Faculty

Institution

Unit

Venue

Robert Lefkowitz

Chancellor's Distinguished Professor of Medicine Professor of Medicine Professor of Chemistry Professor of Pathology Professor of Biochemistry Associate of the Duke Initiative for Science & Society Member of the Duke Cancer Institute

Duke University

Affiliations

Duke University School of Medicine

Biochemistry

Medical Scientist Training Program (md/phd)

Medical Scientist Training Program - Md/phd

Molecular Cancer Biology

Pathology

Trinity College of Arts & Sciences

Chemistry

Robert Lefkowitz is a Chancellor's Distinguished Professor of Medicine, Professor of Medicine, Chemistry, Pathology, and Biochemistry at Duke University, and a member of the Duke Cancer Institute. His research focuses on G protein-coupled receptors (GPCRs), beta-arrestins, and signal transduction, with recent work elucidating G protein coupling specificity, biased agonism at the β2-adrenergic receptor, and beta-arrestin-mediated Src activation via cryo-electron microscopy. His 2024 publications include reviews in *Circulation Research* and the *Journal of Clinical Investigation*, alongside structural studies in *Science Advances*. He has received numerous NIH grants supporting his work on beta-arrestins and GPCR kinases in cardiovascular function, and collaborates extensively with institutions across the US, Canada, France, Germany, Japan, and China.

Honors

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Experiences

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Robert Lefkowitz

Duke University

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pharmacology biochemistry receptors neuroscience molecular biology cell signaling protein science biological chemistry membrane biology neuropharmacology endocrinology signal transduction receptor (biochemistry) molecular pharmacology molecular physiology medicinal research g protein-coupled receptor gene expression mammalian biology molecular regulation biochemical sciences animal physiology redox biology cardiovascular research pharmacological research enzyme inhibition cellular physiology cellular biochemistry neurochemistry functional regulation cardiovascular physiology liver physiology circulatory physiology protein phosphorylation signaling pathways cell regulation cardiovascular pharmacology clinical biochemistry pharmacokinetics adenylate cyclase adrenergic receptors beta-adrenergic receptor b-adrenergic receptors receptor tyrosine kinases clinical physiology insulin signaling endocrine research clinical medicine mammalian physiology experimental pharmacology beta-adrenergic receptors molecular neurobiology cardiac muscle cellular biology biomolecular interactions in vivo systems b-adrenergic receptor biological inorganic chemistry physiological regulation alpha-adrenergic receptors photoaffinity labeling b-adrenergic receptor kinase clinical pharmacology pathway analysis frog erythrocytes functional modification host specificity gene regulation seven-transmembrane receptors transgenic mice cardiovascular function molecular substrates beta-adrenergic receptor kinase g-protein-coupled receptors guanine nucleotides a-adrenergic receptors

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure and Dynamics Determine G Protein Coupling Specificity at a Class a Gpcr. Science Advances (2025)

Marina CasiraghiHaoqing WangPatrick C. BrennanChris HabrianHarald HübnerMaximilian F. SchmidtLuis MaulBiswaranjan PaniSherif M. F. M. BahrizBing XuNico StaffenTufa E. AssafaBohan ChenElizabeth WhiteRoger K. SunaharaAsuka InoueYang K. XiangRobert J. LefkowitzEhud Y. IsacoffNathaniel NucciPeter GmeinerMichael T. LerchBrian K. Kobilka

biophysicsprotein structure predictioncomputational biologyprotein sciencebiomolecular structureprotein foldingprotein modelingbiochemistrymolecular biophysicsprotein assemblymolecular biologyg protein-coupled receptorprotein structureprotein bioinformaticsstructural molecular biologystructural biology

Beta-Arrestin 1 Mediated Src Activation via Src Sh3 Domain Revealed by Cryo-Electron Microscopy. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Natalia PakharukovaBrittany N. ThomasHarsh BansiaLinus LiRinat R. AbzalimovJihee KimAlem W. KahsaiBiswaranjan PaniDana K. BassfordShibo LiuXingdong ZhangAmedee des GeorgesRobert J. Lefkowitz

biophysicsprotein sciencecryo-electron microscopycell biologyprotein assemblysrc activationmolecular biologygene expressiondna repairstructural biology

G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation Research (2024)

Samuel LiuPreston J. AndersonSudarshan RajagopalRobert J. LefkowitzHoward A. Rockman

circulatory physiologyphysiologyneurosciencepharmacologydrug discoverystructural biology

G Protein–Coupled Receptors: From Radioligand Binding to Cellular Signaling. Journal of Clinical Investigation (2024)

Howard A RockmanRobert J Lefkowitz

cell signalingimmunologyclinical investigationneurosciencepharmacologyclinical research

Molecular Insights Into G Protein Specificity and Biased Agonism at the β2-Adrenergic Receptor. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Marina CasiraghiHaoqing WangPatrick BrennanChris HabrianHarald HubnerMaximilian F SchmidtLuis MaulBiswaranjan PaniSherif MFM BahrizBing XuElizabeth WhiteRoger K SunaharaYang K XiangRobert J LefkowitzEhud Y IsacoffNathaniel NucciPeter GmeinerMichael LerchBrian K Kobilka

localized excited stateprotein sciencecell signalingmedicinal researchreceptor (biochemistry)molecular physiologymembrane biologypharmacologymolecular biologymolecular pharmacologyg protein-coupled receptorsignal transductionin vivo systemsreceptorsgenetics

