Faculty

Institution

Unit

Venue

Sam Hanash

The University of Texas MD Anderson Cancer Center

Affiliations

Center Of Sheikh Ahmed Pancreatic Cancer Research

Duncan Family Institute for Cancer Prevention and Risk Assessment

Sam Hanash is a Senior Professor at The University of Texas MD Anderson Cancer Center. His research focuses on cancer biology, with particular emphasis on lung cancer and pancreatic cancer, integrating tumor biology, pathology, and cell biology. His recent work includes spatial and multiomics analyses of lung adenocarcinoma precursors, identifying TIM-3 as a target for precancer interception, and investigating blood-based protein biomarkers for early pancreatic cancer detection. He has also explored metabolic vulnerabilities in pancreatic cancers, such as long-chain sulfatide enrichment in IPMN-associated tumors, and mechanisms of acquired resistance to KRAS-targeted therapy in gastrointestinal cancers. His publications appear in leading journals including Cancer Cell, Gut, and the Journal of Thoracic Oncology.

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Sam Hanash

The University of Texas MD Anderson Cancer Center

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cancer research oncology cancer biology tumor biology cell biology pathology cancer cells lung cancer molecular cancer health sciences thoracic oncology immunology oncogenes pancreatic cancer biomarkers molecular diagnostics medicinal research cancer discovery cancer care cancer genomics cancer immunotherapy gastrointestinal oncology cancer treatment carcinogenesis clinical proteomics prognostic biomarkers ovarian cancer cancer risk biomarker discovery cancer genetics gynecologic oncology surgical oncology colorectal cancer tumor targeting respiratory medicine biomarker (medicine) cancer growth lung adenocarcinoma cellular therapy tumor suppressors extracellular microvesicles tumor heterogeneity disease progression oncogenic agent digestive diseases enzyme inhibition vascular biology genitourinary cancers early detection adaptive immune system malignant disease metabolomic profiling metabolic profiling molecular pathology innovative diagnostics rna biology clinical evidence disease risk assessment long non-coding rna anti-cancer agents clinical measurements pancreatic adenocarcinoma gastric adenocarcinoma progression blood-based biomarker panel gastric adenocarcinoma biomarker studies risk assessment active surveillance tumor microbiome diversity high prevalence exosome-derived dna intratumoral heterogeneity lineage diversity single-cell dissection metastatic gastric adenocarcinoma cancer-specific exosomal cargo

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4020: Utility of Ca19-9 for Prediction of Asymptomatic Pancreatic Cancer Among Patients With New Onset Diabetes. Cancer Research (2026)

diabetes carebiostatisticspathologyprognostic biomarkersasymptomatic pancreatic cancernew onset diabetesdiabetesdiabetes researchcancer researchcancer discoverypancreatic cancerbiomarkersabstract 4020cancer careoncology

Abstract 1884: Pancreatic Cyst Fluid Proteins Distinguish Dysplasia Grade of Intraductal Papillary Mucinous Neoplasm. Cancer Research (2025)

pancreatic cyst fluidpathologygastroenterologypancreatic fluid collectionsurgical pathologyabstract 1884cancer researchhistopathologypancreatic cancerdistinguish dysplasia gradeanatomical pathologytumoral pathology

Abstract 1913: Cystic Fluid Acetylated Polyamines Predict Risk of Malignancy of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Cancer Research (2025)

pathologypancreatitissurgical pathologyhistopathologypancreatic cancerabstract 1913anatomical pathologypancreatic surgerycystic fluid

Combination Surface Targeting Strategies in Relapsed Small Cell Lung Cancer (Sclc) to Overcome Intratumoral Heterogeneity Associated With Treatment Resistance. Journal of Thoracic Oncology (2025)

treatment resistanceradiation oncologytumor targetingdrug targetingcell biologylung cancercancer discoverytherapeutic targetsthoracic oncologycancer treatmenttumor microenvironment

Cyst Fluid Proteins Stratify Malignant Risk of Intraductal Papillary Mucinous Neoplasm of the Pancreas. Cancer Letters (2025)

pathologypancreatic fluid collectioncell biologysurgical pathologycyst fluid proteinscancer researchhistopathologypancreatic cancermalignant riskanatomical pathologypancreatic surgerytumoral pathology

Elevated Levels of Circulating Microbial-Associated Uremic Toxins Are Associated With Metastatic Duodenopancreatic Neuroendocrine Tumors in Patients With Multiple Endocrine Neoplasia Type 1. Cancer Letters (2025)

bladder cancerpathologyendocrine-related cancerskidney cancerneuroendocrine disordersmicrobial-associated uremic toxinselevated levelsurology

Impact of Comorbidities on the Mortality Benefits of Lung Cancer Screening: A Post-Hoc Analysis of the Plco and Nlst Trials. Journal of Thoracic Oncology (2025)

Sebastien GendarmeEhsan IrajizadJames P. LongJohannes F. FahrmannJennifer B. DennisonSeyyed Mahmood GhasemiRongzhang DouRobert J. VolkRafael MezaIakovos ToumazisFlorence Canoui-PoitrineSamir M. HanashEdwin J. Ostrin

public healthcancer screeningmortality benefitslung cancerlung cancer screeningthoracic oncologyclinical trialsoncologynlst trialspost-hoc analysis

Kap1 Promotes Gastric Adenocarcinoma Progression by Activating Hippo/Yap1 Signaling via Binding to Hnrnpab. Cancer Letters (2025)

