Faculty

Institution

Unit

Venue

Linda J. Pike

Alumni Endowed Professor

Washington University in St. Louis

Affiliations

School of Medicine

Department of Biochemistry and Molecular Biophysics

Linda J. Pike is currently serving as a Biochemistry And Molecular Biophysics Alumni Endowed Professor at Washington University In St. Louis.

Honors

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Experiences

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Education

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Linda J. Pike

Washington University in St. Louis

Alumni Endowed Professor

You can click a keyword to filter the displayed items

biochemistry molecular biology receptors biological chemistry membrane biology signal transduction cell signaling cell biology receptor (biochemistry) pharmacology protein science medicinal research vascular biology molecular physiology lipids epidermal growth factor endocrinology enzymes molecular and cellular biology receptor tyrosine kinases enzyme inhibition protein phosphorylation lipid science lipid rafts redox biology molecular cell biology cellular physiology mammalian biology cellular biochemistry lipid movement lipid chemistry cancer biology egf receptor cutaneous biology signaling pathways liver physiology clinical lipidology cellular biology cell growth cell regulation insulin signaling peptide science biochemical sciences oncogenes lipid disorders molecular regulation inhibitory activity lipid analysis lipoprotein metabolism proteinlipid interaction adenylate cyclase membrane transport g protein-coupled receptor host specificity integrative biology protein function protein synthesis cellular regulatory mechanism oocytes enzyme specificity pharmaceutical sciences growth factor receptors negative cooperativity growth factor allosteric regulation phosphatidylinositol kinase xenopus oocytes frog erythrocytes lipid peroxidation morphological impact benthic-pelagic coupling cell function keystone symposium high seas arachidonic acid hormone-stimulated phosphatidylinositol turnover developmental biology hormone receptors hormonal receptor physiology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Extracellular Domain Mutations of the Egf Receptor Differentially Modulate High-Affinity and Low-Affinity Responses to Egf Receptor Ligands. Journal of Biological Chemistry (2024)

Jennifer L. Macdonald-ObermannLinda J. Pike

low-affinity responsesreceptor (biochemistry)biochemistryextracellular domain mutationsmolecular biologybiological chemistryegf receptorreceptorsreceptor ligands

Allosteric Regulation of Epidermal Growth Factor (Egf) Receptor Ligand Binding by Tyrosine Kinase Inhibitors. Journal of Biological Chemistry (2018)

Jennifer L. Macdonald-ObermannLinda J. Pike

vascular biologyreceptor tyrosine kinasesepidermal growth factorreceptor ligand bindingtyrosine kinase inhibitorsbiochemistryenzyme inhibitionreceptor (biochemistry)chemical biologyallosteric regulationmolecular biologybiological chemistrysystems biologysignal transductionreceptorsmolecular regulation

Epidermal Growth Factor Receptors Containing a Single Tyrosine in Their C-Terminal Tail Bind Different Effector Molecules and Are Signaling-Competent. Journal of Biological Chemistry (2017)

Kamaldeep GillJennifer L. Macdonald-ObermannLinda J. Pike

single tyrosinevascular biologyendocrinologyreceptor tyrosine kinasest-regulatory cellprotein sciencecell signalingmedicinal researchsignaling pathwaysbiochemistryreceptor (biochemistry)chemical biologycutaneous biologymolecular biologybiological chemistrysystems biologysignal transductionreceptors

Different Epidermal Growth Factor Receptor (Egfr) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins. Journal of Biological Chemistry (2016)

Tom RonanJennifer L. Macdonald-ObermannLorel HuelsmannNicholas J. BessmanKristen M. NaegleLinda J. Pike

growth factoroncogenesegf receptor ligandscancer cellsreceptor tyrosine kinasescell signalingcell biologymolecular cancersignaling pathwaysreceptor (biochemistry)ensemble clusteringcancer growthpharmacologysignal transductionpharmacological researchreceptors

Egfr Oligomerization Organizes Kinase-Active Dimers Into Competent Signalling Platforms. Nature Communications (2016)

Sarah R. NeedhamSelene K. RobertsAnton ArkhipovVenkatesh P. MysoreChristopher J. TynanLaura C. Zanetti-DominguesEric T. KimValeria LosassoDimitrios KorovesisMichael HirschDaniel J. RolfeDavid T. ClarkeMartyn D. WinnAlireza LajevardipourAndrew H. A. ClaytonLinda J. PikeMichela PeraniPeter J. ParkerYibing ShanDavid E. ShawMarisa L. Martin-Fernandez

immunologyneurosciencegeneticsenzymescell signalingenzyme inhibitionmolecular neurosciencemedicinal researchkinase-active dimersegfr oligomerizationhost specificitymolecular substratescompetent signalling platformsprotein sciencefunctional selectivitymembrane biologyin vivo systemscatalyst activationsignal transductionmammalian biologyredox biology

Different Epidermal Growth Factor (Egf) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation. Journal of Biological Chemistry (2014)

Jennifer L. Macdonald-ObermannLinda J. Pike

biophysicsheterodimer formationprotein sciencedistinct kineticsbiochemistryreceptor (biochemistry)partial agonismchemical biologymolecular biologybiological chemistryreceptors

Dynamic Analysis of the Epidermal Growth Factor (Egf) Receptor-Erbb2-Erbb3 Protein Network by Luciferase Fragment Complementation Imaging. Journal of Biological Chemistry (2013)

