Faculty

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Sharon Krinsky-McHale

Adjunct Associate Research Scientist in the Gertrude H Sergievsky Center

Columbia University

Affiliations

Columbia University

P&S

P&S Centers and Institutes

SGV Research

Sharon Krinsky-McHale is an Adjunct Associate Research Scientist at the Gertrude H. Sergievsky Center, Columbia University. Her research focuses on the intersection of Alzheimer's disease, dementia, and Down syndrome, specifically investigating the neuropathological and cognitive trajectories of aging in this population. Her recent work includes leading the Alzheimer's Biomarker Consortium–Down Syndrome (ABC-DS) 10-year report, predicting amyloid and tau deposition via plasma biomarkers in The Lancet Neurology, and utilizing eye tracking and 7T postmortem MRI to detect early neuropathological changes. She also examines behavioral and psychological symptoms of dementia and the genetic modifiers of Alzheimer's risk, such as APOE ε4, in adults with Down syndrome.

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Sharon Krinsky-McHale

Columbia University

Adjunct Associate Research Scientist in the Gertrude H Sergievsky Center

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alzheimer's disease neurology neuroscience dementia cognitive impairment neuroscience of aging neurodegenerative diseases psychiatry geriatrics cognitive science neuropsychology geriatric psychiatry intellectual disability neuropsychological rehabilitation down syndrome experimental gerontology neurodevelopmental disorders molecular neurodegeneration ageing developmental cognitive neuroscience applied cognitive psychology translational psychiatry molecular psychiatry memory study aging cell disease assessment aging-associated diseases attention disorders child neurology brain pathology neuroimaging biomarkers degenerative disease plasma biomarkers biological psychiatry psychiatric research cerebrovascular disease geriatric medicine geriatric neurology mild cognitive impairment neurolinguistics prognostic biomarkers vascular dementia clinical gerontology brain science genetic disorders clinical neuroscience cross-sectional studies clinical neurology healthy aging developmental disabilities later adulthood clinical evidence vision research elderly care outcome measures learning disability cross-sectional studies cognitive decline plasma neurofilament light prospective cohort studies retrospective cohort studies outcome assessment social gerontology lifespan development brain health social intelligence status attainment neurodiversity exceptional children alzheimer-related cerebrovascular disease csf biomarkers autosomal dominant alzheimer plasma total-tau neurofilament light chain diagnostic biomarkers wechsler intelligence scale

Notable Scholarly Works

Notable Federal Grants

Collaborators

Apoe ε4 Does Not Increase Rate of Amyloid Accumulation or Tau Phosphorylation in Adults With Down Syndrome. Apollo (University of Cambridge) (2026)

neurologyaging-associated diseasesprotein misfoldingcognitive impairmentmolecular neurodegenerationneuroscience of agingneuroscienceneurodegenerative diseaseshealth sciences

A Comparison of Multiple Amyloid Pet Radiotracers for Down Syndrome Clinical Trials. Brain Communications (2025)

neurologyradiologyneuroimaging biomarkersneuroimagingneuroradiologycognitive impairmentneuroscience of agingneuroscienceneurodegenerative diseases

Behavioral and Psychological Symptoms of Dementia and Alzheimer’s Disease Progression in Down Syndrome. Journal of Neurodevelopmental Disorders (2025)

Melissa R JenkinsJamie C PevenLauren KubicBenjamin L HandenSharon J Krinsky-McHaleChristy L HomAlice LeeDana L TudorascuMax McLachlanMatthew ZammitDavneet MinhasWeiquan LuoCharles LaymonJoseph H LeeIra LottAnnie CohenBeau M AncesH Diana RosasFlorence LaiShahid H ZamanElizabeth HeadMark MapstoneBradley T ChristianSigan L Hartley

behavioral disorderscognitive impairmentchild neurologymolecular psychiatryneuroscience of agingbehavioral neurosciencebehavioral sciencespsychological symptomsneurodegenerative diseasesmemory losspsychologypsychiatrydementianeurodevelopmental disordersdegenerative diseasevascular dementiapsychiatric diseasesalzheimer's diseasegeriatric neurology

Correlating Hippocampal and Amygdala Volumes With Neuropathological Burden in Down Syndrome and Alzheimer’s Disease and Related Neurodegenerative Pathologies Using 7T Postmortem Mri. Journal of Neuropathology & Experimental Neurology (2025)

Jr-Jiun LiouJinghang LiJacob BerardinelliHecheng JinTales SantiniJaehoon NohNadim FarhatMinjie WuHoward J AizensteinJoseph M MettenburgWilliam H YongElizabeth HeadMilos D IkonomovicTamer S IbrahimJulia K KoflerBeau M AncesHoward F AndrewsKaren BellRasmus M BirnAdam M BrickmanPeter BulovaAmrita CheemaKewei ChenBradley T ChristianIsabel ClareLorraine ClarkAnn D CohenJohn N ConstantinoEric W DoranAnne FaganEleanor FeingoldTatiana M ForoudBenjamin L HandenSigan L HartleyRachel HensonChristy HomLawrence HonigSterling C JohnsonCourtney JordanM Ilyas KambohDavid KeatorWilliam E KlunkWilliam Charles KreislSharon J Krinsky-McHaleFlorence LaiPatrick LaoCharles LaymonJoseph Hyungwoo LeeIra T LottVictoria LupsonMark MapstoneChester A MathisDavneet Singh MinhasNeelesh NadkarniSid O'BryantDeborah PangMelissa PetersenJulie C PriceMargaret PulsiferMichael RafiiEric ReimanBatool RizviHerminia Diana RosasMarwan N SabbaghNicole SchupfWayne P SilvermanDana L TudorascuRameshwari TumuluruBenjamin TyckoBadri VaradarajanDesiree A WhiteMichael A YassaShahid ZamanFan Zhang

