Faculty

Institution

Unit

Venue

Steven E. Mansoor, M.D., Ph.D.

Associate Professor of Chemical Physiology and Biochemistry School of Medicine Associate Professor of Medicine Division of Cardiovascular Medicine School of Medicine

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Bob And Charlee Moore Institute For Nutrition And Wellness

Center For Developmental Health (Formerly Heart Research Center)

Department Of Medicine

Cardiovascular Medicine

Center Of The Amyloidosis

Division Of Cardiology

Institute Of Knight Cardiovascular

Department Of Physiology And Pharmacology

Department of Medicine

Division of General Cardiology

Center For Developmental Health (Formerly Heart Research Center)

Institute Of Knight Cardiovascular

Oregon Health & Science University

Bob And Charlee Moore Institute For Nutrition And Wellness

School Of Medicine

Division Of Cardiology

School Of Medicine

Steven E. Mansoor, M.d., Ph.d. is currently serving as a Bob And Charlee Moore Institute For Nutrition And Wellness Associate Professor of Chemical Physiology and Biochemistry School of Medicine Associate Professor of Medicine Division of Cardiovascular Medicine School of Medicine at Oregon Health & Science University.

Honors

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Experiences

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Education

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Steven E. Mansoor, M.D., Ph.D.

Oregon Health & Science University

Associate Professor of Chemical Physiology and Biochemistry School of Medicine Associate Professor of Medicine Division of Cardiovascular Medicine School of Medicine

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receptors receptor (biochemistry) biochemistry molecular biology pharmacology pharmacological research mechanisms of action cell biology molecular pharmacology molecular physiology protein science cellular physiology cellular biochemistry g protein-coupled receptor exploratory data analysis energy data large-scale datasets protein structure structural molecular biology medicinal research molecular cell biology structural biology biophysical chemistry fluorescence spectroscopy fluorescence biological chemistry pharmacological agents enzymes biomolecular structure enzyme inhibition biological function neuropeptide receptors membrane transport single molecule biophysics protein chemistry biomolecular interactions functional selectivity rational drug design biochemical sciences molecular science molecular structure biological macromolecules clinical otolaryngology molecular communication single-molecule detection lipid science human sciences protein function gene regulation structural bioinformatics protein modeling drug targets drug targeting auditory physiology auditory science human hearing degenerative pathology system pharmacology pulmonary vascular disease chest injury human p2x3 receptor antagonist action x-ray structures tryptophan residues bimane fluorescence distance mapping tryptophan-induced quenching rhodopsin self-associates asolectin liposomes creb-binding properties variant camp-regulated enhancers bimane derivative site-directed fluorescence labeling solvent accessibility fluorescent probe monobromobimane protein secondary structure

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Brain-Penetrant P2X7R Antagonist Mitigates Alzheimer’s Disease Pathology. bioRxiv (Cold Spring Harbor Laboratory) (2026)

neuroscience of agingalzheimer's diseasedegenerative pathologymolecular neurodegenerationneuropharmacologyneuropsychopharmacologyneuroscienceneurodegenerative diseasespharmacologydisease pathology

A Polycyclic Scaffold Identified by Structure-Based Drug Design Effectively Inhibits the Human P2X7 Receptor. Nature Communications (2025)

human p2x7 receptorbiological macromoleculesdrug targetingpolycyclic scaffolddrug targetsmedicinal researchpharmacological agentsenzyme inhibitionrational drug designstructure-based drug designpharmacologytherapeutic targetsdrug discoverypharmacological researchreceptorsbiomolecular engineeringmechanisms of action

Bps2025 - Cryo-Em Structures of the Human P2X1 Receptor Reveal Subtype-Specific Architecture and Antagonism by Supramolecular Ligand-Binding. Biophysical Journal (2025)

structural molecular biologysupramolecular ligand-bindingcell biologyreceptor (biochemistry)cryo-em structuresmolecular cell biologymolecular biologymolecular pharmacologybiomolecular interactionspharmacological researchreceptorsmechanisms of action

Bps2025 - Human P2X4 Receptor Gating is Modulated by a Stable Cytoplasmic Cap and Putative Lipid Binding Sites. Biophysical Journal (2025)

lipidscell signalingcell biologymembrane proteinscellular physiologybiochemistryreceptor (biochemistry)molecular physiologymembrane biologymolecular cell biologymolecular biologybiological chemistryg protein-coupled receptorstable cytoplasmic capsignal transductionreceptorscellular biochemistry

Bps2025 - Molecular Pharmacology of Human P2X7 Receptor Ligands Visualized by Cryo-Em. Biophysical Journal (2025)

medicinal researchbiochemistryreceptor (biochemistry)pharmacologysystem pharmacologymolecular pharmacologypharmacological researchreceptorsmechanisms of action

Giant Pulmonary Artery Masquerading as Pneumonia. BMJ Case Reports (2025)

respiratory medicinegiant pulmonary arteryinterstitial lung diseasepneumothoraxpulmonary vascular diseasechest injurycritical care

