Faculty

Institution

Unit

Venue

Steven Roose

Professor of Clinical Psychiatry

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

PSY Geriatric Psychiatry

Steven Roose is a Professor of Clinical Psychiatry at Columbia University, where he specializes in geriatric psychiatry, particularly the psychopathology and treatment of late-life depression. His research interests center on antidepressant augmentation strategies, treatment-resistant depression, brain-cognition relationships, and clinical moderators of remission in older adults. He leads the OPTIMUM clinical trial, and his recent 2024–2025 publications examine predictors of remission, sleep disturbances, substance use, and the relationship between PHQ-9 and MADRS scales in geriatric patients, contributing to evidence-based psychiatric care for this population.

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Steven Roose

Columbia University

Professor of Clinical Psychiatry

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psychiatry depression geriatric psychiatry psychopathology psychology psychiatric research mental health psychological medicine translational psychiatry psychiatric epidemiology affective disorders clinical psychology medicine psychiatric care pharmacology geriatrics biological psychiatry pharmacotherapy jama psychiatry clinical trials therapeutic approach clinical psychiatry symptom management older adults counseling psychology sexual medicine neuroscience of aging applied pharmacology psychological methods psychotropic medication psychiatric disorders psychopharmacology late-life depression psychoneuroendocrinology molecular psychiatry later adulthood treatment-resistant depression late life depression psychiatric diseases psychoanalytic psychotherapy clinical gerontology frailty geriatric medicine mood symptom subcortical ischemic depression drug treatment pilot study psychodynamic neuropsychiatry depressive symptoms age-related hearing loss later life brain imaging biogerontology magnetic resonance imaging randomized controlled trials antidepressant clinical trials major depression ischemic heart disease antidepressant treatment erectile dysfunction sexual dysfunction covid-19 pandemic meta-analysis geriatric assessment population aging geriatric neurology sex therapy comorbid psychiatric disorders clinical pharmacology drug safety cardiovascular pharmacology treatment and prevention cognitive decline placebo-controlled trial major depressive disorder

Notable Scholarly Works

Notable Federal Grants

Collaborators

Augmentation vs. Switching Medications in Older Patients With Treatment-Resistant Depression: Clinical Moderators That Matter. European Psychiatry (2025)

older patientsmedicinetreatment-resistant depressiondrug treatmentmental healthgeriatric psychiatrydepressionpharmacotherapytherapy resistanceclinical moderatorspsychiatrygeriatricspsychiatric carepsychological medicineaffective disorderstreatment optionspsychotropic medication

Brain-Cognition Relationships and Markers Predicting Remission in Treatment-Resistant Late-Life Depression. Biological Psychiatry (2025)

psychiatric disordersmood symptommental healthpsychopathologygeriatric psychiatrydepressionpsychologysubcortical ischemic depressionpsychiatrytranslational psychiatrycognitive impairmentmarkers predicting remissionaffective disordersneuroscience

Brain-Cognition Relationships and Treatment Outcome in Treatment-Resistant Late-Life Depression. Research Square (2025)

mood symptomgeriatric psychiatrypsychopathologydepressionpsychologypsychiatric researchsubcortical ischemic depressionpsychiatrytranslational psychiatryaffective disordersbrain-cognition relationshipscognitive therapypsychological medicine

Moderators of Antidepressant Augmentation Versus Switch in the Optimum Randomised Controlled Trial. The British Journal of Psychiatry (2025)

medicinepsychopharmacologydrug treatmentdepressionpharmacotherapypsychiatric researchrelapse preventionclinical trialspsychiatrypsychiatric carepsychological medicinetreatment optionspsychotropic medication

0959 Sleep and Pharmacotherapy in Treatment-Resistant Late-Life Depression: Findings From the Optimum Clinical Trial. SLEEP (2024)

Michael MakMarie Anne GebaraEric LenzeDaniel BlumbergerPatrick BrownPilar CristanchoAlastair FlintJordan KarpHelen LavretskyJ Philip MillerCharles Reynolds IIISteven RooseBenoit MulsantSarah Stahl

pharmacologysleep medicinedepressionpharmacotherapysleeppsychiatryclinical trialsoptimum clinical trialtreatment-resistant late-life depression

Alcohol and Substance Use in Older Adults With Treatment‐Resistant Depression. International Journal of Geriatric Psychiatry (2024)

Maytinee SrifuengfungEric J. LenzeSteven P. RoosePatrick J. BrownHelen LavretskyJordan F. KarpCharles F. ReynoldsMichael YinglingNaratip Sa‐nguanpanichBenoit H. Mulsant

alcohol (drug)treatment-resistant depressionolder adultsmental healthgeriatric psychiatrylater adulthooddepressionalcohol misusepsychiatrysubstance use

