Faculty

Institution

Unit

Venue

Pamela Mellon

Professor of Neurosciences

University of California, San Diego

Affiliations

School Of Medicine

Neurosciences

Pamela Mellon is currently serving as a Neurosciences Professor of Neurosciences at University of California, San Diego.

Honors

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Experiences

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Education

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Pamela Mellon

University of California, San Diego

Professor of Neurosciences

You can click a keyword to filter the displayed items

endocrinology molecular biology gene expression reproductive biology genetics cell biology developmental biology reproductive endocrinology mammalian biology psychoneuroendocrinology molecular and cellular biology hormonal receptor cell signaling molecular physiology endocrine mechanisms neuroendocrine mechanisms signal transduction transcription factors transcription regulation transcription (biology) developmental endocrinology gene regulation reproductive science gene function pituitary gland reproductive physiology behavioral neuroendocrinology endocrine research molecular cell biology molecular regulation protein science gonadotropin-releasing hormone reproductive medicine animal physiology reproductive immunology reproductive hormones vascular biology signaling pathways cell regulation transgenic mice molecular neurodegeneration comparative endocrinology genome biology biological chemistry cellular physiology cellular neurobiology mammalian physiology gene characterization female mice neuroscience of aging neural science protein expression chronobiology homeostatic mechanisms gonadotropin-releasing hormone gene kisspeptin neurons glucocorticoids inhibitory activity developmental genetics female reproductive system clinical neuroscience pituitary disease key site pituitary gonadotropes immortalized hypothalamic neurons male mice female fertility endocrine-related cancers tissue development targeted oncogenesis hypercholesterolaemic mice discrete stages metabolic phenotypes activin regulation synergistic induction gnrh gene growth factor regulation stem cell research systems biology diabetes research

Notable Scholarly Works

Notable Federal Grants

Collaborators

7251 Heterozygous Sox2 Knockout Mice Have Delayed Puberty, Fertility Deficiencies, and a Decreased Number of Gnrh Neurons. Journal of the Endocrine Society (2024)

Jessica CassinRyan D NguyenKaren J TonsfeldtGeneva A DunnVivian ChenSeung E YeoPamela L Mellon

endocrinologyknockout micefertility deficienciesdevelopmental biologygnrh neurons

Fri285 Evidence for Zic1 as a Novel Gene for Isolated Hypogonadotropic Hypogonadism With Phenotypic Pleiotropic Intersection With Cerebellar Malformation. Journal of the Endocrine Society (2023)

Jessica CassinDavid L KeefeKaitlin E SungCeline C BojoGisselle SantiagoLacey PlummerKathryn B SalnikovStephanie B SeminaraRavikumar BalasubramaniaPamela L Mellon

gene expressionphenotypic pleiotropic intersectioncerebellar malformationendocrinologygeneticsisolated hypogonadotropic hypogonadismnovel genemolecular evidence

Heterozygous Mutations in Sox2 May Cause Idiopathic Hypogonadotropic Hypogonadism via Dominant-Negative Mechanisms. JCI Insight (2023)

Jessica CassinMaria I. StamouKimberly W. KeefeKaitlin E. SungCeline C. BojoKaren J. TonsfeldtRebecca A. RojasVanessa Ferreira LopesLacey PlummerKathryn B. SalnikovDavid L. KeefeMetin OzataMyron GenelNeoklis A. GeorgopoulosJanet E. HallWilliam F. CrowleyStephanie B. SeminaraPamela L. MellonRavikumar Balasubramanian

idiopathic hypogonadotropic hypogonadismdevelopmental biologygeneticsdominant-negative mechanismsmolecular biologyheterozygous mutationsepigeneticshuman genetics

The Transcription Factor Vax1 in Vip Neurons of the Suprachiasmatic Nucleus Impacts Circadian Rhythm Generation, Depressive-Like Behavior, and the Reproductive Axis in a Sex-Specific Manner in Mice. Frontiers in Endocrinology (2023)

