Faculty

Institution

Unit

Venue

Robert M. O'Doherty

Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Microbiology and Molecular Genetics

Robert M. O'doherty is currently serving as an Interdisciplinary Biomedical Graduate Program Professor at University of Pittsburgh.

Honors

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Experiences

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Education

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Robert M. O'Doherty

University of Pittsburgh

Professor

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physiology endocrinology liver physiology membrane biology biochemistry pharmacology obesity metabolism molecular physiology hepatology mammalian biology metabolic regulation cell biology gene expression animal physiology exercise physiology biological chemistry cellular physiology diabetes endocrine research cell metabolism nutritional biochemistry redox biology applied physiology comparative endocrinology human physiology skeletal muscle insulin signaling mammalian physiology molecular metabolism nutrient physiology energy metabolism circulatory physiology mitochondrial function secondary metabolism protein science cardiovascular research lipoprotein metabolism protein expression biochemical sciences physiological research molecular regulation clinical lipidology rna biology muscle function transcription regulation biological function cell regulation insulin resistance diet-induced obesity renal function biochemical genetics clinical physiology protein function in vivo systems gene regulation comparative physiology gene function human muscle gut microbiota acute exercise hyperlipidemia energy homeostasis endocrine diseases functional regulation mouse models intermittent hypoxia normal rats metabolic impact hepatic steatosis hexokinase ii glycogen synthase mrna lipid-induced insulin resistance metabolic abnormalities hepatic overexpression glycogen synthesis fatty liver disease medicine inflammation metabolic syndrome diabetes research diabetes mellitus

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Nitroalkene Derivative of Salicylate Alleviates Diet-Induced Obesity by Activating Creatine Metabolism and Non-Shivering Thermogenesis. Research Square (Research Square) (2023)

Carlos EscandeKarina CalAlejandro LeyvaJorge Rodriguez-DuarteSantiago RuizLeonardo SantosLucía ColellaMariana IngoldCecilia VilasecaGerman GalliussiLucía ZieglerThais PeclatMariana BresqueRachel HandyRachel KingLarisa Menezes dos ReisCamila EspasandinPeter BreiningRosina DapuetoAndres LopezKatie ThompsonGuillermo AgorrodyEvan DeVallanceEthan MeadowsSara LewisGabriele Santana BarbosaLeonardo Osbourne Lai de SouzaMarina Santos ChichierchioValeria ValezAdrian AicardoPaola ContrerasMikkel VendelboSteen JakobsenAndres KamaidWilliams PorcalAldo CalliariJose VerdesJianhai DuYekai WangJohn HollanderThomas WhiteRafael RadiGuillermo MoynaCelia QuijanoRobert O'DohertyPedro Manoel Moraes-VieiraGraham HollowayRoberta LeonardiMarcelo MoriJuliana Camacho-PereiraEric KelleyRosario DuranGloria LopezCarlos BatthyanyEduardo Chini

pharmacologymembrane biologynitroalkene derivativeendocrinologyobesityliver physiologymetabolic regulationmolecular physiologybiochemistryredox biologyclinical nutritionsecondary metabolismcreatine metabolismenergy metabolismnon-shivering thermogenesismetabolismphysiology

Hepatocyte High-Mobility Group Box 1 Protects Against Steatosis and Cellular Stress During High Fat Diet Feeding. Research Square (Research Square) (2020)

Minjie LinJungke LongWenbo LiChenxuan YangPatricia LoughranRobert O’DohertyTimothy R. BilliarMeihong DengMelanie J. Scott

hepatologymedicinehepatocyte high-mobility groupmolecular medicineendocrinologyliver physiologycellular stressdiabetesimmunologyphysiology

Adropin Reduces Blood Glucose Levels in Mice by Limiting Hepatic Glucose Production. Physiological Reports (2019)

Dharendra ThapaBingxian XieJanet R. ManningManling ZhangMichael W. StonerBrydie R. HuckesteinLia R. EdmundsXueyang ZhangNikolaos L. DedousisRobert M. O'DohertyMichael J. JurczakIain Scott

pharmacologyanimal physiologyapplied physiologyhepatic glucose productionmammalian physiologyendocrinologyliver physiologyneurosciencehuman biologyhuman physiologycirculatory physiologyclinical physiologyphysiological researchneurophysiologymammalian biologyelectrophysiologyphysiology

