Faculty

Institution

Unit

Venue

Samuel Herberg

Associate Professor

Upstate Medical University

Affiliations

Center For Vision Research

Department Of Ophthalmology And Visual Science

Center For Vision Research

College of Graduate Studies

Department Of Ophthalmology And Visual Science

Norton College of Medicine

Department Of Cell And Developmental Biology

Department Of Neuroscience And Physiology

Department Of Psychiatry And Behavioural Neuroscience

Departments Of Psychiatry And Neuroscience

Upstate Medical University

Samuel Herberg is an Associate Professor at Upstate Medical University, where his research integrates tissue engineering, biomedical engineering, and cell biology to address challenges in ophthalmology and regenerative medicine. His work focuses on mechanobiology and biomaterials, particularly investigating how mechanical cues and cell signaling drive ocular pathophysiology. Recent breakthroughs include elucidating TRPV4 activation by TGFβ2 in enhancing cellular contractility and ocular hypertension (eLife, 2025), and exploring YAP/TAZ mechanosignaling in trabecular meshwork dysfunction (Vision Research, 2024). His latest studies also examine compression injury effects on astrocytes in 3D hydrogels and substrate stiffness-induced endothelial-to-mesenchymal transition in corneal cells.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Samuel Herberg

Upstate Medical University

Associate Professor

You can click a keyword to filter the displayed items

tissue engineering biomedical engineering regenerative medicine cell biology biological engineering bone research mechanobiology physiology cellular physiology biomaterials stem cell research biofabrication orthopedic surgery orthopaedic research matrix biology visual science mesenchymal stem cells trabecular meshwork translational medicine experimental medicine ocular surface experimental ophthalmology cell biomechanics gene expression synthetic biology experimental gerontology cell transplantation bone marrow transplantation vascular biology stem cell transplantation biomaterials design 3d bioprinting ocular disease bone repair biopolymer gel ocular surface physiology mammalian biology biogerontology synthetic bone substitute bone homeostasis cell-matrix interactions signaling pathways stem-cell therapy bone morphogenic protein biomedical modeling adipokine leptin bone development mechanical cues ocular hypertension liver physiology animal physiology skeletal muscle muscle function geriatric endocrinology mammalian physiology biocompatible materials stem cell mobilization treatment development bone metabolism bone health biomaterial modeling periodontology functional tissue engineering fracture healing tissue regeneration aged mice endochondral ossification complex tissues modular strategy canal cell dysfunction astrocyte morphology mesenchymal condensations skeletal muscle mass murine model remote ischemic perconditioning embolic stroke developmental neurobiology bio-inspired computation neuroscience biosystems biophotonics ophthalmology photomedicine medical optical imaging developmental biology visual system confocal microscopy biomedical imaging biotechnology advance biological imaging neural engineering cell engineering optogenetics artificial life developmental cell neuro-ophthalmology glaucoma ophthalmology retina tissue (biology) vision rehabilitation biophysics regeneration (biology) biomolecular engineering developmental system biomimetic materials computational neuroscience nature method science advance biophysical review

Notable Scholarly Works

Notable Federal Grants

Collaborators

Author Response: Trpv4 Overactivation Enhances Cellular Contractility and Drives Ocular Hypertension in Tgfβ2 Overexpressing Eyes. (2025)

ocular hypertensioncell signalingcell biologyocular surfaceocular diseasesignal transductionophthalmology retinaocular surface physiologyophthalmologyauthor responseglaucoma

Compression Injury Regulates Astrocyte Morphology, Metabolic Function, and Extracellular Matrix Modification in a 3D Hydrogel. bioRxiv (Cold Spring Harbor Laboratory) (2025)

biophysicsbiopolymer gelneural tissue engineeringmolecular neurodegenerationmatrix biologycell biomechanicscell biologycellular physiologycompression injuryextracellular matrix modificationbiomedical engineeringmechanobiologyextracellular matrixbiomaterialsspinal cordneuroregenerationastrocyte morphology

Decreased Substrate Stiffness Leads to Mitochondrial Dysfunctions and Endothelial to Mesenchymal Transition Through Focal Adhesion Kinase Activity in Corneal Endothelial Cells. bioRxiv (Cold Spring Harbor Laboratory) (2025)

extracellular matrixmitochondrial dysfunctionsmatrix biologyphysiologycell signalingocular tissuescell biologycellular physiologyocular surfacecorneal endothelial cellsmechanobiologycorneal dystrophyophthalmologysubstrate stiffness

Mechanobiology in the Eye. npj Biological Physics and Mechanics. (2025)

ocular surfacevisual systemocular surface physiologyophthalmologyvisual science

Trpv4 Activation by Tgfβ2 Enhances Cellular Contractility and Drives Ocular Hypertension. eLife (2025)

vascular biologyocular hypertensioncell signalingcell biologyocular surfaceocular diseasemolecular physiologysignal transductionocular surface physiologyophthalmologyreceptorstrpv4 activationglaucoma

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Investigative Ophthalmology & Visual Science (2024)

