Faculty

Institution

Unit

Venue

Richard Chamberlin

Professor and Chair of Pharmaceutical Sciences Professor Emeritus of Chemistry

University of California, Irvine

Affiliations

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Richard Chamberlin is currently serving as a Pharmaceutical Sciences Professor and Chair of Pharmaceutical Sciences Professor Emeritus of Chemistry at University of California, Irvine.

Honors

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Experiences

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Education

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Richard Chamberlin

University of California, Irvine

Professor and Chair of Pharmaceutical Sciences Professor Emeritus of Chemistry

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pharmacology chemistry organic synthesis medicinal chemistry cheminform abstract organic chemistry drug discovery chemical synthesis biomolecular engineering enzyme inhibition neuroscience bioorganic chemistry pharmaceutical chemistry medicinal research neuropharmacology protein science clinical chemistry stereoselective synthesis enzymes total synthesis neurochemistry biological evaluation oncogenes cancer biology conformational studies enantioselective synthesis tumor targeting biological chemistry molecular cancer leukemia cellular therapy protein biosynthesis cellular neurobiology functional selectivity combinatorial chemistry transcription regulation cancer growth sodium-dependent glutamate transporters structural molecular biology structural chemistry pharmacotherapy molecular science peptide engineering cancer genomics cancer genetics molecular regulation functional modification bioconjugation site-specific delivery pharmaceutical sciences neurotransmission rational drug design protein synthesis therapeutic patent glutamate uptake selective inhibition fluorescent probes site-specific incorporation solid-phase rna synthesis non-natural residues noncoded amino acids microcystin analogues microwave-assisted organic synthesis matrix biology nanoparticle research cancer cells enzymatic modification inhibitory activity molecular substrates nucleic acid amplification molecular basis gene regulation cell regulation neurotransmitter analogs genetic code ribosome-mediated incorporation pharmacological research future medicinal chemistry mechanisms of action hiv integrase biochemistry chemical biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

DOTAP: Structure, Hydration, and the Counterion Effect. Biophysical Journal (2023)

Mihaela MihailescuDavid L. WorcesterChristopher L. CarrollA. Richard ChamberlinStephen H. White

physiologybiophysicsexperimental biophysicsprotein structurebiologycounterion effect

Supplementary Figures 1-4 From Small Molecule Targeting the Hec1/Nek2 Mitotic Pathway Suppresses Tumor Cell Growth in Culture and in Animal. (2023)

Guikai WuXiao-Long QiuLongen ZhouJiewen ZhuRichard ChamberlinJohnson LauPhang-Lang ChenWen-Hwa Lee

cell growthtumor cell growthcell biologytumor targetingleukemiatumor suppressorstherapeutic targetscancer growthtumor biologyimmunologycarcinogenesisreceptorsenzyme inhibitionpharmacologygliomascell cultureoncogenesmedicinal researchcellular therapy

Bis-Cinnamamide Derivatives as Ape/Ref-1 Inhibitors for the Treatment of Human Melanoma. Molecules (2022)

Razan AlhazmiShirley TongShaban DarwishElina KhanjaniBharti KhungarSwati ChawlaZhonghui ZhengRichard ChamberlinKeykavous ParangSun Yang

medicinal chemistrypharmaceutical chemistrymelanomachemoprevention strategiesmolecular sciencemolecular canceranti-cancer agentsbis-cinnamamide derivativesdermatologytherapeutic targetscancer immunotherapybioactive compoundscancer treatmentenzyme inhibitionpharmacologybiomolecular engineeringoncologyoncogenesmedicinal researchhuman melanoma

Author Response: Regulation of Mrna Translation by a Photoriboswitch. (2020)

Kelly A RotstanMichael M AbdelsayedLuiz FM PassalacquaFabio ChizzoliniKasireddy SudarshanA Richard ChamberlinJiří MíšekAndrej Luptak

author responsetranscription regulationfunctional genomicsgeneticsmolecular biologyrna biologymrna translationbiochemistry

Regulation of Mrna Translation by a Photoriboswitch. eLife (2020)

Kelly A RotstanMichael M AbdelsayedLuiz FM PassalacquaFabio ChizzoliniKasireddy SudarshanA Richard ChamberlinJiří MíšekAndrej Luptak

materials sciencetranscription regulationgeneticsmolecular regulationmrna translationmolecular biologyrna biologymembrane biology

Tautomycetin Synthetic Analogues: Selective Inhibitors of Protein Phosphatase I. ChemMedChem (2020)

Zachary R. WoydziakA. John YucelA. Richard Chamberlin

medicinal chemistryenzyme inhibitionpharmacologytautomycetin synthetic analoguesselective inhibitorsdrug discovery

A Small Molecule Screen Identifies a Novel Compound That Induces a Homeotic Transformation in Hydra. Development (2015)

Kristine M. GlauberCatherine E. DanaSteve S. ParkDavid A. ColbyYukihiko NoroToshitaka FujisawaA. Richard ChamberlinRobert E. Steele

small moleculesavian biologymammalian biologynovel compounddevelopmental biologyhomeotic transformation

Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model. Journal of Medicinal Chemistry (2015)

Parminder KaurA. Richard ChamberlinThomas L. PoulosIrina F. Sevrioukova

medicinal chemistrystructure-based inhibitor designpharmacology

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Rad51 Inhibitors. European Journal of Medicinal Chemistry (2015)

Jiewen ZhuHongyuan ChenXuning Emily GuoXiao-Long QiuChun-Mei HuA. Richard ChamberlinWen-Hwa Lee

medicinal chemistrypharmaceutical chemistrypharmacologybiological evaluationdrug discoverymolecular modeling

