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Mustafa Yalcinkaya

Associate Research Scientist in the Department of Medicine

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

MED Molecular Medicine

P&S

P&S Clinical

Mustafa Yalcinkaya is an Associate Research Scientist in the Department of Medicine at Columbia University. His research focuses on the molecular mechanisms of atherosclerosis, particularly the post-translational regulation of the NLRP3 inflammasome in clonal hematopoiesis, cholesterol crystal-induced inflammatory signaling, and macrophage efferocytosis. His recent work has delineated how COPI coatomer regulates HDL metabolism and how inflammatory crosstalk impairs phagocytic receptors during atherogenesis. He has published in the *Journal of Clinical Investigation* and the *Journal of Lipid Research*, and received a 2024 award for investigating NLRP3 deubiquitylation in *Tet2*-deficient models.

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Mustafa Yalcinkaya

Columbia University

Associate Research Scientist in the Department of Medicine

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atherosclerosis immunology vascular biology pharmacology cell biology inflammation lipids cardiology hematology molecular medicine cell signaling haematopoiesis clinical lipidology medicinal research biochemistry cardiovascular research thrombosis cell death molecular physiology angiology metabolic syndrome liver physiology cellular physiology cellular biochemistry hemostasis clinical investigation diabetic medicine diabetes research clinical biochemistry free radical biology chronic inflammation cell regulation molecular immunology vascular disease lipoprotein metabolism phagocytes diabetes therapy transendothelial transport inflammasome activation heme homeostasis adaptive immune system cellular immune responses blood flow cerebrovascular disease venous thrombosis protein transport angiogenesis lipid disorders hyperlipidemia lipid peroxidation immunosuppression inflammatory diseases autoinflammatory disease medical genetics genetic disorders genetic factors epigenetic changes cell autophagy cytokines clonal haematopoiesis macrophage ferroptosis atherosclerotic plaques cholesterol accumulation myeloid lxr foamy macrophages cross talk arterial thrombosis platelet activation high-density lipoprotein clonal hematopoiesis epigenetic regulation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Transient Efferocytosis-Induced Activation of Ikkβ Reprograms Macrophages to Promote Tissue Resolution. bioRxiv (Cold Spring Harbor Laboratory) (2026)

cytokinesimmune responsesinflammationautophagycell autophagyphagocytescellular physiologycell signalingimmunologycell biologycell death

Cholesterol Crystals as Triggers of Nlrp3 Inflammasome Activation in Atherosclerosis. Current Atherosclerosis Reports (2025)

inflammationcardiovascular researchautoinflammatory diseaselipidsatherosclerosisimmunologyvascular biologycell biologycardiovascular disease

The Copi Coatomer Regulates Several Steps of Hdl Metabolism. medRxiv (2025)

molecular medicinecell metabolismmolecular metabolismmolecular biologycell biologymolecular and cellular biologymetabolic pathways

Abstract 108: Inflammasome Activation via Brcc3-Mediated Nlrp3 Deubiquitylation Promotes Atherosclerosis in Tet2 Clonal Hematopoiesis. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Mustafa YalcinkayaWenli LiuTONG XIAOSandra AbramowiczNan WangMarit WesterterpAlan Tall

hepatologypharmacologyangiologyhealth scienceshaematopoiesiscardiologythrombosisatherosclerosisinflammasome activationimmunologyvascular biologyhematology

Cholesterol Trafficking to the Er Leads to the Activation of Camkii/Jnk/Nlrp3 and Promotes Atherosclerosis. Journal of Lipid Research (2024)

Mustafa YalcinkayaWenli LiuTong XiaoSandra AbramowiczRanran WangNan WangMarit WesterterpAlan R. Tall

inflammationvascular diseaseclinical lipidologybiochemistryoxidative stresslipidsmolecular biologyatherosclerosisredox biologymetabolic syndromecirculatory physiologylipid disordersvascular biologycardiovascular diseasehyperlipidemialipoprotein metabolismlipid peroxidationphysiology

Genetic and Epigenetic Regulation of Inflammasomes: Role in Atherosclerosis. Atherosclerosis (2024)

Mustafa YalcinkayaAlan R Tall

geneticshuman geneticsmolecular geneticsgenomicsgenetic disordersgenetic factorsneurosciencemedical geneticsatherosclerosisgenome biologyimmunologyepigeneticsepigenetic changesepigenetic regulation

Inflammatory Crosstalk Impairs Phagocytic Receptors and Aggravates Atherosclerosis in Clonal Hematopoiesis in Mice. Journal of Clinical Investigation (2024)

Wenli LiuBrian D. HardawayEunyoung KimJessica PauliJustus Leonard WettichMustafa YalcinkayaCheng-Chieh HsuTong XiaoMuredach P. ReillyIra TabasLars MaegdefesselKai SchlepckowHaass ChristianNan WangAlan R. Tall

liver physiologychronic inflammationphagocytesimmunosuppressioninflammatory diseasesmolecular immunologyrheumatologyhaematopoiesisvascular biologyclonal hematopoiesisallergypharmacologyreceptorsinflammationfree radical biologyimmunologyclinical investigationatherosclerosismedicinal research

Blockade of Il-6 Signaling Alleviates Atherosclerosis in Tet2-Deficient Clonal Hematopoiesis. Nature Cardiovascular Research (2023)

