Faculty

Institution

Unit

Venue

Michela Ottolia

Professor-in-Residence

University of California, Los Angeles

Affiliations

the College

Molecular, Cellular & Integrative Physiology

Michela Ottolia is currently serving as a Molecular, Cellular & Integrative Physiology Professor-in-Residence at University of California, Los Angeles.

Honors

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Experiences

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Education

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Michela Ottolia

University of California, Los Angeles

Professor-in-Residence

You can click a keyword to filter the displayed items

biophysics physiology electrophysiology cardiology molecular biology signal transduction membrane biology biochemistry cellular physiology molecular physiology cell signaling structural biology biological chemistry circulatory physiology receptors redox biology protein science experimental biophysics transition metal chemistry cardiovascular physiology animal physiology mammalian biology biological inorganic chemistry ion exchange cardiac muscle inorganic chemistry molecular regulation cell physiology applied physiology coordination chemistry structural molecular biology structural chemistry experimental medicine respiratory medicine respiration (physiology) receptor (biochemistry) neurotransmission experimental biology sodium battery heat exchangers tissue physiology electrolyte disturbance mutational analysis conformational changes structural mechanisms reproductive biology veterinary physiology translational physiology human physiology female reproductive system high voltage engineering skeletal muscle release mechanism human sciences biomolecular interactions cell interactions biochemical interaction single-molecule detection single-cell analysis nanosensors cell detection charge carrier transport cell trafficking large conductance voltage-controlled gating mefenamic acids ryanodine receptor calcium sensor disulfide bond skeletal ryanodine receptor functional interaction cytoplasmic domain single cells intracellular glucose dynamic modulation ph regulation

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bps2026 – Cav3.1-Channel Voltage-Sensing Domains Activate Near the Resting Membrane Potential. Biophysical Journal (2026)

biophysicsbiomedical circuitscirculatory physiologybioelectronicsneuronselectrophysiologymembrane proteinsbiophysical reviewmembranesmembrane biologymembrane sciencephysiologyneurophysiologyelectrical engineeringcellular physiologymolecular physiologycellular biochemistry

The Four Voltage-Sensing Domains of T-Type Calcium Channels Activate Near the Resting Membrane Potential. Nature Communications (2026)

biophysicsbiomedical circuitsreceptorscirculatory physiologybioelectronicsneuronselectrophysiologyneurosciencebiophysical reviewmembrane biologyphysiologymembrane scienceneurophysiologyneural circuitscellular physiologymolecular physiologycellular biochemistry

Bps2025 - Cardiac Glycoside-Driven Positive Inotropy Requires Allosteric Inactivation of the Sodium-Calcium Exchanger by Intracellular Sodium. Biophysical Journal (2025)

Kyle ScrantonScott JohnRui ZhangJoshua I. GoldhaberRiccardo OlceseMichela Ottolia

biophysicsbiophysical modelingallosteric inactivationsodium-calcium exchangerintracellular sodiumbiophysical chemistry

Bps2025 - Pmca1: An Overlooked Regulator of Calcium Homeostasis in the Heart. Biophysical Journal (2025)

cellular physiologycirculatory physiologycardiovascular interventionscardiologycell biologycell signalingelectrophysiologyheart failurevascular biologypharmacologyphysiologysignal transductioncardiovascular researchcell metabolismmolecular medicinecardiovascular diseasemolecular physiology

Calcium Overload Prevented During Acidosis in the Ph-Insensitive Cardiac Sodium-Calcium Exchanger Mouse. Journal of Molecular and Cellular Cardiology Plus (2025)

circulatory physiologycardiologycardiovascular physiologycardiovascular functioncalcium overload preventedelectrophysiologyelectrolyte disturbanceheart failurepharmacologyphysiologycardiovascular researchcardiac muscle

Regulation of Na/Ca Exchange by Cytoplasmic Protons Modifies Intracellular Calcium Dynamics and the Cardiac Response to Ischemia. Proceedings of the National Academy of Sciences (2025)

receptorscirculatory physiologycardiologycell biologycell signalingelectrophysiologymolecular pharmacologyvascular biologypharmacologyphysiologysignal transductioncardiovascular researchcell metabolismneurophysiologycellular physiologymolecular physiologycellular biochemistry

