Faculty

Institution

Unit

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Minerva Garcia-Barrio

Morehouse School of Medicine

Affiliations

Cardiovascular Research Institute

Department Of Cardiovascular Disease

Department Of Cardiovascular Medicine

Division Of Cardiovascular Medicine

MSM External Event Request Form

Morehouse School of Medicine

Minerva Garcia-Barrio is a Senior Professor at Morehouse School of Medicine. Her research integrates vascular biology, pharmacology, and cell biology to elucidate the molecular mechanisms underlying atherosclerosis, thrombosis, and cardiometabolic disease. Recent breakthroughs include demonstrating that IDOL deficiency inhibits cholesterol-rich diet-induced atherosclerosis in rabbits (2025) and identifying endothelial KLF11 as a novel protector against diabetic atherosclerosis (2024). She has also uncovered roles for PRDM16 deficiency in vascular smooth muscle cells exacerbating abdominal aortic aneurysm (2023) and myeloid BAF60a deficiency in metabolic dysregulation. Her genome-wide association meta-analysis highlighted PCSK9 as a therapeutic target for abdominal aortic aneurysm (2023), with collaborative work extending to oxalate metabolism and endometriosis.

Honors

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Minerva Garcia-Barrio

Morehouse School of Medicine

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vascular biology pharmacology cell biology physiology cardiology atherosclerosis cardiovascular research inflammation thrombosis membrane biology hematology cellular physiology health sciences liver physiology angiology cardiovascular disease endocrinology molecular cell biology vascular disease molecular physiology endothelial dysfunction circulatory physiology angiogenesis gene expression abdominal aortic aneurysm applied physiology free radical biology respiratory medicine transcription regulation arterial disease vascular pharmacology vascular adaptation redox biology medicinal research clinical lipidology antiviral research medical virology single-cell analysis cardiovascular function cardiovascular physiology medical genetics cell cycle human retrovirus apoptosis reactive oxygen species cellular biology perivascular adipose tissue endothelial tfeb treatment and prevention translational physiology human physiology neovascularization liver disease clinical medicine clinical physiology biomedical research secondary metabolism redox signaling vascular aging microvascular dysfunction chromosome biology chronic viral infections cellular regulatory mechanism transcriptional regulation nitrolinoleic acid gut microbiome glutathione synthesis fatty acid oxidation cellular heterogeneity single-cell rna sequencing nitro-fatty acids nitrated fatty acids kruppel-like factor 4 vascular function endometriotic stromal cells angiogenic effects

Notable Scholarly Works

Notable Federal Grants

Collaborators

Idol Deficiency Inhibits Cholesterol-Rich Diet–Induced Atherosclerosis in Rabbits. Arteriosclerosis Thrombosis and Vascular Biology (2025)

metabolismclinical lipidologynutritionlipid disordersdyslipidemiaphysiologylipidshealth sciencesatherosclerosis

Endothelial Klf11 is a Novel Protector Against Diabetic Atherosclerosis. Cardiovascular Diabetology (2024)

diabetesinflammationcell biologyblood vesselsendothelial klf11pharmacologyvascular biologyendothelial dysfunctionvascular diseasecardiovascular researchdiabetic medicinediabetes researchatherosclerosiscardiovascular disease

Inhibition of Hepatic Oxalate Overproduction Ameliorates Metabolic Dysfunction-Associated Steatohepatitis. Nature Metabolism (2024)

Sandeep DasAlexandra C FinneySumit Kumar AnandSumati RohillaYuhao LiuNilesh PandeyAlia GhrayebDhananjay KumarKelley NunezZhipeng LiuFabio AriasYing ZhaoBrenna H Pearson-GallionM Peyton McKinneyKoral S E RichardJose A Gomez-VidalChowdhury S AbdullahElizabeth D CockerhamJoseph EniafeAndrew D YurochkoTarek MagdyChristopher B PattilloChristopher G KevilBabak RazaniMd Shenuarin BhuiyanErin H SeeleyGretchen E GallianoBo WeiLin TanIqbal MahmudIda SurakkaMinerva T Garcia-BarrioPhilip L LorenziEyal GottliebEduardo SalidoJifeng ZhangA Wayne OrrWanqing LiuMonica Diaz-GavilanY Eugene ChenNirav DhaneshaPaul T ThevenotAri J CohenArif YurdagulOren Rom

hepatologyhematologymetabolismliver physiologyinflammationbiochemistrypharmacologyphysiologyliver diseasecardiovascular diseasehepatic oxalate overproduction

Abstract 684: Hepatic Oxalate Overproduction as a Driver and Therapeutic Target in Nash and Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology (2023)

