Faculty

Institution

Unit

Venue

Po-Chao Wen

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Po-chao Wen is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

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Experiences

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Education

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Po-Chao Wen

UIUC

Research Scientist

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biochemistry biophysics membrane biology membrane proteins membrane transport membranes structural molecular biology membrane science biomolecular structure molecular biology molecular modelling protein science proteinlipid interaction biophysical chemistry molecular biophysics cellular biochemistry membrane systems protein structure computational biophysics cell biology protein transport membrane permeation conformational studies membrane structure structural biology biological macromolecules membrane computing lipid movement molecular cell biology biophysical modeling membrane transporters biological chemistry biomolecules biophysical review biomolecular interactions mitochondrial function molecular dynamics antimicrobial agents cell metabolism abc transporters cellular physiology theoretical biology molecular physiology outer membrane membrane channels cellular membrane cell death intracellular trafficking macromolecular machines apoptosis neurotransmitters nanodisc antimicrobial susceptibility conformational dynamics atp hydrolysis microscopic view active transport mechanisms of action neurotransmission carbohydrate-protein interactions glycosylation single-molecule detection cell adhesion biochemical interaction nucleic acid chemistry antibiotic adjuvant dysbiosis structural dynamics lipid science lipid chemistry mitochondrial vdac1 new classification structural homology serotonin transporter-ibogaine complexes large flexibility inward-facing state protein-lipid interactions membrane-active peptides

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Orchestrated Interaction Network at the Binding Site of Human Sert Enables the Serotonin Occlusion and Import. Biochemistry (2025)

Zhiyu ZhaoPo-Chao WenEmad Tajkhorshid

biomolecular interactionsbiophysicsserotonin occlusionprotein structuremolecular modellingmolecular dynamicsconformational studiesserotonin importmolecular biologystructural molecular biologybiomolecular structureprotein sciencebiochemistry

Bps2025 - Refining Gram-Negative Antibiotic Discovery Using AI and Molecular Simulation. Biophysical Journal (2025)

Alexander M. MortensonMorgan GuggerHale S. HasdemirAlexandre M. PlastowPo-Chao WenPaul HergenrotherEmad Tajkhorshid

antimicrobial agentsantimicrobial resistancebiological engineeringantimicrobial compoundsclinical microbiologyantimicrobial susceptibilitygram-negative antibiotic discoveryantibioticsmicrobiologymolecular simulation

Cryo-Em Structure of the Tissue Factor/Factor Viia Complex With a Factor X Mimetic Reveals a Novel Allosteric Mechanism. Blood (2025)

Josepha C SedzroAmanda L. PhotenhauerFabienne BirkleKatarina MezeAlex MortensonCade DuckworthPo-Chao WenSarah KearnsMichael A. CianfroccoEmad TajkhorshidMelanie D. OhiJames H. Morrissey

cryo-em structurebiomolecular interactionsbiophysical chemistrybiophysicsmembrane surfacemolecular biologymembrane proteinsstructural molecular biologynanodiscactive siteprotein sciencemembrane biologycell biology

Dissecting Large-Scale Structural Transitions in Membrane Transporters Using Advanced Simulation Technologies. The Journal of Physical Chemistry B (2025)

Shashank PantSepehr Dehghani-GhahnaviyehNoah TrebeschAli RasouliTianle ChenKaran KapoorPo-Chao WenEmad Tajkhorshid

membrane formationtransport phenomenamolecular modellingmembrane permeationmembrane sciencebiochemistryalternating access modelmembrane transportmembrane structurelarge-scale structural changesprotein sciencemembrane transportersmolecular biophysicsmembrane systemsmembrane proteinsbiophysicsmembranesbiomolecular engineeringstructural molecular biology

Molecular Dynamics Simulations of Biological Membranes and Membrane-Associated Phenomena Across Scales. Current Opinion in Structural Biology (2025)

Noah TrebeschHale S HasdemirTianle ChenPo-Chao WenEmad Tajkhorshid

computational biophysicsmolecular dynamics simulationsmolecular biophysicsbiophysicsmembranesmembrane-associated phenomenamolecular modellingmembrane computingbiological membranesmolecular biologymembrane sciencemembrane structuretheoretical biologymembrane biology

Probing the Role of Membrane in Neutralizing Activity of Antibodies Against Influenza Virus. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Defne G. OzgulbasTimothy J. C. TanPo-Chao WenQi Wen TeoHuibin LvZhaleh GhaemiMartin FrankNicholas C. WuEmad Tajkhorshid

protein structureantibody engineeringvaccinesantiviral researchinfluenza vaccinemembrane bindinginfluenzaprotein scienceinfluenza virusvirus structuremedical virologymembrane proteinsviral structural proteinimmunologyvirus researchneutralization activitybiomolecular engineeringvirologystructural molecular biology

A Gram-Negative-Selective Antibiotic That Spares the Gut Microbiome. Nature (2024)

Kristen A. MuñozRebecca J. UlrichArchit K. VasanMatt SinclairPo-Chao WenJessica R. HolmesHyang Yeon LeeChien-Che HungChristopher J. FieldsEmad TajkhorshidGee W. LauPaul J. Hergenrother

microbiomeantimicrobial agentsgut microbesantimicrobial resistanceantibiotic adjuvantantibioticsdysbiosisgut microbiomemicrobiology

