Faculty

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Sue Leurgans

Rush University

Affiliations

Rush Medical College

Center Of Rush Alzheimer'S Disease

News & Events

Rush University

Sue Leurgans is a Senior Professor at Rush University, specializing in the neuroscience of aging, dementia, and neurodegenerative diseases. Her research integrates neuropathology, neuroimaging, and clinical epidemiology to elucidate the determinants of cognitive decline in older populations. Her recent work links aberrant mitochondrial metabolism and ferroptosis to Alzheimer's disease, examines hippocampal neuronal loss in LATE-NC and ADNC, and investigates the MIND diet's association with hippocampal sclerosis. She also studies cerebrovascular pathology in Black decedents and deep gray matter morphometry, contributing to landmark studies on aging and dementia.

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Sue Leurgans

Rush University

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neuroscience neurology neuroscience of aging alzheimer's disease geriatrics cognitive impairment dementia neurodegenerative diseases ageing neuropathology aging-associated diseases parkinson's disease cognitive science rehabilitation later adulthood experimental gerontology movement disorders neurorehabilitation molecular neurodegeneration older adults geriatric neurology social gerontology cognitive decline neuroradiology brain health brain pathology cerebrovascular disease vascular dementia brain function community-dwelling older adults neuropsychological rehabilitation cerebral blood flow biological psychiatry motor disorders geriatric medicine aging cell mild cognitive impairment vascular cognitive disorder mobility memory loss elderly care stroke rehabilitation neuropsychopharmacology neuropsychiatry degenerative disease healthy aging community-dwelling older persons older persons cohort studies active ageing clinical neurology neurovascular diseases motor function translational psychiatry psychiatric research frailty clinical neuroscience alzheimer disease physical aging neurotology tic disorders stereotypic movement disorder brain science loneliness magnetic resonance imaging old age older black adults molecular psychiatry early life exposures brain imaging parkinson disease tourette syndrome alzheimer ’ cognitive function physical frailty motor decline

Notable Scholarly Works

Notable Federal Grants

Collaborators

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress With Ferroptosis. Advanced Science (2025)

neurologyaberrant mitochondrial metabolismfree radical biologyredox biologymitochondrial functionmolecular metabolismcognitive impairmentmolecular neurodegenerationmetabolismdegenerative pathologyalzheimer's diseaseoxidative stressneurodegenerative diseasesbiochemistrycell metabolism

Arteriolosclerosis in Cns Tissues Outside the Cerebrum and Late-Life Motor Impairment. Stroke (2025)

neurologyneurovascular diseasesbrain circulationneuropathologyarterial diseaseneuroradiologycns tissueslate-life motor impairmentcerebral blood flowcentral nervous systemneuroscienceblood vessels

Arts is Associated With Vascular Risk Factors, MCI, Dementia, and Stroke. Alzheimer s & Dementia (2025)

neurologyvascular dementiaart educationcerebrovascular diseasevascular cognitive disorderart therapyarts-based researchdementiavisual artscognitive impairmentcerebral blood flowvascular risk factorsstrokeneuroscience of agingartcardiovascular disease

Association of an in Vivo Classifier for Arteriolosclerosis (Arts) With Cortical Thickness and Cognition in Older Adults. Neurobiology of Aging (2025)

peripheral artery diseaseneurologyrehabilitationvascular cognitive disorderolder adultsneurorehabilitationarterial diseasecortical thicknessvascular agingcognitive impairmentcerebral blood flowvivo classifierneuroscience of agingblood vesselscardiovascular disease

Cerebral Amyloid Angiopathy is Associated With Higher R 2 Relaxation Rate: An Mri and Pathology Study. Annals of Clinical and Translational Neurology (2025)

neurologybrain pathologyradiologyneurovascular diseasesneuroimagingneuropathologypathology studyneuroradiologymolecular neurodegenerationneuroscience of agingcerebral blood flowalzheimer's diseaseneuroscienceneurodegenerative diseases

