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Robert Bridges

Rosalind Franklin University of Medicine and Science

NoneRobert Bridges is currently serving as a Center For Genetic Diseases faculty at Rosalind Franklin University of Medicine And Science.

Honors

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Education

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Robert Bridges

Rosalind Franklin University of Medicine and Science

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membrane biology cellular physiology cell biology pharmacology physiology molecular physiology cystic fibrosis cell physiology respiratory medicine molecular biology cell signaling signal transduction membrane transport electrophysiology cellular biochemistry liver physiology membranes pulmonary pharmacology protein transport chloride secretion membrane proteins molecular and cellular biology protein science tissue physiology pharmacological research respiration (physiology) protein secretion membrane science molecular cell biology intracellular trafficking respiratory neurobiology cell trafficking fibrosis applied physiology cell research biological chemistry biochemical sciences vascular biology molecular informatics molecular gastroenterology intercellular communication membrane permeation receptor (biochemistry) translational physiology physiological regulation cell regulation oligonucleotides bicarbonate secretion physiological research clinical physiology human physiology experimental pharmacology medical biophysics high-throughput screening gastrointestinal pharmacology proteinlipid interaction lipid movement disease physiology endocytic pathway membrane systems protein function mammalian physiology ion transport small molecule correctors functional reconstitution plasma membrane recycling future directions current status cftr modulator theratyping efficient correction evolved sequences simple assay salt-secreting epithelial cells agonist-regulated cl synthetic aminoglycosides potential therapeutics

Notable Scholarly Works

Notable Federal Grants

Collaborators

Vx-445 (Elexacaftor) Inhibits Chloride Secretion Across Human Bronchial Epithelial Cells by Directly Blocking Kca3.1 Channels. PNAS Nexus (2025)

physiologyreceptorspulmonary pharmacologypharmacologycellular physiologycell signalingmolecular pharmacologycell physiologyreceptor (biochemistry)intercellular communicationrespiratory medicinechloride secretionkca3.1 channelssignal transductionmolecular physiologymembrane biologypharmacological researchcell biology

In Vitro Modulator Responsiveness of 655 Cftr Variants Found in People With Cystic Fibrosis. Journal of Cystic Fibrosis (2024)

Hermann BihlerAndrey SivachenkoLinda MillenPriyanka BhattAmita Thakerar PatelJustin ChinViolaine BaileyIsaac MusisiAndré LaPanNormand E. AllaireJoshua ConteNoah R. SimonAmalia S. MagaretKaren S. RaraighGarry R. CuttingWilliam R. SkachRobert J. BridgesPhilip J. ThomasMartin Mense

immunologypharmacologycftr variantsgeneticscystic fibrosisvitro modulator responsiveness

Potentiation of Bkca Channels by Cystic Fibrosis Transmembrane Conductance Regulator Correctors Vx-445 and Vx-121. Journal of Clinical Investigation (2024)

Aaron Kolski-AndreacoStefanie TaicletMichael M. MyerburgJohn SembratRobert J. BridgesAdam C. StraubZachary P. WillsMichael B. ButterworthDaniel C. Devor

pharmacologybkca channelsgeneticscystic fibrosisclinical researchmembrane biologyclinical investigationclinical medicineneuroscience

Systematic Deletion of Symmetrical Cftr Exons Reveals New Therapeutic Targets for Exon Skipping Antisense Oligonucleotides. NAR Molecular Medicine (2024)

Cecilia Pena-RasgadoElvia Rodriguez-ManriquezMiroslav DundrRobert J BridgesMichelle L HastingsWren E Michaels

gene therapymolecular biologyoligonucleotidessystematic deletionantisense oligonucleotides

153 Potentiation of the Large-Conductance, Ca2+-Activated K+ Channel by Cftr Correctors Induces K+ Secretion Across Human Bronchial Epithelial Cells, Vasorelaxation, and Decreased Action Potential Firing in Hippocampal Neurons. Journal of Cystic Fibrosis (2023)

A. Kolski-AndreacoS. TaicletR. BridgesZ. WillsA. StraubM. ButterworthD. Devor

physiologyneurologyelectrophysiologyrespiratory neurobiologycell signalingneurochemistrybenchmark studiescftr correctorscentral nervous systemhippocampal neuronssignal transductionneuroscienceneurophysiologyneurostimulation

154 Inhibition of the Intermediate (Kca3.1) and Small (Kca2.3 and Kca2.2) Conductance, Ca2+-Activated K+ Channels by Cftr Correctors. Journal of Cystic Fibrosis (2023)

A. Kolski-AndreacoR. BridgesD. Devor

physiologypharmacologycftr correctorscystic fibrosismolecular biologysignal transductionmembrane biology

In Vitro Modulator Responsiveness of 655 Cftr Variants Found in People With Cf. bioRxiv (Cold Spring Harbor Laboratory) (2023)

in vitro toxicologygene expressionvariant interpretationgeneticsallelic variantmolecular biologypopulation geneticscell biology

