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Muhammad Murtaza Hassan

Assistant Professor of Chemistry

University of Virginia

Affiliations

College and Graduate School of Arts and Sciences

Department of Chemistry

Muhammad Murtaza Hassan is currently serving as a College And Graduate School Of Arts And Sciences Assistant Professor of Chemistry at University of Virginia.

Honors

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Experiences

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Education

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Muhammad Murtaza Hassan

University of Virginia

Assistant Professor of Chemistry

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medicinal chemistry biochemistry pharmacology drug discovery enzyme inhibition chemistry chemical biology pharmaceutical chemistry structural biology pharmacological research rational drug design enzymes organic chemistry therapeutic targets pharmacotherapy organic process research structural molecular biology cancer discovery protein chemistry molecular docking synthesis methods cancer treatment immunology catalysis biological chemistry chemical sciences leukemia cellular therapy protein science molecular informatics cancer care molecular cancer cancer imaging crystal research chemical bond molecular chemistry radical (chemistry) hematological malignancies drug development pharmaceutical sciences biomolecular interactions molecular characterization biocatalysis enzyme catalysis heterocycle chemistry cancer management cancer genomics cancer biology cancer education structure elucidation structure determination crystal structures synthetic chemistry anti-cancer agents schistosomiasis covalent molecular glues cysteine-reactive chemistry chemical specification catalytic tunnel biological characterization model chemotype template-assisted covalent modification molecular glue degraders ccdc 2023399

Notable Scholarly Works

Notable Federal Grants

Collaborators

Improved Pharmacokinetic Profiles of Hdac6 Inhibitors via Cap Group Modifications. Journal of Medicinal Chemistry (2025)

medicinal chemistryenzyme inhibitionpharmacologypharmaceutical chemistryrational drug designpharmacotherapypharmacological research

Exploration of the Tunability of Brd4 Degradation by Dcaf16 Trans-Labelling Covalent Glues. European Journal of Medicinal Chemistry (2024)

Muhammad Murtaza HassanYen-Der LiMichelle W MaMingxing TengWoong Sub ByunKedar PuvarRyan LumpkinBrittany SandovalJustine C RutterCyrus Y JinMichelle Y WangShawn XuAnna M SchmokerHakyung CheongBrian J GroendykeJun QiEric S FischerBenjamin L EbertNathanael S Gray

medicinal chemistrypharmaceutical chemistrychemical biologydrug discoverypharmaceutical sciences

Template-Assisted Covalent Modification Underlies Activity of Covalent Molecular Glues. Nature Chemical Biology (2024)

Yen-Der LiMichelle W. MaMuhammad Murtaza HassanMoritz HunkelerMingxing TengKedar PuvarJustine C. RutterRyan J. LumpkinBrittany SandovalCyrus Y. JinAnna M. SchmokerScott B. FicarroHakyung CheongRebecca J. MetivierMichelle Y. WangShawn XuWoong Sub ByunBrian J. GroendykeInchul YouLogan H. SiguaIsidoro TavaresCharles ZouJonathan M. TsaiPaul M. C. ParkHojong YoonFelix C. MajewskiHaniya T. SperlingJarrod A. MartoJun QiRadosław P. NowakKatherine A. DonovanMikołaj SłabickiNathanael S. GrayEric S. FischerBenjamin L. Ebert

chemical bondcovalent molecular glueschemical biologybiological chemistrychemical sciencesmolecular chemistrybiochemistry

Abstract 3424: Template-Assisted Covalent Modification of Dcaf16 Enables Brd4 Molecular Glue Degraders. Cancer Research (2023)

Yen-Der LiMichelle W. MaMuhammad Murtaza HassanKedar PuvarMingxing TengBrittany SandovalRyan LumpkinScott B. FicarroMichelle Y. WangShawn XuBrian J. GroendykeLogan H. SiguaIsidoro TavaresCharles ZouJonathan M. TsaiPaul M. ParkHojong YoonRadosław P. NowakJarrod A. MartoJun QiKatherine A. DonovanMikołaj SłabickiNathanael S. GrayEric S. FischerBenjamin L. Ebert

medicinal chemistryprotein structuremolecular informaticscancer carecancer managementmolecular cancercancer genomicsstructural biologycancer biologycancer researchcancer immunotherapycancer treatmenttumor biologybiomedical engineeringcancer educationcancer discoverycancer imagingclinical researchoncologystructural molecular biologytemplate-assisted covalent modificationmolecular glue degraders

Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry. Journal of the American Chemical Society (2023)

