocrinology

George Stark

Institution

Case Western Reserve University

molecular biology

immunology

Kamel Khalili

Institution

Temple University

neuroscience

neurodegenerative disease

Jens Meiler

Institution

Vanderbilt University

molecular informatics

biomolecular engineering

Gary Johnson

Institution

University of North Carolina at Chapel Hill

mapk kinase

apoptosis

Frank Mccormick

Institution

University of California, San Francisco

signaling pathway

cancer cell

Benjamin G. Neel, MD, PhD

Institution

New York University

gynecologic oncology

breast cancer

Salvatore Vincent Pizzo

Institution

Duke University

pharmacology

biochemistry

Jonathan D Licht

Institution

University of Florida

oncology

pathology

Similar Faculty Members

Alan Wells

Institution

University of Pittsburgh

stem cell

stem-cell therapy

Donald McDonnell

Institution

Duke University

pharmacology

endocrinology

George Stark

Institution

Case Western Reserve University

molecular biology

immunology

Kamel Khalili

Institution

Temple University

neuroscience

neurodegenerative disease

Jens Meiler

Institution

Vanderbilt University

molecular informatics

biomolecular engineering

Gary Johnson

Institution

University of North Carolina at Chapel Hill

mapk kinase

apoptosis

Frank Mccormick

Institution

University of California, San Francisco

signaling pathway

cancer cell

Benjamin G. Neel, MD, PhD

Institution

New York University

gynecologic oncology

breast cancer

Salvatore Vincent Pizzo

Institution

Duke University

pharmacology

biochemistry

Jonathan D Licht

Institution

University of Florida

oncology

pathology