Faculty

Institution

Unit

Venue

MVSc Prashant Nighot

Associate Professor and Vice Chair for Research

Pennsylvania State University

Affiliations

Penn State College of Medicine

Department of Medicine

Division of Gastroenterology and Hepatology

Mvsc Prashant Nighot is currently serving as a Medicine Associate Professor and Vice Chair for Research at Pennsylvania State University.

Honors

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Experiences

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Education

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MVSc Prashant Nighot

Pennsylvania State University

Associate Professor and Vice Chair for Research

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gastroenterology cell biology membrane biology digestive diseases immunology inflammation vascular biology physiology pharmacology gut barrier hepatology autophagy digestive tract mucosal immunology gene expression cellular physiology veterinary medicine liver physiology clinical microbiology mammalian biology immune responses signal transduction gastrointestinal pharmacology cell physiology molecular physiology gut microbes redox biology cellular biology arbovirus cell autophagy intestinal inflammation cell research animal physiology pathway analysis intracellular trafficking molecular immunology experimental colitis biological chemistry matrix biology molecular pathology cell-matrix interactions translational physiology functional regulation clinical immunology tissue physiology protein expression ingestion signaling pathways virus-host interactions gut-organ axis intestinal epithelium intestinal barrier function murine gastric glands circulatory physiology child neurology host factors microbial physiology pediatric surgery disease physiology clinical pathology general pathology veterinary pathology redox signaling cell biomechanics viral pathogenesis lipopolysaccharide regulation mast cell blockade delayed weaning gastrointestinal dysfunction early weaning lipopolysaccharide-induced increase experimental dss colitis ischemic porcine ileum mucosal barrier function novel agonist intestinal barrier dysfunction pathology aryl hydrocarbon pathogenesis ulcerative colitis inflammatory bowel disease molecular gastroenterology

Notable Scholarly Works

Notable Federal Grants

Collaborators

107 Autophagy Ameliorates Er Stress-Mediated Intestinal Tight Junction Barrier Dysfunction. Gastroenterology (2024)

Priya ArumugamAshwinkumar Subramenium GanapathyKushal SahaPrashant Nighot

functional gastrointestinal disordersdigestive diseasesgut barrierinflammationautophagycell autophagygastroenterologymolecular gastroenterologyoxidative stressmolecular biologysecondary metabolismsystems biologycell signalingautophagy amelioratescell biologyautoimmunity

Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways. Inflammatory Bowel Diseases (2024)

Priya ArumugamKushal SahaPrashant Nighot

pathologynovel pathwaysgut barrierinflammatory bowel diseasegastroenterology

Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury. Digestive Diseases and Sciences (2024)

Jackson B RadlerAmanda R McBrideKushal SahaPrashant NighotGregory M Holmes

treatment and preventioncellular physiologyspinal cord medicinedigestive system surgeryregenerative medicineclinical gastroenterologyhepatologydigestive diseasesapplied physiologydigestive tractregional heterogeneityvascular biologyneurologyspinal cord injurygastroenterologytissue injurynephrologyhealth sciencesmesenteric perfusionphysiology

282 Alpha-Tocopherylquinone Activate Ahr/Nrf2 Pathway and Enhances Intestinal Epithelial Tight Junction Barrier via Differential Modulation of Claudins. Gastroenterology (2023)

Ashwinkumar Subramenium GanapathyKushal SahaAlexandra WangViszwapriya DharmaprakashGregory S. YochumWalter KoltunMeghali T. NighotThomas Y. MaPrashant K. Nighot

medicinemolecular gastroenterologyhematologyclinical gastroenterologyhepatologymembrane biologydigestive diseasesgastrointestinal pharmacologydigestive tractpharmacological researchpharmacologygene expressiongastroenterologyredox biologypathway analysissignaling pathwaysdifferential modulationmedicinal researchphysiology

664 Intestinal Epithelia-Specific Deletion of Aryl Hydrocarbon Receptor (Ahr) Reduces Paracellular Tight Junction Permeability and Hinders Immunogenic Tolerance. Gastroenterology (2023)