Brooke M. Van LohAlexandra M. YawJoseph A. BreuerBrooke JacksonDuong NguyenKrystal JangFabiola RamosEmily V. HoLaura J. CuiDominique L. M. GilletteLorenzo F. SempereMichael R. GormanKaren J. TonsfeldtPamela L. MellonHanne M. Hoffmann

mammalian physiologybehavioral neuroscienceendocrinologytranscription factorsbehavioral neuroendocrinologypsychoneuroendocrinologycomparative endocrinologychronobiologyreproductive axisanimal physiologydepressive-like behaviormolecular neurosciencemammalian biologysystems neuroscienceaffective neurosciencevip neuronsmolecular physiologycellular neurobiologyphysiologygeneticssex-specific mannerneuroscience

Deletion of the Homeodomain Gene Six3 From Kisspeptin Neurons Causes Subfertility in Female Mice. Molecular and Cellular Endocrinology (2022)

Shanna N. LavalleTeresa ChouJacqueline HernandezNay Chi P. NaingMichelle Y. HeKaren J. TonsfeldtPamela L. Mellon

gametogenesisknockout micekisspeptin neuronsneuroendocrine mechanismsreproductive immunologyendocrinologyreproductive biologydevelopmental neurobiologypsychoneuroendocrinologyneurogeneticsmolecular and cellular biologymammalian biologyreproductive physiologymolecular neurodegenerationgeneticsfertilisationmolecular biologyinfertilityneurosciencefemale mice

Female Fertility Does Not Require Bmal1 in Suprachiasmatic Nucleus Neurons Expressing Arginine Vasopressin, Vasoactive Intestinal Peptide, or Neuromedin-S. Frontiers in Endocrinology (2022)

Karen J. TonsfeldtLaura J. CuiJinkwon LeeThijs J. WalbeekLiza E. BrusmanYe JinMichihiro MiedaMichael R. GormanPamela L. Mellon

arginine vasopressinendocrinologyvasoactive intestinal peptidefemale fertilityreproductive biologysuprachiasmatic nucleus neuronsneuroscienceneuroendocrine mechanisms

Androgen Receptor Positively Regulates Gonadotropin-Releasing Hormone Receptor in Pituitary Gonadotropes. Molecular and Cellular Endocrinology (2021)

Genevieve E. RyanStephanie C. BohaczukJessica CassinEmily A. WithamShadi ShojaeiEmily V. HoVarykina G. ThackrayPamela L. Mellon

gonadotropin-releasing hormone receptorendocrinologypituitary gonadotropesandrogen receptormolecular biology

Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge. Endocrinology (2021)

Karen J TonsfeldtPamela L MellonHanne M Hoffmann

physiologychronobiologyendocrinologyneuroscience

Deletion of Six3 in Post-Proliferative Neurons Produces Weakened Scn Circadian Output, Improved Metabolic Function, and Dwarfism in Male Mice. Molecular Metabolism (2021)

Jason D. MeadowsJoseph A. BreuerShanna N. LavalleMichael R. HirschenbergerMeera M. PatelDuong NguyenAlyssa KimJessica CassinMichael R. GormanDavid K. WelshPamela L. MellonHanne M. Hoffmann

cell deathcryptochromesmammalian physiologymetabolic functionmetabolismneural sciencechronobiologyanimal physiologymolecular neurosciencemammalian biologymale micemolecular metabolismsystems neurosciencemolecular physiologyneuronsphysiologyscn circadian outputmitochondrial functiongeneticsneuroscienceneurophysiology

Distal Enhancer Potentiates Activin- and Gnrh-Induced Transcription of Fshb. Endocrinology (2021)

Stephanie C BohaczukJessica CassinTheresa I SlaiwaVarykina G ThackrayPamela L Mellon

distal enhancerendocrinologymolecular biologygnrh-induced transcription

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Pamela Mellon

Professor of Neurosciences

University of California, San Diego

Affiliations

School Of Medicine

Neurosciences

Pamela Mellon is currently serving as a Neurosciences Professor of Neurosciences at University of California, San Diego.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Pamela Mellon

