Faculty

Institution

Unit

Venue

Michael Fill

Rush University

Affiliations

College of Health Sciences

Department Of Clinical Nutrition

Department Of Molecular Biophysics And Physiology

Rush University

NoneMichael Fill is currently serving as a College Of Health Sciences faculty at Rush University.

Honors

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Experiences

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Education

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Michael Fill

Rush University

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physiology molecular physiology electrophysiology receptors cellular physiology pharmacology cardiovascular physiology signal transduction neuroscience cardiology cardiovascular research neurophysiology cell biology receptor (biochemistry) cell physiology membrane biology circulatory physiology cardiac muscle neurotransmission molecular pharmacology cell signaling pharmacological research applied physiology cardiovascular pharmacology protein science cellular biochemistry human physiology cardiomyopathy muscle function skeletal muscle medicinal research biological chemistry molecular cell biology cardiovascular function mechanisms of action membrane transport animal physiology enzyme inhibition vascular biology biophysical review clinical physiology cardiac mechanics cardiac pathologies g protein-coupled receptor ventricular myocytes addiction biology chronobiology molecular neurobiology physiological regulation signaling pathways alcohol misuse experimental biophysics biophysical modeling veterinary physiology experimental pharmacology tissue physiology cellular neurobiology unitary ca2+ current common defect ryanodine receptor adaptation single channel function calcium regulation ca2+ release intermittently connected device localized excited state dependently typed programming in vivo systems bcl-xl forms synthetic lipid membranes ion channel isoform-specific function functional reconstitution ventricular cardiac myocytes quasi-physiological ionic conditions luminal ca2+ regulation ryr2 mutations associated biochemistry neuropsychopharmacology molecular neuroscience neurons molecular biology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Age‐Dependent Effects of Muscle Resting Calcium on Fasting Blood Glucose: Implications for Prediabetes Risk. Endocrinology Diabetes & Metabolism (2025)

sarcopeniamuscle resting calciumhealth sciencesage‐dependent effectsfasting blood glucosediabetic neuropathymetabolic syndromediabetes researchdiabetesdiabetes mellitusmetabolismphysiology

Disrupting the Feed-Forward Cycle of Ryr1 Ca 2+ Leak and Oxidative Stress Mitigates Doxorubicin-Induced Skeletal Myopathy. bioRxiv (Cold Spring Harbor Laboratory) (2025)

skeletal musclefeed-forward cyclesignal transductionmuscular dystrophiescell metabolismmolecular physiologybiochemistrymechanobiologyoxidative stresscellular physiologymyositiscell biologycell physiologymusculoskeletal disordersmuscle functionphysiology

Abstract Mo065: An Anti-Arrhythmic Action and Novel Molecular Mechanisms of Alda-1 in Holiday Heart Syndrome. Circulation Research (2024)

Saugat KhanalJiajie YanYuanyuan CaoNikola RicchiutiAlma NaniWayne ChenMichael FillDan BareXun Ai

anti-arrhythmic actioncongenital heart defectsmolecular evidencecardiac pathologiesbiochemistrycerebral blood flowmechanobiologycardiomyopathyholiday heart syndromevascular biologycardiovascular diseaseheart failurenovel molecular mechanismscardiovascular researchcardiologyimmunologyhealth sciencescardiovascular pharmacologymetabolic syndromeatherosclerosismedicinal research

Alda-1 Attenuation of Binge Alcohol-Caused Atrial Arrhythmias Through a Novel Mechanism of Suppressed C-Jun N-Terminal Kinase-2 Activity. Journal of Molecular and Cellular Cardiology (2024)

Jiajie YanSaugat KhanalYuanyuan CaoNikola RicchiutiAlma NaniS.R. Wayne ChenMichael FillDan J. BareXun Ai

alcohol (drug)cardiovascular physiologysubstance use disordersalcohol misusecardiovascular researchmechanisms of actioncardiologycardiac musclecardiac pathologiesbiochemistrymechanobiologymolecular biologyaddiction biologycirculatory physiologymolecular and cellular biologynovel mechanismphysiology

Inositol 1,4,5-Trisphosphate Receptor 1 Gain-Of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans. Circulation (2024)

Bo SunMingke NiYanhui LiZhenpeng SongHui WangHai-Lei ZhuJinhong WeiDarrell BelkeShitian CaiWenting GuoJinjing YaoShanshan TianJohn Paul EstilloreRuiwu WangMads Toft SondergaardMalene BrohusPalle Duun RohdeYongxin MuAlexander VallmitjanaRaul BenitezLeif Hove-MadsenMichael Toft OvergaardGlenn I. FishmanJu ChenShubhayan SanataniArthur A.M. WildeMichael FillJosefina Ramos-FrancoMette NyegaardS.R. Wayne Chen

thrombosisbiochemistrycerebral blood flowcardiovascular physiologymolecular physiologyvascular biologyreceptorscardiovascular researchcardiac arrhythmiascardiologyneuropeptide receptorsimmunologyblood flowreceptor (biochemistry)cardiac mechanicscell signalingneuropharmacologygain-of-function increaseselectrophysiologyphysiology

Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals. The Journal of Membrane Biology (2024)

