Faculty

Institution

Unit

Venue

Rujia Dai

Upstate Medical University

Affiliations

Norton College of Medicine

Psychiatry

Rujia Dai is a Senior Professor at Upstate Medical University, specializing in psychiatric genetics and molecular psychiatry. Her research integrates single-cell transcriptomics, gene expression regulation, and neurogenetics to dissect the biological underpinnings of schizophrenia and other psychiatric disorders. Recent landmark studies include a single-cell multi-cohort dissection of the schizophrenia transcriptome and a cross-ancestry atlas of brain QTLs, both published in *Science*, enhancing the interpretation of genome-wide association studies. Her work also explores transcriptomic sex differences in psychiatric patients and regulatory elements in the developing human cortex, advancing precision in psychiatric diagnostics and therapeutic development.

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Rujia Dai

Upstate Medical University

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neuroscience psychiatry genetics psychiatric genetics neurogenetics gene expression molecular psychiatry schizophrenia biological psychiatry psychiatric research genomics bioinformatics molecular biology cognitive neuroscience human genetics neuropsychopharmacology systems neuroscience molecular neurodegeneration genome biology molecular cell biology epigenetic changes single-cell analysis gene regulation transcriptomics technology neuropsychiatry epigenomics neuroinformatics clinical neuroscience psychotic disorders gene function psychiatric disorders bipolar disorder developmental cognitive neuroscience translational psychiatry biomedical informatics medical genetics genome-wide association studies molecular neurobiology developmental genetics psychoneuroimmunology brain-immune interaction spatiotemporal database developmental science neurodevelopmental disorders analytical atomic spectrometry cryptographic hardware biomedical analysis science advance sex differences transcription regulation long non-coding rna brain mapping data-driven science brain imaging brain structure spectrochemical analysis neuroinflammation brain function mood spectrum neuropsychological functioning bioinformatics database transcriptome-wide isoform-level dysregulation human cortical development epigenome landscape schizophrenia transcriptome single-cell multi-cohort dissection brain tissue gene coexpression network chromatin architecture brain disorders glial 3d sex-differential dna methylation sex-biased risks data-driven single-cell human prefrontal cortex spatial transcriptomic map

Notable Scholarly Works

Notable Federal Grants

Collaborators

Precision and Accuracy in Quantitative Measurement of Gene Expression From Single-Cell/Nucleus Rna Sequencing Data. Genomics Proteomics & Bioinformatics (2025)

geneticsmicroarray data analysissingle-cell analysisbioinformaticsgene expressionquantitative measurementnucleic acidsgene expression profilingsingle cell sequencingsystems biologygenome biologytranscriptomics technologytranscriptomeomicsbiomedical informatics

59. Unveiling Cell-Type-Specific Changes in Schizophrenia: Insights From Cell Composition, Gene Expression, and Genetic Risk Enrichment. European Neuropsychopharmacology (2024)

geneticsbiological psychiatrypsychotic disordersmolecular psychiatrypsychiatric geneticsneurogeneticsgene expressionpsychiatric researchneurosciencepsychiatryschizophrenia

A Data-Driven Single-Cell and Spatial Transcriptomic Map of the Human Prefrontal Cortex. Science (2024)

Louise A. Huuki-MyersAbby SpanglerNicholas J. EaglesKelsey D. MontgomerySang Ho KwonBoyi GuoMelissa Grant-PetersHeena R. DivechaMadhavi TippaniChaichontat SriworaratAnnie B. NguyenPrashanthi RavichandranMatthew N. TranArta SeyedianThomas M. HydeJoel E. KleinmanAlexis BattleStephanie C. PageMina RytenStephanie C. HicksKeri MartinowichLeonardo Collado-TorresKristen R. MaynardSchahram AkbarianAlexej AbyzovNadav AhituvDhivya ArasappanJose Juan Almagro ArmenterosBrian J. BeliveauJaroslav BendlSabina BerrettaRahul A. BharadwajArjun BhattacharyaLucy BicksKristen BrennandDavide CapautoFrances A. ChampagneTanima ChatterjeeChris ChatzinakosYuhang ChenH. Isaac ChenYuyan ChengLijun ChengAndrew ChessJo-fan ChienZhiyuan ChuDeclan ClarkeAshley ClementLeonardo Collado-TorresGregory M. CooperGregory E. CrawfordRujia DaiNikolaos P. DaskalakisJose Davila-VelderrainAmy Deep-SoboslayChengyu DengChristopher P. DiPietroStella DrachevaShiron DrusinskyZiheng DuanDuc DuongCagatay DursunNicholas J. EaglesJonathan EdelsteinPrashant S. EmaniJohn F. FullardKiki GalaniTimur GaleevMichael J. GandalSophia GaynorMark GersteinDaniel H. GeschwindKiran GirdharFernando S. GoesWilliam GreenleafJennifer GrundmanHanmin GuoQiuyu GuoChirag GuptaYoav HadasJoachim HallmayerXikun HanVahram HaroutunianNatalie HawkenChuan HeElla HenryStephanie C. HicksMarcus HoLi-Lun HoGabriel E. HoffmanYiling HuangLouise A. Huuki-MyersAhyeon HwangThomas M. HydeArtemis IatrouFumitaka InoueAarti JajooMatthew JensenLihua JiangPeng Jin

