Faculty

Institution

Unit

Venue

Nicholas Burgis

Eastern Washington University

Affiliations

Chemistry and Biochemistry

College of Arts, Humanities & Social Sciences

Studies Of American Indian

Physics

NoneNicholas Burgis is currently serving as a Chemistry And Biochemistry faculty at Eastern Washington University.

Honors

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Experiences

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Education

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Nicholas Burgis

Eastern Washington University

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biochemistry molecular biology enzymes genetics protein science mutagenesis (molecular biology technique) protein structure structural biology human genetics biochemical sciences enzyme inhibition biological chemistry structural molecular biology allergy biomarkers autoimmune diseases clinical research clinical biochemistry molecular diagnostics molecular physiology experimental medicine molecular cell biology nucleic acids biomolecular structure molecular metabolism cancer cells cell metabolism allelic variant disease susceptibility disease mechanisms disease gene identification nucleic acid amplification molecular substrates disease physiology mutagenesis protein genetics protein modeling structure-function enzyme kinetics structural dynamics protein function biochemical genetics hematological malignancies metabolic remodeling disease spectrum itpa variation vivo characterization site-directed mutagenesis molecular dynamics simulations inosine triphosphate pyrophosphatase itpa function itpa enzyme multiple myeloma cells aberrant protein metabolism human itpase

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Itpa Enzyme With Improved Substrate Selectivity. The Protein Journal (2023)

Nicholas E. BurgisKandise VanWormerDevin RobbinsJonathan Smith

biochemistryenzymesitpa enzyme

Arginine-178 is an Essential Residue for Itpa Function. Archives of Biochemistry and Biophysics (2023)

itpa functionbiochemical sciencesenzymeschemical biologyprotein sciencestructural molecular biologyprotein structurebiological chemistrybiochemistrymolecular biologyprotein functionbiochemical geneticsstructural biology

Structural Dynamics of Inosine Triphosphate Pyrophosphatase (Itpa) Protein and Two Clinically Relevant Mutants: Molecular Dynamics Simulations. Journal of Biomolecular Structure and Dynamics (2020)

biophysicsenzymesstructural dynamicsprotein sciencemolecular dynamics simulationsstructural molecular biologyprotein structurebiomolecular structurebiochemistryinosine triphosphate pyrophosphatasestructure-function enzyme kineticsprotein modelingmolecular biologystructural biology

A Disease Spectrum for Itpa Variation: Advances in Biochemical and Clinical Research. Journal of Biomedical Science (2016)

molecular diagnosticsclinical researchautoimmune diseasesitpa variationdisease susceptibilitygenetic epidemiologydisease spectrumpathologyhuman geneticsallelic variantclinical biochemistrybiomarkersallergy

Analysis of Human Itpase Nucleobase Specificity by Site-Directed Mutagenesis. Biochimie (2013)

mutagenesis (molecular biology technique)dna replicationgeneticsenzymessite-directed mutagenesisnucleic acidsmolecular cell biologybiological chemistryprotein geneticsmutagenesismolecular biologyenzyme inhibition

Evidence That Aberrant Protein Metabolism Contributes to Chemoresistance in Multiple Myeloma Cells. Oncology Reports (2012)

tumor biologymolecular metabolismcancer researchhematological malignanciesaberrant protein metabolismcell biologycancer cellsmetabolic remodelingbiochemistrymultiple myeloma cellscell metabolism

The P32T Variant of Human Itpase is Functional in Vitro and in Vivo. International Journal of Molecular Medicine (2010)

Nicholas E BurgisG HertingK BarberM R ZappalaR P Cunningham

geneticshuman geneticshuman itpaseneurosciencemolecular biologymolecular medicine

Quantitative in Vitro and in Vivo Characterization of the Human P32T Mutant Itpase. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2009)

Greg HertingKatie BarberMaria R. ZappalaRichard P. CunninghamNicholas E. Burgis

protein sciencedisease mechanismsexperimental medicinemolecular substratesgene expressionmolecular physiologymutagenesis (molecular biology technique)nucleic acid amplificationenzymesmolecular biologymembrane biologybiochemical sciencesgeneticsdisease gene identificationbiochemistrydisease physiologyvivo characterizationprotein engineeringenzyme inhibition

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Nicholas Burgis

Eastern Washington University

Affiliations

Chemistry and Biochemistry

College of Arts, Humanities & Social Sciences

Studies Of American Indian

Physics

NoneNicholas Burgis is currently serving as a Chemistry And Biochemistry faculty at Eastern Washington University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Nicholas Burgis

Eastern Washington University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

An Itpa Enzyme With Improved Substrate Selectivity. The Protein Journal (2023)

Nicholas E. BurgisKandise VanWormerDevin RobbinsJonathan Smith

biochemistryenzymesitpa enzyme

Arginine-178 is an Essential Residue for Itpa Function. Archives of Biochemistry and Biophysics (2023)

Structural Dynamics of Inosine Triphosphate Pyrophosphatase (Itpa) Protein and Two Clinically Relevant Mutants: Molecular Dynamics Simulations. Journal of Biomolecular Structure and Dynamics (2020)

A Disease Spectrum for Itpa Variation: Advances in Biochemical and Clinical Research. Journal of Biomedical Science (2016)

Analysis of Human Itpase Nucleobase Specificity by Site-Directed Mutagenesis. Biochimie (2013)

Evidence That Aberrant Protein Metabolism Contributes to Chemoresistance in Multiple Myeloma Cells. Oncology Reports (2012)

tumor biologymolecular metabolismcancer researchhematological malignanciesaberrant protein metabolismcell biologycancer cellsmetabolic remodelingbiochemistrymultiple myeloma cellscell metabolism

The P32T Variant of Human Itpase is Functional in Vitro and in Vivo. International Journal of Molecular Medicine (2010)

Nicholas E BurgisG HertingK BarberM R ZappalaR P Cunningham

geneticshuman geneticshuman itpaseneurosciencemolecular biologymolecular medicine

Quantitative in Vitro and in Vivo Characterization of the Human P32T Mutant Itpase. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (2009)

Greg HertingKatie BarberMaria R. ZappalaRichard P. CunninghamNicholas E. Burgis

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