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities. Diabetes (2019)

Daniel B. HarmonW. Kyle MandlerIan J. SipulaNikolaos DedousisSara E. LewisJeremy T. EckelsJianhai DuYekai WangBrydie R. HuckesteinPatrick J. PaganoEugenia Cifuentes-PaganoGregg E. HomanicsThomas J. Van’t ErveMaja Stefanovic-RacicMichael J. JurczakRobert M. O’DohertyEric E. Kelley

hepatologypharmacologyxanthine oxidoreductasemedicineendocrinologyobesitymammalian biologywhole-body inhibitionmetabolic abnormalitiesdiabetesimmunologyhepatocyte-specific ablationhematology

Petite Integration Factor 1 (Pif1) Helicase Deficiency Increases Weight Gain in Western Diet-Fed Female Mice Without Increased Inflammatory Markers or Decreased Glucose Clearance. PLoS ONE (2019)

Frances R. BelmonteNikolaos DedousisIan SipulaNikita A. DesaiAatur D. SinghiYanxia ChuYingze ZhangSylvie BannwarthVéronique Paquis-FlucklingerLea HarringtonSruti ShivaMichael J. JurczakRobert M. O’DohertyBrett A. Kaufman

nutritional neuroscienceexperimental nutritionhepatologynutrient physiologyanimal nutritionplo biologypharmacologynutritional sciencesinflammationdietary healthavian medicineplant physiologynutritional biochemistryhealth sciencesendocrinologyobesityglucose clearancemetabolismphysiology

Adipose Tissue-Derived Free Fatty Acids Initiate Myeloid Cell Accumulation in Mouse Liver in States of Lipid Oversupply. AJP Endocrinology and Metabolism (2018)

Daniel B. HarmonChao WuNikolaos DedousisIan J. SipulaMaja Stefanovic-RacicGabriele SchoiswohlChristopher P. O’DonnellLaura C. AlonsoErin E. KershawEric E. KelleyRobert M. O’Doherty

liver physiologylipid oversupplyhepatologymembrane biologycomparative endocrinologyinflammationendocrine researchmetabolic regulationmyeloid cell accumulationsecondary metabolismimmunologymammalian biologyanimal physiologygeriatric endocrinologyhealth sciencesendocrinologyclinical lipidologymouse livermetabolismphysiology

Elevated Metabolic Rate and Skeletal Muscle Oxidative Metabolism Contribute to the Reduced Susceptibility of Nf- κ B P50 Null Mice to Obesity. Physiological Reports (2018)

Bankim A. BhattNikolaos DedousisIan J. SipulaRobert M. O'Doherty

geneticsanimal physiologyskeletal musclehealth sciencesexercise physiologyobesitymetabolic ratehuman physiologyphysiological researchmammalian biologymammalian physiologyphysiology

Neutrophil Extracellular Traps Promote Inflammation and Development of Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis. Hepatology (2018)

Dirk J. van der WindtVikas SudHongji ZhangPatrick R. VarleyJulie GoswamiHamza O. YazdaniSamer TohmePatricia LoughranRobert M. O'DohertyMarta I. MinerviniHai HuangRichard L. SimmonsAllan Tsung

hepatologypathologyimmune responsesfatty liver diseaseinflammationtumor microenvironmentliver physiologychronic inflammationliver cancerhepatocellular carcinomafatty livermolecular gastroenterologyneutrophil extracellular trapsnet formationtumor biologyimmunologycell biologyliver disease

Nrf2 Deletion From Adipocytes, but Not Hepatocytes, Potentiates Systemic Metabolic Dysfunction After Long-Term High-Fat Diet-Induced Obesity in Mice. American Journal of Physiology-Endocrinology and Metabolism (2018)

Dionysios V. ChartoumpekisDushani L. PalliyaguruNobunao WakabayashiMarco FazzariNicholas K. H. KhooFrancisco J. SchopferIan SipulaYoko YagishitaGeorge K. MichalopoulosRobert M O’DohertyThomas W. Kensler

liver physiologybiochemistrycellular physiologycell biologymembrane biologycell metabolismmolecular physiologynutrient physiologycomparative endocrinologygene expressionendocrine researchmetabolic regulationanimal physiologymetabolic dysfunctionendocrinologyobesityenergy metabolismmetabolismphysiology