Cftr Bearing Variant P.Phe312Del Exhibits Function Inconsistent With Phenotype and Negligible Response to Ivacaftor. JCI Insight (2022)

Karen S. RaraighKathleen C. PaulJennifer L. GoralskiErin N. WorthingtonAnna V. FainoStanley SciortinoYiting WangMelis A. AksitHua LingDerek L. OsorioFrankline M. OnchiriShivani U. PatelChristian A. MerloKristina MontemayorRonald L. GibsonNatalie E. WestAmita ThakerarRobert J. BridgesDavid N. SheppardNeeraj SharmaGarry R. Cutting

immunologynegligible responseveterinary medicine

Functional Rescue of Cftr by Aerosolized Delivery of Optimized Cftr Mrna Using Recode-Lnps in Primary Human Bronchial Epithelial Cells Derived From Patients With Cystic Fibrosis. (2022)

gene therapypulmonary diseasespulmonary pharmacologyfibrosisfunctional rescuebiomedical engineeringoptimized cftr mrnalung depositioncystic fibrosischronic obstructive pulmonary diseaserespiratory medicinedrug deliverytranslational medicinecell biology

Kca3.1 Potentiation Stimulates CL − Secretion in F508Del and G551D Cftr-Corrected Primary Human Bronchial Epithelial Cells. American Journal of Physiology-Cell Physiology (2022)

Daniel C. DevorMatthew D. GreenRobert J. Bridges

physiologyliver physiologyelectrophysiologypharmacologycellular physiologyprotein secretionapplied physiologyrespiratory neurobiologyendocrinologycell signalingcell physiologytissue physiologyrespiratory medicinemolecular physiologymembrane biologycell biology

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Robert Bridges

Rosalind Franklin University of Medicine and Science

NoneRobert Bridges is currently serving as a Center For Genetic Diseases faculty at Rosalind Franklin University of Medicine And Science.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Robert Bridges

Rosalind Franklin University of Medicine and Science

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Vx-445 (Elexacaftor) Inhibits Chloride Secretion Across Human Bronchial Epithelial Cells by Directly Blocking Kca3.1 Channels. PNAS Nexus (2025)

In Vitro Modulator Responsiveness of 655 Cftr Variants Found in People With Cystic Fibrosis. Journal of Cystic Fibrosis (2024)

immunologypharmacologycftr variantsgeneticscystic fibrosisvitro modulator responsiveness

Potentiation of Bkca Channels by Cystic Fibrosis Transmembrane Conductance Regulator Correctors Vx-445 and Vx-121. Journal of Clinical Investigation (2024)

Aaron Kolski-AndreacoStefanie TaicletMichael M. MyerburgJohn SembratRobert J. BridgesAdam C. StraubZachary P. WillsMichael B. ButterworthDaniel C. Devor

pharmacologybkca channelsgeneticscystic fibrosisclinical researchmembrane biologyclinical investigationclinical medicineneuroscience

Systematic Deletion of Symmetrical Cftr Exons Reveals New Therapeutic Targets for Exon Skipping Antisense Oligonucleotides. NAR Molecular Medicine (2024)

Cecilia Pena-RasgadoElvia Rodriguez-ManriquezMiroslav DundrRobert J BridgesMichelle L HastingsWren E Michaels

gene therapymolecular biologyoligonucleotidessystematic deletionantisense oligonucleotides

A. Kolski-AndreacoS. TaicletR. BridgesZ. WillsA. StraubM. ButterworthD. Devor

154 Inhibition of the Intermediate (Kca3.1) and Small (Kca2.3 and Kca2.2) Conductance, Ca2+-Activated K+ Channels by Cftr Correctors. Journal of Cystic Fibrosis (2023)

A. Kolski-AndreacoR. BridgesD. Devor

physiologypharmacologycftr correctorscystic fibrosismolecular biologysignal transductionmembrane biology

In Vitro Modulator Responsiveness of 655 Cftr Variants Found in People With Cf. bioRxiv (Cold Spring Harbor Laboratory) (2023)

in vitro toxicologygene expressionvariant interpretationgeneticsallelic variantmolecular biologypopulation geneticscell biology

Cftr Bearing Variant P.Phe312Del Exhibits Function Inconsistent With Phenotype and Negligible Response to Ivacaftor. JCI Insight (2022)

immunologynegligible responseveterinary medicine

Functional Rescue of Cftr by Aerosolized Delivery of Optimized Cftr Mrna Using Recode-Lnps in Primary Human Bronchial Epithelial Cells Derived From Patients With Cystic Fibrosis. (2022)

Kca3.1 Potentiation Stimulates CL − Secretion in F508Del and G551D Cftr-Corrected Primary Human Bronchial Epithelial Cells. American Journal of Physiology-Cell Physiology (2022)

Daniel C. DevorMatthew D. GreenRobert J. Bridges

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