Catherine CarvajalJiajie YanAlma NaniJaime DeSantiagoXiaoping WanIsabelle DeschenesXun AiMichael Fill

biologymembrane biologyreceptorsmembranesmammalian biologymammalian physiology

Ligand Sensitivity of Type-1 Inositol 1,4,5-Trisphosphate Receptor is Enhanced by the D2594K Mutation. Pflügers Archiv - European Journal of Physiology (2023)

pharmacological researchreceptorsmolecular cell biologysignal transductionbiological chemistryreceptor (biochemistry)mechanisms of actionligand sensitivityenzyme inhibitionbiochemistrymolecular biologyd2594k mutationg protein-coupled receptorcellular pharmacologycell biologymolecular pharmacologycellular biochemistry

A Gain‐of‐Function Mutation in the Itpr1 Gating Domain Causes Male Infertility in Mice. Journal of Cellular Physiology (2022)

Bo SunMingke NiShanshan TianWenting GuoShitian CaiMads T. SondergaardYongxiang ChenYongxin MuJohn P. EstilloreRuiwu WangJu ChenMichael T. OvergaardMichael FillJosefina Ramos‐FrancoMette NyegaardSui Rong Wayne Chen

geneticsinfertilityreproductive physiologyreproductive biologymolecular biologycellular physiologyfertilitygain-of-function mutationcell biology

Cardiac Ryanodine Receptor Calcium Release Deficiency Syndrome. Science Translational Medicine (2021)

pharmacologycardiovascular physiologyreceptorscardiovascular researchmolecular physiologycellular physiologycardiomyopathycirculatory physiologymolecular pharmacologyelectrophysiologyphysiology

Simulating Cardiac Ca2+ Release Units: Effects of Ryr Cluster Size and Ca2+ Buffers on Diastolic Ca2+ Leak. Pflügers Archiv - European Journal of Physiology (2021)

cardiovascular physiologycritical carecardiovascular researchca2+ bufferscardiologycardiac mechanicsryr cluster sizediastolic ca2+ leakcardiovascular interventionscirculatory physiologycardiovascular functionelectrophysiologyphysiology

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Michael Fill

Rush University

Affiliations

College of Health Sciences

Department Of Clinical Nutrition

Department Of Molecular Biophysics And Physiology

Rush University

NoneMichael Fill is currently serving as a College Of Health Sciences faculty at Rush University.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael Fill

Rush University

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Age‐Dependent Effects of Muscle Resting Calcium on Fasting Blood Glucose: Implications for Prediabetes Risk. Endocrinology Diabetes & Metabolism (2025)

sarcopeniamuscle resting calciumhealth sciencesage‐dependent effectsfasting blood glucosediabetic neuropathymetabolic syndromediabetes researchdiabetesdiabetes mellitusmetabolismphysiology

Disrupting the Feed-Forward Cycle of Ryr1 Ca 2+ Leak and Oxidative Stress Mitigates Doxorubicin-Induced Skeletal Myopathy. bioRxiv (Cold Spring Harbor Laboratory) (2025)

Abstract Mo065: An Anti-Arrhythmic Action and Novel Molecular Mechanisms of Alda-1 in Holiday Heart Syndrome. Circulation Research (2024)

Saugat KhanalJiajie YanYuanyuan CaoNikola RicchiutiAlma NaniWayne ChenMichael FillDan BareXun Ai

Alda-1 Attenuation of Binge Alcohol-Caused Atrial Arrhythmias Through a Novel Mechanism of Suppressed C-Jun N-Terminal Kinase-2 Activity. Journal of Molecular and Cellular Cardiology (2024)

Jiajie YanSaugat KhanalYuanyuan CaoNikola RicchiutiAlma NaniS.R. Wayne ChenMichael FillDan J. BareXun Ai

Inositol 1,4,5-Trisphosphate Receptor 1 Gain-Of-Function Increases the Risk for Cardiac Arrhythmias in Mice and Humans. Circulation (2024)

Isolated Cardiac Ryanodine Receptor Function Varies Between Mammals. The Journal of Membrane Biology (2024)

Catherine CarvajalJiajie YanAlma NaniJaime DeSantiagoXiaoping WanIsabelle DeschenesXun AiMichael Fill

biologymembrane biologyreceptorsmembranesmammalian biologymammalian physiology

Ligand Sensitivity of Type-1 Inositol 1,4,5-Trisphosphate Receptor is Enhanced by the D2594K Mutation. Pflügers Archiv - European Journal of Physiology (2023)

A Gain‐of‐Function Mutation in the Itpr1 Gating Domain Causes Male Infertility in Mice. Journal of Cellular Physiology (2022)

geneticsinfertilityreproductive physiologyreproductive biologymolecular biologycellular physiologyfertilitygain-of-function mutationcell biology

Cardiac Ryanodine Receptor Calcium Release Deficiency Syndrome. Science Translational Medicine (2021)

pharmacologycardiovascular physiologyreceptorscardiovascular researchmolecular physiologycellular physiologycardiomyopathycirculatory physiologymolecular pharmacologyelectrophysiologyphysiology

Simulating Cardiac Ca2+ Release Units: Effects of Ryr Cluster Size and Ca2+ Buffers on Diastolic Ca2+ Leak. Pflügers Archiv - European Journal of Physiology (2021)

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