Shumei SongYibo FanGengyi ZouLongfei HuoJanani KumarYuan LiRuiping WangEnyu DaiJiankang JinAiling W ScottShan ShaoMelissa Pool PizziJody V VykoukalHiryuki KatayamaSamir HanashGeorge A CalinXing ZhangMin Gyu LeeZhenning WangYuan-Hung LoQiong GanRebecca E WatersFeng YinLinghua WangXiaodong ChengJaffer A AjaniShilpa S Dhar

pathologyimmunologydisease progressioncancer discoverytumor biologycancer immunotherapycancer researchcancer cellscancer treatmenttumoral pathologyoncogenesgastrointestinal oncologymolecular cancersignaling pathwaysmolecular gastroenterologygastric adenocarcinoma progressionsystems biologytumor microenvironmentoncology

Lead Time Trajectory of Blood-Based Protein Biomarkers for Detection of Pancreatic Cancer Based on Repeat Testing. Cancer Letters (2025)

Johannes F. FahrmannMichele Yip-SchneiderJody VykoukalRachelle SpencerJennifer B. DennisonKim-Anh DoJames.P. LongAnirban MaitraJianjun ZhangC Max SchmidtSamir HanashEhsan Irajizad

biostatisticslead time trajectoryblood-based protein biomarkerscancer researchbiomarkerscancer letterbiomarker (medicine)

Long-Chain Sulfatide Enrichment is an Actionable Metabolic Vulnerability in Intraductal Papillary Mucinous Neoplasm (Ipmn)-Associated Pancreatic Cancers. Gut (2025)

Yihui ChenRiccardo BallaròMarta SansFredrik Ivar ThegeMingxin ZuoRongzhang DouJimin MinMichele Yip-SchneiderJ ZhangRanran WuEhsan IrajizadYuki MakinoKimal I RajapaksheHamid K RudsariMark W HurdRicardo A León-LetelierHiroyuki KatayamaEdwin OstrinJody VykoukalJennifer B DennisonKim-Anh DoSamir M HanashRobert A WolffPaolo A GuerreroMichael KimC Max SchmidtAnirban MaitraJohannes F Fahrmann

pathologyradiation oncologytumor biologymutant krassulfatide enrichmentmolecular cancercancer researchcancer discoverymolecular diagnosticsmetabolomicspancreatic cancermass spectrometrycancer cellstumor heterogeneityoncologycancer biology

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Sam Hanash

The University of Texas MD Anderson Cancer Center

Affiliations

Center Of Sheikh Ahmed Pancreatic Cancer Research

Duncan Family Institute for Cancer Prevention and Risk Assessment

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Sam Hanash

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 4020: Utility of Ca19-9 for Prediction of Asymptomatic Pancreatic Cancer Among Patients With New Onset Diabetes. Cancer Research (2026)

Abstract 1884: Pancreatic Cyst Fluid Proteins Distinguish Dysplasia Grade of Intraductal Papillary Mucinous Neoplasm. Cancer Research (2025)

Abstract 1913: Cystic Fluid Acetylated Polyamines Predict Risk of Malignancy of Intraductal Papillary Mucinous Neoplasms of the Pancreas. Cancer Research (2025)

pathologypancreatitissurgical pathologyhistopathologypancreatic cancerabstract 1913anatomical pathologypancreatic surgerycystic fluid

Combination Surface Targeting Strategies in Relapsed Small Cell Lung Cancer (Sclc) to Overcome Intratumoral Heterogeneity Associated With Treatment Resistance. Journal of Thoracic Oncology (2025)

treatment resistanceradiation oncologytumor targetingdrug targetingcell biologylung cancercancer discoverytherapeutic targetsthoracic oncologycancer treatmenttumor microenvironment

Cyst Fluid Proteins Stratify Malignant Risk of Intraductal Papillary Mucinous Neoplasm of the Pancreas. Cancer Letters (2025)

bladder cancerpathologyendocrine-related cancerskidney cancerneuroendocrine disordersmicrobial-associated uremic toxinselevated levelsurology

Impact of Comorbidities on the Mortality Benefits of Lung Cancer Screening: A Post-Hoc Analysis of the Plco and Nlst Trials. Journal of Thoracic Oncology (2025)

public healthcancer screeningmortality benefitslung cancerlung cancer screeningthoracic oncologyclinical trialsoncologynlst trialspost-hoc analysis

Kap1 Promotes Gastric Adenocarcinoma Progression by Activating Hippo/Yap1 Signaling via Binding to Hnrnpab. Cancer Letters (2025)

Lead Time Trajectory of Blood-Based Protein Biomarkers for Detection of Pancreatic Cancer Based on Repeat Testing. Cancer Letters (2025)

Johannes F. FahrmannMichele Yip-SchneiderJody VykoukalRachelle SpencerJennifer B. DennisonKim-Anh DoJames.P. LongAnirban MaitraJianjun ZhangC Max SchmidtSamir HanashEhsan Irajizad

biostatisticslead time trajectoryblood-based protein biomarkerscancer researchbiomarkerscancer letterbiomarker (medicine)

Long-Chain Sulfatide Enrichment is an Actionable Metabolic Vulnerability in Intraductal Papillary Mucinous Neoplasm (Ipmn)-Associated Pancreatic Cancers. Gut (2025)

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