Novel Small Molecules Disrupting Hec1/Nek2 Interaction Ablate Tumor Progression by Triggering Nek2 Degradation Through a Death-Trap Mechanism. Oncogene (2014)

C-M HuJ ZhuX E GuoW ChenX-L QiuB NgoR ChienY V WangC Y TsaiG WuY KimR LopezA R ChamberlinEY-HP LeeW-H Lee

gene expressionpharmacologycell deathcancer researchcell interactionsdeath-trap mechanismgeneticscancer growthmolecular biologyoncologyoncogenescancer biologytumor biology

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Richard Chamberlin

Professor and Chair of Pharmaceutical Sciences Professor Emeritus of Chemistry

University of California, Irvine

Affiliations

School of Pharmacy and Pharmaceutical Sciences

Department of Pharmaceutical Sciences

Richard Chamberlin is currently serving as a Pharmaceutical Sciences Professor and Chair of Pharmaceutical Sciences Professor Emeritus of Chemistry at University of California, Irvine.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Richard Chamberlin

University of California, Irvine

Professor and Chair of Pharmaceutical Sciences Professor Emeritus of Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

DOTAP: Structure, Hydration, and the Counterion Effect. Biophysical Journal (2023)

Mihaela MihailescuDavid L. WorcesterChristopher L. CarrollA. Richard ChamberlinStephen H. White

physiologybiophysicsexperimental biophysicsprotein structurebiologycounterion effect

Supplementary Figures 1-4 From Small Molecule Targeting the Hec1/Nek2 Mitotic Pathway Suppresses Tumor Cell Growth in Culture and in Animal. (2023)

Guikai WuXiao-Long QiuLongen ZhouJiewen ZhuRichard ChamberlinJohnson LauPhang-Lang ChenWen-Hwa Lee

Bis-Cinnamamide Derivatives as Ape/Ref-1 Inhibitors for the Treatment of Human Melanoma. Molecules (2022)

Razan AlhazmiShirley TongShaban DarwishElina KhanjaniBharti KhungarSwati ChawlaZhonghui ZhengRichard ChamberlinKeykavous ParangSun Yang

Author Response: Regulation of Mrna Translation by a Photoriboswitch. (2020)

Kelly A RotstanMichael M AbdelsayedLuiz FM PassalacquaFabio ChizzoliniKasireddy SudarshanA Richard ChamberlinJiří MíšekAndrej Luptak

author responsetranscription regulationfunctional genomicsgeneticsmolecular biologyrna biologymrna translationbiochemistry

Regulation of Mrna Translation by a Photoriboswitch. eLife (2020)

Kelly A RotstanMichael M AbdelsayedLuiz FM PassalacquaFabio ChizzoliniKasireddy SudarshanA Richard ChamberlinJiří MíšekAndrej Luptak

materials sciencetranscription regulationgeneticsmolecular regulationmrna translationmolecular biologyrna biologymembrane biology

Tautomycetin Synthetic Analogues: Selective Inhibitors of Protein Phosphatase I. ChemMedChem (2020)

Zachary R. WoydziakA. John YucelA. Richard Chamberlin

medicinal chemistryenzyme inhibitionpharmacologytautomycetin synthetic analoguesselective inhibitorsdrug discovery

A Small Molecule Screen Identifies a Novel Compound That Induces a Homeotic Transformation in Hydra. Development (2015)

Kristine M. GlauberCatherine E. DanaSteve S. ParkDavid A. ColbyYukihiko NoroToshitaka FujisawaA. Richard ChamberlinRobert E. Steele

small moleculesavian biologymammalian biologynovel compounddevelopmental biologyhomeotic transformation

Structure-Based Inhibitor Design for Evaluation of a Cyp3A4 Pharmacophore Model. Journal of Medicinal Chemistry (2015)

Parminder KaurA. Richard ChamberlinThomas L. PoulosIrina F. Sevrioukova

medicinal chemistrystructure-based inhibitor designpharmacology

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Rad51 Inhibitors. European Journal of Medicinal Chemistry (2015)

Jiewen ZhuHongyuan ChenXuning Emily GuoXiao-Long QiuChun-Mei HuA. Richard ChamberlinWen-Hwa Lee

medicinal chemistrypharmaceutical chemistrypharmacologybiological evaluationdrug discoverymolecular modeling

Novel Small Molecules Disrupting Hec1/Nek2 Interaction Ablate Tumor Progression by Triggering Nek2 Degradation Through a Death-Trap Mechanism. Oncogene (2014)

C-M HuJ ZhuX E GuoW ChenX-L QiuB NgoR ChienY V WangC Y TsaiG WuY KimR LopezA R ChamberlinEY-HP LeeW-H Lee

gene expressionpharmacologycell deathcancer researchcell interactionsdeath-trap mechanismgeneticscancer growthmolecular biologyoncologyoncogenescancer biologytumor biology

1
2
3
4
5
15
10 / page

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University of Arizona

biochemistry

drug development

Stephen Frye

Institution

University of North Carolina at Chapel Hill

medicinal chemistry

protein science

Arun Sharma

Institution

Pennsylvania State University

cancer letter

future medicinal chemistry

Charles E. McKenna

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University of Southern California

future medicinal chemistry

medicinal chemistry

Daniel Romo

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organic synthesis

chemistry

Richard B. Silverman

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pharmacology

medicinal chemistry

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anti-cancer agent

molecular pathway

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medicinal chemistry

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marine cyanobacteria

natural product biosynthesis