Faculty

Institution

Unit

Venue

Santhakumar Manicassamy

Professor

Augusta University

Affiliations

Medical College of Georgia

Department of Medicine

Santhakumar Manicassamy is currently serving as a Medicine Professor at Augusta University.

Honors

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Experiences

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Education

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Santhakumar Manicassamy

Augusta University

Professor

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immunology immune responses pharmacology oncology dendritic cells cell signaling adaptive immune system medicinal research tumor biology cell biology inflammation cancer biology colorectal cancer cancer treatment cancer immunotherapy gene expression mammalian biology medicine molecular cancer cancer care cell regulation t-regulatory cell cytokines cellular immune responses receptors oncogenes cellular therapy tumor targeting virus research stem cell research digestive diseases in vivo systems mucosal immunology innate immune system influenza virus infection canonical wnt applied physiology gut microbes leukemia neuroinflammation treatment and prevention renal pathophysiology renal function novel therapies gastrointestinal oncology clinical immunology tolerogenic responses renal tubular cells maladaptive kidney repair mouse models colitis-associated colon cancer antiviral research preventive medicine infection control vascular biology g protein-coupled receptor pathway analysis insulin signaling tolerance induction immunomodulation biomarker target molecular regulation receptor (biochemistry) molecular immunology cancer management virus-host interactions host response functional selectivity colonic inflammation commensal metabolite butyrate immunity versus tolerance toll-like receptor-mediated induction plasmacytoid dendritic cells dendritic cell control intestinal dendritic cell functional specializations adaptive immune responses novel vaccines allergy immunity (medicine) experimental medicine

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 3022: Gpr109a Activation Limits Cell Growth by Inducing P53 and Its Targets in Human Colon Cancer Cells. Cancer Research (2024)

Muthusamy ThangarajuNanditi N. ThangarajuLauren GilstrapMadison ChimentiTulshi PatelSathish SivaprakasamNikhil PatelSanthakumar ManicassamyPuttur D. PrasadVadivel Ganapathy

oncogenescolorectal cancerpathologyradiation oncologytumor biologyanti-cancer agentsmedicinal researchcellular therapycarcinogenesisleukemiacancer researchcancer growthpharmacologytherapeutic targetscancer treatmentenzyme inhibitiononcologycancer biology

Autophagy Activates Egr1 via Mapk/Erk to Induce Fgf2 in Renal Tubular Cells for Fibroblast Activation and Fibrosis During Maladaptive Kidney Repair. Autophagy (2023)

Man J. LivingstonMing ZhangSang-Ho KwonJian-Kang ChenHonglin LiSanthakumar ManicassamyZheng Dong

neurologyfibrosisregenerative medicinerenal functionnephrologymaladaptive kidney repairfibroblast activationautophagypharmacologyrenal tubular cellsurologygene expressioncell regulation

Data From Combined Inhibition of Dnmt and Hdac Blocks the Tumorigenicity of Cancer Stem-Like Cells and Attenuates Mammary Tumor Growth. (2023)

Rajneesh PathaniaSabarish RamachandranGurusamy MariappanPriyanka ThakurHuidong ShiJeong-Hyeon ChoiSanthakumar ManicassamyRavindra KolhePuttur D. PrasadSuash SharmaBal L. LokeshwarVadivel GanapathyMuthusamy Thangaraju

pathologyanti-cancer agentscarcinogenesispharmacologybreast cancertumor biologystem-cell therapycell biologycancer treatmenthdac blocksoncogenesmedicinal researchmolecular cancercellular therapycombined inhibitioncancer caremetastasistumor targetingcancer stem-like cellscancer genomicsoncology

Data From Rad51Ap1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. (2023)

Allison E. BridgesSabarish RamachandranKavin TamizhmaniUtkarsh ParwalAdrienne LesterPragya RajpurohitDaley S. MoreraSarrah L. HasanaliPachiappan ArjunanRavirajsinh N. JedejaNikhil PatelPamela M. MartinHasan KorkayaNagendra SinghSanthakumar ManicassamyPuttur D. PrasadVinata B. LokeshwarBal L. LokeshwarVadivel GanapathyMuthusamy Thangaraju

biostatisticscolorectal cancerradiation oncologycancer researchdata sciencecancer treatmentcancer careoncology

Fibroblast Growth Factor 2 is Produced by Renal Tubular Cells to Act as a Paracrine Factor in Maladaptive Kidney Repair After Cisplatin Nephrotoxicity. Laboratory Investigation (2023)

X HuZ MaS LiL WenY HuoG WuS ManicassamyZ Dong

experimental toxicologypharmacologyrenal tubular cellslaboratory methodsnephrologynovel therapieshematologylaboratory hematologyradiation oncologymedicinal researchclinical investigationlaboratory investigationcisplatin nephrotoxicityparacrine factormaladaptive kidney repairurologylaboratory medicinetissue engineeringinflammationregenerative medicinefibroblast growth factorsclinical transplantation

Supplemental Materials and Methods From Combined Inhibition of Dnmt and Hdac Blocks the Tumorigenicity of Cancer Stem-Like Cells and Attenuates Mammary Tumor Growth. (2023)

stem cell researchsurgical oncologydermatologypharmacologythoracic oncologybreast cancertumor biologycancer researchtumor suppressorscancer treatmentradiation oncologynanomedicinemedicinal researchsupplemental materialscombined inhibitioncancer carecancer biologytumor targetingcancer growthcancer stem-like cellsoncology

Supplementary Figure S5 From β-Catenin Promotes Regulatory T-Cell Responses in Tumors by Inducing Vitamin a Metabolism in Dendritic Cells. (2023)