neuroinformaticssingle-cell analysisbioinformaticsneurosciencebrain mappingspatial transcriptomic mapmolecular biologyneuroanatomygenome biologytranscriptomics technologysystems neurosciencehuman prefrontal cortexcell biologycognitive neurosciencecomputational neurosciencedata-driven single-celldata-driven science

Brain Eqtls of European, African American, and Asian Ancestry Improve Interpretation of Schizophrenia Gwas. medRxiv (2024)

Yu ChenSihan LiuZongyao RenFeiran WangYi JiangRujia DaiFangyuan DuanCong HanZhilin NingYan XiaMiao LiKai YuanWenying QiuXiao-Xin YanJiapei DaiRichard F. KoppJufang HuangShuhua XuBeisha TangEric R. GamazonTim BigdeliElliot GershonHailiang HuangChao MaChunyu LiuChao Chen

psychopathologypsychotic disordersmolecular psychiatryasian ancestryneuropsychiatrytranslational psychiatrygeneticsneurosciencemental healthschizophreniaschizophrenia gwasgenome-wide association studiespsychiatric researchworld psychiatryforensic psychiatrypsychiatryneurogeneticsvariant interpretationbrain eqtlspsychiatric epidemiologypsychiatric genetics

Cam3.0: Determining Cell Type Composition and Expression From Bulk Tissues With Fully Unsupervised Deconvolution. Bioinformatics (2024)

Chiung-Ting WuDongping DuLulu ChenRujia DaiChunyu LiuGuoqiang YuSaurabh BhardwajSarah J ParkerZhen ZhangRobert ClarkeDavid M HerringtonYue Wang

bioinformaticsmachine learningcomputational biologybulk tissuesinformaticsmolecular biologyunsupervised deconvolutioncell biology

Cross-Ancestry Analysis of Brain Qtls Enhances Interpretation of Schizophrenia Genome-Wide Association Studies. The American Journal of Human Genetics (2024)

Yu ChenSihan LiuZongyao RenFeiran WangQiuman LiangYi JiangRujia DaiFangyuan DuanCong HanZhilin NingYan XiaMiao LiKai YuanWenying QiuXiao-Xin YanJiapei DaiRichard F KoppJufang HuangShuhua XuBeisha TangLingqian WuEric R GamazonTim BigdeliElliot GershonHailiang HuangChao MaChunyu LiuChao Chen

geneticshuman geneticsgenotype-phenotype associationgenome-wide association studiespsychiatric geneticsgenomicsbrain qtlscross-ancestry analysisschizophrenia

Cross-Ancestry Atlas of Gene, Isoform, and Splicing Regulation in the Developing Human Brain. Science (2024)

Cindy WenMichael MargolisRujia DaiPan ZhangPawel F. PrzytyckiDaniel D. VoArjun BhattacharyaNana MatobaMiao TangChuan JiaoMinsoo KimEllen TsaiCeline HohNil AygünRebecca L. WalkerChristos ChatzinakosDeclan ClarkeHenry PrattMette A. PetersMark GersteinNikolaos P. DaskalakisZhiping WengAndrew E. JaffeJoel E. KleinmanThomas M. HydeDaniel R. WeinbergerNicholas J. BrayNenad SestanDaniel H. GeschwindKathryn RoederAlexander GusevBogdan PasaniucJason L. SteinMichael I. LoveKatherine S. PollardChunyu LiuMichael J. GandalSchahram AkbarianAlexej AbyzovNadav AhituvDhivya ArasappanJose Juan Almagro ArmenterosBrian J. BeliveauJaroslav BendlSabina BerrettaRahul A. BharadwajLucy BicksKristen BrennandDavide CapautoFrances A. ChampagneTanima ChatterjeeChris ChatzinakosYuhang ChenH. Isaac ChenYuyan ChengLijun ChengAndrew ChessJo-fan ChienZhiyuan ChuAshley ClementLeonardo Collado-TorresGregory M. CooperGregory E. CrawfordJose Davila-VelderrainAmy Deep-SoboslayChengyu DengChristopher P. DiPietroStella DrachevaShiron DrusinskyZiheng DuanDuc DuongCagatay DursunNicholas J. EaglesJonathan EdelsteinPrashant S. EmaniJohn F. FullardKiki GalaniTimur GaleevSophia GaynorKiran GirdharFernando S. GoesWilliam GreenleafJennifer GrundmanHanmin GuoQiuyu GuoChirag GuptaYoav HadasJoachim HallmayerXikun HanVahram HaroutunianNatalie HawkenChuan HeElla HenryStephanie C. HicksMarcus HoLi-Lun HoGabriel E. HoffmanYiling HuangLouise A. Huuki-MyersAhyeon Hwang

geneticsgene expressiongenomicsneurogeneticsdevelopmental sciencecross-ancestry atlasmedical geneticsdevelopmental biologymolecular biologygenome biologydevelopmental neurobiologydevelopmental geneticshuman brain