Nrf2 Prevents Notch-Induced Insulin Resistance and Tumorigenesis in Mice. JCI Insight (2018)

Dionysios V. ChartoumpekisYoko YagishitaMarco FazzariDushani L. PalliyaguruUma N.M. RaoApostolos ZaravinosNicholas K.H. KhooFrancisco J. SchopferKurt R. WeissGeorge K. MichalopoulosIan SipulaRobert M. O’DohertyThomas W. KenslerNobunao Wakabayashi

neurologypathologygene expressionknockout miceneurosciencetumor biologymammalian biologyprotein sciencein vivo systems

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Robert M. O'Doherty

Professor

University of Pittsburgh

Affiliations

Medicine

Interdisciplinary Biomedical Graduate Program

Microbiology and Molecular Genetics

Robert M. O'doherty is currently serving as an Interdisciplinary Biomedical Graduate Program Professor at University of Pittsburgh.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Robert M. O'Doherty

University of Pittsburgh

Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

A Nitroalkene Derivative of Salicylate Alleviates Diet-Induced Obesity by Activating Creatine Metabolism and Non-Shivering Thermogenesis. Research Square (Research Square) (2023)

Hepatocyte High-Mobility Group Box 1 Protects Against Steatosis and Cellular Stress During High Fat Diet Feeding. Research Square (Research Square) (2020)

Minjie LinJungke LongWenbo LiChenxuan YangPatricia LoughranRobert O’DohertyTimothy R. BilliarMeihong DengMelanie J. Scott

hepatologymedicinehepatocyte high-mobility groupmolecular medicineendocrinologyliver physiologycellular stressdiabetesimmunologyphysiology

Adropin Reduces Blood Glucose Levels in Mice by Limiting Hepatic Glucose Production. Physiological Reports (2019)

Dharendra ThapaBingxian XieJanet R. ManningManling ZhangMichael W. StonerBrydie R. HuckesteinLia R. EdmundsXueyang ZhangNikolaos L. DedousisRobert M. O'DohertyMichael J. JurczakIain Scott

Hepatocyte-Specific Ablation or Whole-Body Inhibition of Xanthine Oxidoreductase in Mice Corrects Obesity-Induced Systemic Hyperuricemia Without Improving Metabolic Abnormalities. Diabetes (2019)

hepatologypharmacologyxanthine oxidoreductasemedicineendocrinologyobesitymammalian biologywhole-body inhibitionmetabolic abnormalitiesdiabetesimmunologyhepatocyte-specific ablationhematology

Petite Integration Factor 1 (Pif1) Helicase Deficiency Increases Weight Gain in Western Diet-Fed Female Mice Without Increased Inflammatory Markers or Decreased Glucose Clearance. PLoS ONE (2019)

Adipose Tissue-Derived Free Fatty Acids Initiate Myeloid Cell Accumulation in Mouse Liver in States of Lipid Oversupply. AJP Endocrinology and Metabolism (2018)

Daniel B. HarmonChao WuNikolaos DedousisIan J. SipulaMaja Stefanovic-RacicGabriele SchoiswohlChristopher P. O’DonnellLaura C. AlonsoErin E. KershawEric E. KelleyRobert M. O’Doherty

Elevated Metabolic Rate and Skeletal Muscle Oxidative Metabolism Contribute to the Reduced Susceptibility of Nf- κ B P50 Null Mice to Obesity. Physiological Reports (2018)

Bankim A. BhattNikolaos DedousisIan J. SipulaRobert M. O'Doherty

geneticsanimal physiologyskeletal musclehealth sciencesexercise physiologyobesitymetabolic ratehuman physiologyphysiological researchmammalian biologymammalian physiologyphysiology

Neutrophil Extracellular Traps Promote Inflammation and Development of Hepatocellular Carcinoma in Nonalcoholic Steatohepatitis. Hepatology (2018)

Dirk J. van der WindtVikas SudHongji ZhangPatrick R. VarleyJulie GoswamiHamza O. YazdaniSamer TohmePatricia LoughranRobert M. O'DohertyMarta I. MinerviniHai HuangRichard L. SimmonsAllan Tsung

Nrf2 Prevents Notch-Induced Insulin Resistance and Tumorigenesis in Mice. JCI Insight (2018)

neurologypathologygene expressionknockout miceneurosciencetumor biologymammalian biologyprotein sciencein vivo systems

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5
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