High-Affinity Agonism at the P2X7 Receptor is Mediated by Three Residues Outside the Orthosteric Pocket (Abstract Id: 191502). Journal of Pharmacology and Experimental Therapeutics (2025)

orthosteric pockethigh-affinity agonismpharmacologyg protein-coupled receptorcell signalingp2x7 receptor ismolecular biologyreceptorscellular biochemistrymechanisms of actionbiochemistrybiological chemistryprotein sciencefunctional selectivityreceptor (biochemistry)molecular physiologymolecular pharmacologysignal transductionpharmacological research

High-Resolution Structures of the Human P2X2 Receptor – an Atp-Gated Ion Channel (Abstract Id: 190950). Journal of Pharmacology and Experimental Therapeutics (2025)

biophysicsatp-gated ion channelphysiologymembrane transportabstract idneuronscellular physiologyreceptor (biochemistry)human p2x2 receptorpharmacological researchreceptors

Human P2X4 Receptor Gating is Modulated by a Stable Cytoplasmic Cap and a Unique Allosteric Pocket. Science Advances (2025)

cell signalingcell biologycellular physiologybiochemistryreceptor (biochemistry)molecular physiologymolecular cell biologymolecular biologyg protein-coupled receptorstable cytoplasmic capsignal transductionunique allosteric pocketreceptorscellular biochemistrymechanisms of action

Molecular Mechanisms of P2X Receptor Desensitization. Structural Dynamics (2025)

cell signalingcell biologycellular physiologyreceptor (biochemistry)p2x receptor desensitizationmolecular physiologypharmacologymolecular pharmacologysignal transductionpharmacological researchreceptors

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Steven E. Mansoor, M.D., Ph.D.

Associate Professor of Chemical Physiology and Biochemistry School of Medicine Associate Professor of Medicine Division of Cardiovascular Medicine School of Medicine

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Bob And Charlee Moore Institute For Nutrition And Wellness

Center For Developmental Health (Formerly Heart Research Center)

Department Of Medicine

Cardiovascular Medicine

Center Of The Amyloidosis

Division Of Cardiology

Institute Of Knight Cardiovascular

Department Of Physiology And Pharmacology

Department of Medicine

Division of General Cardiology

Center For Developmental Health (Formerly Heart Research Center)

Institute Of Knight Cardiovascular

Oregon Health & Science University

Bob And Charlee Moore Institute For Nutrition And Wellness

School Of Medicine

Division Of Cardiology

School Of Medicine

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Steven E. Mansoor, M.D., Ph.D.

Oregon Health & Science University

Associate Professor of Chemical Physiology and Biochemistry School of Medicine Associate Professor of Medicine Division of Cardiovascular Medicine School of Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Brain-Penetrant P2X7R Antagonist Mitigates Alzheimer’s Disease Pathology. bioRxiv (Cold Spring Harbor Laboratory) (2026)

neuroscience of agingalzheimer's diseasedegenerative pathologymolecular neurodegenerationneuropharmacologyneuropsychopharmacologyneuroscienceneurodegenerative diseasespharmacologydisease pathology

A Polycyclic Scaffold Identified by Structure-Based Drug Design Effectively Inhibits the Human P2X7 Receptor. Nature Communications (2025)

Bps2025 - Cryo-Em Structures of the Human P2X1 Receptor Reveal Subtype-Specific Architecture and Antagonism by Supramolecular Ligand-Binding. Biophysical Journal (2025)

Bps2025 - Human P2X4 Receptor Gating is Modulated by a Stable Cytoplasmic Cap and Putative Lipid Binding Sites. Biophysical Journal (2025)

Bps2025 - Molecular Pharmacology of Human P2X7 Receptor Ligands Visualized by Cryo-Em. Biophysical Journal (2025)

medicinal researchbiochemistryreceptor (biochemistry)pharmacologysystem pharmacologymolecular pharmacologypharmacological researchreceptorsmechanisms of action

Giant Pulmonary Artery Masquerading as Pneumonia. BMJ Case Reports (2025)

respiratory medicinegiant pulmonary arteryinterstitial lung diseasepneumothoraxpulmonary vascular diseasechest injurycritical care

High-Affinity Agonism at the P2X7 Receptor is Mediated by Three Residues Outside the Orthosteric Pocket (Abstract Id: 191502). Journal of Pharmacology and Experimental Therapeutics (2025)

High-Resolution Structures of the Human P2X2 Receptor – an Atp-Gated Ion Channel (Abstract Id: 190950). Journal of Pharmacology and Experimental Therapeutics (2025)

biophysicsatp-gated ion channelphysiologymembrane transportabstract idneuronscellular physiologyreceptor (biochemistry)human p2x2 receptorpharmacological researchreceptors

Human P2X4 Receptor Gating is Modulated by a Stable Cytoplasmic Cap and a Unique Allosteric Pocket. Science Advances (2025)

Molecular Mechanisms of P2X Receptor Desensitization. Structural Dynamics (2025)

1
2
3
4
10 / page