Faculty

Institution

Unit

Venue

Siok Lam Lim

University of California, Irvine

Affiliations

Program in Public Health

Department of Environmental and Occupational Health

NoneSiok Lam Lim is currently serving as a Environmental And Occupational Health faculty at University of California, Irvine.

Honors

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Experiences

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Education

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Siok Lam Lim

University of California, Irvine

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alzheimer's disease neuroscience neurology genetics toxicology neuroinflammation dermatology human genetics cognitive neuroscience gene expression neuropathology vascular biology pathway analysis clinical neuroscience hematopoietic cell kinase genetic epidemiology population genetics clinical microbiology mammalian biology developmental science clinical nutrition regulatory toxicology in vitro toxicology analytical toxicology free radical biology experimental medicine respiratory medicine medicinal research ocular disease medical microbiology angiogenesis angiology biochemical genetics genetic factors developmental genetics medical nutrition human nutrition metabolic regulation dietary health experimental toxicology clinical toxicology bioactive metal trace metals brain-immune interaction particulate matter molecular neurobiology oxidized phospholipids age-related macular degeneration cognitive decline mouse model glial glutamate transporter tau pathology systemic inflammation dietary regulation p-gp function disease model copper-induced upregulation chronic copper exposure early stage alzheimer microglial function quasi-ultrafine particulate matter

Notable Scholarly Works

Notable Federal Grants

Collaborators

Exposure to Quasi-Ultrafine Particulate Matter Accelerates Memory Impairment and Alzheimer’s Disease-Like Neuropathology in the Appnl-G-F Knock-in Mouse Model. Toxicological Sciences (2023)

Jason G KilianMarina Mejias-OrtegaHeng-Wei HsuDavid A HermanJanielle VidalRebecca J ArechavalaSamantha RenuschHansal DalalIrene HasenAmanda TingCarlos J Rodriguez-OrtizSiok-Lam LimXiaomeng LinJoan VuTakashi SaitoTakaomi C SaidoMichael T KleinmanMasashi Kitazawa

public healthparticulate matterquasi-ultrafine particulate mattermemory impairmenttoxicologyrespiratory medicinealzheimer's diseaseneurosciencehealth sciencesair pollution

Chronic Copper Exposure Directs Microglia Towards Degenerative Expression Signatures in Wild-Type and J20 Mouse Model of Alzheimer’s Disease. Journal of Trace Elements in Medicine and Biology (2020)

Siok Lam LimCarlos J. Rodriguez-OrtizHeng-Wei HsuJie WuJoannee ZumkehrJason KilianJanielle VidalPinar AyataMasashi Kitazawa

immunologyneurologycognitive neuroscienceneuroinflammationexperimental medicineclinical neurosciencechronic copper exposuretrace metalsimmune responsesalzheimer's diseaseneurosciencebrain-immune interaction

Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer’s Disease–Like Neuropathology in Tg2576 Mice. Molecular Neurobiology (2020)

Siok Lam LimDiana Nguyen TranZanett KieuChristine ChenEmmanuel VillanuevaSagar GhiaarVictoria GallupJoannee ZumkehrDavid H. CribbsCarlos J. Rodriguez-OrtizMasashi Kitazawa

hematopoietic cell kinaseneuropathologygeneticsgenetic ablationalzheimer's diseasemolecular neurobiology

Copper-Induced Upregulation of Micrornas Directs the Suppression of Endothelial Lrp1 in Alzheimer’s Disease Model. Toxicological Sciences (2019)

Heng-Wei HsuCarlos J Rodriguez-OrtizSiok Lam LimJoannee ZumkehrJason G KilianJanielle VidalMasashi Kitazawa

molecular pharmacologytoxicologypathway analysispathologyin vitro toxicologyenvironmental toxicologyneuroinflammationvascular biologyclinical toxicologydisease modelbioactive metalanalytical toxicologyexperimental toxicologyregulatory toxicologyimmunologypharmacologyfree radical biologycopper-induced upregulationepigeneticsalzheimer's disease

