Faculty

Institution

Unit

Venue

Robert L. Satcher

Professor Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Orthopaedic Oncology

Departments Of Sarcoma Medical Oncology And Paediatrics

The University of Texas MD Anderson Cancer Center

Robert L. Satcher is a Professor at The University of Texas MD Anderson Cancer Center, where he specializes in orthopaedic surgery and surgical oncology. His research focuses on the biology of bone metastasis, including the immune-excluded tumor microenvironment, macrophage-mediated iron recycling, and the osteogenic differentiation of NG2+ cells during bone colonization. He has published in leading journals such as *Cell* and contributes to NCCN clinical practice guidelines for bone cancer. His work integrates single-cell profiling and niche-labeling approaches to uncover convergent mechanisms across cancer types, advancing both basic cancer biology and clinical care for sarcoma and metastatic disease.

Honors

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Experiences

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Education

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Robert L. Satcher

The University of Texas MD Anderson Cancer Center

Professor Associate Professor

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oncology metastasis bone research cancer research radiation oncology surgical oncology orthopaedic surgery surgery orthopedic surgery cancer biology urology prostate cancer tumor biology cancer care sarcoma cancer cells orthopaedic research cancer treatment medicinal research arthroplasty vascular biology surgical pathology oncogenes bone fracture genitourinary cancers bone health radiation therapy cellular therapy clinical radiation oncology cancer management bone metastases leukemia histopathology angiogenesis cancer genetics bone metastasis reconstructive microsurgery molecular cancer reconstructive surgery surgical stabilization bone metabolism spinal oncology malignant disease therapy resistance cancer genomics bone homeostasis cancer discovery tumor targeting joint replacement musculoskeletal surgery biomaterials design skeletal trauma bone repair bone cancer preoperative radiotherapy tumor growth bone density musculoskeletal research therapeutic efficacy anti-cancer agents apoptosis prosthesis novel therapies cell regulation tumoral pathology fluid forces soft tissue sarcomas prostate cancer cells bone regeneration nccn guidelines insights biomimetic mineralization nanofiber matrix porous titanium hybrid bone implants nonspine bone metastases pain relief internal medicine craniofacial surgery plastic surgery translational research maxillofacial surgery knee surgery thoracic surgery neuro-oncology musculoskeletal disorders osteoarthritis anatomical pathology microsurgery gross anatomy pathology medicine outcomes research anatomy jama oncology spinal cord injury oral radiology neurosurgery regenerative medicine surgical education cancer letter biomechanics biomechanical engineering radiology biomedical engineering thoracic oncology mesothelioma cancer imaging clinical research osteoporosis

Notable Scholarly Works

Notable Federal Grants

Collaborators

Preoperative Radiotherapy for Appendicular Bone Metastases: Outcomes. BMJ Supportive & Palliative Care (2026)

orthopedic surgeryoncologyclinical radiation oncologyradiation oncologysurgical oncologyradiationmetastasisradiation therapypreoperative radiotherapycancer care

Unbiased Niche Labeling Maps Immune-Excluded Niche in Bone Metastasis. Cell (2026)

cancer cellstumor microenvironmenttumor heterogeneityimmunologycell biology

Bone Cancer, Version 2.2025, Nccn Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network (2025)

J. Sybil BiermannAngela HirbeShivani AhlawatNicholas M. BernthalOdion BinitieSarah BolesBrian BrigmanAlexandra K. CallanCara CiprianoLee D. CranmerJessica DavisEric DonnellyMichael FergusonAnn GrahamJohn GroundlandMatthew HessSusan M. HinikerMargo L. Hoover-ReganJason L. HornickBrandon JonardJoseph B. KuechleDieter LindskogJoel L. MayersonSean V. McGarryCarol D. MorrisDaniel OlsonPeter S. RoseVictor M. SantanaRobert L. SatcherHerbert SchwartzRebecca M. ShulmanSteven W. ThorpeBreelyn A. WilkyRosanna L. WustrackJanet YoonLisa E. HangFrankie JonesNicholas SansoneMegan Lyons

prospective cohort studiescancer cellslung cancerclinical practice guidelinesretrospective cohort studiesbone cancergliomascarcinogenesisvascular biologyclinical evidencecohort studiesneurologykidney cancersystematic literature studiesimmunologystem cell researchprostate cancerurologyoncogenesleukemia

Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Yujiao HanHirak SarkarZhan XuSereno Lopez- DarwinYong WeiXiang HangFengshuo LiuKimberley TranWei WangJennifer M. MillerChristina J. DeCosteDylan S. BlohmRobert L. SatcherXiang H.-F. ZhangYibin Kang

foster erythroblast mimicryinflammationbone metastasisimmunologyniche macrophages

Single-Cell Profiling of Bone Metastasis Ecosystems From Multiple Cancer Types Reveals Convergent and Divergent Mechanisms of Bone Colonization. Cell Genomics (2025)

Fengshuo LiuYunfeng DingZhan XuXiaoxin HaoTianhong PanGeorge MilesSiyue WangYi-Hsuan WuJun LiuIgor L BadoWeijie ZhangLing WuYang GaoLiqun YuDavid G EdwardsHilda L ChanSergio AguirreMichael Warren DieffenbachElina ChenYichao ShenDane HoffmanLuis Becerra DominguezCharlotte Helena RivasXiang ChenHai WangZbigniew GugalaRobert L SatcherXiang H-F Zhang

single-cell profilingbone colonizationbone metastasis

Supplementary Raw Data From Bone Metastasis Initiation is Coupled With Bone Remodeling Through Osteogenic Differentiation of Ng2 Sup + /Sup Cells. (2025)

cellular differentiationdevelopmental biologymetastasiscellular physiologycell researchbone researchstem cell researchbone metastasis initiationcell biologysupplementary raw databone remodelingbone metabolismosteogenic differentiationstem cells

Tumors Hijack Macrophages for Iron Supply to Promote Bone Metastasis and Anemia. Cell (2025)

pathologymyelopoiesisinflammationtumor microenvironmentbone metastasisradiation oncologyiron supplymetastasismineral metabolismtumor biologyimmunologybone researchbone marrow transplantationcancer cellshematologybone marrow failure

A Randomized, Non-Comparative Phase 2 Study of Neoadjuvant Immune-Checkpoint Blockade in Retroperitoneal Dedifferentiated Liposarcoma and Extremity/Truncal Undifferentiated Pleomorphic Sarcoma. Nature Cancer (2024)

Christina L. RolandElise F. Nassif HaddadEmily Z. KeungWei-Lien WangAlexander J. LazarHeather LinManoj ChelvanambiEdwin R. ParraKhalida WaniB. Ashleigh GuadagnoloAndrew J. BishopElizabeth M. BurtonKelly K. HuntKeila E. TorresBarry W. FeigChristopher P. ScallyValerae O. LewisJustin E. BirdRavin RatanDejka AraujoM. Alexandra ZarzourShreyaskumar PatelRobert BenjaminAnthony P. ConleyJ. Andrew LivingstonVinod RaviHussein A. TawbiPatrick P. LinBryan S. MoonRobert L. SatcherBilal MujtabaRussell G. WittRaymond S. TraweekBrandon CopeRossana LazcanoChia-Chin WuXiao ZhouMohammad M. MohammadRandy A. ChuJianhua ZhangAshish DamaniaPranoti SahasrabhojaneTaylor TateKate CallahanSa NguyenDavis IngramRohini MoreyShadarra CrosbyGrace MathewSheila DuncanCibelle F. LimaJean-Yves BlayWolf Herman FridmanKenna ShawIgnacio WistubaAndrew FutrealNadim AjamiJennifer A. WargoNeeta Somaiah

cancer immunotherapypharmacologycancer biologycancer treatmentcancer cellstumor targetingcancer researchoncologysurgical oncologytherapeutic efficacysarcomacellular therapyimmunologyimmunotherapyradiologymedicinal researchimmune checkpoint inhibitorsneoadjuvant immune-checkpoint blockade