University of California, San Diego

Professor of Neurosciences

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

7251 Heterozygous Sox2 Knockout Mice Have Delayed Puberty, Fertility Deficiencies, and a Decreased Number of Gnrh Neurons. Journal of the Endocrine Society (2024)

Jessica CassinRyan D NguyenKaren J TonsfeldtGeneva A DunnVivian ChenSeung E YeoPamela L Mellon

endocrinologyknockout micefertility deficienciesdevelopmental biologygnrh neurons

Fri285 Evidence for Zic1 as a Novel Gene for Isolated Hypogonadotropic Hypogonadism With Phenotypic Pleiotropic Intersection With Cerebellar Malformation. Journal of the Endocrine Society (2023)

Jessica CassinDavid L KeefeKaitlin E SungCeline C BojoGisselle SantiagoLacey PlummerKathryn B SalnikovStephanie B SeminaraRavikumar BalasubramaniaPamela L Mellon

gene expressionphenotypic pleiotropic intersectioncerebellar malformationendocrinologygeneticsisolated hypogonadotropic hypogonadismnovel genemolecular evidence

Heterozygous Mutations in Sox2 May Cause Idiopathic Hypogonadotropic Hypogonadism via Dominant-Negative Mechanisms. JCI Insight (2023)

idiopathic hypogonadotropic hypogonadismdevelopmental biologygeneticsdominant-negative mechanismsmolecular biologyheterozygous mutationsepigeneticshuman genetics

Deletion of the Homeodomain Gene Six3 From Kisspeptin Neurons Causes Subfertility in Female Mice. Molecular and Cellular Endocrinology (2022)

Shanna N. LavalleTeresa ChouJacqueline HernandezNay Chi P. NaingMichelle Y. HeKaren J. TonsfeldtPamela L. Mellon

Female Fertility Does Not Require Bmal1 in Suprachiasmatic Nucleus Neurons Expressing Arginine Vasopressin, Vasoactive Intestinal Peptide, or Neuromedin-S. Frontiers in Endocrinology (2022)

Karen J. TonsfeldtLaura J. CuiJinkwon LeeThijs J. WalbeekLiza E. BrusmanYe JinMichihiro MiedaMichael R. GormanPamela L. Mellon

arginine vasopressinendocrinologyvasoactive intestinal peptidefemale fertilityreproductive biologysuprachiasmatic nucleus neuronsneuroscienceneuroendocrine mechanisms

Androgen Receptor Positively Regulates Gonadotropin-Releasing Hormone Receptor in Pituitary Gonadotropes. Molecular and Cellular Endocrinology (2021)

Genevieve E. RyanStephanie C. BohaczukJessica CassinEmily A. WithamShadi ShojaeiEmily V. HoVarykina G. ThackrayPamela L. Mellon

gonadotropin-releasing hormone receptorendocrinologypituitary gonadotropesandrogen receptormolecular biology

Circadian Rhythms in the Neuronal Network Timing the Luteinizing Hormone Surge. Endocrinology (2021)

Karen J TonsfeldtPamela L MellonHanne M Hoffmann

physiologychronobiologyendocrinologyneuroscience

Deletion of Six3 in Post-Proliferative Neurons Produces Weakened Scn Circadian Output, Improved Metabolic Function, and Dwarfism in Male Mice. Molecular Metabolism (2021)

Jason D. MeadowsJoseph A. BreuerShanna N. LavalleMichael R. HirschenbergerMeera M. PatelDuong NguyenAlyssa KimJessica CassinMichael R. GormanDavid K. WelshPamela L. MellonHanne M. Hoffmann

Distal Enhancer Potentiates Activin- and Gnrh-Induced Transcription of Fshb. Endocrinology (2021)

Stephanie C BohaczukJessica CassinTheresa I SlaiwaVarykina G ThackrayPamela L Mellon

distal enhancerendocrinologymolecular biologygnrh-induced transcription

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imaging genomics

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endocrinology

prostate hormonal carcinogenesis