Ted S. AcottMichael P. FautschWeiming MaoC. Ross EthierAlex S. HuangMary J. KelleyMini AgaSanjoy K. BhattacharyaTerete BorrasDiane BovenkampUttio Roy ChowdhuryAbbot F. ClarkMohammed I. DibasYiqin DuMichael H. ElliottJennifer A. FaralliHaiyan GongSamuel HerbergMurray A. JohnstonePaul L. KaufmanKate E. KellerRuth A. KellyDavid KrizajMarkus H. KuehnHoi Lam LiRaquel LiebermanShan C. LinYutao LiuFiona S. McDonnellColleen M. McDowellGillian J. McLellanPhilip MzykKayarat Saidas NairDarryl R. OverbyDonna M. PetersVijayKrishna RaghunathanPonugoti Vasantha RaoGavin W. RoddyNajam A. SharifMyoung Sup ShimYang SunBenjamin R. ThomsonCarol B. TorisColin E. WilloughbyHao F. ZhangThomas F. FreddoRudolf FuchshoferKamisha R. HillAlireza KarimiKrishnakumar KizhatilCasey C. KopcyznskiPaloma LitonGaurang PatelMichael PengPadmanabhan P. PattabiramanGanesh PrasannaEster Reina-TorresE. Griffen SamplesJohn R. SamplesCynthia L. SteelClemens A. StrohmaierPreeti SubramanianChenna Kesavulu SugaliJoseph van Batenburg-SherwoodCydney WongHannah YoungbloodGulab S. ZodeElizabeth WhiteW. Daniel Stamer

medical optical imagingintraocular pressure regulationexperimental ophthalmologyocular tissuesocular surfacevision researchoutflow facilityocular surface physiologyophthalmologyvisual science

Ecm Biomaterials for Modeling of Outflow Cell Biology in Health and Disease. Biomaterials and Biosystems (2024)

biological engineeringmatrix biologybioengineering modelbiomaterials designbiomedical engineeringoutflow cell biologyextracellular matrixbiomaterial modelingbiomaterialsecm biomaterialstissue engineeringbiofabrication

Role of the Actin/Myosin System in the Trabecular Meshwork. Elsevier eBooks (2024)

biophysicsmatrix biologycell biomechanicscellular physiologymechanotransductioncytoskeletonmolecular motorsmechanobiologycell motilityactin/myosin systemtissue (biology)cellular biochemistry

The Role of Yap/Taz Mechanosignaling in Trabecular Meshwork and Schlemm’s Canal Cell Dysfunction. Vision Research (2024)

cell biologycellular physiologymechanotransductioncanal cell dysfunctionschlemm ’mechanobiologyophthalmologytrabecular meshworkspinal cordperipheral nervebiomechanics

Three-Dimensional Extracellular Matrix Protein Hydrogels for Human Trabecular Meshwork Cell Studies. Methods in molecular biology (2024)

biopolymer gelbiological macromoleculesmatrix biologybiomaterials design3d bioprintingbiopolymersbiomedical engineeringcell engineeringextracellular matrixbiomaterialsbiomolecular engineeringtissue engineeringbiofabrication

1
2
3
4
5
6
7
10 / page

Samuel Herberg

Associate Professor

Upstate Medical University

Affiliations

Center For Vision Research

Department Of Ophthalmology And Visual Science

Center For Vision Research

College of Graduate Studies

Department Of Ophthalmology And Visual Science

Norton College of Medicine

Department Of Cell And Developmental Biology

Department Of Neuroscience And Physiology

Department Of Psychiatry And Behavioural Neuroscience

Departments Of Psychiatry And Neuroscience

Upstate Medical University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Samuel Herberg

Upstate Medical University

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Author Response: Trpv4 Overactivation Enhances Cellular Contractility and Drives Ocular Hypertension in Tgfβ2 Overexpressing Eyes. (2025)

ocular hypertensioncell signalingcell biologyocular surfaceocular diseasesignal transductionophthalmology retinaocular surface physiologyophthalmologyauthor responseglaucoma

Compression Injury Regulates Astrocyte Morphology, Metabolic Function, and Extracellular Matrix Modification in a 3D Hydrogel. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Mechanobiology in the Eye. npj Biological Physics and Mechanics. (2025)

ocular surfacevisual systemocular surface physiologyophthalmologyvisual science

Trpv4 Activation by Tgfβ2 Enhances Cellular Contractility and Drives Ocular Hypertension. eLife (2025)

vascular biologyocular hypertensioncell signalingcell biologyocular surfaceocular diseasemolecular physiologysignal transductionocular surface physiologyophthalmologyreceptorstrpv4 activationglaucoma

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Investigative Ophthalmology & Visual Science (2024)

medical optical imagingintraocular pressure regulationexperimental ophthalmologyocular tissuesocular surfacevision researchoutflow facilityocular surface physiologyophthalmologyvisual science

Ecm Biomaterials for Modeling of Outflow Cell Biology in Health and Disease. Biomaterials and Biosystems (2024)

Role of the Actin/Myosin System in the Trabecular Meshwork. Elsevier eBooks (2024)

biophysicsmatrix biologycell biomechanicscellular physiologymechanotransductioncytoskeletonmolecular motorsmechanobiologycell motilityactin/myosin systemtissue (biology)cellular biochemistry

The Role of Yap/Taz Mechanosignaling in Trabecular Meshwork and Schlemm’s Canal Cell Dysfunction. Vision Research (2024)

cell biologycellular physiologymechanotransductioncanal cell dysfunctionschlemm ’mechanobiologyophthalmologytrabecular meshworkspinal cordperipheral nervebiomechanics

Three-Dimensional Extracellular Matrix Protein Hydrogels for Human Trabecular Meshwork Cell Studies. Methods in molecular biology (2024)

1
2
3
4
5
6
7
10 / page