Wenli LiuMustafa YalcinkayaInés Fernández MaestreMalgorzata OlszewskaPatrick B. AmpomahJ. Brett HeimlichRanran WangPablo Sánchez VelaTong XiaoAlexander G. BickRoss LevineEirini P. PapapetrouPeter LibbyIra TabasNan WangAlan R. Tall

pharmacologyadaptive immune systemcellular immune responsescardiovascular researchhaematopoiesiscardiologyatherosclerosishemostasiscell signalingimmunologydermatologymedicinal researchvascular biologyhematologymolecular immunology

Brcc3-Mediated Nlrp3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis. Circulation (2023)

Mustafa YalcinkayaWenli LiuLeigh-Anne ThomasMalgorzata OlszewskaTong XiaoSandra AbramowiczEirini P. PapapetrouMarit WesterterpNan WangIra TabasAlan R. Tall

pharmacologyinflammationcardiovascular researchhaematopoiesiscardiologychronic inflammationheme homeostasisatherosclerosishemostasiscell regulationimmunologydermatologymedicinal researchvascular biologyinflammasome activationhematology

Jak2 V617F Clonal Hematopoiesis Promotes Arterial Thrombosis via Platelet Activation and Cross Talk. Blood (2023)

Wenli LiuJoachim PircherArt SchuermansQurrat Ul AinZhe ZhangMichael C. HonigbergMustafa YalcinkayaTetsushi NakaoAshley PournamadriTong XiaoMohammad Ali HajebrahimiLisa WasnerDavid StegnerTobias PetzoldPradeep NatarajanSteffen MassbergAlan R. TallChristian SchulzNan Wang

medicinelaboratory medicinethrombosisvascular diseasehematologyarterial thrombosishaematopoiesiscross talkvascular biologyvenous thrombosisplatelet activationcardiovascular diseasecardiologycerebrovascular diseasenephrologyhealth sciencesblood flowhemostasisphysiology

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Mustafa Yalcinkaya

Associate Research Scientist in the Department of Medicine

Columbia University

Affiliations

Columbia University

P&S

P&S Clinical

MED Molecular Medicine

P&S

P&S Clinical

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Mustafa Yalcinkaya

Columbia University

Associate Research Scientist in the Department of Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Transient Efferocytosis-Induced Activation of Ikkβ Reprograms Macrophages to Promote Tissue Resolution. bioRxiv (Cold Spring Harbor Laboratory) (2026)

cytokinesimmune responsesinflammationautophagycell autophagyphagocytescellular physiologycell signalingimmunologycell biologycell death

Cholesterol Crystals as Triggers of Nlrp3 Inflammasome Activation in Atherosclerosis. Current Atherosclerosis Reports (2025)

inflammationcardiovascular researchautoinflammatory diseaselipidsatherosclerosisimmunologyvascular biologycell biologycardiovascular disease

The Copi Coatomer Regulates Several Steps of Hdl Metabolism. medRxiv (2025)

molecular medicinecell metabolismmolecular metabolismmolecular biologycell biologymolecular and cellular biologymetabolic pathways

Abstract 108: Inflammasome Activation via Brcc3-Mediated Nlrp3 Deubiquitylation Promotes Atherosclerosis in Tet2 Clonal Hematopoiesis. Arteriosclerosis Thrombosis and Vascular Biology (2024)

Mustafa YalcinkayaWenli LiuTONG XIAOSandra AbramowiczNan WangMarit WesterterpAlan Tall

hepatologypharmacologyangiologyhealth scienceshaematopoiesiscardiologythrombosisatherosclerosisinflammasome activationimmunologyvascular biologyhematology

Cholesterol Trafficking to the Er Leads to the Activation of Camkii/Jnk/Nlrp3 and Promotes Atherosclerosis. Journal of Lipid Research (2024)

Mustafa YalcinkayaWenli LiuTong XiaoSandra AbramowiczRanran WangNan WangMarit WesterterpAlan R. Tall

Genetic and Epigenetic Regulation of Inflammasomes: Role in Atherosclerosis. Atherosclerosis (2024)

Mustafa YalcinkayaAlan R Tall

geneticshuman geneticsmolecular geneticsgenomicsgenetic disordersgenetic factorsneurosciencemedical geneticsatherosclerosisgenome biologyimmunologyepigeneticsepigenetic changesepigenetic regulation

Inflammatory Crosstalk Impairs Phagocytic Receptors and Aggravates Atherosclerosis in Clonal Hematopoiesis in Mice. Journal of Clinical Investigation (2024)

Blockade of Il-6 Signaling Alleviates Atherosclerosis in Tet2-Deficient Clonal Hematopoiesis. Nature Cardiovascular Research (2023)

Brcc3-Mediated Nlrp3 Deubiquitylation Promotes Inflammasome Activation and Atherosclerosis in Tet2 Clonal Hematopoiesis. Circulation (2023)

Mustafa YalcinkayaWenli LiuLeigh-Anne ThomasMalgorzata OlszewskaTong XiaoSandra AbramowiczEirini P. PapapetrouMarit WesterterpNan WangIra TabasAlan R. Tall

Jak2 V617F Clonal Hematopoiesis Promotes Arterial Thrombosis via Platelet Activation and Cross Talk. Blood (2023)

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