P2‐159: Deciphering the Role of Spleen Tyrosine Kinase as a Key Mediator of Amyloid‐B Clearance by Microglia. Alzheimer s & Dementia (2019)

Siok Lam LimHeng Wei HsuJason KilianMasashi Kitazawa

neurologymedicineneuroinflammationkey mediatorclinical neurosciencedementiaspleen tyrosine kinaseamyloid-b clearancemedicinal researchalzheimer's diseasepathway analysisneuroscienceneurodegenerative diseases

Inhibition of Hematopoietic Cell Kinase Dysregulates Microglial Function and Accelerates Early Stage Alzheimer's Disease‐Like Neuropathology. Glia (2018)

Siok Lam LimDiana Nguyen TranJoannee ZumkehrChristine ChenSagar GhiaarZanett KieuEmmanuel VillanuevaVictoria GallupCarlos J. Rodriguez‐OrtizMasashi Kitazawa

neurologyhematopoietic cell kinaseneuropathologymicroglial functionalzheimer's diseaseneuroscienceearly stage alzheimer

Ceftriaxone Ameliorates Tau Pathology and Cognitive Decline via Restoration of Glial Glutamate Transporter in a Mouse Model of Alzheimer's Disease. Neurobiology of Aging (2015)

Joannee ZumkehrCarlos J. Rodriguez-OrtizDavid ChengZanett KieuThin WaiCharlesice HawkinsJason KilianSiok Lam LimRodrigo MedeirosMasashi Kitazawa

cognitive declineneurologycognitive neurosciencemouse modeltau pathologyalzheimer's diseaseglial glutamate transporterneuroscience

Infection, Systemic Inflammation, and Alzheimer's Disease. Microbes and Infection (2015)

Siok Lam LimCarlos J. Rodriguez-OrtizMasashi Kitazawa

public healthclinical microbiologysystemic inflammationinfectious diseasesalzheimer's diseasemedical microbiologymicrobiology

Complement Factor H Genotypes Impact Risk of Age-Related Macular Degeneration by Interaction With Oxidized Phospholipids. Proceedings of the National Academy of Sciences (2012)

Peter X. ShawLi ZhangMing ZhangHongjun DuLing ZhaoClara LeeSeanna GrobSiok Lam LimGuy HughesJanet LeeMatthew BedellMark H. NelsonFang LuMartin KrupaJing LuoHong OuyangZhidan TuZhiguang SuJin ZhuXinran WeiZishan FengYaou DuanZhenglin YangHenry FerreyraDirk-Uwe BartschIgor KozakLiangfang ZhangFeng LinHui SunHong FengKang Zhang

dermatologyophthalmologyage-related macular degenerationgeneticsoxidized phospholipidsgenetic epidemiologyhuman geneticspopulation geneticsocular disease

High Temperature Requirement Factor A1 (Htra1) Gene Regulates Angiogenesis Through Transforming Growth Factor-β Family Member Growth Differentiation Factor 6. Journal of Biological Chemistry (2011)

Li ZhangSiok Lam LimHongjun DuMing ZhangIgor KozakGregory HannumXiaolei WangHong OuyangGuy HughesLing ZhaoXuemei ZhuClara LeeZhiguang SuXinrong ZhouRobert ShawDongho GeumXinran WeiJin ZhuTrey IdekerChio OkaNingli WangZhenglin YangPeter X. ShawKang Zhang

dermatologygene expressionangiogenesisgenetic factorsbiochemical geneticsvascular biologygeneticsmammalian biologydevelopmental geneticsangiologymolecular geneticsdevelopmental biologystrokedevelopmental sciencecellular differentiationhuman genetics

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Siok Lam Lim

University of California, Irvine

Affiliations

Program in Public Health

Department of Environmental and Occupational Health

NoneSiok Lam Lim is currently serving as a Environmental And Occupational Health faculty at University of California, Irvine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Siok Lam Lim