Anirudh VenkateshKushal SahaAshwinkumar Subramenium GanapathyAlexandra WangNathan M. MorrisMeghali T. NighotThomas Y. MaPrashant K. Nighot

intestinal epithelia-specific deletiongastroenterologyimmunologyaryl hydrocarbon receptor

955 Alpha-Tocopherylquinone (Tq) Reduces Intestinal Inflammation by Inhibiting Nfkb and Stat3 Signaling in an Aryl Hydrocarbon Receptor (Ahr) Dependent Mechanism. Gastroenterology (2023)

Kushal SahaAshwinkumar Subramenium GanapathyAlexandra WangNathan M. MorrisLeonard HarrisGregory S. YochumWalter KoltunMeghali T. NighotThomas Y. MaPrashant K. Nighot

hepatologypharmacologyintestinal inflammationinflammationgastroenterologyaryl hydrocarbon receptordependent mechanismimmunologycell biology

Alpha-Tocopherylquinone Differentially Modulates Claudins to Enhance Intestinal Epithelial Tight Junction Barrier via Ahr and Nrf2 Pathways. Cell Reports (2023)

Ashwinkumar Subramenium GanapathyKushal SahaAlexandra WangPriya ArumugamViszwapriya DharmaprakashGregory YochumWalter KoltunMeghali NighotGary PerdewTodd A. ThompsonThomas MaPrashant Nighot

hepatologypharmacologymembrane biologygene expressionsignal transductionredox biologydigestive tractcellular physiologycell interactionspathway analysiscell signalingcell researchvascular biologymedicinal researchcell biologycell physiologycellular biologyphysiology

Alpha-Tocopherylquinone-Mediated Activation of the Aryl Hydrocarbon Receptor Regulates the Production of Inflammation-Inducing Cytokines and Ameliorates Intestinal Inflammation. Mucosal Immunology (2023)

Kushal SahaAshwinkumar Subramenium GanapathyAlexandra WangPriya ArumugamNathan Michael MorrisLeonard HarrisGregory YochumWalter KoltunGary H. PerdewMeghali NighotThomas MaPrashant Nighot

cytokinespharmacologyintestinal inflammationinflammationmucosal immunologyaryl hydrocarbon receptoralpha-tocopherylquinone-mediated activationimmunologyinflammation-inducing cytokines

352: Ppi Administration Induced Colonic Tight Junction Barrier Dysfunction is Associated With Increase in Ph, Mlck and Enetrococcus Fecalis.. Gastroenterology (2022)

Nathan M. MorrisKushal SahaAshwinkumar Subramenium GanapathyPrashant K. NighotKofi ClarkeThomas Y. MaMeghali T. Nighot

ppi administrationpharmacologydigestive diseasesenetrococcus fecalisgastroenterologyclinical gastroenterologyepidemiology

596: Ap2m1 and Lc3 Lipidation Guides Claudin-2 Into Autolysosome. Gastroenterology (2022)

Ashwinkumar Subramenium GanapathyKushal SahaAlexandra WangMeghali T. NighotThomas Y. MaPrashant Nighot

gene expressionautophagygastroenterologycell metabolismbiochemistryoxidative stressmolecular biologylipidsvascular biologycell biologylipid peroxidation

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MVSc Prashant Nighot

Associate Professor and Vice Chair for Research

Pennsylvania State University

Affiliations

Penn State College of Medicine

Department of Medicine

Division of Gastroenterology and Hepatology

Mvsc Prashant Nighot is currently serving as a Medicine Associate Professor and Vice Chair for Research at Pennsylvania State University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

MVSc Prashant Nighot

Pennsylvania State University

Associate Professor and Vice Chair for Research

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

107 Autophagy Ameliorates Er Stress-Mediated Intestinal Tight Junction Barrier Dysfunction. Gastroenterology (2024)

Priya ArumugamAshwinkumar Subramenium GanapathyKushal SahaPrashant Nighot

Intestinal Epithelial Tight Junction Barrier Regulation by Novel Pathways. Inflammatory Bowel Diseases (2024)

