Faculty

Institution

Unit

Venue

Raghu Kalluri

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

Center Of Sheikh Ahmed Pancreatic Cancer Research

Department Of Biology And Biochemistry

Department Of Rheumatology

MD Anderson UTHealth Houston Graduate School

Raghu Kalluri is a Senior Professor at The University of Texas MD Anderson Cancer Center. His research focuses on cancer biology, specifically the tumor microenvironment, extracellular microvesicles, and pancreatic cancer. Recent work includes identifying tumor-restraining fibroblasts that emerge after chemotherapy in responders, and engineering exosomes with KrasG12D-specific siRNA for pancreatic cancer, demonstrated in a Phase I study with immunological correlates. He also investigates the evolutionary fingerprints of epithelial-to-mesenchymal transition and advances in extracellular vesicle diagnostics, from bulk measurements to single-vesicle analysis. His publications appear in Nature, Nature Communications, and ACS Nano.

Honors

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Raghu Kalluri

The University of Texas MD Anderson Cancer Center

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cell biology tumor biology cancer cells vascular biology nephrology immunology pathology cancer research cancer biology matrix biology tumor microenvironment pharmacology extracellular matrix oncogenes medicinal research stem cell research angiogenesis oncology molecular cancer extracellular microvesicles renal pathophysiology cellular therapy pancreatic cancer fibrosis cellular physiology renal function inflammation kidney research cell-matrix interactions gene expression molecular cell biology tumor targeting cancer growth neovascularization liver physiology bone research cell research cardiovascular research cellular biochemistry fibroblast growth factors mammalian biology biological microenvironments cancer genomics cancer immunosurveillance cancer treatment type iv collagen extracellular vesicles kidney failure tissue development renal fibrosis angiology small rna non-coding rna bone morphogenic protein cellular immune responses in vivo systems novel therapies stem-cell therapy goodpasture syndrome mesenchymal stem cells diabetic kidney disease cardiac muscle endothelial dysfunction alport syndrome cellular biology epithelial-mesenchymal transition kidney fibrosis basement membranes epithelial cells liver fibrosis cancer progression tumor growth collagen iv bone morphogenic protein-7 endogenous inhibitors author correction

Notable Scholarly Works

Notable Federal Grants

Collaborators

Advancements in Extracellular Vesicle Research. Extracellular Vesicle (2026)

biophysicscell biologyextracellular vesicle researchmembranesmembrane biologycell and molecular biologycell researchmatrix biologyintracellular traffickingextracellular microvesiclescellular biochemistry

Hype Versus Reality of Artificial Intelligence (AI) Platforms: Unmasking the Limitations of Large Language Models in the Use of Scientific Writing and Reporting. Extracellular Vesicle (2026)

hype versus realitynatural language generationscientific writinglinguisticssemantic evaluationintelligent computingresponsible aiai architectureapplied linguisticshuman-ai interactionlanguage technologiesartificial intelligencelanguagelanguage models

Tumor-Restraining Fibroblasts Emerge After Chemotherapy Specifically in Responders. Cancer Cell (2026)

oncologyradiation oncologycancer cellscancer treatmenttumor targetingtumor microenvironmenttumor-restraining fibroblasts

Abstract Ct265: Krasg12dtargeting Using Engineered Exosomes in Pancreatic Cancer: Results From the Iexplore Phase 1 Trial. Cancer Research (2025)

tumor biologycancer researchgastrointestinal oncologycancer biologycell biologycancer cellspancreatic canceroncogenesiexplore phase 1tumor targetingextracellular microvesiclesmolecular biologyabstract ct265tumor microenvironment

Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics. Journal of Clinical Medicine (2025)

Morten KarsdalThomas R. CoxAmelia L. ParkerNicholas WillumsenJannie Marie Bülow SandGisli JenkinsHenrik H. HansenAnouk OldenburgerKerstin E. Geillinger-KaestleAnna Thorsø LarsenDarcey BlackFederica GenoveseAlexander EckersleyAndrea HeinzAlexander NyströmSigne Holm NielsenLucas BenninkLars JohannssonAnne-Christine Bay-JensenDana E. OrangeScott FriedmanMads RøpkeVincent FioreDetlef SchuppanFlorian RiederBenjamin SimonaLee BorthwickMark SkarsfeldtHaakan WennboParesh ThakkerRuedi StoffelGraham W. ClarkeRaghu KalluriDarren RuaneFaiez ZannadJoachim Høg MortensenDovile SinkeviciuteFred SundbergMolly CosenoChristian ThudiumAdam P. CroftDinesh KhannaMichael CooremanAndre BroermannDiana Julie LeemingAli MobasheriSylvie Ricard-Blum

molecular diagnosticsmedicineextracellular matrix-associated diagnosticsmatrix biologyextracellular matrixdiagnostic testsclinical medicine

Amniotic Fluid Extracellular Vesicle and Cell-Free Rna Profiling Reveals Fetal Adaptations in Twin-Twin Transfusion Syndrome. American Journal of Obstetrics & Gynecology MFM (2025)