Small Molecule Modulators of Beta-Arrestins. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Alem W. KahsaiNatalia PakharukovaHenry Y. KwonKunal S. ShahJason G. Liang-LinCaroline T. del RealPaul J. ShimMason A. LeeVan A. NgoBowie N. ShreiberSamuel LiuAllison M. SchwalbEmmanuel F. EspinozaBrittany N. ThomasCal A. KunzleJeffrey S. SmithJialu WangJihee KimXingdong ZhangHoward A. RockmanAlex R. B. ThomsenLindsay A.M. ReinLei ShiSeungkirl AhnAli MasoudiRobert J. Lefkowitz

small moleculessmall molecule modulatorsmolecular biology

Abstract P2154: A Novel Allosteric Modulator of the β 1 Ar Identified by Dna-Encoded Small Molecule Library Screening Demonstrates Unique Pharmacology and Function. Circulation Research (2023)

Alyssa GroganSeungkirl AhnDavid IsraelAlex ShaginianQiuxia ChenJian LiuMax WilkeyJialu WangAlem KahsaiRobert J LefkowitzHoward A Rockman

cell biologyneurosciencepharmacologymolecular pharmacologydrug discovery

Allosteric Modulator Potentiates β2Ar Agonist–Promoted Bronchoprotection in Asthma Models. Journal of Clinical Investigation (2023)

Seungkirl AhnHarm MaarsinghJulia K.L. WalkerSamuel LiuAkhil HegdeHyeje C. SumajitAlem W. KahsaiRobert J. Lefkowitz

asthmaasthma modelscardiologyagonist-promoted bronchoprotectionclinical medicineimmunologyrespiratory medicineclinical investigationdermatologyclinical physiologypharmacologyclinical research

How Carvedilol Does Not Activate β2-Adrenoceptors. Nature Communications (2023)

Robert J. LefkowitzHoward A. RockmanPaul J. ShimSamuel LiuSeungkirl AhnBiswaranjan PaniSudarshan RajagopalSudha K. ShenoyMichel BouvierJeffrey L. BenovicStephen B. LiggettRobert R. RuffoloMichael R. BristowMilton Packer

receptorspharmacologyneuropharmacology

Loss of Biased Signaling at a G Protein-Coupled Receptor in Overexpressed Systems. PLoS ONE (2023)

Angus LiSamuel LiuRennica HuangSeungkirl AhnRobert J. Lefkowitz

overexpressed systemsplo biologybiased signalingcell signalingneurosciencepharmacologyg protein-coupled receptorsignal transductionreceptorsgenetics

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Robert Lefkowitz

Duke University

Affiliations

Duke University School of Medicine

Biochemistry

Medical Scientist Training Program (md/phd)

Medical Scientist Training Program - Md/phd

Molecular Cancer Biology

Pathology

Trinity College of Arts & Sciences

Chemistry

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Robert Lefkowitz

Duke University

You can click a keyword to filter the displayed items

Video Presentations

Notable Scholarly Works

Notable Federal Grants

Collaborators

Structure and Dynamics Determine G Protein Coupling Specificity at a Class a Gpcr. Science Advances (2025)

Beta-Arrestin 1 Mediated Src Activation via Src Sh3 Domain Revealed by Cryo-Electron Microscopy. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Natalia PakharukovaBrittany N. ThomasHarsh BansiaLinus LiRinat R. AbzalimovJihee KimAlem W. KahsaiBiswaranjan PaniDana K. BassfordShibo LiuXingdong ZhangAmedee des GeorgesRobert J. Lefkowitz

biophysicsprotein sciencecryo-electron microscopycell biologyprotein assemblysrc activationmolecular biologygene expressiondna repairstructural biology

G Protein-Coupled Receptors: A Century of Research and Discovery. Circulation Research (2024)

Samuel LiuPreston J. AndersonSudarshan RajagopalRobert J. LefkowitzHoward A. Rockman

circulatory physiologyphysiologyneurosciencepharmacologydrug discoverystructural biology

G Protein–Coupled Receptors: From Radioligand Binding to Cellular Signaling. Journal of Clinical Investigation (2024)

Howard A RockmanRobert J Lefkowitz

cell signalingimmunologyclinical investigationneurosciencepharmacologyclinical research

Molecular Insights Into G Protein Specificity and Biased Agonism at the β2-Adrenergic Receptor. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Small Molecule Modulators of Beta-Arrestins. bioRxiv (Cold Spring Harbor Laboratory) (2024)

small moleculessmall molecule modulatorsmolecular biology

Abstract P2154: A Novel Allosteric Modulator of the β 1 Ar Identified by Dna-Encoded Small Molecule Library Screening Demonstrates Unique Pharmacology and Function. Circulation Research (2023)

Alyssa GroganSeungkirl AhnDavid IsraelAlex ShaginianQiuxia ChenJian LiuMax WilkeyJialu WangAlem KahsaiRobert J LefkowitzHoward A Rockman

cell biologyneurosciencepharmacologymolecular pharmacologydrug discovery

Allosteric Modulator Potentiates β2Ar Agonist–Promoted Bronchoprotection in Asthma Models. Journal of Clinical Investigation (2023)

Seungkirl AhnHarm MaarsinghJulia K.L. WalkerSamuel LiuAkhil HegdeHyeje C. SumajitAlem W. KahsaiRobert J. Lefkowitz

asthmaasthma modelscardiologyagonist-promoted bronchoprotectionclinical medicineimmunologyrespiratory medicineclinical investigationdermatologyclinical physiologypharmacologyclinical research

How Carvedilol Does Not Activate β2-Adrenoceptors. Nature Communications (2023)

receptorspharmacologyneuropharmacology

Loss of Biased Signaling at a G Protein-Coupled Receptor in Overexpressed Systems. PLoS ONE (2023)

Angus LiSamuel LiuRennica HuangSeungkirl AhnRobert J. Lefkowitz

overexpressed systemsplo biologybiased signalingcell signalingneurosciencepharmacologyg protein-coupled receptorsignal transductionreceptorsgenetics

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