Faculty

Institution

Unit

Venue

Pierre T. Moenne-Loccoz

Professor of Chemical Physiology and Biochemistry

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Bob And Charlee Moore Institute For Nutrition And Wellness

Center Of The Amyloidosis

Division Of Cardiology

OGI School of Science and Engineering

Department Of Chemistry, Biochemistry And Molecular Biology

Department Of Physiology And Pharmacology

Oregon Health & Science University

Bob And Charlee Moore Institute For Nutrition And Wellness

School Of Medicine

Division Of Cardiology

School Of Medicine

Pierre T. Moenne-Loccoz is a Professor of Chemical Physiology and Biochemistry at Oregon Health & Science University. His research integrates biochemistry, inorganic chemistry, and molecular biology to investigate redox biology and metalloprotein structure. His recent work focuses on heme protein reactivity, including the characterization of an ultrareduced heme state in myoglobin, well-defined heme peroxynitrite model systems, and the conformational dynamics of PhuS governing heme-responsive DNA binding in Pseudomonas aeruginosa. He also studies nonheme iron nitrosyl complexes and HNO release, nitric oxide/oxygen-binding proteins, and regulatory metalloproteins. His publications appear in the Journal of the American Chemical Society, Biochemistry, and the Journal of Biological Chemistry.

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Pierre T. Moenne-Loccoz

Oregon Health & Science University

Professor of Chemical Physiology and Biochemistry

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biochemistry enzymes chemistry transition metal chemistry redox biology molecular biology inorganic chemistry coordination chemistry microbiology biological chemistry redox chemistry biological inorganic chemistry chemical biology biophysical chemistry structural biology protein structure protein science heme degradation heme signaling bacteria reactive nitrogen species structural molecular biology biochemical sciences free radical biology nitrosative stress structural chemistry chemical sciences heme transport biomolecular structure bioenergetics enzyme inhibition organometallic chemistry molecular microbiology nitric oxide coordination complex enzyme catalysis molecular metabolism raman spectroscopy molecular structure inorganic compounds bacteriology inorganic synthesis protein chemistry heme homeostasis structure-function enzyme kinetics metalloproteins pulmonary tuberculosis mycoprotein bioorganometallic chemistry microbial physiology oxygen reduction reaction nitric oxide reductase active site hemophore hasap dioxygen reactivity heme oxygenase heme trafficking surface reactivity molecular complexes yeast biomolecular interactions structural characterization superoxide reductase escherichia coli spectroscopic characterization biochemical interaction cellular enzymology hydrogen bond microbial genetics reactivity (chemistry) non-heme diiron proteins oxygen activation nonheme iron flavodiiron proteins hemin acquisition model complexes

Notable Scholarly Works

Notable Federal Grants

Collaborators

Phus Conformational Dynamics Are Essential for Dna Binding and Heme-Responsive Control of the Prrf Operon in Pseudomonas Aeruginosa. Journal of Biological Chemistry (2026)

dna bindingbiophysicsmolecular biophysicsprotein sciencebacteriologybacteriaprotein structureapplied microbiologymolecular microbiologybiomolecular structurephus conformational dynamicsprrf operonmolecular biologystructural molecular biologystructural biologybiofilmsmicrobiologynucleic acids

A Single Outer-Sphere Amino-Acid Substitution Turns on the No Reactivity of a Hemerythrin-Like Protein. Chemical Science (2025)

biophysical chemistrybiological macromoleculesprotein chemistrystructure-function enzyme kineticschemical biologyenzymeshemerythrin-like proteinmolecular biologybiological chemistryno reactivityprotein sciencebiochemistry

Electronic Modification of a Reduced Mononuclear Nonheme Iron Nitrosyl Complex Leads to Hno Release. Journal of the American Chemical Society (2025)

oxygen reduction reactionhno releasechemical engineeringphysical chemistrycatalysiscoordination chemistryredox chemistryelectronic modificationchemistryinorganic chemistryreactive nitrogen speciestransition metal chemistry

From Transient to Metastable: Generation, Characterization, and Biomimetic Reactivity Studies of Well-Defined Heme Peroxynitrite Model Systems. Journal of the American Chemical Society (2025)

biophysical chemistrychemical kineticschemical physicschemical engineeringphysical chemistrybiomimetic reactivity studiesredox biologyheme degradationredox chemistrychemical biologychemical scienceschemistrychemical reaction engineeringdeoxygenationbioenergetics

Methionine Coordination to the Heme Iron and Its Displacement by Nitric Oxide in the Ccop Subunit of Pseudomonas Aeruginosa Cytochrome Cbb3 Oxidase. Journal of Inorganic Biochemistry (2025)

heme signalingmethionine coordinationbacteriaprotein structureapplied microbiologyredox biologynitric oxideenzymesmolecular metabolismbiological inorganic chemistrymolecular biologybiological chemistryheme ironstructural biologybioenergeticsmicrobiologybiochemistry

Oxidative Activation of the Heme Nitric Oxide/Oxygen-Binding Protein (H-Nox) From Caulobacter Crescentus. Biochemistry (2025)

nitrosative stressapplied microbiologyheme degradationbiological chemistrymicroorganismsmicrobial cell factoryoxidative activationbioenergeticsbiochemistrychemical biologyenzymesbacteriamicrobial pathogenesisreactive nitrogen speciesheme signalingfree radical biologyredox biologymolecular biologyoxidative stressmicrobiology

The Activation of the Metal-Containing Regulatory Protein Niar From Thermotoga Maritima by Its Effector, Nicotinic Acid. JBIC Journal of Biological Inorganic Chemistry (2025)

metalloproteinsprotein structurebiotechnologyenzymesbiological inorganic chemistrybiological chemistrybiochemistry

Unveiling an Ultrareduced State of Heme in Myoglobin. Journal of the American Chemical Society (2025)

Yunling DengTherese AlbertCasey Van StappenPhilip M. PalaciosMaria L. AmadorSudharsan DwaraknathYisong GuoPierre Moënne-LoccozYi Lu

biophysical chemistryheme signalingheme homeostasisheme proteinsporphyrin macrocycleredox biologyheme degradationultrareduced stateenzymesmolecular biologybiological chemistrytransition metal chemistryprotein sciencebiochemistry

A Nonheme Iron(III) Superoxide Complex Leads to Sulfur Oxygenation. Journal of the American Chemical Society (2024)

Sudha YadavVishal YadavMaxime A. SieglerPierre Moënne-LoccozGuy N. L. JamesonDavid P. Goldberg

nonheme ironcoordination chemistryredox chemistrychemistryinorganic chemistrytransition metal chemistry

Biocompatible Cobalt Oxide Nanoparticles for X-Ray Fluorescence Microscopy. Research Square (2024)

Christian ScottSophia MillerPierre Moenne-LoccozCraig BarnesMartina Ralle

nanobiotechnologymaterials sciencebiomedical imagingradiologynanomedicinebiomedical engineeringpharmaceutical nanotechnologynanoparticle researchphotomedicinex-ray fluorescence microscopymicroscopyx-ray fluorescencenanomaterialsdrug deliverynanotechnology