Faculty

Institution

Unit

Venue

Shareef Khalid

Bioinformatician

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

MED Cardiology

P&S

P&S Clinical

Shareef Khalid is a Senior Professor and Bioinformatician at Columbia University. His research integrates human genetics, genetic epidemiology, statistical genetics, and genomics to elucidate the physiological impact of rare and common genetic variants. Recent breakthroughs include characterizing ANGPTL8 loss-of-function variants, the role of SLC30A8 in glucose metabolism, and genetic determinants of bradyarrhythmia. His work also explores inflammatory pathways, including caspase-8–meteorin signaling in MASH fibrosis and CD33 deficiency effects on white blood cell counts. Khalid’s publications appear in Nature Genetics, Nature Metabolism, and Diabetologia, reflecting his translational focus bridging genetics, hematology, and metabolic disease.

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Shareef Khalid

Columbia University

Bioinformatician

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genetics human genetics genomics genetic epidemiology epidemiology medical genetics biostatistics statistical genetics hematology cardiovascular research population genetics genome biology genome-wide association studies molecular biology diabetes genetic variation thrombosis genotype-phenotype association uk biobank population-based cohort study heredity respiratory medicine biobanks cohort studies thrombotic risk metabolic syndrome cell metabolism molecular metabolism forensic genetics population genomics sequence analysis prospective cohort studies variant interpretation host genetics exome sequencing older adults genetic susceptibility biological psychiatry molecular psychiatry psychiatric research orthopaedic research bone research musculoskeletal disorders liver physiology meta-analysis meta data diabetes mellitus omics datasets genome sequencing dna sequencing genome analysis plant genetics genome studies animal genetics mendelian inheritance polygenic risk psychiatric genetics bone density bone health bone disease genetic disorders cardiomyopathy colorectal cancer cancer genetics liver disease viral evolution multi-ancestry meta-analysis human genetics research yields risk scores genome-wide analysis severe disease genetic evidence etiological differences rare genetic variation cardiometabolic diseases whole exome sequencing genetic basis human variation behavioural genetics evolutionary biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Unraveling the Physiological Impact of Angptl8 Loss-Of-Function Variants in Humans. Scientific Reports (2026)

cardiovascular researchvascular biologyclinical lipidologyneurogeneticsmolecular neurodegenerationphysiologymolecular medicineblood vesselscell biologyatherosclerosisdevelopmental biologymolecular physiologyexperimental medicineclinical proteomicshuman geneticsgenetic epidemiologyreceptors

A Non-Apoptotic Caspase-8–Meteorin Pathway in Hepatocytes Promotes Mash Fibrosis. Nature Metabolism (2025)

fibrosisinflammationpathologyliver physiologymolecular metabolismcell deathcell biologymetabolic pathwayshepatologybiochemistrycell metabolism

Caspase 1–Deficient Humans Survive Into Late Adulthood Despite Dramatically Lower Canonical Inflammasome Activity. Journal of Allergy and Clinical Immunology (2025)

inflammationaging cellpathologymolecular neurodegenerationcell deathcell signalingmolecular medicineimmunologycell biologyneurodegenerative diseasesneuroimmunologyimmune responsesautophagyexperimental medicineautoimmune diseasesmolecular gastroenterologycell research

Complete Loss of Slc30A8 in Humans Improves Glucose Metabolism and Beta Cell Function. Diabetologia (2025)

diabetes therapymetabolic syndromemetabolismmolecular metabolismphysiologymolecular medicinecell biologymetabolic pathwayscell metabolismdiabetes researchneurodegenerative diseasesdiabetic medicinemolecular neuroscienceendocrinologyhealth sciencesdiabetesobesity medicine

Human Cd33 Deficiency is Associated With Mild Alteration of Circulating White Blood Cell Counts. PLoS Genetics (2025)

pathologyimmunologycell biologyblood cellshematologybone marrow transplantationimmune dysregulationhuman cd33 deficiencyimmune responsesimmunity (medicine)primary immunodeficienciesautoimmunityleukemiamild alterationinborn errors of immunity

The Impact of Common and Rare Genetic Variants on Bradyarrhythmia Development. Nature Genetics (2025)

Lu-Chen WengJoel T. RämöSean J. JurgensShaan KhurshidMark ChaffinAmelia Weber HallValerie N. MorrillXin WangVictor NauffalYan V. SunDominik BeerSimon LeeGirish N. NadkarniThuyVy DuongBiqi WangTomasz CzubaThomas R. AustinZachary T. YonedaDaniel J. FriedmanAnne ClaytonMatthew C. HymanRenae L. JudyAllan C. SkanesKate M. OrlandTimothy M. TreuMatthew T. OetjensAlvaro AlonsoElsayed Z. SolimanHonghuang LinKathryn L. LunettaJesper van der PalsTariq Z. IssaNavid A. NafissiHeidi T. MayPeter Leong-SitCarolina RoselliSeung Hoan ChoiGoncalo AbecasisAris BarasMichael CantorGiovanni CoppolaAris EconomidesLuca A. LottaJohn D. OvertonJeffrey G. ReidAlan ShuldinerChristina BeechertCaitlin ForsytheErin D. FullerZhenhua GuMichael LattariAlexander LopezThomas D. SchleicherMaria Sotiropoulos PadillaLouis WidomSarah E. WolfManasi PradhanKia ManoochehriRicardo H. UlloaXiaodong BaiSuganthi BalasubramanianAndrew BlumenfeldBoris BoutkovGisu EomLukas HabeggerAlicia HawesShareef KhalidOlga KrashenininaRouel LancheAdam J. MansfieldEvan K. MaxwellMrunali NafdeSean O’KeeffeMax OrelusRazvan PaneaTommy PolancoAyesha RasoolWilliam SalernoJeffrey C. StaplesMarcus B. JonesLyndon J. MitnaulHabib R. KhanStacey KnightRichard Karlsson LinnérConnie R. BezzinaSamuli RipattiSusan R. HeckbertJ. Michael GazianoRuth J. F. LoosBruce M. PsatyJ. Gustav SmithEmelia J. BenjaminDan E. ArkingDaniel J. RaderSvati H. ShahDan M. RodenScott M. DamrauerLee L. EckhardtJason D. RobertsMichael J. Cutler