neurologyneuropathological burdenpostmortem mrineuroimagingneuropathologyexperimental neuropathologydown syndromeamygdala volumesalzheimer's diseaseneurodegenerative diseasesrelated neurodegenerative pathologies

Examination of Metabolic Syndrome in Down Syndrome and Association With Dementia. Alzheimer s & Dementia (2025)

neurologyvascular dementiametabolic disordersmetabolic syndromechronic diseasespsychiatrydementiacognitive impairmentdown syndromeneuroscience of aginghealth sciencesneurodegenerative diseases

Eye Tracking as a Tool for Detecting Alzheimer's Disease in People With Down Syndrome. Journal of Intellectual Disability Research (2025)

neurologyvisual sciencevisual impairmentsophthalmologyvision researchneuro-ophthalmologydown syndromecognitive impairmentneuroscience of agingeye trackingvisual diagnosisneuroscienceneurodegenerative diseasesalzheimer's disease

Factors Associated With Atypical Cognitive Trajectories in Older Adults With Down Syndrome. Alzheimer s & Dementia (2025)

geriatric neurologypsychologypsychiatrydementiacognitive impairmentcognitive scienceneuroscience of aging

Genome‐Wide Association Analyses Identify Candidate Loci for Amyloid Imaging and Plasma Biomarkers in Adults With Down Syndrome. Alzheimer s & Dementia (2025)

neurologyamyloid imaginggeneticsdisease gene identificationmolecular diagnosticsdown syndromemolecular neurodegenerationmolecular psychiatryalzheimer's diseasegenetic epidemiologygenome-wide association studiesplasma biomarkers

Genome‐Wide Association of Tau Neuroimaging and Plasma Biomarkers in Adults With Down Syndrome. Alzheimer s & Dementia (2025)

imaging genomicsplasma biomarkerstau neuroimaginggeneticsneurochemical biomarkersdown syndromemolecular neurodegenerationdegenerative diseasemolecular psychiatrygenetic epidemiologyneuroscienceneurodegenerative diseases

Imaging and Plasma Biomarkers for Pathological Accumulation in Down Syndrome. Brain (2025)

neuroimaging biomarkersneuroimagingneuroradiologypathologyneuroscience

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Sharon Krinsky-McHale

Adjunct Associate Research Scientist in the Gertrude H Sergievsky Center

Columbia University

Affiliations

Columbia University

P&S

P&S Centers and Institutes

SGV Research

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Sharon Krinsky-McHale

Columbia University

Adjunct Associate Research Scientist in the Gertrude H Sergievsky Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Apoe ε4 Does Not Increase Rate of Amyloid Accumulation or Tau Phosphorylation in Adults With Down Syndrome. Apollo (University of Cambridge) (2026)

neurologyaging-associated diseasesprotein misfoldingcognitive impairmentmolecular neurodegenerationneuroscience of agingneuroscienceneurodegenerative diseaseshealth sciences

A Comparison of Multiple Amyloid Pet Radiotracers for Down Syndrome Clinical Trials. Brain Communications (2025)

neurologyradiologyneuroimaging biomarkersneuroimagingneuroradiologycognitive impairmentneuroscience of agingneuroscienceneurodegenerative diseases

Behavioral and Psychological Symptoms of Dementia and Alzheimer’s Disease Progression in Down Syndrome. Journal of Neurodevelopmental Disorders (2025)

Examination of Metabolic Syndrome in Down Syndrome and Association With Dementia. Alzheimer s & Dementia (2025)

neurologyvascular dementiametabolic disordersmetabolic syndromechronic diseasespsychiatrydementiacognitive impairmentdown syndromeneuroscience of aginghealth sciencesneurodegenerative diseases

Eye Tracking as a Tool for Detecting Alzheimer's Disease in People With Down Syndrome. Journal of Intellectual Disability Research (2025)

Factors Associated With Atypical Cognitive Trajectories in Older Adults With Down Syndrome. Alzheimer s & Dementia (2025)

geriatric neurologypsychologypsychiatrydementiacognitive impairmentcognitive scienceneuroscience of aging

Genome‐Wide Association Analyses Identify Candidate Loci for Amyloid Imaging and Plasma Biomarkers in Adults With Down Syndrome. Alzheimer s & Dementia (2025)

Genome‐Wide Association of Tau Neuroimaging and Plasma Biomarkers in Adults With Down Syndrome. Alzheimer s & Dementia (2025)

Imaging and Plasma Biomarkers for Pathological Accumulation in Down Syndrome. Brain (2025)

neuroimaging biomarkersneuroimagingneuroradiologypathologyneuroscience

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5
13
10 / page