Faculty

Institution

Unit

Venue

Ming-Lei Guo

Associate Professor

Eastern Virginia Medical School

Affiliations

Biomedical Sciences Research

Doctoral Programs

Pathology & Anatomy

Schools, Institutes, Centers & Departments

Ming-lei Guo is currently serving as a Biomedical Sciences Research Associate Professor at Eastern Virginia Medical School.

Honors

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Experiences

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Education

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Ming-Lei Guo

Eastern Virginia Medical School

Associate Professor

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neuroscience hiv autophagy neuroinflammation immunology brain-immune interaction neurology inflammation neuroimmunology pharmacology neuropharmacology medicinal research central nervous system molecular neurobiology molecular neuroscience sleep addiction biology neurovirology cell death vascular biology redox biology neurobiological mechanisms cell autophagy addictive behaviors addiction medicine molecular neurodegeneration neuroscience of aging mitochondrial function immune dysregulation psychoneuroimmunology neurochemistry clinical pharmacology er stress-autophagy axis cocaine-mediated downregulation enzyme inhibition medical virology mammalian biology neuropsychopharmacology substance use molecular psychiatry degenerative pathology degenerative disease cerebral organoids mitophagy gut-organ axis cellular biology gene regulation brain organization neurotransmission clinical neurology brain science cell proliferation anti-inflammatory opioid use disorder disease transmission viral persistence personalized treatments drug treatment toxicokinetics sleep medicine redox signaling fibrosis neurodegenerative disorders endoplasmic reticulum stress neural progenitors cocaine-mediated microglial activation er stress-mediated activation cocaine induces superoxide dismutase mimetics defective mitophagy microglial activation cocaine-mediated mitochondrial damage gut microbiota colonization mucosal barrier integrity promoter dna methylation antiretroviral-mediated microglial activation human retrovirus drug addiction primary immunodeficiencies autoinflammatory disease

Notable Scholarly Works

Notable Federal Grants

Collaborators

Anti–Heat Shock Protein 70 Autoantibodies From Patients With Idiopathic Pulmonary Fibrosis Epigenetically Enhance Lung Fibroblast Apoptosis Resistance and Bcl-2 Expression. The Journal of Immunology (2024)

Baiyun ZhongJennifer Q. ZhouXing LyuHui LiuKayu YuanMing-Lei GuoSteven R. DuncanYan Y. Sanders

fibrosisimmunologyidiopathic pulmonary fibrosisimmune responses

Hiv-Tat Dysregulates Microglial Lipid Metabolism Through Srebp2/Mir-124 Axis: Implication of Lipid Droplet Accumulation Microglia in Neurohiv. Brain Behavior and Immunity (2024)

Yan ChengJaekeun JungLiyang GuoDorela D Shuboni-MulliganJian-Fu ChenWenhui HuMing-Lei Guo

lipidsimmunologyhivneuroscienceneuroimmunologybrain-immune interaction

Lipid Droplets Accumulation in the Brain of Hiv Transgenic Rat: Implication in the Accelerated Aging of Hiv Infected Individuals. Aging and Disease (2024)

Ming-Lei GuoYan ChengDamian Martinez PinedaRachael E DempseyLifang Yang

lipidshivneurosciencegeneticshiv transgenic rathealthy aginginfectious diseasescerebral blood flowaging-associated diseasesneurovirologylipid droplets accumulationbrain-immune interactionneuroimmunologyvascular agingvirus researchneuroscience of agingaging cellaccelerated agingageingantiviral researchactive ageing

Type-1-To-Type-2 Transition of Brain Microvascular Pericytes Induced by Cytokines and Disease-Associated Proteins: Role in Neuroinflammation and Blood-Brain Barrier Disruption. Journal of Cerebral Blood Flow & Metabolism (2024)

Diana G BohannonLaurie L WellmanMarcus KaulElena V GalkinaMing-Lei GuoPrasun K DattaWoong-Ki Kim

immunologyneuroscienceneurophysiologyneurovascular diseasesblood-brain barrier disruptionvascular biologyneuroinflammationcerebral blood flowbrain-immune interactionmolecular neurodegenerationneuroimmunologydisease-associated proteinsneurologyinflammationbrain tumor researchbrain circulationneuropathologybrain microvascular pericytescentral nervous systemcytokines

Cocaine Regulates Nlrp3 Inflammasome Activity and Crf Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines (2023)

Yan ChengRachael Elizabeth DempseySoheil Kazemi RoodsariDorela D. Shuboni-MulliganOlivier GeorgeLarry D. SanfordMing-Lei Guo

neurologyinflammationneurochemistryneuropharmacologypharmaceutical sciencesbiomedical researchmedicinal researchneuroinflammationcrf signalingmedicinepharmacologyrat brainclinical researchsex-dependent mannerclinical pharmacology

Hiv Tat-Mediated Altered Oligodendrocyte Maturation Involves Autophagy-Lysosomal Dysfunction. NeuroImmune Pharmacology and Therapeutics (2023)

Ashutosh TripathiPalsamy PeriyasamyMing-Lei GuoShilpa Buch

inflammationviral pathogenesiscell deathhuman retrovirushivimmunologycell biologydisease progressionautophagy-lysosomal dysfunctionneuroimmunologyantiviral researchimmune responsesautophagymolecular biologybrain-immune interactioncell autophagyoligodendrocyte maturationvirus research

Investigating Hiv-1 Tat Protein Role in Atherogenesis. The Journal of Immunology (2023)

