Faculty

Institution

Unit

Venue

Seyed Javad M. Moghaddam

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Biology And Biochemistry

Department Of Immunology

Department Of Pulmonary Medicine

Department Of Pulmonology

Department Of Rheumatology

The University of Texas MD Anderson Cancer Center

Seyed Javad M. Moghaddam is a Senior Professor at The University of Texas MD Anderson Cancer Center. His research focuses on lung cancer biology, tumor immunology, and thoracic oncology, with particular emphasis on the molecular mechanisms of oncogene-driven tumorigenesis and the tumor–microenvironment crosstalk driving non-small cell lung cancer (NSCLC) progression and therapy resistance. His recent work employs multimodal spatial-omics to trace the co-evolution of alveolar progenitors and proinflammatory niches during lung precursor lesion progression, and investigates the repurposing of macrolide antibiotics such as clarithromycin for lung cancer prevention. He has also explored cigarette smoke-induced angiogenic activation via endothelial microRNA dysregulation and nebulized pattern recognition receptor agonists for immunotherapy in influenza-associated pulmonary aspergillosis. His contributions appear in Nature Reviews Clinical Oncology, Cancer Cell, and Communications Biology.

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Seyed Javad M. Moghaddam

The University of Texas MD Anderson Cancer Center

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lung cancer cancer research cancer biology immunology thoracic oncology tumor biology oncology respiratory medicine oncogenes cell biology tumor microenvironment immune responses cancer cells radiation oncology chronic obstructive pulmonary disease pathology medicinal research inflammation cancer treatment carcinogenesis molecular cancer bronchial neoplasm cancer discovery pulmonary diseases smoking related lung disease oncogenic agent cancer genetics tumor suppressors mouse model cancer growth tumor targeting cellular therapy tobacco control cytokines lung adenocarcinoma vascular biology genitourinary cancers chronic inflammation pancreatic cancer immunologic mechanisms advanced lung disease cancer management k-ras-mutant lung cancer lung tumor microenvironment cancer imaging infectious respiratory disease respiratory infections signaling pathways cellular immune responses cigarette smoke exposure lung cancer chemoprevention infection control cellular physiology nature communicable diseases inhalation toxicology host response cancer immunosurveillance molecular immunology cancer risk lung tumorigenesis epithelial cell states lung carcinogenesis aml progression pulmonary circulation malignant disease host factors immunopathology lineage plasticity liver cancer airway defence epithelial barrier dysfunction critical pathogenic role neutrophil elastase mucus hypersecretion contributes muc5ac expression asthma epidemiology pediatric pulmonology cell death pharmacology cystic fibrosis translational research preventive medicine cancer immunotherapy immunotherapy allergy interstitial lung disease jama oncology biomarkers pharmacotherapy health sciences pediatric allergy translational medicine molecular diagnostics urology cancer letter cancer care in vitro toxicology metastasis preventive healthcare molecular medicine clinical epidemiology lung microbiome histopathology internal medicine medicine experimental medicine clinical research

Notable Scholarly Works

Notable Federal Grants

Collaborators

Supplementary Table From Repurposing of the Macrolide Antibiotic Clarithromycin for the Prevention of Lung Cancer. (2026)

lung cancerantibiotic resistancemedicineantimicrobial agentsinfectious diseasesantimicrobial chemotherapysupplementary tableantibioticsthoracic oncologypharmacologyantibacterial agentstherapeutic targetsantimicrobial resistancedrug discoverymedicinal researchmacrolide antibiotic clarithromycin

Abstract 2225: Diet With High Soluble Fiber Induces Favorable Gut Microbiota and Metabolomic Profiles, Increases Anti-Tumor Immunity, and Suppresses Lung Cancer Progression. Cancer Research (2025)

Manvi SharmaYuejiang LiuAltai EnkhbayarSujuan YangInti C. ReischleMohamed A. JamalTieling ZhouZahraa RahalB. Lorena I.Hannah MorenoMatthew C. RossLin TanChidera O. ChukwuochaEleeka NiaAnusha S. ThomasJennifer A. WargoNadim J. AjamiPhilip L. LorenziRobert R. JenqSeyed Javad MoghaddamKristi L. HoffmanHumam Kadara

metabolomic profileslung cancer progressioncancer researchanti-tumor immunityhealth sciences

Abstract 5843: Selective Small Molecule Inhibitor of Stat3 Suppresses Tumor Growth and Improves Immune Checkpoint Inhibitor Efficacy in Kras Mutant Lung Cancer. Cancer Research (2025)

lung cancertumor biologycancer immunotherapysmall molecule inhibitorcancer growthmolecular cancercancer biologycell biologycancer cellsimmune checkpoint inhibitorsoncogenesoncogenic agentimmunologytherapeutic targetsabstract 5843medicinal research

Abstract 7311: Targeting Stat3 to Prevent Non-Small Cell Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease. Cancer Research (2025)

Katherine E. LarsenLeticia G. Hamana ZorrillaT Kris EckolsMoses M. KasembeliMichael J. ClowersAvantika KrishnaMaria T. GrimaldoNastaran KarimiShanshan DengVignesh GunasekharanLuisa M. Solis SotoDavid J. TweardySeyed Javad Moghaddam

lung cancerchronic obstructive pulmonary diseasehealth sciencescancer research

Abstract Lb385: Immunomodulatory Role of Muc5Ac in Lung Adenocarcinoma: A Potential Therapeutic Target. Cancer Research (2025)

lung cancercancer immunotherapyabstract lb385cell biologycancer cellsoncogenic agentimmunologythoracic oncologylung adenocarcinomatherapeutic targetsimmunomodulatory rolebronchial neoplasm