The Mechanism of Action of Digoxin Requires the Sodium-Dependent Inactivation of the Sodium-Calcium Exchanger. Science Advances (2025)

receptorsbiochemical sciencesdrug metabolismpharmacological researchoxidative stresschemical biologyelectrophysiologyredox biologybiological chemistrybiochemistrypharmacologyfree radical biologyphysiologysignal transductionmolecular pharmacologycellular physiologymolecular physiology

Allosteric Mechanism of Cav3.1 Inhibition by Z944, a Selective T-Type Channel Antagonist. Biophysical Journal (2024)

Marina AngeliniMoira McVicarSavana MaxfieldNicoletta SavalliScott A. JohnAlan NeelyAntonios PantazisMichela OttoliaRiccardo Olcese

biophysicspharmacologycell signalingallosteric mechanism

Cardiac Function is Regulated by the Sodium-Dependent Inhibition of the Sodium-Calcium Exchanger Ncx1. Nature Communications (2024)

Kyle ScrantonScott JohnMarina AngeliniFederica SteccanellaSoban UmarRui ZhangJoshua I. GoldhaberRiccardo OlceseMichela Ottolia

sodium-dependent inhibitioncardiologycardiac functionelectrophysiologyneurosciencepharmacology

Dual Network Structure of the Av Node. PubMed (2024)

Anna V MaltsevYasir Z BarlasAdina HazanRui ZhangMichela OttoliaJoshua I Goldhaber

network sciencedual network structurecomputer scienceav node

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Michela Ottolia

Professor-in-Residence

University of California, Los Angeles

Affiliations

the College

Molecular, Cellular & Integrative Physiology

Michela Ottolia is currently serving as a Molecular, Cellular & Integrative Physiology Professor-in-Residence at University of California, Los Angeles.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michela Ottolia

University of California, Los Angeles

Professor-in-Residence

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Bps2026 – Cav3.1-Channel Voltage-Sensing Domains Activate Near the Resting Membrane Potential. Biophysical Journal (2026)

The Four Voltage-Sensing Domains of T-Type Calcium Channels Activate Near the Resting Membrane Potential. Nature Communications (2026)

Bps2025 - Cardiac Glycoside-Driven Positive Inotropy Requires Allosteric Inactivation of the Sodium-Calcium Exchanger by Intracellular Sodium. Biophysical Journal (2025)

Kyle ScrantonScott JohnRui ZhangJoshua I. GoldhaberRiccardo OlceseMichela Ottolia

biophysicsbiophysical modelingallosteric inactivationsodium-calcium exchangerintracellular sodiumbiophysical chemistry

Bps2025 - Pmca1: An Overlooked Regulator of Calcium Homeostasis in the Heart. Biophysical Journal (2025)

Calcium Overload Prevented During Acidosis in the Ph-Insensitive Cardiac Sodium-Calcium Exchanger Mouse. Journal of Molecular and Cellular Cardiology Plus (2025)

Regulation of Na/Ca Exchange by Cytoplasmic Protons Modifies Intracellular Calcium Dynamics and the Cardiac Response to Ischemia. Proceedings of the National Academy of Sciences (2025)

The Mechanism of Action of Digoxin Requires the Sodium-Dependent Inactivation of the Sodium-Calcium Exchanger. Science Advances (2025)

Allosteric Mechanism of Cav3.1 Inhibition by Z944, a Selective T-Type Channel Antagonist. Biophysical Journal (2024)

Marina AngeliniMoira McVicarSavana MaxfieldNicoletta SavalliScott A. JohnAlan NeelyAntonios PantazisMichela OttoliaRiccardo Olcese

biophysicspharmacologycell signalingallosteric mechanism

Cardiac Function is Regulated by the Sodium-Dependent Inhibition of the Sodium-Calcium Exchanger Ncx1. Nature Communications (2024)

Kyle ScrantonScott JohnMarina AngeliniFederica SteccanellaSoban UmarRui ZhangJoshua I. GoldhaberRiccardo OlceseMichela Ottolia

sodium-dependent inhibitioncardiologycardiac functionelectrophysiologyneurosciencepharmacology

Dual Network Structure of the Av Node. PubMed (2024)

Anna V MaltsevYasir Z BarlasAdina HazanRui ZhangMichela OttoliaJoshua I Goldhaber

network sciencedual network structurecomputer scienceav node

1
2
3
4
5
10
10 / page

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glucose homeostasis

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