Faculty

Institution

Unit

Venue

Rosa F. Hwang

Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Breast Surgical Oncology

Department Of Head And Neck Surgery

Division Of Surgery

Section Of Hepato-Pancreato-Biliary

Department Of Surgical Oncology

Division Of Surgery

Department Of Surgical Oncology

Division Of Surgical Oncology

The University of Texas MD Anderson Cancer Center

Rosa F. Hwang is a Professor at The University of Texas MD Anderson Cancer Center. Her research focuses on the tumor microenvironment in pancreatic and breast cancer, particularly the role of cancer-associated fibroblasts (CAFs) in chemoresistance and DNA repair. Her recent work identified NDRG1-mediated R-loop processing as a mechanism by which CAFs regulate DNA repair in pancreatic cancer, published in *Nature Cell Biology* (2026). She has also investigated de-escalation strategies for invasive breast cancer, including omitting breast surgery and sentinel lymph node biopsy, with findings published in *JAMA Oncology* and *Cancer*. Her research integrates surgical oncology, tumor biology, and translational approaches to improve therapeutic outcomes.

Honors

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Experiences

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Education

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Rosa F. Hwang

The University of Texas MD Anderson Cancer Center

Professor

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oncology breast cancer cancer research tumor biology pathology pancreatic cancer surgical oncology cell biology breast oncology radiation oncology surgery cancer cells cancer care cancer biology tumor microenvironment breast surgery molecular cancer metastasis oncogenes cancer treatment medicinal research cell signaling cancer imaging cellular therapy carcinogenesis cancer management cancer detection surgical pathology signaling pathways tumor targeting breast cancer patients cancer discovery cancer genomics plastic surgery breast imaging pancreatic ductal adenocarcinoma molecular cell biology reconstructive surgery gastrointestinal oncology cancer genetics cancer growth gynecologic oncology matrix biology cellular physiology pancreatic surgery tumor suppressors cell regulation cell-matrix interactions pancreatic adenocarcinoma gastrointestinal surgery general surgery malignant disease lymphoid neoplasia ductal carcinoma clinical surgery disease progression tumoral pathology radiation therapy neoadjuvant systemic therapy neoadjuvant chemotherapy stellate cells treatment and prevention surgical care lymphatic system breast cancer nomogram breast conservation therapy systemic therapy clinical implementation cancer risk node-positive breast cancer clinicopathologic factors exceptional responders early-stage breast cancer american college pancreatic cancer cells autologous fat grafting

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cancer-Associated Fibroblasts Regulate Dna Repair in Pancreatic Cancer Through Ndrg1-Mediated R-Loop Processing. Nature Cell Biology (2026)

oncogenestumor biologycell biologycarcinogenesiscancer researchmolecular cell biologypancreatic cancermolecular biologycancer geneticsndrg1-mediated r-loop processingcancer cellsdna repairtumor microenvironmentcancer biology

A Novel Dna Repair Protein, N-Myc Downstream Regulated Gene 1 (Ndrg1), Links Stromal Tumour Microenvironment to Chemoresistance. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Nina KozlovaKayla A CruzHanna M DohAntoine A RuzetteNicholas A WillisSu Min HongRaul S GonzalezMonika VyasLaura M SelforsStephan B DreyerRosie Upstill-GoddardKerrie L FaiaSteve WenglowskyJosh CloseAlica K. BeutelZeljka JutricMichael U J OliphantByanjana ThapaMartin TaylorVenla MustonenPradeep MangalathChristopher J HalbrookJoseph E GrossmanRosa F HwangJohn G ClohessySalla RuskamoPetri KursulaBoryana PetrovaNaama KanarekP. A. ColeDavid ChangSimon F NorrelykkeRalph ScullyTaru Muranen

n-myc downstreamdna repairmolecular biologystromal tumour microenvironment

Assessment of Pectoralis Muscle Invasion Using Combined Dbt and Contrast-Enhanced Mammography: Retrospective Multi-Reader Study. Current Problems in Diagnostic Radiology (2025)

medical imagingdiagnosisretrospective multi-reader studyradiologypectoralis muscle invasioncontrast-enhanced mammographybreast imagingbreast cancer

Axillary Management After Neoadjuvant Endocrine Therapy (Net). Annals of Surgical Oncology (2025)

endocrine oncologysurgerysurgical oncologyaxillary managementmedicineendocrine surgerypharmacotherapycancer careoncologybreast cancer

Implications of Omitting Sentinel Lymph Node Biopsy on Adjuvant Decision Making for Patients With Small Breast Cancers. Cancer (2025)

breast oncologysmall breast cancersmetastasisradiation oncologysurgical oncologyadjuvant decision makingbreast surgerymedicinecancer careoncologybreast cancer

Predicting Pathologic ≥N2 Disease in Women With Breast Cancer. npj Breast Cancer (2025)

breast oncologygynecologic oncologypathologycancer riskbreast imagingoncologybreast cancer

Selective Elimination of Breast Surgery for Invasive Breast Cancer. JAMA Oncology (2025)

breast oncologyaesthetic surgerysurgerysurgical oncologyselective eliminationbreast surgeryplastic surgeryaesthetic plastic surgeryoncologybreast cancer