Priya ArumugamKushal SahaPrashant Nighot

pathologynovel pathwaysgut barrierinflammatory bowel diseasegastroenterology

Regional Heterogeneity in Intestinal Epithelial Barrier Permeability and Mesenteric Perfusion After Thoracic Spinal Cord Injury. Digestive Diseases and Sciences (2024)

Jackson B RadlerAmanda R McBrideKushal SahaPrashant NighotGregory M Holmes

282 Alpha-Tocopherylquinone Activate Ahr/Nrf2 Pathway and Enhances Intestinal Epithelial Tight Junction Barrier via Differential Modulation of Claudins. Gastroenterology (2023)

Ashwinkumar Subramenium GanapathyKushal SahaAlexandra WangViszwapriya DharmaprakashGregory S. YochumWalter KoltunMeghali T. NighotThomas Y. MaPrashant K. Nighot

664 Intestinal Epithelia-Specific Deletion of Aryl Hydrocarbon Receptor (Ahr) Reduces Paracellular Tight Junction Permeability and Hinders Immunogenic Tolerance. Gastroenterology (2023)

Anirudh VenkateshKushal SahaAshwinkumar Subramenium GanapathyAlexandra WangNathan M. MorrisMeghali T. NighotThomas Y. MaPrashant K. Nighot

intestinal epithelia-specific deletiongastroenterologyimmunologyaryl hydrocarbon receptor

955 Alpha-Tocopherylquinone (Tq) Reduces Intestinal Inflammation by Inhibiting Nfkb and Stat3 Signaling in an Aryl Hydrocarbon Receptor (Ahr) Dependent Mechanism. Gastroenterology (2023)

Kushal SahaAshwinkumar Subramenium GanapathyAlexandra WangNathan M. MorrisLeonard HarrisGregory S. YochumWalter KoltunMeghali T. NighotThomas Y. MaPrashant K. Nighot

hepatologypharmacologyintestinal inflammationinflammationgastroenterologyaryl hydrocarbon receptordependent mechanismimmunologycell biology

Alpha-Tocopherylquinone Differentially Modulates Claudins to Enhance Intestinal Epithelial Tight Junction Barrier via Ahr and Nrf2 Pathways. Cell Reports (2023)

Ashwinkumar Subramenium GanapathyKushal SahaAlexandra WangPriya ArumugamViszwapriya DharmaprakashGregory YochumWalter KoltunMeghali NighotGary PerdewTodd A. ThompsonThomas MaPrashant Nighot

Kushal SahaAshwinkumar Subramenium GanapathyAlexandra WangPriya ArumugamNathan Michael MorrisLeonard HarrisGregory YochumWalter KoltunGary H. PerdewMeghali NighotThomas MaPrashant Nighot

cytokinespharmacologyintestinal inflammationinflammationmucosal immunologyaryl hydrocarbon receptoralpha-tocopherylquinone-mediated activationimmunologyinflammation-inducing cytokines

352: Ppi Administration Induced Colonic Tight Junction Barrier Dysfunction is Associated With Increase in Ph, Mlck and Enetrococcus Fecalis.. Gastroenterology (2022)

Nathan M. MorrisKushal SahaAshwinkumar Subramenium GanapathyPrashant K. NighotKofi ClarkeThomas Y. MaMeghali T. Nighot

ppi administrationpharmacologydigestive diseasesenetrococcus fecalisgastroenterologyclinical gastroenterologyepidemiology

596: Ap2m1 and Lc3 Lipidation Guides Claudin-2 Into Autolysosome. Gastroenterology (2022)

Ashwinkumar Subramenium GanapathyKushal SahaAlexandra WangMeghali T. NighotThomas Y. MaPrashant Nighot

gene expressionautophagygastroenterologycell metabolismbiochemistryoxidative stressmolecular biologylipidsvascular biologycell biologylipid peroxidation

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Institution

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gastroenterology

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Terrence Barrett

Institution

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gastroenterology

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Institution

Case Western Reserve University

gastroenterology

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Izumi Kaji

Institution

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Institution

University of North Carolina at Chapel Hill

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innate immune system

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Kim Barrett

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physiology

pharmacology

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mucosal immunology

immunology

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digestive endoscopy

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