Faculty

Institution

Unit

Venue

Michelle Hamm

Professor of Chemistry

University of Richmond

Affiliations

School of Arts & Sciences

Department of Chemistry

University of Richmond

Michelle Hamm is currently serving as a Chemistry Professor of Chemistry at University of Richmond.

Honors

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Experiences

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Education

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Michelle Hamm

University of Richmond

Professor of Chemistry

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biochemistry molecular biology enzymes biological chemistry bioorganic chemistry enzyme inhibition nucleic acids biochemical sciences nucleic acid chemistry mutagenesis (molecular biology technique) protein science mutagenesis oligonucleotides oligonucleotide incorporation pharmacology tumor biology organic chemistry structural biology redox biology cancer genetics deoxygenation biochemical genetics enzymatic modification substrate specificity base pair stability mutagenic potential genetics hepatology cancer research cancer cells molecular cancer oncogenes molecular science medicinal research biomolecules organic process research molecular cell biology free radical biology organic chemistry frontier anti-cancer agents liver cancer oncogenic agent hepatocellular carcinoma glycosylation carbohydrate-protein interactions redox chemistry bioorganometallic chemistry cancer biology synthetic chemistry experimental toxicology molecular substrates enzyme specificity bacteriology enzyme catalysis major role human hepatocellular carcinoma muty glycosylase mismatch detection structure-activity relationships ‘ -deoxycytidine 8-oxo-2 ‘ -deoxyguanosine cellular repair synthetic analogs oxidative dna damage family polymerases c8 positions

Notable Scholarly Works

Notable Federal Grants

Collaborators

Biochemical Investigations Into the Incorporation of 8-Oxo-2′-Deoxyguanosine-5′-Triphosphate With Two A-Family Polymerases. Bioorganic & Medicinal Chemistry Letters (2025)

biochemical sciencesenzymesenzyme catalysisbiochemical engineeringbiosynthesisbiological chemistrybiochemistrya-family polymerasesenzymatic modificationmolecular biologybiochemical investigations

Cellular Repair of Synthetic Analogs of Oxidative Dna Damage Reveals a Key Structure–Activity Relationship of the Cancer-Associated Mutyh Dna Repair Glycosylase. ACS Central Science (2024)

Savannah G. ConlonCindy KhuuCarlos H. Trasviña-ArenasTian XiaMichelle L. HammAlan G. RaetzSheila S. David

tumor biologyoncologycancer biologybiological engineeringcell biologymolecular cell biologysynthetic analogsredox biologycellular repairmembrane biologyfree radical biologydna repairmolecular biologycancer geneticsstructural biologyoxidative dna damage

The Importance of Ile716 Toward the Mutagenicity of 8-Oxo-2’-Deoxyguanosine With Bacillus Fragment Dna Polymerase. DNA repair (2020)

microbiologymutagenesis (molecular biology technique)dna replicationenzymesbiochemical sciencesnucleic acidsnucleic acid chemistrybacteria8-oxo-2 ’ -deoxyguanosinebiochemistrybacteriologybiotechnologymutagenesismolecular biologytoxinsapplied microbiology

Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the Muty Glycosylase. ACS Chemical Biology (2017)

Amelia H. ManlovePaige L. McKibbinEmily L. DoyleChandrima MajumdarMichelle L. HammSheila S. David

enzymeschemical biologyprotein sciencemismatch detectionbiochemistrypharmacologymuty glycosylasestructure-activity relationships

Insights Into the Substrate Specificity of the Mutt Pyrophosphohydrolase Using Structural Analogues of 8-Oxo-2′-Deoxyguanosine Nucleotide. Bioorganic & Medicinal Chemistry Letters (2016)

Michelle L. HammEmily J. McFaddenMichael GhioMaria A.M. LindellKenneth S. GerienSuzanne F. O’Handley

enzymesbiomolecular engineeringmedicinal chemistryprotein sciencebioorganic chemistrymutt pyrophosphohydrolasebiological chemistrybiochemistrystructural analoguesenzyme specificitysubstrate specificitymolecular substratesmolecular biologyenzyme inhibitiondrug discoverystructural biology

Biochemical Investigations Into the Mutagenic Potential of 8-Oxo-2′-Deoxyguanosine Using Nucleotide Analogues. Chemical Research in Toxicology (2012)

mutagenesis (molecular biology technique)biochemical sciencesenzymesin vitro toxicologymutagenic potentialexperimental toxicologybiological chemistrybiochemistrydeoxygenationmutagenesismolecular biologybiochemical investigationsbiochemical geneticstoxicology

