Faculty

Institution

Unit

Venue

Ronald DePinho

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

Department Of Biology And Biochemistry

Department Of Pathology And Genomic Medicine

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Ronald DePinho is a Senior Professor at The University of Texas MD Anderson Cancer Center. His research focuses on tumor biology, oncogenes, and molecular cancer, with recent work elucidating mechanisms of immunogenic cell death and resistance to KRAS-targeted therapies in pancreatic and gastrointestinal cancers. His latest publications include studies on viral mimicry in immunogenic cell death (PNAS, 2026), mitochondrial function in oncogene-ablation-resistant pancreatic cancer cells (Nature, 2026), and therapeutic targeting of the syndecan-1 axis to overcome acquired KRAS resistance (Cell Reports Medicine, 2025). He recently received a 2026 award for prevention of chemotherapy-induced neuronal injury.

Honors

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Experiences

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Ronald DePinho

The University of Texas MD Anderson Cancer Center

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cell biology genetics tumor biology cancer research molecular biology cancer biology oncology gene expression oncogenes cancer genetics molecular cancer medicinal research cancer cells pharmacology carcinogenesis mammalian biology cancer genomics molecular cell biology cell signaling membrane biology pancreatic cancer brain tumor research vascular biology cell regulation gene function genome biology enzyme inhibition tumor suppressors cancer treatment molecular and cellular biology cell death gene regulation stem cell research tumor targeting protein science cancer discovery transcription regulation cellular physiology molecular physiology cancer growth colorectal cancer molecular regulation cellular senescence oncogenic agent signaling pathways cellular biology apoptosis melanoma telomere dysfunction skin cancer metabolic regulation anti-cancer agents chromosome biology cell cycle genome instability hematological malignancies pancreatic ductal adenocarcinoma medical genetics functional regulation mitochondrial function insulin signaling cell proliferation transgenic mice essential role genomic stability cellular transformation telomerase-deficient mouse tumor formation pancreatic cancer growth kras-regulated metabolic pathway malignant glioma tumor cells telomerase reactivation human cancer pancreas cancer foxo transcription factors

Notable Scholarly Works

Notable Federal Grants

Collaborators

Author Correction: Oncogene Ablation-Resistant Pancreatic Cancer Cells Depend on Mitochondrial Function. Nature (2026)

cancer researchpancreatic cancermitochondrial functiononcologyoncogenescancer cellscell metabolismpathologytumor biologyauthor correctioncell biology

Viral Mimicry May Help Explain Immunogenic Cell Death. Proceedings of the National Academy of Sciences (2026)

immunologyvirus researchpathogenesisviral mimicrymedical virologygeneral virologyviral pathogenesisvirologyimmune responsesinfectious diseasesimmunity (medicine)

Abstract 3921: Development of a Kras-G12C-Driven Pancreatic Cancer Mouse Model. Cancer Research (2025)

carcinogenesiscancer researchmolecular cancerpancreatic cancercell researchcancer discoveryabstract 3921oncogenic agentoncogenescancer cellscancer biologypathologytumor biologycell biology

Abstract 5100: Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer. Cancer Research (2025)

metastasiscancer researchbreast oncologybreast canceroncologyoncogenescancer biologycell biology

Abstract 5246: Chromosomal Instability Promotes Colorectal Cancer Progression Through Manipulation of Gamma Delta T Cells. Cancer Research (2025)

immunologycarcinogenesiscancer geneticscolorectal cancer progressionmolecular cancercell researchabstract 5246oncogenescancer cellsdna repaircolorectal cancerchromosomal instabilitypathologycell biology

Data From Combined Kras Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous Pdac Model. (2025)

immunologymathematical biologyimmune responsessystem immunologyexperimental medicineimmunotherapy

