Faculty

Institution

Unit

Venue

Thomas B. Kepler

Professor

Boston University

Affiliations

Chobanian & Avedisian School of Medicine

Basic Science Departments

Virology, Immunology & Microbiology

Thomas B. Kepler is currently serving as a Basic Science S Professor at Boston University.

Honors

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Experiences

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Education

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Thomas B. Kepler

Boston University

Professor

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immunology virology hiv immune responses genetics molecular biology antibody engineering virus research infectious diseases virus-host interactions adaptive immune system general virology vaccination genomics viral evolution viral genetics vaccines viral pathogenesis bioinformatics medical virology medicinal research mammalian biology population genetics antiviral research clinical microbiology antiviral therapy innate immune system vaccine research genome biology respiratory medicine molecular virology cellular immune responses molecular immunology affinity maturation theoretical biology infection control clinical immunology neutralizing antibodies antiviral responses human retrovirus histocompatibility immunogenetics vaccine development somatic hypermutation experimental medicine host response viral diagnostics experimental biology host-microbe interactions flow cytometry germinal centers neutralization breadth avian biology clinical investigation bayesian analysis biomedical informatics antibody screening genetic diversity tolerance induction transplantation medicine cell migration viral dynamics computational genomics sequence analysis viral persistence immunochemistry immune pressure thymus transplantation b-cell clonal lineage antibody development key mutations mutation rates luria-delbruck distribution rhesus macaques hiv infection founder virus global health mathematical bioscience system immunology social determinants of health immunity (medicine) multilevel systems epidemiology

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Characterizing Adjuvants’ Effects at Murine Immunoglobulin Repertoire Level. iScience (2023)

Feng FengRachel YuenYumei WangAxin HuaThomas B. KeplerLee M. Wetzler

pharmacologyimmunity (medicine)immunologymedicine

Diversity of B Cell Populations and Ig Repertoire in Human Lungs. The Journal of Immunology (2023)

Fumiaki AiharaYumei WangAnna C. BelkinaRachel FearnsJoseph P. MizgerdFeng FengThomas B. Kepler

geneticsig repertoireadaptive immune systemimmune responsesrespiratory medicinehistocompatibilityinnate immune systemimmunologyhuman tissuescell biologymammalian biologyhuman lungs

An Epitope-Enriched Immunogen Expands Responses to a Conserved Viral Site. Cell Reports (2022)

Timothy M. CaradonnaLarance RonsardAshraf S. YousifIan W. WindsorRachel HechtThalia Bracamonte-MorenoAnne A. RofflerMax J. MaronDaniel P. MaurerJared FeldmanElisa MarchioriRalston M. BarnesDaniel RohrerNils LonbergThomas H. OguinGregory D. SempowskiThomas B. KeplerMasayuki KuraokaDaniel LingwoodAaron G. Schmidt

immune responsesvirologyepitope-enriched immunogenvirus-host interactionscell culturevirus researchimmunologyconserved viral sitecell biologyviral persistence

Clonal and Diversity Differences of Extravascular B Cells in the Influenza-Experienced Lung. The Journal of Immunology (2022)

Michael P BreenFeng FengFumiaki AiharaNeelou EtesamiRachel FearnsJoseph MizgerdThomas B Kepler

adaptive immune systemhealth sciencesimmune responsesrespiratory medicineinfluenza-experienced lungdiversity differencesimmunologycell biologyinfluenza

Development of Neutralization Breadth Against Diverse Hiv‐1 by Increasing Ab–Ag Interface on V2. Advanced Science (2022)