Roman C. SarottInchul YouYen-Der LiSean T. ToenjesKatherine A. DonovanPooreum SeoMartha OrdonezWoong Sub ByunMuhammad Murtaza HassanFranziska WachterEdward T. ChouchaniMikołaj SłabickiEric S. FischerBenjamin L. EbertStephen M. HinshawNathanael S. Gray

protein chemistrypharmacologycysteine-reactive chemistrychemical specificationenzymeschemistrybiochemistry

Discovery of Hdac6-Selective Inhibitor Nn-390 With in Vitro Efficacy in Group 3 Medulloblastoma. (2022)

pharmacologycancer discoveryanti-cancer agentsdrug discoverycancer treatment

Phenotypic Screening of Histone Deacetylase (Hdac) Inhibitors Against Schistosoma Mansoni. ChemMedChem. (2022)

medicinal chemistryenzyme inhibitionpharmacologyparasitologyschistosomiasistherapeutic targetschemical biologyinvertebrate pathologydrug discoverymedicinal researchpathologybiochemical sciencesbiochemistry

Developing Conformationally Constrained L-Shaped Hdac8 Selective Inhibitors for Epigenetic Therapies. TSpace (2021)

enzyme inhibitionrational drug designmolecular dockingdrug discoverymolecular biologyepigeneticsstructural biology

Development of Hdac Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia. Journal of Medicinal Chemistry (2021)

immunologymedicinal chemistryhematological malignanciesleukemiapharmacologyenzyme inhibitionpharmaceutical chemistrypharmacotherapytherapeutic targetscellular therapydrug developmentpharmacological research

Unique Molecular Interaction With the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of Medicinal Chemistry (2021)

Olasunkanmi O. OlaoyeParis R. WatsonNabanita NawarMulu GeletuAbootaleb SedighiShazreh BukhariYasir S. RaoufPimyupa ManaswiyoungkulFettah ErdoganAyah AbdeldayemAaron D. CabralMuhammad Murtaza HassanKrimo ToutahAndrew E. ShouksmithJustyna M. GawelJohan IsraelianTudor B. RaduNiyati KachhiyapatelElvin D. de AraujoDavid W. ChristiansonPatrick T. Gunning

catalytic tunnelbiomolecular interactionsprotein chemistrycatalysisbiological characterizationenzymesmolecular characterizationbiocatalysismolecular biologystructural molecular biologyenzyme catalysismodel chemotypestructural biologyprotein scienceprotein engineeringbiological engineeringbiochemistry

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Muhammad Murtaza Hassan

Assistant Professor of Chemistry

University of Virginia

Affiliations

College and Graduate School of Arts and Sciences

Department of Chemistry

Muhammad Murtaza Hassan is currently serving as a College And Graduate School Of Arts And Sciences Assistant Professor of Chemistry at University of Virginia.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Muhammad Murtaza Hassan

University of Virginia

Assistant Professor of Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Improved Pharmacokinetic Profiles of Hdac6 Inhibitors via Cap Group Modifications. Journal of Medicinal Chemistry (2025)

medicinal chemistryenzyme inhibitionpharmacologypharmaceutical chemistryrational drug designpharmacotherapypharmacological research

Exploration of the Tunability of Brd4 Degradation by Dcaf16 Trans-Labelling Covalent Glues. European Journal of Medicinal Chemistry (2024)

medicinal chemistrypharmaceutical chemistrychemical biologydrug discoverypharmaceutical sciences

Template-Assisted Covalent Modification Underlies Activity of Covalent Molecular Glues. Nature Chemical Biology (2024)

chemical bondcovalent molecular glueschemical biologybiological chemistrychemical sciencesmolecular chemistrybiochemistry

Abstract 3424: Template-Assisted Covalent Modification of Dcaf16 Enables Brd4 Molecular Glue Degraders. Cancer Research (2023)

Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry. Journal of the American Chemical Society (2023)

protein chemistrypharmacologycysteine-reactive chemistrychemical specificationenzymeschemistrybiochemistry

Discovery of Hdac6-Selective Inhibitor Nn-390 With in Vitro Efficacy in Group 3 Medulloblastoma. (2022)

pharmacologycancer discoveryanti-cancer agentsdrug discoverycancer treatment

Phenotypic Screening of Histone Deacetylase (Hdac) Inhibitors Against Schistosoma Mansoni. ChemMedChem. (2022)

Developing Conformationally Constrained L-Shaped Hdac8 Selective Inhibitors for Epigenetic Therapies. TSpace (2021)

enzyme inhibitionrational drug designmolecular dockingdrug discoverymolecular biologyepigeneticsstructural biology

Development of Hdac Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia. Journal of Medicinal Chemistry (2021)

Unique Molecular Interaction With the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype. Journal of Medicinal Chemistry (2021)

1
2
10 / page