Yuan HongIndumathi ManoharanAmol SuryawanshiTanmay MajumdarMelinda L. Angus-HillPandelakis A. KoniBalaji ManicassamyAndrew L. MellorDavid H. MunnSanthakumar Manicassamy

metabolismtumor biologyimmunologymedicinal researchcancer researchimmune responsesdendritic cellspharmacologyoncologycancer biologycytokines

Supplementary Methods From Rad51Ap1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. (2023)

colorectal cancerradiation oncologycancer researchpharmacologycancer treatmentsupplementary methodsoncology

The Transcription Factor Rxrα in Cd11C+ Apcs Regulates Intestinal Immune Homeostasis and Inflammation. The Journal of Immunology (2023)

Indumathi ManoharanArulkumaran ShanmugamMalarvizhi RamalingamNikhil PatelMuthusamy ThangarajuSatyanarayana AndeRafal PacholczykPuttur D. PrasadSanthakumar Manicassamy

inflammationimmunologytranscription factorscell biologyintestinal immune homeostasismucosal immunologymolecular biologytranscription regulationtranscription factor rxra

Genetic Deletion of Lrp5 and Lrp6 in Macrophages Exacerbates Colitis-Associated Systemic Inflammation and Kidney Injury in Response to Intestinal Commensal Microbiota. The Journal of Immunology (2022)

Indumathi ManoharanDaniel SwaffordArulkumaran ShanmugamNikhil PatelPuttur D. PrasadRiyaz MohamedQingqing WeiZheng DongMuthusamy ThangarajuSanthakumar Manicassamy

inflammationgenetic deletionimmunologydermatologyinflammatory bowel diseasekidney injuryintestinal commensal microbiotagenetics

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Santhakumar Manicassamy

Professor

Augusta University

Affiliations

Medical College of Georgia

Department of Medicine

Santhakumar Manicassamy is currently serving as a Medicine Professor at Augusta University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Santhakumar Manicassamy

Augusta University

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 3022: Gpr109a Activation Limits Cell Growth by Inducing P53 and Its Targets in Human Colon Cancer Cells. Cancer Research (2024)

Muthusamy ThangarajuNanditi N. ThangarajuLauren GilstrapMadison ChimentiTulshi PatelSathish SivaprakasamNikhil PatelSanthakumar ManicassamyPuttur D. PrasadVadivel Ganapathy

Autophagy Activates Egr1 via Mapk/Erk to Induce Fgf2 in Renal Tubular Cells for Fibroblast Activation and Fibrosis During Maladaptive Kidney Repair. Autophagy (2023)

Man J. LivingstonMing ZhangSang-Ho KwonJian-Kang ChenHonglin LiSanthakumar ManicassamyZheng Dong

neurologyfibrosisregenerative medicinerenal functionnephrologymaladaptive kidney repairfibroblast activationautophagypharmacologyrenal tubular cellsurologygene expressioncell regulation

Data From Combined Inhibition of Dnmt and Hdac Blocks the Tumorigenicity of Cancer Stem-Like Cells and Attenuates Mammary Tumor Growth. (2023)

Data From Rad51Ap1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. (2023)

biostatisticscolorectal cancerradiation oncologycancer researchdata sciencecancer treatmentcancer careoncology

Fibroblast Growth Factor 2 is Produced by Renal Tubular Cells to Act as a Paracrine Factor in Maladaptive Kidney Repair After Cisplatin Nephrotoxicity. Laboratory Investigation (2023)

X HuZ MaS LiL WenY HuoG WuS ManicassamyZ Dong

Supplemental Materials and Methods From Combined Inhibition of Dnmt and Hdac Blocks the Tumorigenicity of Cancer Stem-Like Cells and Attenuates Mammary Tumor Growth. (2023)

Supplementary Figure S5 From β-Catenin Promotes Regulatory T-Cell Responses in Tumors by Inducing Vitamin a Metabolism in Dendritic Cells. (2023)

Yuan HongIndumathi ManoharanAmol SuryawanshiTanmay MajumdarMelinda L. Angus-HillPandelakis A. KoniBalaji ManicassamyAndrew L. MellorDavid H. MunnSanthakumar Manicassamy

metabolismtumor biologyimmunologymedicinal researchcancer researchimmune responsesdendritic cellspharmacologyoncologycancer biologycytokines

Supplementary Methods From Rad51Ap1 Loss Attenuates Colorectal Cancer Stem Cell Renewal and Sensitizes to Chemotherapy. (2023)

colorectal cancerradiation oncologycancer researchpharmacologycancer treatmentsupplementary methodsoncology

The Transcription Factor Rxrα in Cd11C+ Apcs Regulates Intestinal Immune Homeostasis and Inflammation. The Journal of Immunology (2023)

Indumathi ManoharanArulkumaran ShanmugamMalarvizhi RamalingamNikhil PatelMuthusamy ThangarajuSatyanarayana AndeRafal PacholczykPuttur D. PrasadSanthakumar Manicassamy

inflammationimmunologytranscription factorscell biologyintestinal immune homeostasismucosal immunologymolecular biologytranscription regulationtranscription factor rxra

Indumathi ManoharanDaniel SwaffordArulkumaran ShanmugamNikhil PatelPuttur D. PrasadRiyaz MohamedQingqing WeiZheng DongMuthusamy ThangarajuSanthakumar Manicassamy

inflammationgenetic deletionimmunologydermatologyinflammatory bowel diseasekidney injuryintestinal commensal microbiotagenetics

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cancer letter

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