Faculty

Institution

Unit

Venue

Peter Brzovic

Associate Professor of Biochemistry

University of Washington

Affiliations

School of Medicine

Biochemistry

Peter Brzovic is currently serving as a Biochemistry Associate Professor of Biochemistry at University of Washington.

Honors

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Experiences

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Education

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Peter Brzovic

University of Washington

Associate Professor of Biochemistry

You can click a keyword to filter the displayed items

molecular biology biochemistry structural biology enzymes protein science protein structure genetics biological chemistry biophysics structural molecular biology membrane biology biomolecular structure protein function microbial pathogenesis gene expression molecular cell biology pathogenic bacteria epigenetics enzyme inhibition molecular regulation protein chemistry molecular structure biochemical sciences enzyme catalysis rna biology clinical microbiology transcription regulation cancer biology conformational studies liver physiology gene function cancer genetics gene regulation cell regulation biocatalysis enzyme specificity surface reactivity cancer genomics allosteric interactions catalytic activity allosteric regulation salmonella typhimurium half-site reactivity chromatin recruitment cell research proteome research molecular physiology oncogenes antimicrobial agents toxins protein bioinformatics molecular complexes sequence assembly multi-protein assembly protein assembly protein expression protein genetics mutagenesis brain mapping virulence factors cell cycle epigenetic changes structural genomics hla typing biophysical aspect biochemical genetics ring/hect hybrids allosteric mechanism fuzzy complex high-throughput mutagenesis activity-enhancing mutations functional domains structural studies single legionella effector ubiquitin transfer bifunctional role

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 6096: Brca1-Bard1 Ubiquitylates Histones for Genome Maintenance. Cancer Research (2023)

Wenjing LiSamuel R. WitusMeiling WangPeter S. BrzovicRachel E. KlevitWeixing Zhao

cancer genomicsgenome maintenancegeneticsoncologycancer researchcancer biologycytogeneticsgenomicsmolecular biology

Bacterial Ligases Reveal Fundamental Principles of Polyubiquitin Specificity. Molecular Cell (2023)

Tyler G. FranklinPeter S. BrzovicJonathan N. Pruneda

molecular cell biologybacterial ligasesfundamental principlesbiochemistrypharmacologypolyubiquitin specificitymolecular biologymolecular medicine

Bacterial Mimicry of Eukaryotic Hect Ubiquitin Ligation. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Tyler G. FranklinPeter S. BrzovicJonathan N. Pruneda

microbiologybacterial mimicrybacteria

Crucial Roles of the Brca1-Bard1 E3 Ubiquitin Ligase Activity in Homology-Directed Dna Repair. Molecular Cell (2023)

Meiling WangWenjing LiNozomi TomimatsuCorey H. YuJae-Hoon JiSalvador AlejoSamuel R. WitusDauren AlimbetovO’Taveon FitzgeraldBo WuQijing WangYuxin HuangYaqi GanFelix DongYoungho KwonGangadhara R. SareddyTyler J. CurielAmyn A. HabibRobert HromasCarolina dos Santos PassosTingting YaoDmitri N. IvanovPeter S. BrzovicSandeep BurmaRachel E. KlevitWeixing Zhao

homology-directed dna repairgeneticsbiochemistrycrucial rolesdna repairmolecular biology

Brca1 / Bard1 Intrinsically Disordered Regions Facilitate Chromatin Recruitment and Ubiquitylation. The EMBO Journal (2023)

Samuel R WitusLisa M TuttleWenjing LiAlex ZelterMeiling WangKlaiten E KermoadeDamien B WilburnTrisha N DavisPeter S BrzovicWeixing ZhaoRachel E Klevit

geneticschromosome biologyneurosciencechromatin recruitmentrna biologydna repairmolecular biology

Antibacterial Potency of Type VI Amidase Effector Toxins is Dependent on Substrate Topology and Cellular Context. eLife (2022)

Atanas RadkovAnne L SapiroSebastian FloresCorey HendersonHayden SaundersRachel KimSteven MassaSamuel ThompsonChase MateusiakJacob BiboyZiyi ZhaoLea M StaritaWilliam L HatlebergWaldemar VollmerAlistair B RussellJean-Pierre SimorreSpencer Anthony-CahillPeter BrzovicBeth HayesSeemay Chou

virologysubstrate topologyantibacterial potencyclinical microbiologycellular contextpharmacology

Author Reply to Peer Reviews of Antibacterial Potency of Type VI Amidase Effector Toxins is Dependent on Substrate Topology and Cellular Context. (2022)

Seemay ChouBeth HayesPeter BrzovicSpencer Anthony-CahillJean-Pierre SimorreAlistair B. RussellWaldemar VollmerWilliam HatlebergLea M. StaritaZiyi ZhaoJacob BiboyChase MateusiakSamuel ThompsonSteven MassaRachel KimHayden SaundersCorey HendersonSebastian FloresAnne L SapiroAtanas Radkov

microbiologyvirologysubstrate topologyantibacterial potencyclinical microbiologyimmunologypharmacologycellular context