Sandeep DasAlexandra C FinneyDhananjay kumarYuhao LiuSumati RohillaSumit Kumar AnandKelly Nunezzhipeng liuBrenna Pearson-GallionChowdhury S. AbdullahElizabeth D CockerhamMd Shenuarin BhuiyanWayne W OrrMinerva T Garcia-BarrioJifeng ZhangWanqing LiuY. Eugene ChenPaul ThevenotAri CohenArif YurdagulOren Rom

hepatologyliver physiologyangiologycardiologypharmacologymembrane biologyvascular biologythrombosishealth sciencesatherosclerosisepidemiologyhepatic oxalate overproduction

Genome-Wide Association Meta-Analysis Identifies Risk Loci for Abdominal Aortic Aneurysm and Highlights Pcsk9 as a Therapeutic Target. Nature Genetics (2023)

Tanmoy RoychowdhuryDerek KlarinMichael G. LevinJoshua M. SpinYae Hyun RheeAlicia DengColwyn A. HeadleyNoah L. TsaoCorry GellatlyVerena ZuberFred ShenWhitney E. HornsbyIna Holst LaursenShefali S. VermaAdam E. LockeGudmundur EinarssonGudmar ThorleifssonSarah E. GrahamOzan DikilitasJack W. PatteeRenae L. JudyFerran Pauls-VergesJonas B. NielsenBrooke N. WolfordBen M. BrumptonJaume DilméOlga PeypochLaura Calsina JuscafresaTodd L. EdwardsDadong LiKarina BanasikSøren BrunakRikke L. JacobsenMinerva T. Garcia-BarrioJifeng ZhangLars M. RasmussenRegent LeeAshok HandaAnders WanhainenKevin ManiJes S. LindholtLasse M. ObelEwa StraussGrzegorz OszkinisChristopher P. NelsonKatie L. SaxbyJoost A. van HerwaardenSander W. van der LaanJessica van SettenMercedes CamachoFrank M. DavisRachael WasikowskiLam C. TsoiJohann E. GudjonssonJonathan L. EliasonDawn M. ColemanPeter K. HenkeSanthi K. GaneshY. Eugene ChenWeihua GuanJames S. PankowNathan PankratzOle B. PedersenChristian ErikstrupWeihong TangKristian HveemDaniel GudbjartssonSolveig GretarsdottirUnnur ThorsteinsdottirHilma HolmKari StefanssonManuel A. FerreiraAris BarasIftikhar J. KulloMarylyn D. RitchieAlex H. ChristensenKasper K. IversenNikolaj EldrupHenrik SillesenSisse R. OstrowskiHenning BundgaardHenrik UllumStephen BurgessDipender GillKatherine GallagherMaria Sabater-LlealFrank DudbridgeNilesh J. SamaniIda SurakkaGregory T. JonesMatthew J. BownPhilip S. TsaoCristen J. WillerScott M. Damrauer

abdominal aortic aneurysmcancer genomicsgeneticsmedical geneticsgenomicshuman geneticshealth sciencesgenome-wide association studies

Loss-Of-Sting Function by Nitro-Fatty Acids Reduces Endometriotic Lesion Formation in a Syngeneic Model of Endometriosis. Physiology (2023)

Mareena PittsWei XuMinerva Garcia-BarrioFrancisco SchopferWinston ThompsonLuis Villacorta

gynecologyendocrinologysyngeneic modelphysiologyloss-of-sting function

Myeloid Baf60A Deficiency Alters Metabolic Homeostasis and Exacerbates Atherosclerosis. Cell Reports (2023)

Yang ZhaoYuhao LiuGuizhen ZhaoHaocheng LuYaozhong LiuChao XueZiyi ChangHongyu LiuYongjie DengWenying LiangHuilun WangOren RomMinerva T. Garcia-BarrioTianqing ZhuYanhong GuoLin ChangJiandie LinY. Eugene ChenJifeng Zhang

hematologygeneticsdermatologycell biologyatherosclerosis

Prdm16 Deficiency in Vascular Smooth Muscle Cells Aggravates Abdominal Aortic Aneurysm. JCI Insight (2023)

Zhenguo WangXiangjie ZhaoGuizhen ZhaoYanhong GuoHaocheng LuWenjuan MuJuan ZhongMinerva Garcia-BarrioJifeng ZhangY. Eugene ChenLin Chang

abdominal aortic aneurysmvascular malformationsinflammationvascular biologyphysiologyvascular diseasecardiovascular researchmicrovascular dysfunction

Baf60C Prevents Abdominal Aortic Aneurysm Formation Through Epigenetic Control of Vascular Smooth Muscle Cell Homeostasis. Journal of Clinical Investigation (2022)

Guizhen ZhaoYang ZhaoHaocheng LuZiyi ChangHongyu LiuHuilun WangWenying LiangYuhao LiuTianqing ZhuOren RomYanhong GuoLin ChangBo YangMinerva T. Garcia-BarrioJiandie D. LinY. Eugene ChenJifeng Zhang

clinical investigationtranslational medicinecardiologyapplied physiologyclinical physiologypharmacologyvascular biologyphysiologyepigenetic controlclinical researchhealth sciencesclinical medicine