Cerebrovascular Pathology and Cognitive Outcomes in Older Black Decedents. Stroke (2025)

neurologyvascular dementiaageingcognitive outcomesvascular cognitive disorderaging-associated diseasesneuropathologyneuroradiologydementiacognitive impairmentneuroscience of agingcerebral blood flowneuroscience

Contributions of Major Tau Kinase Activation and Phospho-Tau Accumulation to Cortical and Hippocampal Tangle Formation and Cognition in Older Adults. Neurobiology of Disease (2025)

brain pathologyageinghippocampal tangle formationolder adultsaging-associated diseasescognitive impairmentmolecular neurodegenerationneuroscience of agingdegenerative pathologyphospho-tau accumulationalzheimer's diseaseneuroscienceneurodegenerative diseasescell biology

Dietary Patterns Associated With Risk of Intracranial Atherosclerosis in Older Adults With Hypertension or Myocardial Infarction. Neurology (2025)

public healthneurologydyslipidemiaclinical lipidologynutritional epidemiologydietary healtholder adultsatherosclerosismedicinal foodsdietary patterns associatedintracranial atherosclerosismedical nutritionclinical nutritionnutritionhealth sciencespublic health nutritioncardiovascular disease

Elevated Neuroinflammation, Autoimmunity, and Altered Igg Glycosylation Profile in the Cerebral Spinal Fluid of Severe Covid-19 Patients. Brain Behavior and Immunity (2025)

immunologyneurologyneuroinflammationcovid-19immunologic diseasesneuroimmunologyigg glycosylation profilecerebral spinal fluidautoimmunitysevere covid-19 patientsautoinflammatory diseasebrain-immune interactioninflammation

Excess Deaths Due to Incident Alzheimer’s Dementia in Women and Men in the United States. medRxiv (2025)

public healthvascular dementiaageingexperimental gerontologyaging-associated diseasesalzheimer ’nursingfamily medicineunited statesdementiacognitive impairmentalzheimer's diseaseexcess deathsneuroscience of agingmortality

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Sue Leurgans

Rush University

Affiliations

Rush Medical College

Center Of Rush Alzheimer'S Disease

News & Events

Rush University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Sue Leurgans

Rush University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Aberrant Mitochondrial Metabolism in Alzheimer's Disease Links Energy Stress With Ferroptosis. Advanced Science (2025)

Arteriolosclerosis in Cns Tissues Outside the Cerebrum and Late-Life Motor Impairment. Stroke (2025)

neurologyneurovascular diseasesbrain circulationneuropathologyarterial diseaseneuroradiologycns tissueslate-life motor impairmentcerebral blood flowcentral nervous systemneuroscienceblood vessels

Arts is Associated With Vascular Risk Factors, MCI, Dementia, and Stroke. Alzheimer s & Dementia (2025)

Association of an in Vivo Classifier for Arteriolosclerosis (Arts) With Cortical Thickness and Cognition in Older Adults. Neurobiology of Aging (2025)

Cerebral Amyloid Angiopathy is Associated With Higher R 2 Relaxation Rate: An Mri and Pathology Study. Annals of Clinical and Translational Neurology (2025)

Cerebrovascular Pathology and Cognitive Outcomes in Older Black Decedents. Stroke (2025)

Contributions of Major Tau Kinase Activation and Phospho-Tau Accumulation to Cortical and Hippocampal Tangle Formation and Cognition in Older Adults. Neurobiology of Disease (2025)

Dietary Patterns Associated With Risk of Intracranial Atherosclerosis in Older Adults With Hypertension or Myocardial Infarction. Neurology (2025)

Elevated Neuroinflammation, Autoimmunity, and Altered Igg Glycosylation Profile in the Cerebral Spinal Fluid of Severe Covid-19 Patients. Brain Behavior and Immunity (2025)

Excess Deaths Due to Incident Alzheimer’s Dementia in Women and Men in the United States. medRxiv (2025)

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