Jacqueline G ParchemHuihui FanLovepreet K MannKadeshia M CampbellSujuan YangWencai MaJong H WonJing WangRamesha PapannaRaghu Kalluri

gynecologyobstetrics and gynaecologymaternal-fetal medicineobstetricsblood transfusionmaternal healthfetal complicationstwin-twin transfusion syndromehealth sciencesfetal medicine

An Allele-Agnostic Mutant-Kras Inhibitor Suppresses Tumor Maintenance Signals and Reprograms Tumor Immunity in Pancreatic Cancer. Science Translational Medicine (2025)

maintenance signalstumor biologycancer immunotherapycancer researchmolecular cancercancer biologycell biologycancer cellspancreatic canceroncogenesimmunologytherapeutic targetscancer discovery

Cdk8 Remodels the Tumor Microenvironment to Resist the Therapeutic Efficacy of Targeted Kras G12D Inhibition in Pancreatic Ductal Adenocarcinoma. bioRxiv (Cold Spring Harbor Laboratory) (2025)

tumor biologypancreatic ductal adenocarcinomacancer researchmolecular cancercancer biologycell biologycancer cellspancreatic canceroncogenesimmunologytherapeutic targetstumor microenvironmenttherapeutic efficacy

Distinct Small Molecule Inhibitors of Kras Specifically Prime Ctla4 Blockade Therapy to Transcriptionally Reprogram Tregs and Overcome Resistance to Suppress Pancreas Cancer. bioRxiv (Cold Spring Harbor Laboratory) (2025)

pancreas cancercancer immunotherapymolecular cancercell biologycancer cellspancreatic canceroncogenesdrug targetstherapeutic targetsmolecular biology

Durotaxis is a Driver and Potential Therapeutic Target in Lung Fibrosis and Metastatic Pancreatic Cancer. Nature Cell Biology (2025)

metastasislung cancertumor biologylung fibrosisbronchial neoplasmoncologyradiation oncologymolecular cancercancer biologycancer cellspancreatic canceroncogenesmetastatic pancreatic cancerthoracic oncologypotential therapeutic targettumor microenvironmentpathology

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Raghu Kalluri

The University of Texas MD Anderson Cancer Center

Affiliations

Center For Rna Interference And Non-Coding Rna

Department Of Cancer Biology

Center Of Sheikh Ahmed Pancreatic Cancer Research

Department Of Biology And Biochemistry

Department Of Rheumatology

MD Anderson UTHealth Houston Graduate School

Honors

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Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Raghu Kalluri

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Advancements in Extracellular Vesicle Research. Extracellular Vesicle (2026)

Hype Versus Reality of Artificial Intelligence (AI) Platforms: Unmasking the Limitations of Large Language Models in the Use of Scientific Writing and Reporting. Extracellular Vesicle (2026)

Tumor-Restraining Fibroblasts Emerge After Chemotherapy Specifically in Responders. Cancer Cell (2026)

oncologyradiation oncologycancer cellscancer treatmenttumor targetingtumor microenvironmenttumor-restraining fibroblasts

Abstract Ct265: Krasg12dtargeting Using Engineered Exosomes in Pancreatic Cancer: Results From the Iexplore Phase 1 Trial. Cancer Research (2025)

Advances in Extracellular Matrix-Associated Diagnostics and Therapeutics. Journal of Clinical Medicine (2025)

molecular diagnosticsmedicineextracellular matrix-associated diagnosticsmatrix biologyextracellular matrixdiagnostic testsclinical medicine

Amniotic Fluid Extracellular Vesicle and Cell-Free Rna Profiling Reveals Fetal Adaptations in Twin-Twin Transfusion Syndrome. American Journal of Obstetrics & Gynecology MFM (2025)

Jacqueline G ParchemHuihui FanLovepreet K MannKadeshia M CampbellSujuan YangWencai MaJong H WonJing WangRamesha PapannaRaghu Kalluri

gynecologyobstetrics and gynaecologymaternal-fetal medicineobstetricsblood transfusionmaternal healthfetal complicationstwin-twin transfusion syndromehealth sciencesfetal medicine

An Allele-Agnostic Mutant-Kras Inhibitor Suppresses Tumor Maintenance Signals and Reprograms Tumor Immunity in Pancreatic Cancer. Science Translational Medicine (2025)

maintenance signalstumor biologycancer immunotherapycancer researchmolecular cancercancer biologycell biologycancer cellspancreatic canceroncogenesimmunologytherapeutic targetscancer discovery

Cdk8 Remodels the Tumor Microenvironment to Resist the Therapeutic Efficacy of Targeted Kras G12D Inhibition in Pancreatic Ductal Adenocarcinoma. bioRxiv (Cold Spring Harbor Laboratory) (2025)

pancreas cancercancer immunotherapymolecular cancercell biologycancer cellspancreatic canceroncogenesdrug targetstherapeutic targetsmolecular biology

Durotaxis is a Driver and Potential Therapeutic Target in Lung Fibrosis and Metastatic Pancreatic Cancer. Nature Cell Biology (2025)

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