Nan GaoYanxin GaiLina MengChu WangWei WangXiaojun LiTiejun GuMark K. LouderNicole A. Doria‐RoseKevin WieheAlexandra F. NazzariAdam S. OliaJason GormanReda RawiWenmin WuClayton SmithHtet KhantNatalia de ValBin YuJunhong LuoHaitao NiuYaroslav TsybovskyHuaxin LiaoThomas B. KeplerPeter D. KwongJohn R. MascolaChuan QinTongqing ZhouXianghui YuFeng Gao

vaccinesinfection controlviral evolutionantiviral responsesimmune responsesclinical microbiologyanti-virus techniqueab-ag interfaceantiviral therapyvaccinationneutralization breadthvirologyvirus researchimmunologyglobal healthhivvirus-host interactionspublic healthantiviral researchgeneral virology

Augmenting Neutralization Breadth Against Diverse Hiv-1 by Increasing the Ab-Ag Interface on V2. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Nan GaoYanxin GaiLina MengChu WangWei WangXiaojun LiTiejun GuMark K. LouderNicole A. Doria-RoseKevin WieheAlexandra F. NazzariAdam S. OliaJason GormanReda RawiWenmin WuClayton SmithHtet KhantNatalia de ValBin YuJunhong LuoHaitao NiuYaroslav TsybovskyHuaxin LiaoThomas B. KeplerPeter D. KwongJohn R. MascolaChuan QinTongqing ZhouXianghui YuFeng Gao

vaccinesinfection controlviral evolutionimmune responsesclinical microbiologyhuman retrovirusab-ag interfaceantiviral therapyvaccinationneutralization breadthvirologyvirus researchimmunologyglobal healthhivepidemiologyvirus-host interactionsantiviral researchviral geneticsgeneral virology

Lung Resident Memory B Cells Confer Protection Against Local Bacterial Infection. (2021)

N.S. EtesamiK.A. BarkerA.T. ShenoyE.I. ArafaC. Lyon De AnaI.M.C. MartinW.N. GoltryX. ZhongT.B. KeplerJ.L. BrowningM.R. JonesL.J. QuintonJ.P. Mizgerd

neurologyinfection controladaptive immune systemrespiratory medicineneuroscienceinnate immune systemimmunologyveterinary medicinelocal bacterial infectionimmune responses

Antibody Evolution Immunogens. OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (2020)

Haynes, Barton F.Liao, Hua-XinLynch, Rebecca M.Zhou, TongqingGao, FengBoyd, ScottShaw, George M.Hahn, Beatrice H.Kepler, Thomas B.Korber, Bette T.Kwong, PeterMascola, John R.

antibody evolution immunogensimmunologyantibody engineering

Egyptian Rousette Ifn-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells. Frontiers in Immunology (2020)

Stephanie S. PavlovichTamarand DarlingAdam J. HumeRobert A. DaveyFeng FengElke MühlbergerThomas B. Kepler

geneticstranscriptional responsesvirologyinfectious diseasesvirus-host interactionsvirus researchimmunologyconspecific cells

Fab-Dimerized Glycan-Reactive Antibodies Neutralize Hiv and Are Prevalent in Humans and Rhesus Macaques. bioRxiv (Cold Spring Harbor Laboratory) (2020)

Wilton B. WilliamsR. Ryan MeyerhoffRJ EdwardsHui LiNathan I. NicelyRory HendersonYe ZhouKatarzyna JanowskaKatayoun MansouriKartik ManneVictoria StallsAllen L. HsuMario J. BorgniaGuillaume Stewart-JonesMatthew S. LeeNaomi BronkemaJohn PerfectM. Anthony MoodyKevin WieheTodd BradleyThomas B. KeplerS. Munir AlamRobert J. ParksAndrew FoulgerMattia BonsignoriCelia C. LaBrancheDavid C. MontefioriMichael SeamanSampa SantraJoseph R. FrancicaGeoffrey M. LynnBaptiste AussedatWilliam E. WalkowiczRichard LagaGarnett KelsoeKevin O. SaundersDaniela FeraPeter D. KwongRobert A. SederAlberto BartesaghiGeorge M. ShawPriyamvada AcharyaBarton F. Haynes

pharmacologyhealth sciencesvirologyfab-dimerized glycan-reactive antibodiesrhesus macaquesimmunologyhivclinical microbiology