Brca1/Bard1 Intrinsically Disordered Regions Facilitate Chromatin Recruitment and Ubiquitylation. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Samuel R. WitusLisa M. TuttleWenjing LiAlex ZelterMeiling WangKlaiten E. KermoadeDamien B. WilburnTrisha N. DavisPeter S. BrzovicWeixing ZhaoRachel E. Klevit

biophysicsepigeneticscytogeneticschromatin recruitmentbiologyrna biologymolecular biology

Brca1/Bard1 is a Nucleosome Reader and Writer. Trends in Biochemical Sciences (2022)

Samuel R. WitusWeixing ZhaoPeter S. BrzovicRachel E. Klevit

biochemical sciencesgenomicsbiologybiochemistryrna biologydna repairmolecular biologygenome biology

Cullin-Independent Recognition of Hhari Substrates by a Dynamic Rbr Catalytic Domain. Structure (2022)

Katherine H. ReiterAlex ZelterMaria K. JanowskaMichael RiffleNicholas ShulmanBrendan X. MacLeanKaipo TamuraMatthew C. ChambersMichael J. MacCossTrisha N. DavisMiklos GuttmanPeter S. BrzovicRachel E. Klevit

biophysicscullin-independent recognitionmolecular recognitionenzymessurface reactivitymolecular structureprotein scienceneuroscienceprotein structuremolecular biophysicsbiomolecular structurestructural molecular biologyhhari substratesmolecular substratesmolecular biologystructural biologystructural chemistry

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Peter Brzovic

Associate Professor of Biochemistry

University of Washington

Affiliations

School of Medicine

Biochemistry

Peter Brzovic is currently serving as a Biochemistry Associate Professor of Biochemistry at University of Washington.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Peter Brzovic

University of Washington

Associate Professor of Biochemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 6096: Brca1-Bard1 Ubiquitylates Histones for Genome Maintenance. Cancer Research (2023)

Wenjing LiSamuel R. WitusMeiling WangPeter S. BrzovicRachel E. KlevitWeixing Zhao

cancer genomicsgenome maintenancegeneticsoncologycancer researchcancer biologycytogeneticsgenomicsmolecular biology

Bacterial Ligases Reveal Fundamental Principles of Polyubiquitin Specificity. Molecular Cell (2023)

Tyler G. FranklinPeter S. BrzovicJonathan N. Pruneda

molecular cell biologybacterial ligasesfundamental principlesbiochemistrypharmacologypolyubiquitin specificitymolecular biologymolecular medicine

Bacterial Mimicry of Eukaryotic Hect Ubiquitin Ligation. bioRxiv (Cold Spring Harbor Laboratory) (2023)

Tyler G. FranklinPeter S. BrzovicJonathan N. Pruneda

microbiologybacterial mimicrybacteria

Crucial Roles of the Brca1-Bard1 E3 Ubiquitin Ligase Activity in Homology-Directed Dna Repair. Molecular Cell (2023)

homology-directed dna repairgeneticsbiochemistrycrucial rolesdna repairmolecular biology

Brca1 / Bard1 Intrinsically Disordered Regions Facilitate Chromatin Recruitment and Ubiquitylation. The EMBO Journal (2023)

Samuel R WitusLisa M TuttleWenjing LiAlex ZelterMeiling WangKlaiten E KermoadeDamien B WilburnTrisha N DavisPeter S BrzovicWeixing ZhaoRachel E Klevit

geneticschromosome biologyneurosciencechromatin recruitmentrna biologydna repairmolecular biology

Antibacterial Potency of Type VI Amidase Effector Toxins is Dependent on Substrate Topology and Cellular Context. eLife (2022)

virologysubstrate topologyantibacterial potencyclinical microbiologycellular contextpharmacology

Author Reply to Peer Reviews of Antibacterial Potency of Type VI Amidase Effector Toxins is Dependent on Substrate Topology and Cellular Context. (2022)

microbiologyvirologysubstrate topologyantibacterial potencyclinical microbiologyimmunologypharmacologycellular context

Brca1/Bard1 Intrinsically Disordered Regions Facilitate Chromatin Recruitment and Ubiquitylation. bioRxiv (Cold Spring Harbor Laboratory) (2022)

Samuel R. WitusLisa M. TuttleWenjing LiAlex ZelterMeiling WangKlaiten E. KermoadeDamien B. WilburnTrisha N. DavisPeter S. BrzovicWeixing ZhaoRachel E. Klevit

biophysicsepigeneticscytogeneticschromatin recruitmentbiologyrna biologymolecular biology

Brca1/Bard1 is a Nucleosome Reader and Writer. Trends in Biochemical Sciences (2022)

Samuel R. WitusWeixing ZhaoPeter S. BrzovicRachel E. Klevit

biochemical sciencesgenomicsbiologybiochemistryrna biologydna repairmolecular biologygenome biology

Cullin-Independent Recognition of Hhari Substrates by a Dynamic Rbr Catalytic Domain. Structure (2022)

1
2
3
4
5
6
7
10 / page

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protein chaperones

protein structure

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new biotechnology adventures

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clinical infectious disease

infectious disease research

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