Gut Microbiota Production of Trimethyl-5-Aminovaleric Acid Reduces Fatty Acid Oxidation and Accelerates Cardiac Hypertrophy. Nature Communications (2022)

Mingming ZhaoHaoran WeiChenze LiRui ZhanChangjie LiuJianing GaoYaodong YiXiao CuiWenxin ShanLiang JiBing PanSi ChengMoshi SongHaipeng SunHuidi JiangJun CaiMinerva T. Garcia-BarrioY. Eugene ChenXiangbao MengErdan DongDao Wen WangLemin Zheng

secondary metabolismmetabolic healthmetabolismendocrinologymicrobiomegut microbiota productionimmunologypharmacologymembrane biologymammalian biologypublic healthmicrobial physiologycardiac hypertrophy

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Minerva Garcia-Barrio

Morehouse School of Medicine

Affiliations

Cardiovascular Research Institute

Department Of Cardiovascular Disease

Department Of Cardiovascular Medicine

Division Of Cardiovascular Medicine

MSM External Event Request Form

Morehouse School of Medicine

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Minerva Garcia-Barrio

Morehouse School of Medicine

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Idol Deficiency Inhibits Cholesterol-Rich Diet–Induced Atherosclerosis in Rabbits. Arteriosclerosis Thrombosis and Vascular Biology (2025)

metabolismclinical lipidologynutritionlipid disordersdyslipidemiaphysiologylipidshealth sciencesatherosclerosis

Endothelial Klf11 is a Novel Protector Against Diabetic Atherosclerosis. Cardiovascular Diabetology (2024)

Inhibition of Hepatic Oxalate Overproduction Ameliorates Metabolic Dysfunction-Associated Steatohepatitis. Nature Metabolism (2024)

hepatologyhematologymetabolismliver physiologyinflammationbiochemistrypharmacologyphysiologyliver diseasecardiovascular diseasehepatic oxalate overproduction

Abstract 684: Hepatic Oxalate Overproduction as a Driver and Therapeutic Target in Nash and Atherosclerosis. Arteriosclerosis Thrombosis and Vascular Biology (2023)

hepatologyliver physiologyangiologycardiologypharmacologymembrane biologyvascular biologythrombosishealth sciencesatherosclerosisepidemiologyhepatic oxalate overproduction

Genome-Wide Association Meta-Analysis Identifies Risk Loci for Abdominal Aortic Aneurysm and Highlights Pcsk9 as a Therapeutic Target. Nature Genetics (2023)

abdominal aortic aneurysmcancer genomicsgeneticsmedical geneticsgenomicshuman geneticshealth sciencesgenome-wide association studies

Loss-Of-Sting Function by Nitro-Fatty Acids Reduces Endometriotic Lesion Formation in a Syngeneic Model of Endometriosis. Physiology (2023)

Mareena PittsWei XuMinerva Garcia-BarrioFrancisco SchopferWinston ThompsonLuis Villacorta

gynecologyendocrinologysyngeneic modelphysiologyloss-of-sting function

Myeloid Baf60A Deficiency Alters Metabolic Homeostasis and Exacerbates Atherosclerosis. Cell Reports (2023)

hematologygeneticsdermatologycell biologyatherosclerosis

Prdm16 Deficiency in Vascular Smooth Muscle Cells Aggravates Abdominal Aortic Aneurysm. JCI Insight (2023)

Zhenguo WangXiangjie ZhaoGuizhen ZhaoYanhong GuoHaocheng LuWenjuan MuJuan ZhongMinerva Garcia-BarrioJifeng ZhangY. Eugene ChenLin Chang

abdominal aortic aneurysmvascular malformationsinflammationvascular biologyphysiologyvascular diseasecardiovascular researchmicrovascular dysfunction

Baf60C Prevents Abdominal Aortic Aneurysm Formation Through Epigenetic Control of Vascular Smooth Muscle Cell Homeostasis. Journal of Clinical Investigation (2022)

Guizhen ZhaoYang ZhaoHaocheng LuZiyi ChangHongyu LiuHuilun WangWenying LiangYuhao LiuTianqing ZhuOren RomYanhong GuoLin ChangBo YangMinerva T. Garcia-BarrioJiandie D. LinY. Eugene ChenJifeng Zhang

clinical investigationtranslational medicinecardiologyapplied physiologyclinical physiologypharmacologyvascular biologyphysiologyepigenetic controlclinical researchhealth sciencesclinical medicine

Gut Microbiota Production of Trimethyl-5-Aminovaleric Acid Reduces Fatty Acid Oxidation and Accelerates Cardiac Hypertrophy. Nature Communications (2022)

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