Faculty

Institution

Unit

Venue

Sachet A. Shukla

Assistant Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Hematopoietic Biology And Malignancy

Department Of Immunology

The University of Texas MD Anderson Cancer Center

Sachet A. Shukla is an Assistant Professor at The University of Texas MD Anderson Cancer Center, where his research focuses on cancer immunology, tumor biology, and cancer genomics. His work centers on neoantigen discovery and immunotherapy, with recent breakthroughs including a neoantigen vaccine generating antitumour immunity in renal cell carcinoma (Nature, 2025) and the role of HIF-regulated endogenous retroviruses in cancer immunotherapy (Cell, 2025). He has also developed a deep learning-based filtering tool for detecting technical artifacts in whole-genome sequencing data and identified FGFR2b as an actionable cell surface target in intrahepatic cholangiocarcinoma. His research integrates cancer genetics, medicinal research, and translational oncology to advance personalized cancer care.

Honors

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Education

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Sachet A. Shukla

The University of Texas MD Anderson Cancer Center

Assistant Professor

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oncology cancer research immunology cancer biology medicinal research tumor biology cancer immunotherapy cancer genomics genetics cancer care cancer genetics cellular therapy genomics molecular cancer cancer cells cancer treatment clinical research dermatology immunotherapy hematological malignancies molecular biology oncogenes genitourinary cancers genome biology leukemia immune responses brain tumor research tumor targeting anti-cancer agents chronic lymphocytic leukemia immune checkpoint inhibitors cancer immunosurveillance lymphoid neoplasia cancer imaging medical mycology melanoma cancer risk colorectal cancer cancer discovery vaccine research adaptive immune system tumor suppressors gynecologic oncology molecular cell biology clinical immunology viral oncology cancer management clinical mycology cellular immune responses vaccine development renal cell carcinoma molecular diagnostics skin cancer single-cell analysis human cancers enzyme inhibition molecular characterization cell regulation genomic correlates neoantigen load tumor-infiltrating lymphocytes comprehensive molecular characterization therapy resistance epigenomics t-regulatory cell immunosuppression therapeutic vaccines neoantigen vaccine systematic identification integrative molecular characterization predictive biomarkers tumor dna metastatic melanoma genetic properties clonal neoantigens subclonal mutations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1495: A Novel, Deep Learning -Based Filtering Tool for Enhanced Detection of Technical Artifacts in Whole-Genome Sequencing Data. Cancer Research (2026)

genomicsgenome biologylong-read sequencingbiomedical informaticsnext-generation sequencinghigh throughput sequencingtechnical artifactssystems biologyabstract 1495deep learningcomputational genomicsdata sciencemolecular informaticsbioinformatics

Abstract 3075: Fgfr2b is a Highly Prevalent and Actionable Cell Surface Target in Intrahepatic Cholangiocarcinoma. Cancer Research (2026)

intrahepatic cholangiocarcinomaliver cancermolecular cancerbiliary cancerhistopathologyabstract 3075oncologyhepatologycancer cellsoncogenespathologytumor biologycell biology

Abstract Pr001: Exploiting Hif-Driven Endogenous Retroviral Neoantigens to Advance Kidney Cancer Immunotherapy. Cancer Research (2026)

immunologykidney researchkidney cancer immunotherapyabstract pr001cancer researchimmune checkpoint inhibitorscancer immunosurveillanceurologycancer discoverycancer immunotherapykidney cancercancer cellscellular therapyimmunotherapycell biology

Data From Pkcβ Inhibitor Ms-553 Displays Preclinical Efficacy in Both Treatment-NaïVe and Btk Inhibitor–Resistant Chronic Lymphocytic Leukemia. (2026)

immunologymedicineleukemiapharmacologylymphoid neoplasiaoncology

119 Endogenous Retroviruses as Tumor-Specific Antigens in Clear Cell Renal Cell Carcinoma: A New Avenue for Immunotherapy. Regular and Young Investigator Award Abstracts (2025)

immunologyendogenous retrovirusesmedical virologyurologycancer immunotherapynew avenuevirologytumor-specific antigenscancer-associated viruskidney cancercellular therapyviral oncologyimmunotherapy

1228 Immune Escape Through Oncogene-Mediated Editing of the Hla-Ligandome. Regular and Young Investigator Award Abstracts (2025)

immunologyhla typingimmune responsesimmune escapecell transplantation

2601P Peripheral and Tumor Cytokines in Exceptional Responders to Immunotherapy: Results From a Phase III Trial. Annals of Oncology (2025)

immunologyphase iii trialtumor cytokinescancer immunosurveillanceexceptional responderscancer immunotherapyimmunoeditingimmune responsescancer cellstumor microenvironmentimmunomodulationcellular therapyexperimental medicineimmunotherapycell biology

831 Axl Receptor Tyrosine Kinase Expression in Metastatic Renal Cell Carcinoma: Insights From the Meteor Trial. Laboratory Investigation (2025)