Cassandra Lee KirkAlina MoriartyNatalie Ann StahrW. Coles KeeterShelby MaWoong-Ki KimMing-Lei GuoElena Galkina

immunologyhivvirus-host interactions

Microglia Nlrp3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules (2023)

Ming-Lei GuoSoheil Kazemi RoodsariYan ChengRachael Elizabeth DempseyWenhui Hu

anti-inflammatoryneurosciencesubstance useneuroinflammationaddictionbrain-immune interactionopioid use disordermolecular psychiatrysubstance use disordersneuroimmunologyneuroimmune signalingsystems biologyaddictive behaviorsinflammationpsychiatrypsychoneuroimmunologyaddiction medicineaddiction biologysubstance abuse

Modeling Integrated Stress, Sleep, Fear and Neuroimmune Responses: Relevance for Understanding Trauma and Stress-Related Disorders. Neurobiology of Stress (2023)

Larry D. SanfordLaurie L. WellmanAustin M. AdkinsMing-Lei GuoYe ZhangRong RenLinghui YangXiangdong Tang

psychoneuroimmunologysleepneuroimmune responsesstress (biology)neuroscienceneurobiological mechanismsneuroimmunologystress-related disordersintegrated stresspsychological traumatrauma

Role of Dysregulated Autophagy in Hiv Tat, Cocaine, and Cart Mediated Nlrp3 Activation in Microglia. Journal of Neuroimmune Pharmacology (2023)

Seema SinghAnnadurai ThangarajErnest T ChiveroMing-Lei GuoPalsamy PeriyasamyShilpa Buch

inflammationdisease transmissionimmunologyhivmedicinal researchneuroscienceneuroinflammationimmune dysregulationneuroimmunologyhiv tatimmune responsesneurovirologypharmacologyautophagybrain-immune interactionviral persistence

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Ming-Lei Guo

Associate Professor

Eastern Virginia Medical School

Affiliations

Biomedical Sciences Research

Doctoral Programs

Pathology & Anatomy

Schools, Institutes, Centers & Departments

Ming-lei Guo is currently serving as a Biomedical Sciences Research Associate Professor at Eastern Virginia Medical School.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Ming-Lei Guo

Eastern Virginia Medical School

Associate Professor

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Baiyun ZhongJennifer Q. ZhouXing LyuHui LiuKayu YuanMing-Lei GuoSteven R. DuncanYan Y. Sanders

fibrosisimmunologyidiopathic pulmonary fibrosisimmune responses

Hiv-Tat Dysregulates Microglial Lipid Metabolism Through Srebp2/Mir-124 Axis: Implication of Lipid Droplet Accumulation Microglia in Neurohiv. Brain Behavior and Immunity (2024)

Yan ChengJaekeun JungLiyang GuoDorela D Shuboni-MulliganJian-Fu ChenWenhui HuMing-Lei Guo

lipidsimmunologyhivneuroscienceneuroimmunologybrain-immune interaction

Lipid Droplets Accumulation in the Brain of Hiv Transgenic Rat: Implication in the Accelerated Aging of Hiv Infected Individuals. Aging and Disease (2024)

Ming-Lei GuoYan ChengDamian Martinez PinedaRachael E DempseyLifang Yang

Diana G BohannonLaurie L WellmanMarcus KaulElena V GalkinaMing-Lei GuoPrasun K DattaWoong-Ki Kim

Cocaine Regulates Nlrp3 Inflammasome Activity and Crf Signaling in a Region- and Sex-Dependent Manner in Rat Brain. Biomedicines (2023)

Yan ChengRachael Elizabeth DempseySoheil Kazemi RoodsariDorela D. Shuboni-MulliganOlivier GeorgeLarry D. SanfordMing-Lei Guo

Hiv Tat-Mediated Altered Oligodendrocyte Maturation Involves Autophagy-Lysosomal Dysfunction. NeuroImmune Pharmacology and Therapeutics (2023)

Ashutosh TripathiPalsamy PeriyasamyMing-Lei GuoShilpa Buch

Investigating Hiv-1 Tat Protein Role in Atherogenesis. The Journal of Immunology (2023)

Cassandra Lee KirkAlina MoriartyNatalie Ann StahrW. Coles KeeterShelby MaWoong-Ki KimMing-Lei GuoElena Galkina

immunologyhivvirus-host interactions

Microglia Nlrp3 Inflammasome and Neuroimmune Signaling in Substance Use Disorders. Biomolecules (2023)

Ming-Lei GuoSoheil Kazemi RoodsariYan ChengRachael Elizabeth DempseyWenhui Hu

Modeling Integrated Stress, Sleep, Fear and Neuroimmune Responses: Relevance for Understanding Trauma and Stress-Related Disorders. Neurobiology of Stress (2023)

Larry D. SanfordLaurie L. WellmanAustin M. AdkinsMing-Lei GuoYe ZhangRong RenLinghui YangXiangdong Tang

psychoneuroimmunologysleepneuroimmune responsesstress (biology)neuroscienceneurobiological mechanismsneuroimmunologystress-related disordersintegrated stresspsychological traumatrauma

Role of Dysregulated Autophagy in Hiv Tat, Cocaine, and Cart Mediated Nlrp3 Activation in Microglia. Journal of Neuroimmune Pharmacology (2023)

Seema SinghAnnadurai ThangarajErnest T ChiveroMing-Lei GuoPalsamy PeriyasamyShilpa Buch

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University of Nebraska Medical Center

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neuroscience of aging

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