Therapeutic Eradication of Cancer-Associated Fibroblasts Inhibits in Vivo Progression of Pancreatic Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2025)

oncogenespathologytumor targetingtumor biologyvivo progressioncell biologytherapeutic eradicationcellular therapycancer researchpancreatic cancercancer growththerapeutic targetscancer cellstumor microenvironmentcancer biology

Aso Visual Abstract: The Prevalence of Sentinel Lymph Node Positivity and Implications for the Utility of Frozen Section Diagnosis Following Neoadjuvant Systemic Therapy in Patients With Clinically Node-Negative Her2-Positive or Triple-Negative Breast Cancer. Annals of Surgical Oncology (2024)

breast oncologymetastasispathologyradiation oncologysurgical oncologysurgical pathologycancer detectiontriple-negative breast canceraso visual abstractoncologybreast cancer

Author Correction: Cancer-Associated Fibroblast-Derived Acetate Promotes Pancreatic Cancer Development by Altering Polyamine Metabolism via the Acss2–Sp1–Sat1 Axis. Nature Cell Biology (2024)

Divya MurthyKuldeep S. AttriSurendra K. ShuklaRavi ThakurNina V. ChaikaChunbo HeDezhen WangKanupriya JhaAneesha DasguptaRyan J. KingScott E. MulderJoshua SouchekTeklab GebregiworgisVikant RaiRohit PatelTuo HuSandeep RanaSai Sundeep KollalaCamila PachecoPaul M. GrandgenettFang YuVikas KumarAudrey J. LazenbyAdrian R. BlackSusanna UlhannanAjay JainBarish H. EdilDavid L. KlinkebielRobert PowersAmarnath NatarajanMichael A. HollingsworthKamiya MehlaQuan LySarika ChaudharyRosa F. HwangKathryn E. WellenPankaj K. Singh

molecular and cellular biologygenitourinary cancerscellular biologypharmacologypolyamine metabolismcell researchcell physiologytumor biologycell biologycancer researchpancreatic cancercancer cellscellular physiologycellular therapysystems biologycancer biologymembrane biologymolecular cell biologyauthor correctiononcology

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Rosa F. Hwang

Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Breast Surgical Oncology

Department Of Head And Neck Surgery

Division Of Surgery

Section Of Hepato-Pancreato-Biliary

Department Of Surgical Oncology

Division Of Surgery

Department Of Surgical Oncology

Division Of Surgical Oncology

The University of Texas MD Anderson Cancer Center

Honors

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Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Rosa F. Hwang

The University of Texas MD Anderson Cancer Center

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cancer-Associated Fibroblasts Regulate Dna Repair in Pancreatic Cancer Through Ndrg1-Mediated R-Loop Processing. Nature Cell Biology (2026)

A Novel Dna Repair Protein, N-Myc Downstream Regulated Gene 1 (Ndrg1), Links Stromal Tumour Microenvironment to Chemoresistance. bioRxiv (Cold Spring Harbor Laboratory) (2025)

n-myc downstreamdna repairmolecular biologystromal tumour microenvironment

Assessment of Pectoralis Muscle Invasion Using Combined Dbt and Contrast-Enhanced Mammography: Retrospective Multi-Reader Study. Current Problems in Diagnostic Radiology (2025)

medical imagingdiagnosisretrospective multi-reader studyradiologypectoralis muscle invasioncontrast-enhanced mammographybreast imagingbreast cancer

Axillary Management After Neoadjuvant Endocrine Therapy (Net). Annals of Surgical Oncology (2025)

endocrine oncologysurgerysurgical oncologyaxillary managementmedicineendocrine surgerypharmacotherapycancer careoncologybreast cancer

Implications of Omitting Sentinel Lymph Node Biopsy on Adjuvant Decision Making for Patients With Small Breast Cancers. Cancer (2025)

breast oncologysmall breast cancersmetastasisradiation oncologysurgical oncologyadjuvant decision makingbreast surgerymedicinecancer careoncologybreast cancer

Predicting Pathologic ≥N2 Disease in Women With Breast Cancer. npj Breast Cancer (2025)

breast oncologygynecologic oncologypathologycancer riskbreast imagingoncologybreast cancer

Selective Elimination of Breast Surgery for Invasive Breast Cancer. JAMA Oncology (2025)

breast oncologyaesthetic surgerysurgerysurgical oncologyselective eliminationbreast surgeryplastic surgeryaesthetic plastic surgeryoncologybreast cancer

Therapeutic Eradication of Cancer-Associated Fibroblasts Inhibits in Vivo Progression of Pancreatic Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2025)

breast oncologymetastasispathologyradiation oncologysurgical oncologysurgical pathologycancer detectiontriple-negative breast canceraso visual abstractoncologybreast cancer

Author Correction: Cancer-Associated Fibroblast-Derived Acetate Promotes Pancreatic Cancer Development by Altering Polyamine Metabolism via the Acss2–Sp1–Sat1 Axis. Nature Cell Biology (2024)

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