Locked in Place: Deciphering the Conformational Impairment Caused by Tumor-Acquired Somatic Mutation Q393K in Abcg2. Biophysical Journal (2024)

Ali RasouliTomoka GoseSepehr Dehghani-GhahnaviyehPo-Chao WenYao WangJohn LynchYu FukudaTalha ShafiRobert C. FordJohn D. SchuetzEmad Tajkhorshid

cancer geneticsmolecular cancermolecular cell biologyconformational impairmentmolecular geneticsmolecular biologyoncogenescancer cellsdna repaircancer letterstructural molecular biologysomatic varianttumor biologygenome instabilitycell biology

Membrane-Bound Model of the Ternary Complex Between Factor Viia/Tissue Factor and Factor X. Blood Advances (2024)

Melanie P MullerAlex MortensonJosepha C SedzroPo-Chao WenJames H MorrisseyEmad Tajkhorshid

computational biophysicsbiological macromoleculesbiophysicsprotein assemblybiomolecular interactionscoagulation cascadeproteinlipid interactionmolecular modellingmembrane-bound modelmolecular dockingmolecular biologymembrane proteinsstructural molecular biologybiomolecular structureprotein sciencefactor xmembrane biologybiochemistry

Membrane Interaction and Binding of the Displaced Vdac1 N-Terminus. Biophysical Journal (2024)

Po-Chao WenWai-Meng KwokEmad Tajkhorshid

biophysical chemistrymembrane transportproteinlipid interactionmembrane interactionmembrane systemsstructural molecular biologymolecular biologymembrane proteinsbiomolecular structureprotein science

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Po-Chao Wen

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Po-chao Wen is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Po-Chao Wen

UIUC

Research Scientist

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Orchestrated Interaction Network at the Binding Site of Human Sert Enables the Serotonin Occlusion and Import. Biochemistry (2025)

Zhiyu ZhaoPo-Chao WenEmad Tajkhorshid

Bps2025 - Refining Gram-Negative Antibiotic Discovery Using AI and Molecular Simulation. Biophysical Journal (2025)

Alexander M. MortensonMorgan GuggerHale S. HasdemirAlexandre M. PlastowPo-Chao WenPaul HergenrotherEmad Tajkhorshid

Cryo-Em Structure of the Tissue Factor/Factor Viia Complex With a Factor X Mimetic Reveals a Novel Allosteric Mechanism. Blood (2025)

Josepha C SedzroAmanda L. PhotenhauerFabienne BirkleKatarina MezeAlex MortensonCade DuckworthPo-Chao WenSarah KearnsMichael A. CianfroccoEmad TajkhorshidMelanie D. OhiJames H. Morrissey

Dissecting Large-Scale Structural Transitions in Membrane Transporters Using Advanced Simulation Technologies. The Journal of Physical Chemistry B (2025)

Shashank PantSepehr Dehghani-GhahnaviyehNoah TrebeschAli RasouliTianle ChenKaran KapoorPo-Chao WenEmad Tajkhorshid

Molecular Dynamics Simulations of Biological Membranes and Membrane-Associated Phenomena Across Scales. Current Opinion in Structural Biology (2025)

Noah TrebeschHale S HasdemirTianle ChenPo-Chao WenEmad Tajkhorshid

Probing the Role of Membrane in Neutralizing Activity of Antibodies Against Influenza Virus. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Defne G. OzgulbasTimothy J. C. TanPo-Chao WenQi Wen TeoHuibin LvZhaleh GhaemiMartin FrankNicholas C. WuEmad Tajkhorshid

A Gram-Negative-Selective Antibiotic That Spares the Gut Microbiome. Nature (2024)

Kristen A. MuñozRebecca J. UlrichArchit K. VasanMatt SinclairPo-Chao WenJessica R. HolmesHyang Yeon LeeChien-Che HungChristopher J. FieldsEmad TajkhorshidGee W. LauPaul J. Hergenrother

microbiomeantimicrobial agentsgut microbesantimicrobial resistanceantibiotic adjuvantantibioticsdysbiosisgut microbiomemicrobiology

Locked in Place: Deciphering the Conformational Impairment Caused by Tumor-Acquired Somatic Mutation Q393K in Abcg2. Biophysical Journal (2024)

Ali RasouliTomoka GoseSepehr Dehghani-GhahnaviyehPo-Chao WenYao WangJohn LynchYu FukudaTalha ShafiRobert C. FordJohn D. SchuetzEmad Tajkhorshid

Membrane-Bound Model of the Ternary Complex Between Factor Viia/Tissue Factor and Factor X. Blood Advances (2024)

Melanie P MullerAlex MortensonJosepha C SedzroPo-Chao WenJames H MorrisseyEmad Tajkhorshid

Membrane Interaction and Binding of the Displaced Vdac1 N-Terminus. Biophysical Journal (2024)

Po-Chao WenWai-Meng KwokEmad Tajkhorshid

biophysical chemistrymembrane transportproteinlipid interactionmembrane interactionmembrane systemsstructural molecular biologymolecular biologymembrane proteinsbiomolecular structureprotein science

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10 / page