Evaluating Performance and Applications of Sample-Wise Cell Deconvolution Methods on Human Brain Transcriptomic Data. Science Advances (2024)

Rujia DaiTianyao ChuMing ZhangXuan WangAlexandre JourdonFeinan WuJessica MarianiFlora M. VaccarinoDonghoon LeeJohn F. FullardGabriel E. HoffmanPanos RoussosYue WangXusheng WangDalila PintoSidney H. WangChunling ZhangChao ChenChunyu Liu

bioinformaticsbiostatisticsbiomedical data analysisproteomicsneurosciencedata sciencetranscriptomics technologymicroarray data analysisscience advancebiomedical data sciencebiomedical analysisbiomedical informatics

F69. Mirna-Mediated Activation of Gene Expression Through Dna Regulatory Elements in the Human Brain. European Neuropsychopharmacology (2024)

small rnamolecular cell biologygene expressionnon-coding rnamicrorna detectiongene regulationneurosciencenucleic acidscell biologytranscription (biology)

Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations. Molecular Psychiatry (2024)

Cuihua XiaNey Alliey-RodriguezCarol A. TammingaMatcheri S. KeshavanGodfrey D. PearlsonSarah K. KeedyBrett ClementzJennifer E. McDowellDavid ParkerRebekka LencerS. Kristian HillJeffrey R. BishopElena I. IvlevaCindy WenRujia DaiChao ChenChunyu LiuElliot S. Gershon

psychotic disordersmolecular psychiatrygenetic disordersgeneticshuman geneticsforensic geneticsgenomicsbiological psychiatrypsychiatric researchneuropsychopharmacologypsychiatryepidemiologyancestry-adjusted polygenic riskneurogeneticspolygenic riskgenetic epidemiologypsychiatric epidemiologypsychosis biotypesgenetic predispositionpsychiatric genetics

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Rujia Dai

Upstate Medical University

Affiliations

Norton College of Medicine

Psychiatry

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Rujia Dai

Upstate Medical University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Precision and Accuracy in Quantitative Measurement of Gene Expression From Single-Cell/Nucleus Rna Sequencing Data. Genomics Proteomics & Bioinformatics (2025)

59. Unveiling Cell-Type-Specific Changes in Schizophrenia: Insights From Cell Composition, Gene Expression, and Genetic Risk Enrichment. European Neuropsychopharmacology (2024)

geneticsbiological psychiatrypsychotic disordersmolecular psychiatrypsychiatric geneticsneurogeneticsgene expressionpsychiatric researchneurosciencepsychiatryschizophrenia

A Data-Driven Single-Cell and Spatial Transcriptomic Map of the Human Prefrontal Cortex. Science (2024)

Brain Eqtls of European, African American, and Asian Ancestry Improve Interpretation of Schizophrenia Gwas. medRxiv (2024)

Cam3.0: Determining Cell Type Composition and Expression From Bulk Tissues With Fully Unsupervised Deconvolution. Bioinformatics (2024)

Chiung-Ting WuDongping DuLulu ChenRujia DaiChunyu LiuGuoqiang YuSaurabh BhardwajSarah J ParkerZhen ZhangRobert ClarkeDavid M HerringtonYue Wang

bioinformaticsmachine learningcomputational biologybulk tissuesinformaticsmolecular biologyunsupervised deconvolutioncell biology

Cross-Ancestry Analysis of Brain Qtls Enhances Interpretation of Schizophrenia Genome-Wide Association Studies. The American Journal of Human Genetics (2024)

geneticshuman geneticsgenotype-phenotype associationgenome-wide association studiespsychiatric geneticsgenomicsbrain qtlscross-ancestry analysisschizophrenia

Cross-Ancestry Atlas of Gene, Isoform, and Splicing Regulation in the Developing Human Brain. Science (2024)

Evaluating Performance and Applications of Sample-Wise Cell Deconvolution Methods on Human Brain Transcriptomic Data. Science Advances (2024)

F69. Mirna-Mediated Activation of Gene Expression Through Dna Regulatory Elements in the Human Brain. European Neuropsychopharmacology (2024)

small rnamolecular cell biologygene expressionnon-coding rnamicrorna detectiongene regulationneurosciencenucleic acidscell biologytranscription (biology)

Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations. Molecular Psychiatry (2024)

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