Faculty

Institution

Unit

Venue

Steve A N Goldstein

University of California, Irvine

Affiliations

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

NoneSteve A N Goldstein is currently serving as a Pharmaceutical Sciences faculty at University of California, Irvine.

Honors

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Experiences

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Education

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Steve A N Goldstein

University of California, Irvine

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neuroscience biophysics electrophysiology membrane biology physiology signal transduction molecular biology neurophysiology cell signaling gene expression protein science cardiology molecular physiology neuroanatomy cellular physiology cellular neurobiology molecular neurobiology peptides neurochemistry mammalian biology biological chemistry neural science hyperpolarization (biology) cardiac muscle ion channels echocardiography medicinal research nuclear cardiology brain science medical genetics neuroinflammation innate immune system slow inactivation circulatory physiology cardiovascular research membrane transport cell physiology skeletal muscle cellular biology signaling pathways biological inorganic chemistry neurotransmission heme signaling cardiac arrhythmia pore domains periodic paralysis potassium channels mink potassium channels mink-related peptides voltage-sensor movements voltage-gated sodium channels developmental cell developmental science clinical investigation insect molecular biology animal physiology protein purification muscle function upper extremity in vivo systems molecular recognition clinical medicine channel characterization brain circuitry protein assembly peptide therapeutics heme transport human sciences viral genetics blood pressure kcnk family potassium leak channels two-p-domain subunits common polymorphism antibiotic-induced cardiac arrhythmia potassium ions

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bps2026 – a High-Throughput Screening Method Identifies Marine-Derived Small Molecule Inhibitors of Hv1 Channels. Biophysical Journal (2026)

enzyme inhibitionsmall moleculesmarine drugsmall molecule inhibitorsdrug discoverymolecular biologymembrane proteinsmolecular communicationhv1 channelsdrug targetsbiochemistry

Bps2026 – Reconsidering Native Proton Channel Composition and Function: Amyloid Precursor Protein (App) is an Accessory Subunit in Hv1 Channels in Microglia. Biophysical Journal (2026)

neurologyneuroinflammationamyloid precursor proteincellular physiologyneuroimmunologymolecular neuroscienceaccessory subunitmolecular neurodegenerationhv1 channelsmolecular physiologyneurosciencebrain-immune interactionneuronscell biology

Amyloid Precursor Protein and C99 Are Subunits in Human Microglial Hv1 Channels That Enhance Current and Inflammatory Mediator Release. Proceedings of the National Academy of Sciences (2025)

immunologyneuroinflammationamyloid precursor proteinneuroimmunologymolecular neurosciencemolecular neurodegenerationmolecular psychiatryneurosciencebrain-immune interactioninflammatory mediator release

Bps2025 - C6 Ameliorates Pseudomonas Aeruginosa-Induced Acute Lung Injury by Inhibiting Hv1 Channels and Neutrophil Migration. Biophysical Journal (2025)

Punyanuch SophanpanichkulRuiming ZhaoBenjamin LopezNairrita MajumderAndreas SchwingshacklSteve A. Goldstein

immunologybiophysicshost responserespiratory medicineneutrophil migrationmicrobiologyinflammation

Bps2025 - Where Positivity Meets Specificity: A Designer Peptide as a Novel Pore Blocker of the Voltage-Gated Potassium Channel Kv1.5. Biophysical Journal (2025)

Mahasweta NayakRuiming ZhaoSteven Goldstein

biophysical chemistrybiophysicspeptidesbiophysical reviewnovel pore blockerdesigner peptidebiophysical modeling

C6 Peptide Blockade of Hv1 Channels Inhibits Neutrophil Migration Into the Lungs to Suppress Pseudomonas Aeruginosa-Induced Acute Lung Injury. Respiratory Research (2025)

immunologyimmune mediatorsantiviral researchinfectious respiratory diseaseinnate immune systemimmune responsesrespiratory medicinecritical carehv1 channelsneutrophil migrationc6 peptide blockadeinflammation

Selective Block of Human Kv1.1 Channel and Its Epilepsy-Associated Gain-Of-Function Mutation by Aetx-K Peptide. Biophysical Journal (2024)

Punyanuch SophanpanichkulRuiming ZhaoArwa QasimJordan H. ChillSteve A. Goldstein

neurologyepilepsy-associated gain-of-function mutationbiophysicselectrophysiologygene expressionpeptidesgeneticsmembrane proteinsepigeneticsprotein scienceaetx-k peptideepilepsy

The Molecular Basis of Ph Sensing by the Human Fungal Pathogen Candida Albicans Tok Potassium Channel. iScience (2024)

Rían W ManvilleClaire L IlleckAnthony LewisZoe A McCrossanSteven A N GoldsteinGeoffrey W Abbott

microbial pathogenesisph sensingfungal biologyfungusfungal pathogenspotassium channelmicrobiologybiochemistry

Selective Block of Human Kv1.1 Channels and an Epilepsy‐Associated Gain‐of‐Function Mutation by Aetx‐K Peptide. The FASEB Journal (2023)