Importance of the C2, N7, and C8 Positions to the Mutagenic Potential of 8-Oxo-2′-Deoxyguanosine With Two a Family Polymerases. Biochemistry (2011)

c8 positionsmutagenesis (molecular biology technique)enzymesfamily polymerasesnucleic acidsmutagenic potentialredox biologybiochemistrymutagenesismolecular biologyenzyme inhibitionbiochemical genetics

Oligonucleotide Incorporation and Base Pair Stability of 9-Deaza-2′-Deoxyguanosine, an Analogue of 8-Oxo-2′-Deoxyguanosine. The Journal of Organic Chemistry (2010)

enzymesorganic chemistrynucleic acidsnucleic acid chemistrybioorganic chemistrybiological chemistrybiochemistryoligonucleotide incorporationoligonucleotidesbase pair stabilitymolecular biology

Substrate Specificity of Fpg (Mutm) and Hogg1, Two Repair Glycosylases. Journal of the American Chemical Society (2007)

enzymesprotein sciencecarbohydrate-protein interactionsprotein engineeringbiomoleculesbiochemistryglycobiologybiological chemistrysubstrate specificityenzymatic modificationmolecular biologyglycosylation

Synthesis, Oligonucleotide Incorporation and Base Pair Stability of 7-Methyl-8-Oxo-2′-Deoxyguanosine. Organic & Biomolecular Chemistry (2006)

chemical synthesisnucleic acid chemistrysynthetic chemistrybiochemistryoligonucleotide incorporationoligonucleotidesorganic chemistry frontier

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Michelle Hamm

Professor of Chemistry

University of Richmond

Affiliations

School of Arts & Sciences

Department of Chemistry

University of Richmond

Michelle Hamm is currently serving as a Chemistry Professor of Chemistry at University of Richmond.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michelle Hamm

University of Richmond

Professor of Chemistry

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Biochemical Investigations Into the Incorporation of 8-Oxo-2′-Deoxyguanosine-5′-Triphosphate With Two A-Family Polymerases. Bioorganic & Medicinal Chemistry Letters (2025)

biochemical sciencesenzymesenzyme catalysisbiochemical engineeringbiosynthesisbiological chemistrybiochemistrya-family polymerasesenzymatic modificationmolecular biologybiochemical investigations

Cellular Repair of Synthetic Analogs of Oxidative Dna Damage Reveals a Key Structure–Activity Relationship of the Cancer-Associated Mutyh Dna Repair Glycosylase. ACS Central Science (2024)

Savannah G. ConlonCindy KhuuCarlos H. Trasviña-ArenasTian XiaMichelle L. HammAlan G. RaetzSheila S. David

The Importance of Ile716 Toward the Mutagenicity of 8-Oxo-2’-Deoxyguanosine With Bacillus Fragment Dna Polymerase. DNA repair (2020)

Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the Muty Glycosylase. ACS Chemical Biology (2017)

Amelia H. ManlovePaige L. McKibbinEmily L. DoyleChandrima MajumdarMichelle L. HammSheila S. David

enzymeschemical biologyprotein sciencemismatch detectionbiochemistrypharmacologymuty glycosylasestructure-activity relationships

Insights Into the Substrate Specificity of the Mutt Pyrophosphohydrolase Using Structural Analogues of 8-Oxo-2′-Deoxyguanosine Nucleotide. Bioorganic & Medicinal Chemistry Letters (2016)

Michelle L. HammEmily J. McFaddenMichael GhioMaria A.M. LindellKenneth S. GerienSuzanne F. O’Handley

Biochemical Investigations Into the Mutagenic Potential of 8-Oxo-2′-Deoxyguanosine Using Nucleotide Analogues. Chemical Research in Toxicology (2012)

Importance of the C2, N7, and C8 Positions to the Mutagenic Potential of 8-Oxo-2′-Deoxyguanosine With Two a Family Polymerases. Biochemistry (2011)

Oligonucleotide Incorporation and Base Pair Stability of 9-Deaza-2′-Deoxyguanosine, an Analogue of 8-Oxo-2′-Deoxyguanosine. The Journal of Organic Chemistry (2010)

enzymesorganic chemistrynucleic acidsnucleic acid chemistrybioorganic chemistrybiological chemistrybiochemistryoligonucleotide incorporationoligonucleotidesbase pair stabilitymolecular biology

Substrate Specificity of Fpg (Mutm) and Hogg1, Two Repair Glycosylases. Journal of the American Chemical Society (2007)

Synthesis, Oligonucleotide Incorporation and Base Pair Stability of 7-Methyl-8-Oxo-2′-Deoxyguanosine. Organic & Biomolecular Chemistry (2006)

chemical synthesisnucleic acid chemistrysynthetic chemistrybiochemistryoligonucleotide incorporationoligonucleotidesorganic chemistry frontier

1
2
10 / page