Epigenetic Control of Terra by Ftsj3 is Critical for Telomerase-Driven Cancers. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Jared D.W. PriceFrederick S VizeacoumarOmar AbuhusseinVincent MarandaYue ZhangHironori AdachiLiliia KyrylenkoAline Rangel-PozzoHe DongLi Hui GongPrachi WalkeAshtalakshmi GanapathysamyConnor DenomyTanya FreywaldRenuka DahiyaHussain ElhasasnaAnjali SaxenaJeff VizeacoumarHardikkumar PatelKarthic RajamanickamKathryn NguyenDiego M de OliveiraMary Lazell-WrightAlain Morejon-MoralesAanchal AggarwalJia Lin XuNezeka AlliErika P MunhozPeng GaoJayme SalsmanDinesh DahiyaCristina Gonzalez-LopezPatricia Allison ThibaultMichael LevinGraham DellaireNicholas JetteGary GrootAnand KrishnanShahid AhmedChristopher H EskiwKhaled BarakatYuliang WuRonald A DePinhoSabine MaiYi-Tao YuJudy MY WongAndrew FreywaldFranco Vizeacoumar

cancer geneticsepigenetic changestelomerase-driven cancersmolecular biologyepigeneticscancer biologyepigenetic control

Kras Inhibition Activates an Actionable Cd24 “Do Not Eat Me” Signal in Pancreatic Cancer. Cancer Research (2025)

immunologycarcinogenesispancreatic cancercell signalingmolecular canceroncogenescancer cellskras inhibition activatescancer biologytumor biologycell biology

Long-Lived Immunogenic Cell Death Induced by a Water-Soluble Redox Active Au(I) Bis-N-Heterocyclic Carbene. Journal of the American Chemical Society (2025)

immunologycell deathimmunotoxicologyredox biologytoxicological mechanismoxidative stressimmunotherapy

Telescopes, Telomeres and Turning Points. Nature Cancer (2025)

carcinogenesisscientific visualizationcancer researchnature methodastronomy

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Ronald DePinho

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

Department Of Biology And Biochemistry

Department Of Pathology And Genomic Medicine

MD Anderson UTHealth Houston Graduate School

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ronald DePinho

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Author Correction: Oncogene Ablation-Resistant Pancreatic Cancer Cells Depend on Mitochondrial Function. Nature (2026)

cancer researchpancreatic cancermitochondrial functiononcologyoncogenescancer cellscell metabolismpathologytumor biologyauthor correctioncell biology

Viral Mimicry May Help Explain Immunogenic Cell Death. Proceedings of the National Academy of Sciences (2026)

immunologyvirus researchpathogenesisviral mimicrymedical virologygeneral virologyviral pathogenesisvirologyimmune responsesinfectious diseasesimmunity (medicine)

Abstract 3921: Development of a Kras-G12C-Driven Pancreatic Cancer Mouse Model. Cancer Research (2025)

carcinogenesiscancer researchmolecular cancerpancreatic cancercell researchcancer discoveryabstract 3921oncogenic agentoncogenescancer cellscancer biologypathologytumor biologycell biology

Abstract 5100: Mediator Subunit Med4 Enforces Metastatic Dormancy in Breast Cancer. Cancer Research (2025)

metastasiscancer researchbreast oncologybreast canceroncologyoncogenescancer biologycell biology

Abstract 5246: Chromosomal Instability Promotes Colorectal Cancer Progression Through Manipulation of Gamma Delta T Cells. Cancer Research (2025)

Data From Combined Kras Inhibition and Immune Therapy Generates Durable Complete Responses in an Autochthonous Pdac Model. (2025)

immunologymathematical biologyimmune responsessystem immunologyexperimental medicineimmunotherapy

Epigenetic Control of Terra by Ftsj3 is Critical for Telomerase-Driven Cancers. bioRxiv (Cold Spring Harbor Laboratory) (2025)

cancer geneticsepigenetic changestelomerase-driven cancersmolecular biologyepigeneticscancer biologyepigenetic control

Kras Inhibition Activates an Actionable Cd24 “Do Not Eat Me” Signal in Pancreatic Cancer. Cancer Research (2025)

immunologycarcinogenesispancreatic cancercell signalingmolecular canceroncogenescancer cellskras inhibition activatescancer biologytumor biologycell biology

Long-Lived Immunogenic Cell Death Induced by a Water-Soluble Redox Active Au(I) Bis-N-Heterocyclic Carbene. Journal of the American Chemical Society (2025)

immunologycell deathimmunotoxicologyredox biologytoxicological mechanismoxidative stressimmunotherapy

Telescopes, Telomeres and Turning Points. Nature Cancer (2025)

carcinogenesisscientific visualizationcancer researchnature methodastronomy

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