Yasmin LaimonMorgan PaulTejas JammihalFatme GhandourNourhan El AhmarBerkay SimsekSayed MatarThomas DenizeRazan MohannaGabriel Roberti De OliveiraAndrew DelceaSachet ShuklaDavid BraunMaxine SunDana AftabEddy SaadMarc MachaalaniWanling XieToni ChoueiriSabina Signoretti

meteor triallaboratory investigationreceptor tyrosine kinasesmolecular biologykidney cancer

A Multi-Adjuvant Personal Neoantigen Vaccine Generates Potent Immunity in Melanoma. Cell (2025)

immunologyvaccinesdermatologymelanomacancer immunosurveillancecancer immunotherapyimmune responsescancer cellsimmunomodulationimmunity (medicine)cellular therapypotent immunitytherapeutic vaccinesimmunotherapy

A Neoantigen Vaccine Generates Antitumour Immunity in Renal Cell Carcinoma. Nature (2025)

David A. BraunGiorgia MoranzoniVipheaviny CheaBradley A. McGregorEryn BlassChloe R. TuAllison P. VanasseCleo FormanJuliet FormanAlexander B. AfeyanNicholas R. SchindlerYiwen LiuShuqiang LiJackson SouthardSteven L. ChangMichelle S. HirschNicole R. LeBoeufOriol OliveAmbica MehndirattaHaley GreensladeKeerthi ShettySusan KlaegerSiranush SarkizovaChristina B. PedersenMatthew MossanenIsabel CarulliAnna TarrenJoseph Duke-CohanAlexis A. HowardJ. Bryan IorgulescuBohoon ShimJeremy M. SimonSabina SignorettiJon C. AsterLiudmila ElaginaSteven A. CarrIgnaty LeshchinerGad GetzStacey GabrielNir HacohenLars R. OlsenGiacomo OliveiraDonna S. NeubergKenneth J. LivakSachet A. ShuklaEdward F. FritschCatherine J. WuDerin B. KeskinPatrick A. OttToni K. Choueiri

antitumour immunitykidney cancervaccine researchtherapeutic vaccinescell biologyvaccinesneoantigen vaccinemolecular canceranti-cancer agentscancer biologytherapeutic targetscancer immunotherapycancer growthrenal cell carcinomaimmunologycarcinogenesissystems biologycancer discoveryoncogenesmedicinal researchcellular therapy

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Sachet A. Shukla

Assistant Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Hematopoietic Biology And Malignancy

Department Of Immunology

The University of Texas MD Anderson Cancer Center

Honors

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Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Sachet A. Shukla

The University of Texas MD Anderson Cancer Center

Assistant Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1495: A Novel, Deep Learning -Based Filtering Tool for Enhanced Detection of Technical Artifacts in Whole-Genome Sequencing Data. Cancer Research (2026)

Abstract 3075: Fgfr2b is a Highly Prevalent and Actionable Cell Surface Target in Intrahepatic Cholangiocarcinoma. Cancer Research (2026)

intrahepatic cholangiocarcinomaliver cancermolecular cancerbiliary cancerhistopathologyabstract 3075oncologyhepatologycancer cellsoncogenespathologytumor biologycell biology

Abstract Pr001: Exploiting Hif-Driven Endogenous Retroviral Neoantigens to Advance Kidney Cancer Immunotherapy. Cancer Research (2026)

Data From Pkcβ Inhibitor Ms-553 Displays Preclinical Efficacy in Both Treatment-NaïVe and Btk Inhibitor–Resistant Chronic Lymphocytic Leukemia. (2026)

immunologymedicineleukemiapharmacologylymphoid neoplasiaoncology

119 Endogenous Retroviruses as Tumor-Specific Antigens in Clear Cell Renal Cell Carcinoma: A New Avenue for Immunotherapy. Regular and Young Investigator Award Abstracts (2025)

immunologyendogenous retrovirusesmedical virologyurologycancer immunotherapynew avenuevirologytumor-specific antigenscancer-associated viruskidney cancercellular therapyviral oncologyimmunotherapy

1228 Immune Escape Through Oncogene-Mediated Editing of the Hla-Ligandome. Regular and Young Investigator Award Abstracts (2025)

immunologyhla typingimmune responsesimmune escapecell transplantation

2601P Peripheral and Tumor Cytokines in Exceptional Responders to Immunotherapy: Results From a Phase III Trial. Annals of Oncology (2025)

831 Axl Receptor Tyrosine Kinase Expression in Metastatic Renal Cell Carcinoma: Insights From the Meteor Trial. Laboratory Investigation (2025)

meteor triallaboratory investigationreceptor tyrosine kinasesmolecular biologykidney cancer

A Multi-Adjuvant Personal Neoantigen Vaccine Generates Potent Immunity in Melanoma. Cell (2025)

A Neoantigen Vaccine Generates Antitumour Immunity in Renal Cell Carcinoma. Nature (2025)

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