Ruiming ZhaoArwa QasimPunyanuch SophanpanichkulHui DaiMaha NayakInbal SherJordan ChillSteve A. N. Goldstein

neurologyepilepsy-associated gain-of-function mutationpeptidesneurogeneticsgeneticsprotein scienceneuroscienceepilepsy

Sumoylation of Nav1.2 Channels Regulates the Velocity of Backpropagating Action Potentials in Cortical Pyramidal Neurons. eLife (2023)

Oron KotlerYana KhrapunskyArik ShvartsmanHui DaiLeigh D PlantSteven AN GoldsteinIlya Fleidervish

cognitive neuroscienceneurologyelectrophysiologysystems neuroscienceneurodynamicsaction potentialsneural engineeringsignal transductionneurosciencecortical pyramidal neurons

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Steve A N Goldstein

University of California, Irvine

Affiliations

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

NoneSteve A N Goldstein is currently serving as a Pharmaceutical Sciences faculty at University of California, Irvine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Steve A N Goldstein

University of California, Irvine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bps2026 – a High-Throughput Screening Method Identifies Marine-Derived Small Molecule Inhibitors of Hv1 Channels. Biophysical Journal (2026)

enzyme inhibitionsmall moleculesmarine drugsmall molecule inhibitorsdrug discoverymolecular biologymembrane proteinsmolecular communicationhv1 channelsdrug targetsbiochemistry

Bps2026 – Reconsidering Native Proton Channel Composition and Function: Amyloid Precursor Protein (App) is an Accessory Subunit in Hv1 Channels in Microglia. Biophysical Journal (2026)

Amyloid Precursor Protein and C99 Are Subunits in Human Microglial Hv1 Channels That Enhance Current and Inflammatory Mediator Release. Proceedings of the National Academy of Sciences (2025)

Bps2025 - C6 Ameliorates Pseudomonas Aeruginosa-Induced Acute Lung Injury by Inhibiting Hv1 Channels and Neutrophil Migration. Biophysical Journal (2025)

Punyanuch SophanpanichkulRuiming ZhaoBenjamin LopezNairrita MajumderAndreas SchwingshacklSteve A. Goldstein

immunologybiophysicshost responserespiratory medicineneutrophil migrationmicrobiologyinflammation

Bps2025 - Where Positivity Meets Specificity: A Designer Peptide as a Novel Pore Blocker of the Voltage-Gated Potassium Channel Kv1.5. Biophysical Journal (2025)

Mahasweta NayakRuiming ZhaoSteven Goldstein

biophysical chemistrybiophysicspeptidesbiophysical reviewnovel pore blockerdesigner peptidebiophysical modeling

C6 Peptide Blockade of Hv1 Channels Inhibits Neutrophil Migration Into the Lungs to Suppress Pseudomonas Aeruginosa-Induced Acute Lung Injury. Respiratory Research (2025)

Selective Block of Human Kv1.1 Channel and Its Epilepsy-Associated Gain-Of-Function Mutation by Aetx-K Peptide. Biophysical Journal (2024)

Punyanuch SophanpanichkulRuiming ZhaoArwa QasimJordan H. ChillSteve A. Goldstein

neurologyepilepsy-associated gain-of-function mutationbiophysicselectrophysiologygene expressionpeptidesgeneticsmembrane proteinsepigeneticsprotein scienceaetx-k peptideepilepsy

The Molecular Basis of Ph Sensing by the Human Fungal Pathogen Candida Albicans Tok Potassium Channel. iScience (2024)

Rían W ManvilleClaire L IlleckAnthony LewisZoe A McCrossanSteven A N GoldsteinGeoffrey W Abbott

microbial pathogenesisph sensingfungal biologyfungusfungal pathogenspotassium channelmicrobiologybiochemistry

Selective Block of Human Kv1.1 Channels and an Epilepsy‐Associated Gain‐of‐Function Mutation by Aetx‐K Peptide. The FASEB Journal (2023)

Ruiming ZhaoArwa QasimPunyanuch SophanpanichkulHui DaiMaha NayakInbal SherJordan ChillSteve A. N. Goldstein

neurologyepilepsy-associated gain-of-function mutationpeptidesneurogeneticsgeneticsprotein scienceneuroscienceepilepsy

Sumoylation of Nav1.2 Channels Regulates the Velocity of Backpropagating Action Potentials in Cortical Pyramidal Neurons. eLife (2023)

Oron KotlerYana KhrapunskyArik ShvartsmanHui DaiLeigh D PlantSteven AN GoldsteinIlya Fleidervish

cognitive neuroscienceneurologyelectrophysiologysystems neuroscienceneurodynamicsaction potentialsneural engineeringsignal transductionneurosciencecortical pyramidal neurons

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5
13
10 / page

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Yale University

parathyroid hormone

chronic kidney disease

Vladimir Yarov-Yarovoy

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University of California, Davis

protein modeling

protein structure

Jean C. Shih

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University of Southern California

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molecular cell biology

Charles R. Sanders

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protein misfolding

membrane protein

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Heidi E. Hamm, Ph.D.

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neuroscience

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neuroscience

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Jin Zhang

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molecular metabolism

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Alfred George

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