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Thomas B. Kepler

Professor

Boston University

Affiliations

Chobanian & Avedisian School of Medicine

Basic Science Departments

Virology, Immunology & Microbiology

Thomas B. Kepler is currently serving as a Basic Science S Professor at Boston University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Thomas B. Kepler

Boston University

Professor

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Characterizing Adjuvants’ Effects at Murine Immunoglobulin Repertoire Level. iScience (2023)

Feng FengRachel YuenYumei WangAxin HuaThomas B. KeplerLee M. Wetzler

pharmacologyimmunity (medicine)immunologymedicine

Diversity of B Cell Populations and Ig Repertoire in Human Lungs. The Journal of Immunology (2023)

Fumiaki AiharaYumei WangAnna C. BelkinaRachel FearnsJoseph P. MizgerdFeng FengThomas B. Kepler

geneticsig repertoireadaptive immune systemimmune responsesrespiratory medicinehistocompatibilityinnate immune systemimmunologyhuman tissuescell biologymammalian biologyhuman lungs

An Epitope-Enriched Immunogen Expands Responses to a Conserved Viral Site. Cell Reports (2022)

immune responsesvirologyepitope-enriched immunogenvirus-host interactionscell culturevirus researchimmunologyconserved viral sitecell biologyviral persistence

Clonal and Diversity Differences of Extravascular B Cells in the Influenza-Experienced Lung. The Journal of Immunology (2022)

Michael P BreenFeng FengFumiaki AiharaNeelou EtesamiRachel FearnsJoseph MizgerdThomas B Kepler

adaptive immune systemhealth sciencesimmune responsesrespiratory medicineinfluenza-experienced lungdiversity differencesimmunologycell biologyinfluenza

Development of Neutralization Breadth Against Diverse Hiv‐1 by Increasing Ab–Ag Interface on V2. Advanced Science (2022)

Augmenting Neutralization Breadth Against Diverse Hiv-1 by Increasing the Ab-Ag Interface on V2. bioRxiv (Cold Spring Harbor Laboratory) (2021)

Lung Resident Memory B Cells Confer Protection Against Local Bacterial Infection. (2021)

N.S. EtesamiK.A. BarkerA.T. ShenoyE.I. ArafaC. Lyon De AnaI.M.C. MartinW.N. GoltryX. ZhongT.B. KeplerJ.L. BrowningM.R. JonesL.J. QuintonJ.P. Mizgerd

neurologyinfection controladaptive immune systemrespiratory medicineneuroscienceinnate immune systemimmunologyveterinary medicinelocal bacterial infectionimmune responses

Antibody Evolution Immunogens. OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (2020)

Haynes, Barton F.Liao, Hua-XinLynch, Rebecca M.Zhou, TongqingGao, FengBoyd, ScottShaw, George M.Hahn, Beatrice H.Kepler, Thomas B.Korber, Bette T.Kwong, PeterMascola, John R.

antibody evolution immunogensimmunologyantibody engineering

Egyptian Rousette Ifn-ω Subtypes Elicit Distinct Antiviral Effects and Transcriptional Responses in Conspecific Cells. Frontiers in Immunology (2020)

Stephanie S. PavlovichTamarand DarlingAdam J. HumeRobert A. DaveyFeng FengElke MühlbergerThomas B. Kepler

geneticstranscriptional responsesvirologyinfectious diseasesvirus-host interactionsvirus researchimmunologyconspecific cells

Fab-Dimerized Glycan-Reactive Antibodies Neutralize Hiv and Are Prevalent in Humans and Rhesus Macaques. bioRxiv (Cold Spring Harbor Laboratory) (2020)

pharmacologyhealth sciencesvirologyfab-dimerized glycan-reactive antibodiesrhesus macaquesimmunologyhivclinical microbiology

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