Jennifer L. Macdonald-ObermannSangeeta AdakRalf LandgrafDavid Piwnica-WormsLinda J. Pike

biophysicstumor biologyepidermal growth factormedicinal researchneurosciencereceptor (biochemistry)membrane biologymolecular biologybiological chemistryreceptorsstructural biologybreast cancer

Negative Co-Operativity in the Egf Receptor. Biochemical Society Transactions (2012)

Linda J. Pike

biochemistrybiochemical sciencesbiochemical interactionegf receptorreceptorsnegative co-operativity

Quantitation of the Effect of Erbb2 on Epidermal Growth Factor Receptor Binding and Dimerization. Journal of Biological Chemistry (2012)

Yu LiJennifer Macdonald-ObermannCorey WestfallDavid Piwnica-WormsLinda J. Pike

vascular biologytumor biologycell biologyintegrative biologybiochemistrybiologymembrane biologymolecular physiologycutaneous biologybiological chemistrysignal transductionmammalian biologyreceptorsstructural biologybone research

Mechanics of Egf Receptor/Erbb2 Kinase Activation Revealed by Luciferase Fragment Complementation Imaging. Proceedings of the National Academy of Sciences (2011)

Jennifer L. Macdonald-ObermannDavid Piwnica-WormsLinda J. Pike

cell biologymolecular imagingbiochemistrymolecular biologyreceptors

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Linda J. Pike

Alumni Endowed Professor

Washington University in St. Louis

Affiliations

School of Medicine

Department of Biochemistry and Molecular Biophysics

Linda J. Pike is currently serving as a Biochemistry And Molecular Biophysics Alumni Endowed Professor at Washington University In St. Louis.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Linda J. Pike

Washington University in St. Louis

Alumni Endowed Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Extracellular Domain Mutations of the Egf Receptor Differentially Modulate High-Affinity and Low-Affinity Responses to Egf Receptor Ligands. Journal of Biological Chemistry (2024)

Jennifer L. Macdonald-ObermannLinda J. Pike

low-affinity responsesreceptor (biochemistry)biochemistryextracellular domain mutationsmolecular biologybiological chemistryegf receptorreceptorsreceptor ligands

Allosteric Regulation of Epidermal Growth Factor (Egf) Receptor Ligand Binding by Tyrosine Kinase Inhibitors. Journal of Biological Chemistry (2018)

Jennifer L. Macdonald-ObermannLinda J. Pike

Epidermal Growth Factor Receptors Containing a Single Tyrosine in Their C-Terminal Tail Bind Different Effector Molecules and Are Signaling-Competent. Journal of Biological Chemistry (2017)

Kamaldeep GillJennifer L. Macdonald-ObermannLinda J. Pike

Different Epidermal Growth Factor Receptor (Egfr) Agonists Produce Unique Signatures for the Recruitment of Downstream Signaling Proteins. Journal of Biological Chemistry (2016)

Tom RonanJennifer L. Macdonald-ObermannLorel HuelsmannNicholas J. BessmanKristen M. NaegleLinda J. Pike

Egfr Oligomerization Organizes Kinase-Active Dimers Into Competent Signalling Platforms. Nature Communications (2016)

Different Epidermal Growth Factor (Egf) Receptor Ligands Show Distinct Kinetics and Biased or Partial Agonism for Homodimer and Heterodimer Formation. Journal of Biological Chemistry (2014)

Jennifer L. Macdonald-ObermannLinda J. Pike

biophysicsheterodimer formationprotein sciencedistinct kineticsbiochemistryreceptor (biochemistry)partial agonismchemical biologymolecular biologybiological chemistryreceptors

Dynamic Analysis of the Epidermal Growth Factor (Egf) Receptor-Erbb2-Erbb3 Protein Network by Luciferase Fragment Complementation Imaging. Journal of Biological Chemistry (2013)

Jennifer L. Macdonald-ObermannSangeeta AdakRalf LandgrafDavid Piwnica-WormsLinda J. Pike

biophysicstumor biologyepidermal growth factormedicinal researchneurosciencereceptor (biochemistry)membrane biologymolecular biologybiological chemistryreceptorsstructural biologybreast cancer

Negative Co-Operativity in the Egf Receptor. Biochemical Society Transactions (2012)

Linda J. Pike

biochemistrybiochemical sciencesbiochemical interactionegf receptorreceptorsnegative co-operativity

Quantitation of the Effect of Erbb2 on Epidermal Growth Factor Receptor Binding and Dimerization. Journal of Biological Chemistry (2012)

Yu LiJennifer Macdonald-ObermannCorey WestfallDavid Piwnica-WormsLinda J. Pike

Mechanics of Egf Receptor/Erbb2 Kinase Activation Revealed by Luciferase Fragment Complementation Imaging. Proceedings of the National Academy of Sciences (2011)

Jennifer L. Macdonald-ObermannDavid Piwnica-WormsLinda J. Pike

cell biologymolecular imagingbiochemistrymolecular biologyreceptors

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pharmacological research

toxicological mechanism

Jin Zhang

Institution

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molecular metabolism

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Ta Yuan Chang

Institution

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autophagy

obesity

Steven GONIAS

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lipid second messengers

John W Regan

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drug metabolism

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David Bernlohr

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metabolic disorder

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apoptosis

signal transduction pathways

Richard Minshall

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endothelial cell biology

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