Cigarette Smoke Induces Angiogenic Activation in the Cancer Field Through Dysregulation of an Endothelial Microrna. Communications Biology (2025)

Asawari KordeAnuradha RamaswamySeth AndersonLei JinJian-ge ZhangBuqu HuWalter V. VelascoLixia DiaoJing WangMargaret A. PisaniMaor SaulerDaniel J. BoffaJonathan T. PuchalskiXiting YanSeyed Javad MoghaddamShervin S. Takyar

cancer fieldcancer researchcancer biologybiologyvascular biologyendothelial microrna

Comparative Effects of Combustible Cigarette Versus Electronic Cigarette Exposures on Kras Mutant Lung Cancer Promotion. Neoplasia (2025)

lung cancersmoking related lung diseasethoracic oncologytobacco controlcomparative effectstobacco uselung microbiome

CORRECTION: Inflammation Mediated by Gut Microbiome Promotes Immune Suppression and Lung Adenocarcinoma Progression. Cancer Immunology Research (2025)

molecular gastroenterologychronic inflammationimmune responsesgut-organ axislung adenocarcinoma progressioninflammationdysbiosismicrobiomeimmunologygut microbesmucosal immunologypathologylung microbiome

Immunotherapy With Nebulized Pattern Recognition Receptor Agonists Restores Severe Immune Paralysis and Improves Outcomes in Mice With Influenza-Associated Pulmonary Aspergillosis. mBio (2025)

Jezreel Pantaleón GarcíaSebastian WursterNathaniel D. AlbertUddalak BharadwajKeerthi BhodaVikram K. KulkarniMbaya NtitaParis Rodríguez CarstensMadeleine Burch-EapenDaniela Covarrubias LópezJania Foncerrada LizaolaKatherine E. LarsenLauren M. MatulaSeyed J. MoghaddamYongxing WangDimitrios P. KontoyiannisScott E. Evans

receptorsimmune responsesmedicinehost responseinfluenzainfluenza-associated pulmonary aspergillosisinfectious diseasesimmunotherapyimmunologyimmunity (medicine)respiratory medicineimmunosuppressive therapy

Multimodal Spatial-Omics Reveal Co-Evolution of Alveolar Progenitors and Proinflammatory Niches in Progression of Lung Precursor Lesions. Cancer Cell (2025)

developmental biologylung cancerproinflammatory nichesmolecular and cellular biologycellular differentiationcell lineagealveolar progenitorscell biologydevelopmental celllung precursor lesionssystems biologyrespiratory medicinecell and molecular biologybronchial neoplasmlung microbiome

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Seyed Javad M. Moghaddam

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Biology And Biochemistry

Department Of Immunology

Department Of Pulmonary Medicine

Department Of Pulmonology

Department Of Rheumatology

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Seyed Javad M. Moghaddam

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Supplementary Table From Repurposing of the Macrolide Antibiotic Clarithromycin for the Prevention of Lung Cancer. (2026)

Abstract 2225: Diet With High Soluble Fiber Induces Favorable Gut Microbiota and Metabolomic Profiles, Increases Anti-Tumor Immunity, and Suppresses Lung Cancer Progression. Cancer Research (2025)

metabolomic profileslung cancer progressioncancer researchanti-tumor immunityhealth sciences

Abstract 5843: Selective Small Molecule Inhibitor of Stat3 Suppresses Tumor Growth and Improves Immune Checkpoint Inhibitor Efficacy in Kras Mutant Lung Cancer. Cancer Research (2025)

Abstract 7311: Targeting Stat3 to Prevent Non-Small Cell Lung Cancer in Patients With Chronic Obstructive Pulmonary Disease. Cancer Research (2025)

lung cancerchronic obstructive pulmonary diseasehealth sciencescancer research

Abstract Lb385: Immunomodulatory Role of Muc5Ac in Lung Adenocarcinoma: A Potential Therapeutic Target. Cancer Research (2025)

lung cancercancer immunotherapyabstract lb385cell biologycancer cellsoncogenic agentimmunologythoracic oncologylung adenocarcinomatherapeutic targetsimmunomodulatory rolebronchial neoplasm

Cigarette Smoke Induces Angiogenic Activation in the Cancer Field Through Dysregulation of an Endothelial Microrna. Communications Biology (2025)

cancer fieldcancer researchcancer biologybiologyvascular biologyendothelial microrna

Comparative Effects of Combustible Cigarette Versus Electronic Cigarette Exposures on Kras Mutant Lung Cancer Promotion. Neoplasia (2025)

lung cancersmoking related lung diseasethoracic oncologytobacco controlcomparative effectstobacco uselung microbiome

CORRECTION: Inflammation Mediated by Gut Microbiome Promotes Immune Suppression and Lung Adenocarcinoma Progression. Cancer Immunology Research (2025)

Immunotherapy With Nebulized Pattern Recognition Receptor Agonists Restores Severe Immune Paralysis and Improves Outcomes in Mice With Influenza-Associated Pulmonary Aspergillosis. mBio (2025)

Multimodal Spatial-Omics Reveal Co-Evolution of Alveolar Progenitors and Proinflammatory Niches in Progression of Lung Precursor Lesions. Cancer Cell (2025)

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