Faculty

Institution

Unit

Venue

Rutilio Fratti

Professor of Biochemistry Professor of Biophysics & Quantitative Biology

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Rutilio Fratti is currently serving as a College Of Liberal Arts & Sciences Professor of Biochemistry Professor of Biophysics & Quantitative Biology at Uiuc.

Honors

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Experiences

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Education

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Rutilio Fratti

UIUC

Professor of Biochemistry Professor of Biophysics & Quantitative Biology

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cellular biochemistry cell biology molecular cell biology molecular biology membrane biology membrane proteins molecular and cellular biology biochemistry intracellular trafficking protein transport cellular physiology proteinlipid interaction signal transduction biological chemistry secretory pathway lipids protein science immunology cell signaling membranes phagocytes protein phosphorylation membrane fusion biological macromolecules membrane systems membrane transport cell and molecular biology yeast medical mycology autophagy pulmonary tuberculosis lipid movement molecular physiology fungal cell biology protein function lipid chemistry membrane science endocytic pathway clinical mycology protein secretion clinical microbiology medical microbiology antifungal agents fungal physiology cell death vascular biology antimicrobial agents cell metabolism innate immune system endothelial dysfunction endothelial cells cell trafficking fungal pathogens membrane trafficking binding affinities cell research analytical microsystems latex beads mycobacterium tuberculosis phagosome maturation mycobacterial phagosome maturation regulatory lipids new triazole vacuole fusion liposome fusion biological membrane fusion soluble snare fusion machinery endothelial cell phagocytosis microbial disease multi-protein assembly lipid synthesis fusion system design inertial confinement fusion cytokines organelle dynamics biophysics receptor (biochemistry)

Notable Scholarly Works

Notable Federal Grants

Collaborators

Broad-Spectrum Activity and Mechanisms of Action of Sq109 on a Variety of Fungi. ACS Infectious Diseases (2025)

Satish R. MalwalRocio Garcia-RubioMilena KordalewskaHoja PattersonChi ZhangJorge D. CalderinRuijie ZhouAkanksha M. PandeyErika ShorDavid S. PerlinNathan P. WiederholdLuis Ostrosky-ZeichnerRutilio FrattiCarol NacyEric Oldfield

tuberculosis drug sq109fungal pathogensantimicrobial agentsfungusbroad-spectrum activitymicrobiologyfungal geneticspharmacologyfungal ecologyantifungal agentsmedical mycologyfungal physiologymicrobial pathogenesis

Preface. Methods in Molecular Biology (2025)

Rutilio Fratti

Spectroscopic Methods for Detecting Conformational Changes During Sec18-Lipid Interactions. Methods in molecular biology (2025)

Rutilio FrattiJorge D CalderinMatthew L Starr

biophysicslipidslipid chemistrysec18-lipid interactionsproteinlipid interactionvibrational spectroscopybiomolecular structurebiochemistrylipid movementmolecular structurebiophysical chemistry

Use of Bio-Layer Interferometry (Bli) to Measure Binding Affinities of Snares and Phosphoinositides. Methods in molecular biology (2025)

Jorge D CalderinChi ZhangTimothy J C TanNicholas C WuRutilio Fratti

biophysicsbiophysical aspectbiological macromoleculesbiomedical analysisbiological imagingprotein scienceproteinlipid interactionmembrane proteinsbinding affinitiesintracellular traffickingexperimental biophysicsmolecular biologysignal transductionbiophysical chemistrycellular biochemistrybio-layer interferometry

Vacuolar Phosphatidylinositol 3,4,5-Trisphosphate Controls Fusion Through Binding Vam7, and Membrane Microdomain Assembly. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Chi ZhangJorge D. CalderinAliasgar TopiwallaVed ShahJahnavi M. KaratCharlie T. KnappRazeen AhmedDaniel GrudzienElizabeth WilliamsonRutilio A. Fratti

protein phosphorylationpartner vesiclescell biologymembrane proteinsphosphatase ptenbiochemistryintracellular traffickingmembrane biologymolecular cell biologyprotein transportmolecular biologyyeast vacuolessignal transductioncellular biochemistry

Lysophospholipid Headgroup Size, and Acyl Chain Length and Saturation Differentially Affect Vacuole Acidification, Ca2+ Transport, and Fusion. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Chi ZhangYilin FengJorge D. CalderinAdam BalutowskiRazeen AhmedCharlie KnappRutilio A. Fratti

molecular and cellular biologylipidsbiological macromoleculeslipid chemistrybiomoleculeschain lengthmembrane sciencebiophysical chemistryca2+ transportmolecular biologycellular biochemistrymembrane transportmembrane proteinsbiochemistrylysophospholipid headgroup sizebiological chemistryproteinlipid interactionmembrane biologymembraneslipid movement

Sphingolipids Containing Very Long-Chain Fatty Acids Regulate Ypt7 Function During the Tethering Stage of Vacuole Fusion. Journal of Biological Chemistry (2024)