Chapter 61. Treatment During Late Life. American Psychiatric Association Publishing eBooks (2024)

medicineageingexperimental gerontologygeriatric psychiatrypsychiatrygeriatricsdeath study

Poor Sleep is Common in Treatment-Resistant Late-Life Depression and Associated With Poorer Antidepressant Response: Findings From the Optimum Clinical Trial. American Journal of Geriatric Psychiatry (2024)

Michael S B MakMarie Anne GebaraEric J LenzeDaniel M BlumbergerPatrick J BrownPilar CristanchoAlastair J FlintJordan F KarpHelen LavretskyJ Philip MillerCharles F ReynoldsSteven P RooseBenoit H MulsantSarah T Stahl

mental healthinsomniageriatric psychiatrydepressionsleeppoor sleeppsychiatrypoorer antidepressant responseoptimum clinical trialtreatment-resistant late-life depression

Relationship Between Patient Health Questionnaire (Phq-9) and Montgomery-Asberg Depression Rating Scale (Madrs) Total Scores in Older Adults With Major Depressive Disorder: An Analysis of the Optimum Clinical Trial. Journal of Affective Disorders (2024)

Helena K. KimEric J. LenzeNicholas J. AinsworthDaniel M. BlumbergerPatrick J. BrownAlastair J. FlintJordan F. KarpHelen LavretskyEmily LenardJ. Philip MillerCharles F. ReynoldsSteven P. RooseBenoit H. Mulsant

older adultsmajor depressive disordermental healthpatient health questionnairegeriatric psychiatrylater adulthoodpsychiatrypsychometricsgeriatricsoptimum clinical trialtotal scorespsychological assessment

Treatment of Cognitive Impairment in Late Life Depression. American Journal of Geriatric Psychiatry (2024)

Paul A NewhouseSteven P Roose

geriatric psychiatrydepressionpsychiatrycognitive impairmentlate life depressioncognitive therapy

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Steven Roose

Professor of Clinical Psychiatry

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

PSY Geriatric Psychiatry

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Steven Roose

Columbia University

Professor of Clinical Psychiatry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Augmentation vs. Switching Medications in Older Patients With Treatment-Resistant Depression: Clinical Moderators That Matter. European Psychiatry (2025)

Brain-Cognition Relationships and Markers Predicting Remission in Treatment-Resistant Late-Life Depression. Biological Psychiatry (2025)

Brain-Cognition Relationships and Treatment Outcome in Treatment-Resistant Late-Life Depression. Research Square (2025)

Moderators of Antidepressant Augmentation Versus Switch in the Optimum Randomised Controlled Trial. The British Journal of Psychiatry (2025)

0959 Sleep and Pharmacotherapy in Treatment-Resistant Late-Life Depression: Findings From the Optimum Clinical Trial. SLEEP (2024)

Michael MakMarie Anne GebaraEric LenzeDaniel BlumbergerPatrick BrownPilar CristanchoAlastair FlintJordan KarpHelen LavretskyJ Philip MillerCharles Reynolds IIISteven RooseBenoit MulsantSarah Stahl

pharmacologysleep medicinedepressionpharmacotherapysleeppsychiatryclinical trialsoptimum clinical trialtreatment-resistant late-life depression

Alcohol and Substance Use in Older Adults With Treatment‐Resistant Depression. International Journal of Geriatric Psychiatry (2024)

Maytinee SrifuengfungEric J. LenzeSteven P. RoosePatrick J. BrownHelen LavretskyJordan F. KarpCharles F. ReynoldsMichael YinglingNaratip Sa‐nguanpanichBenoit H. Mulsant

alcohol (drug)treatment-resistant depressionolder adultsmental healthgeriatric psychiatrylater adulthooddepressionalcohol misusepsychiatrysubstance use

Chapter 61. Treatment During Late Life. American Psychiatric Association Publishing eBooks (2024)

medicineageingexperimental gerontologygeriatric psychiatrypsychiatrygeriatricsdeath study

mental healthinsomniageriatric psychiatrydepressionsleeppoor sleeppsychiatrypoorer antidepressant responseoptimum clinical trialtreatment-resistant late-life depression

Treatment of Cognitive Impairment in Late Life Depression. American Journal of Geriatric Psychiatry (2024)

Paul A NewhouseSteven P Roose

geriatric psychiatrydepressionpsychiatrycognitive impairmentlate life depressioncognitive therapy

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5
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10 / page