Faculty

Institution

Unit

Venue

Ruth Borghaei

Philadelphia College of Osteopathic Medicine

Affiliations

Bio-Medical Sciences (PCOM Georgia)

Bio-Medical Sciences (PCOM South Georgia)

Division Of Research

Center For Chronic Disorders Of Aging

Center for Chronic Disorders of Aging

Department Of Biomedical Sciences

Department Of Physiology And Pharmacology

Philadelphia College of Osteopathic Medicine

NoneRuth Borghaei is currently serving as a Bio-Medical Sciences (Pcom Georgia) faculty at Philadelphia College of Osteopathic Medicine.

Honors

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Experiences

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Education

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Ruth Borghaei

Philadelphia College of Osteopathic Medicine

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cell biology inflammation immunology immune responses cell signaling clinical periodontology cytokines cell research periodontology transcription factors pathology molecular cell biology molecular biology inflammatory diseases sclerostin oral biology metalloproteins gene expression free radical biology bone research signaling pathways connective tissue disease epigenetics experimental medicine gene regulation fibrosis human tissues cell regulation transcription (biology) cell death arthritis stem cell research transcription regulation immune dysregulation tissue culture novel metalloprotease inhibitor total protein production measure effects dentistry oral pathology oral diseases oral health nucleic acids rheumatism medicinal research inflammatory rheumatic disease immune mediators bone morphogenic protein chronic inflammation epigenetic changes pulmonary diseases lung deposition cell growth epigenomics heme signaling fibroblast growth factors gene function protein function tissue physiology metabolic viability primary serum‐free cultures metalloprotease production serum free culture collagen metabolism serum-free culture collagenase inhibitor novel collagenase inhibitors serum‐free culture

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1732 Augmentation of Transforming Growth Factor-β-Induced Epithelial to Mesenchymal Transition by Interleukin-1β: Role of Dna Methylation. Journal of Biological Chemistry (2025)

molecular cell biologycellular differentiationcell growthcell researchstem cell researchcell biologystem cells

Assessing the Effects of a Novel Metalloprotease Inhibitor, Extracellular Matrix Protection Factor-2, on Primary Human Gingival Fibroblast's Metabolic Viability as Determined by Total Protein Production. Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine) (2021)

matrix biologybiochemistrycell biologyregenerative medicinemetabolic viabilityproteomicssclerostinnovel metalloprotease inhibitortotal protein productionmetalloproteinsvascular biologypharmacologyinflammationclinical proteomicsperiodontologyoral biologycell signalingextracellular matrixclinical periodontology

Measurement of Collagen Metabolism and Metalloprotease Production Demonstrates That Primary Human Gingival Fibroblasts Retain Inflamed Tissue Profile in Serum Free Culture. Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine) (2021)

pathologymatrix biologyperiodontologymetalloprotease productiontissue cultureinflammationserum free cultureconnective tissue diseasecollagen metabolismtissue (biology)human tissuesextracellular matrixcell biologyarthritisclinical periodontology

Assessment of Collagen Metabolism by Human Gingival Fibroblasts Reared in Serum‐Free Conditions. The FASEB Journal (2020)

pathologymatrix biologyconnective tissue diseasetissue (biology)clinical biochemistrybone researchextracellular matrixphysiology

Characterization of Collagen Metabolism in Normal and Chronic Obstructive Pulmonary Diseased Human Lung Fibroblasts Reared in Serum‐Free Medium. The FASEB Journal (2020)

pathologymatrix biologypulmonary diseasestissue (biology)chronic obstructive pulmonary diseaselung depositionfibrosishuman tissuesphysiology

Measuring Effects of Treatment With a Novel Metalloprotease Inhibitor, Extracellular Matrix Protection Factor‐2, on Total Protein Production by Human Gingival Fibroblast Cultures. The FASEB Journal (2020)

matrix biologyperiodontologyclinical proteomicssclerostinnovel metalloprotease inhibitortranslational medicineimmunologymetalloproteinsextracellular matrixcell biologytotal protein productionexperimental medicineregenerative medicineclinical periodontology