Chi ZhangJorge D CalderinLogan R HurstZeynep D GokbayrakMichael R HrabakAdam BalutowskiDavid A Rivera-KohrThomas D D KazmirchukChristopher L BrettRutilio A Fratti

lipidsbiological macromoleculesypt7 functionproteinlipid interactionprotein sciencemembrane proteinsprotein functionbiochemistrymolecular physiologymembrane biologylong-chain fatty acidsmolecular biologytethering stagelipid movementcellular biochemistry

CORRECTION: A Small-Molecule Competitive Inhibitor of Phosphatidic Acid Binding by the Aaa+ Protein Nsf/Sec18 Blocks the Snare-Priming Stage of Vacuole Fusion. Journal of Biological Chemistry (2022)

Robert P. SparksAndres S. ArangoMatthew L. StarrZachary L. AboffLogan R. HurstDavid A. Rivera-KohrChi ZhangKevin A. HarndenJermaine L. JenkinsWayne C. GuidaEmad TajkhorshidRutilio A. Fratti

biophysicssurface plasmon resonancemembrane proteinssmall moleculesmembrane biologychemical biologysnare-priming stageplasmonsmolecular biologyaaa+ protein nsf/sec18biophysical chemistry

Erratum to “High Throughput Analysis of Vacuolar Acidification” [Anal. Biochem. 658C (2022) 114927]. Analytical Biochemistry (2022)

Chi ZhangAdam BalutowskiYilin FengJorge D CalderinRutilio A Fratti

high throughput analysisphysiologyanalytical chemistrybiochemistrybioanalysisclinical chemistry

High Throughput Analysis of Vacuolar Acidification. Analytical Biochemistry (2022)

Chi ZhangAdam BalutowskiYilin FengJorge D. CalderinRutilio A. Fratti

biophysicsbioprocess monitoringhigh throughput analysisanalytical chemistrybioanalysisbioenergetics

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Rutilio Fratti

Professor of Biochemistry Professor of Biophysics & Quantitative Biology

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Rutilio Fratti is currently serving as a College Of Liberal Arts & Sciences Professor of Biochemistry Professor of Biophysics & Quantitative Biology at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Rutilio Fratti

UIUC

Professor of Biochemistry Professor of Biophysics & Quantitative Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Broad-Spectrum Activity and Mechanisms of Action of Sq109 on a Variety of Fungi. ACS Infectious Diseases (2025)

Preface. Methods in Molecular Biology (2025)

Rutilio Fratti

Spectroscopic Methods for Detecting Conformational Changes During Sec18-Lipid Interactions. Methods in molecular biology (2025)

Rutilio FrattiJorge D CalderinMatthew L Starr

biophysicslipidslipid chemistrysec18-lipid interactionsproteinlipid interactionvibrational spectroscopybiomolecular structurebiochemistrylipid movementmolecular structurebiophysical chemistry

Use of Bio-Layer Interferometry (Bli) to Measure Binding Affinities of Snares and Phosphoinositides. Methods in molecular biology (2025)

Jorge D CalderinChi ZhangTimothy J C TanNicholas C WuRutilio Fratti

Vacuolar Phosphatidylinositol 3,4,5-Trisphosphate Controls Fusion Through Binding Vam7, and Membrane Microdomain Assembly. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Chi ZhangJorge D. CalderinAliasgar TopiwallaVed ShahJahnavi M. KaratCharlie T. KnappRazeen AhmedDaniel GrudzienElizabeth WilliamsonRutilio A. Fratti

Lysophospholipid Headgroup Size, and Acyl Chain Length and Saturation Differentially Affect Vacuole Acidification, Ca2+ Transport, and Fusion. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Chi ZhangYilin FengJorge D. CalderinAdam BalutowskiRazeen AhmedCharlie KnappRutilio A. Fratti

Sphingolipids Containing Very Long-Chain Fatty Acids Regulate Ypt7 Function During the Tethering Stage of Vacuole Fusion. Journal of Biological Chemistry (2024)

Chi ZhangJorge D CalderinLogan R HurstZeynep D GokbayrakMichael R HrabakAdam BalutowskiDavid A Rivera-KohrThomas D D KazmirchukChristopher L BrettRutilio A Fratti

Robert P. SparksAndres S. ArangoMatthew L. StarrZachary L. AboffLogan R. HurstDavid A. Rivera-KohrChi ZhangKevin A. HarndenJermaine L. JenkinsWayne C. GuidaEmad TajkhorshidRutilio A. Fratti

biophysicssurface plasmon resonancemembrane proteinssmall moleculesmembrane biologychemical biologysnare-priming stageplasmonsmolecular biologyaaa+ protein nsf/sec18biophysical chemistry

Erratum to “High Throughput Analysis of Vacuolar Acidification” [Anal. Biochem. 658C (2022) 114927]. Analytical Biochemistry (2022)

Chi ZhangAdam BalutowskiYilin FengJorge D CalderinRutilio A Fratti

high throughput analysisphysiologyanalytical chemistrybiochemistrybioanalysisclinical chemistry

High Throughput Analysis of Vacuolar Acidification. Analytical Biochemistry (2022)

Chi ZhangAdam BalutowskiYilin FengJorge D. CalderinRutilio A. Fratti

biophysicsbioprocess monitoringhigh throughput analysisanalytical chemistrybioanalysisbioenergetics

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