cardiovascular researchcardiologygenetic disordersforensic geneticsphysiologycardiomyopathyrare genetic variantsheredityhuman geneticsbradyarrhythmia developmentgenetic epidemiologymedical geneticsstatistical geneticsgenetics

Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis. New England Journal of Medicine (2024)

cardiovascular diseasecardiovascular researchcardiologyheart failurecardiovascular interventionsmedicinecritical care

Identification and Characterization of Human Gdf15 Knockouts. Nature Metabolism (2024)

Allan M GurtanShareef KhalidChristopher KochMaleeha Zaman KhanLindsey B LamarcheIgor SplawskiElizabeth DolanAna M CarrionRichard ZessisMatthew E ClementZhiping ChenLoren D LindsleyYu-Hsin ChiuRyan S StreeperDaniel P DenningAllison B GoldfineBrian DoyonAli AbbasiJennifer L HarrowKazuhisa TsunoyamaMakoto AsaumiIkuyo KouAlan R ShuldinerJuan L Rodriguez-FloresAsif RasheedMuhammad JahanzaibMuhammad Rehan MianMuhammad Bilal LiaqatSyed Shahzaib RazaRiffat SultanaAnjum JalalMuhammad Hamid SaeedShahid AbbasFazal Rehman MemonMohammad IshaqJohn E DominyDanish Saleheen

drug discoverypharmacologyimmunologymedicine

Low Mboat7 Expression, a Genetic Risk for Mash, Promotes a Profibrotic Pathway Involving Hepatocyte Taz Upregulation. Hepatology (2024)

Mary P. MooreXiaobo WangJohn Paul KennellyHongxue ShiYuki IshinoKuniyuki KanoJunken AokiAlessandro CherubiniLuisa RonzoniXiuqing GuoNaga P. ChalasaniShareef KhalidDanish SaleheenMatthew A. MitscheJerome I. RotterKatherine P. YatesLuca ValentiNozomu KonoPeter TontonozIra Tabas

metabolic syndromehepatocyte taz upregulationliver diseasehepatologygenetic riskprofibrotic pathwaygene expressionbiomolecular engineeringgenetics

Macrophage Wdfy3, a Protector Against Autoimmunity. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Xun WuZiyi WangKatherine R. CroceFang LiJian CuiVivette D. D’AgatiRajesh K. SoniShareef KhalidDanish SaleheenIra TabasAi YamamotoHanrui Zhang

immunologyimmune dysregulationimmune responsesimmunity (medicine)autoimmune diseasesautoimmunity

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Shareef Khalid

Bioinformatician

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

MED Cardiology

P&S

P&S Clinical

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Shareef Khalid

Columbia University

Bioinformatician

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Unraveling the Physiological Impact of Angptl8 Loss-Of-Function Variants in Humans. Scientific Reports (2026)

A Non-Apoptotic Caspase-8–Meteorin Pathway in Hepatocytes Promotes Mash Fibrosis. Nature Metabolism (2025)

fibrosisinflammationpathologyliver physiologymolecular metabolismcell deathcell biologymetabolic pathwayshepatologybiochemistrycell metabolism

Caspase 1–Deficient Humans Survive Into Late Adulthood Despite Dramatically Lower Canonical Inflammasome Activity. Journal of Allergy and Clinical Immunology (2025)

Complete Loss of Slc30A8 in Humans Improves Glucose Metabolism and Beta Cell Function. Diabetologia (2025)

Human Cd33 Deficiency is Associated With Mild Alteration of Circulating White Blood Cell Counts. PLoS Genetics (2025)

The Impact of Common and Rare Genetic Variants on Bradyarrhythmia Development. Nature Genetics (2025)

Corin and Left Atrial Cardiomyopathy, Hypertension, Arrhythmia, and Fibrosis. New England Journal of Medicine (2024)

cardiovascular diseasecardiovascular researchcardiologyheart failurecardiovascular interventionsmedicinecritical care

Identification and Characterization of Human Gdf15 Knockouts. Nature Metabolism (2024)

drug discoverypharmacologyimmunologymedicine

Low Mboat7 Expression, a Genetic Risk for Mash, Promotes a Profibrotic Pathway Involving Hepatocyte Taz Upregulation. Hepatology (2024)

metabolic syndromehepatocyte taz upregulationliver diseasehepatologygenetic riskprofibrotic pathwaygene expressionbiomolecular engineeringgenetics

Macrophage Wdfy3, a Protector Against Autoimmunity. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Xun WuZiyi WangKatherine R. CroceFang LiJian CuiVivette D. D’AgatiRajesh K. SoniShareef KhalidDanish SaleheenIra TabasAi YamamotoHanrui Zhang

immunologyimmune dysregulationimmune responsesimmunity (medicine)autoimmune diseasesautoimmunity

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10 / page