Regulation of Dna Methyltransferase 3A Expression by Prostaglandin E2 in Human Fibroblasts. The FASEB Journal (2020)

molecular cell biologygene functiongene expressiongene regulationtranscription factorscell metabolismmolecular metabolismmolecular biologycell regulationepigeneticscell biology

Interleukin 1β and Prostaglandin E2 Affect Expression of Dna Methylating and Demethylating Enzymes in Human Gingival Fibroblasts. International Immunopharmacology (2019)

cytokinesperiodontologyimmune responsesinflammationcell researchimmunologyinflammatory diseasesepigeneticscell biologyclinical periodontology

Extracellular Matrix Protection Factor‐2 Reduces Collagen Degradation in Primary Serum‐Free Cultures of Inflamed Human Gingival Fibroblasts. The FASEB Journal (2018)

matrix biologyprimary serum‐free culturestissue cultureinflammationconnective tissue diseasecell researchimmunologyhuman tissuesextracellular matrixcell biology

Interleukin 1 and Prostaglandin E2 Affect Expression of Dna Methyltransferases and Global Dna Methylation Levels in Human Gingival Fibroblasts. Digital Commons - PCOM (Philadelphia College of Osteopathic Medicine) (2017)

inflammationsclerostinepigenomicscell biologyclinical periodontology

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Ruth Borghaei

Philadelphia College of Osteopathic Medicine

Affiliations

Bio-Medical Sciences (PCOM Georgia)

Bio-Medical Sciences (PCOM South Georgia)

Division Of Research

Center For Chronic Disorders Of Aging

Center for Chronic Disorders of Aging

Department Of Biomedical Sciences

Department Of Physiology And Pharmacology

Philadelphia College of Osteopathic Medicine

NoneRuth Borghaei is currently serving as a Bio-Medical Sciences (Pcom Georgia) faculty at Philadelphia College of Osteopathic Medicine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ruth Borghaei

Philadelphia College of Osteopathic Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 1732 Augmentation of Transforming Growth Factor-β-Induced Epithelial to Mesenchymal Transition by Interleukin-1β: Role of Dna Methylation. Journal of Biological Chemistry (2025)

molecular cell biologycellular differentiationcell growthcell researchstem cell researchcell biologystem cells

Assessment of Collagen Metabolism by Human Gingival Fibroblasts Reared in Serum‐Free Conditions. The FASEB Journal (2020)

pathologymatrix biologyconnective tissue diseasetissue (biology)clinical biochemistrybone researchextracellular matrixphysiology

Characterization of Collagen Metabolism in Normal and Chronic Obstructive Pulmonary Diseased Human Lung Fibroblasts Reared in Serum‐Free Medium. The FASEB Journal (2020)

pathologymatrix biologypulmonary diseasestissue (biology)chronic obstructive pulmonary diseaselung depositionfibrosishuman tissuesphysiology

Regulation of Dna Methyltransferase 3A Expression by Prostaglandin E2 in Human Fibroblasts. The FASEB Journal (2020)

molecular cell biologygene functiongene expressiongene regulationtranscription factorscell metabolismmolecular metabolismmolecular biologycell regulationepigeneticscell biology

Interleukin 1β and Prostaglandin E2 Affect Expression of Dna Methylating and Demethylating Enzymes in Human Gingival Fibroblasts. International Immunopharmacology (2019)

cytokinesperiodontologyimmune responsesinflammationcell researchimmunologyinflammatory diseasesepigeneticscell biologyclinical periodontology

Extracellular Matrix Protection Factor‐2 Reduces Collagen Degradation in Primary Serum‐Free Cultures of Inflamed Human Gingival Fibroblasts. The FASEB Journal (2018)

matrix biologyprimary serum‐free culturestissue cultureinflammationconnective tissue diseasecell researchimmunologyhuman tissuesextracellular matrixcell biology

inflammationsclerostinepigenomicscell biologyclinical periodontology

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3
4
10 / page