University of California, Irvine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Exposure to Quasi-Ultrafine Particulate Matter Accelerates Memory Impairment and Alzheimer’s Disease-Like Neuropathology in the Appnl-G-F Knock-in Mouse Model. Toxicological Sciences (2023)

public healthparticulate matterquasi-ultrafine particulate mattermemory impairmenttoxicologyrespiratory medicinealzheimer's diseaseneurosciencehealth sciencesair pollution

Siok Lam LimCarlos J. Rodriguez-OrtizHeng-Wei HsuJie WuJoannee ZumkehrJason KilianJanielle VidalPinar AyataMasashi Kitazawa

Genetic Ablation of Hematopoietic Cell Kinase Accelerates Alzheimer’s Disease–Like Neuropathology in Tg2576 Mice. Molecular Neurobiology (2020)

Siok Lam LimDiana Nguyen TranZanett KieuChristine ChenEmmanuel VillanuevaSagar GhiaarVictoria GallupJoannee ZumkehrDavid H. CribbsCarlos J. Rodriguez-OrtizMasashi Kitazawa

hematopoietic cell kinaseneuropathologygeneticsgenetic ablationalzheimer's diseasemolecular neurobiology

Copper-Induced Upregulation of Micrornas Directs the Suppression of Endothelial Lrp1 in Alzheimer’s Disease Model. Toxicological Sciences (2019)

Heng-Wei HsuCarlos J Rodriguez-OrtizSiok Lam LimJoannee ZumkehrJason G KilianJanielle VidalMasashi Kitazawa

P2‐159: Deciphering the Role of Spleen Tyrosine Kinase as a Key Mediator of Amyloid‐B Clearance by Microglia. Alzheimer s & Dementia (2019)

Siok Lam LimHeng Wei HsuJason KilianMasashi Kitazawa

Inhibition of Hematopoietic Cell Kinase Dysregulates Microglial Function and Accelerates Early Stage Alzheimer's Disease‐Like Neuropathology. Glia (2018)

Siok Lam LimDiana Nguyen TranJoannee ZumkehrChristine ChenSagar GhiaarZanett KieuEmmanuel VillanuevaVictoria GallupCarlos J. Rodriguez‐OrtizMasashi Kitazawa

neurologyhematopoietic cell kinaseneuropathologymicroglial functionalzheimer's diseaseneuroscienceearly stage alzheimer

Ceftriaxone Ameliorates Tau Pathology and Cognitive Decline via Restoration of Glial Glutamate Transporter in a Mouse Model of Alzheimer's Disease. Neurobiology of Aging (2015)

Joannee ZumkehrCarlos J. Rodriguez-OrtizDavid ChengZanett KieuThin WaiCharlesice HawkinsJason KilianSiok Lam LimRodrigo MedeirosMasashi Kitazawa

cognitive declineneurologycognitive neurosciencemouse modeltau pathologyalzheimer's diseaseglial glutamate transporterneuroscience

Infection, Systemic Inflammation, and Alzheimer's Disease. Microbes and Infection (2015)

Siok Lam LimCarlos J. Rodriguez-OrtizMasashi Kitazawa

public healthclinical microbiologysystemic inflammationinfectious diseasesalzheimer's diseasemedical microbiologymicrobiology

Complement Factor H Genotypes Impact Risk of Age-Related Macular Degeneration by Interaction With Oxidized Phospholipids. Proceedings of the National Academy of Sciences (2012)

dermatologyophthalmologyage-related macular degenerationgeneticsoxidized phospholipidsgenetic epidemiologyhuman geneticspopulation geneticsocular disease

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University of California, Irvine

environmental toxicology

environmental hazard

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neuroscience

neurology

Ameer Taha

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University of California, Davis

environmental toxicology

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metabolomics

health sciences

Benjamin Wolozin

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degenerative disease

human genetics

Neetu Tyagi

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stem cell

endothelial function

Feixiong Cheng

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biomedical informatics

translational data science

Anumantha Kanthasamy

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degenerative disease

free radical biology

Yakeel Quiroz

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Boston University

neuroimaging

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Suzanne M De La Monte

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