Bigh3 Mediates Apoptosis and Gap Junction Failure in Osteocytes During Renal Cell Carcinoma Bone Metastasis Progression. Cancer Letters (2024)

Tianhong PanFengshuo LiuXiaoxin HaoShubo WangMurtaza WasiJian H. SongValerae O. LewisPatrick P. LinBryan MoonJustin E. BirdTheocharis PanaretakisSue-Hwa LinDanielle WuMary C. Farach-CarsonLiyun WangNingyan ZhangZhiqiang AnXiang H.-F. ZhangRobert L. Satcher

medicinetreatment and preventionsurgical oncologygap junction failurecancer biologycancer researchmetastasistumor biologydermatologycell deathbone healthcancer treatmentoncologycellular therapycancer careapoptosiscancer immunotherapyhealth sciencesbone research

Bone Mimetic Environments Support Engineering, Propagation, and Analysis of Therapeutic Response of Patient-Derived Cells, Ex Vivo and in Vivo. Acta Biomaterialia (2024)

Claudia PaindelliVanessa PariettiSergio BarriosPeter ShepherdTianhong PanWei-Lien WangRobert L. SatcherChristopher J. LogothetisNora NavoneMatthew T. CampbellAntonios G. MikosEleonora Dondossola

materials sciencebiomaterials designcell engineeringbiomechanicstreatment developmentorthopaedic researchpatient-derived cellstherapeutic responsecellular therapybone researchmedicinal researchcell therapytissue engineeringbiomedical engineeringregenerative medicinebiological engineering

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Robert L. Satcher

Professor Associate Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Orthopaedic Oncology

Departments Of Sarcoma Medical Oncology And Paediatrics

The University of Texas MD Anderson Cancer Center

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Robert L. Satcher

The University of Texas MD Anderson Cancer Center

Professor Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Preoperative Radiotherapy for Appendicular Bone Metastases: Outcomes. BMJ Supportive & Palliative Care (2026)

orthopedic surgeryoncologyclinical radiation oncologyradiation oncologysurgical oncologyradiationmetastasisradiation therapypreoperative radiotherapycancer care

Unbiased Niche Labeling Maps Immune-Excluded Niche in Bone Metastasis. Cell (2026)

cancer cellstumor microenvironmenttumor heterogeneityimmunologycell biology

Bone Cancer, Version 2.2025, Nccn Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network (2025)

Niche Macrophages Recycle Iron to Tumor Cells and Foster Erythroblast Mimicry to Promote Bone Metastasis and Anemia. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Yujiao HanHirak SarkarZhan XuSereno Lopez- DarwinYong WeiXiang HangFengshuo LiuKimberley TranWei WangJennifer M. MillerChristina J. DeCosteDylan S. BlohmRobert L. SatcherXiang H.-F. ZhangYibin Kang

foster erythroblast mimicryinflammationbone metastasisimmunologyniche macrophages

Single-Cell Profiling of Bone Metastasis Ecosystems From Multiple Cancer Types Reveals Convergent and Divergent Mechanisms of Bone Colonization. Cell Genomics (2025)

single-cell profilingbone colonizationbone metastasis

Supplementary Raw Data From Bone Metastasis Initiation is Coupled With Bone Remodeling Through Osteogenic Differentiation of Ng2 Sup + /Sup Cells. (2025)

Tumors Hijack Macrophages for Iron Supply to Promote Bone Metastasis and Anemia. Cell (2025)

Bigh3 Mediates Apoptosis and Gap Junction Failure in Osteocytes During Renal Cell Carcinoma Bone Metastasis Progression. Cancer Letters (2024)

Bone Mimetic Environments Support Engineering, Propagation, and Analysis of Therapeutic Response of Patient-Derived Cells, Ex Vivo and in Vivo. Acta Biomaterialia (2024)

Claudia PaindelliVanessa PariettiSergio BarriosPeter ShepherdTianhong PanWei-Lien WangRobert L. SatcherChristopher J. LogothetisNora NavoneMatthew T. CampbellAntonios G. MikosEleonora Dondossola

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