Faculty

Institution

Unit

Venue

Michael B. Dwinell

Professor; Founding Director Center for Immunology; Director Bobbie Nick Voss Laboratory for Colon Cancer Research; Hanis-Stepka-Rettig Endowed Chair in Cancer Research

Medical College of Wisconsin

Affiliations

Biochemistry Department

Center for Infectious Disease Research

Graduate School

Microbiology & Immunology

Pancreatic Cancer Program

Michael B. Dwinell is currently serving as a Biochemistry Professor; Founding Director Center for Immunology; Director Bobbie Nick Voss Laboratory for Colon Cancer Research; Hanis-Stepka-Rettig Endowed Chair in Cancer Research at Medical College of Wisconsin.

Honors

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Experiences

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Education

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Michael B. Dwinell

Medical College of Wisconsin

Professor; Founding Director Center for Immunology; Director Bobbie Nick Voss Laboratory for Colon Cancer Research; Hanis-Stepka-Rettig Endowed Chair in Cancer Research

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cell biology tumor biology cancer cells immunology cell signaling cancer research cancer biology oncology pharmacology molecular biology immune responses gastroenterology medicinal research oncogenes digestive diseases pancreatic cancer digestive tract inflammation metastasis molecular cancer molecular gastroenterology mucosal immunology liver physiology cellular physiology molecular physiology cell regulation vascular biology biological chemistry cellular therapy tumor targeting cancer treatment cell migration signaling pathways redox biology colorectal cancer cytokines drug targeting receptor (biochemistry) enzyme inhibition redox signaling gastrointestinal oncology cellular immune responses cancer immunosurveillance mitochondrial bioenergetics free radical biology reproductive immunology angiogenesis molecular regulation gut-organ axis translational physiology intracellular trafficking immunogenetics immunopathology therapeutic targeting related signaling pathways tumor mitochondria lipophilic cationic compounds chemokine receptors antiproliferative effects cyclic amp receptor tyrosine kinases protein expression immunoediting t-regulatory cell tumor suppressors cancer genetics cancer genomics genitourinary cancers angiogenic effects immune cells tumor microenvironment models chemokine receptor expression interferon-inducible t-cell chemoattractants mouse models dna hypermethylation colonic carcinoma metastasis signal transduction pathology inflammatory bowel disease

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cxcl12 Chemokine Dimer Signaling Modulates Acute Myelogenous Leukemia Cell Migration Through Altered Receptor Internalization. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Donovan DrouillardMichael HalykoElizabeth CinquegraniDonna McAllisterFrancis C. PetersonAdriano MarcheseMichael B. Dwinell

cell signalingcell biologyhematological malignanciessignaling pathwaysleukemiareceptor internalizationmolecular biologysystems biologyreceptorscancer biologycytokines

Low-Dose Orthotopic Cancer Implantation Permits Measurement of Longitudinal Functional Changes Associated With Cachexia.. J Appl Physiol (1985) (2024)

radiation oncologylongitudinal functional changesradiologycancer researchcancer managementcancer treatmentcancer lettercancer careoncology

A Modified Elisa Assay Differentiates Ccl20 Locked Dimers From Wild-Type Monomers. Journal of Immunological Methods (2023)

Xuesong WuWilliam R. ClarkeChad A. KoplinskiFrancis C. PetersonMichael B. DwinellGrace WeiEllen ChaoMindy HuynhDaisuke YamadaBrian F. VolkmanSamuel T. Hwang

immunologylaboratory immunology

Fragment-Based Drug Discovery of Small Molecule Ligands for the Human Chemokine Ccl28. SLAS Discov (2023)

fragment-based drug discoverydrug targetsmedicinal researchsmall molecule ligandsmolecular dockingsmall moleculessmall molecule librarypharmacologytherapeutic targetsdrug discoverypharmacological researchbiomolecular engineeringhuman chemokine ccl28

Gait Speed is a Biomarker of Cancer-Associated Cachexia Decline and Recovery.. bioRxiv (2023)

cancer caregait analysishuman movementgait speedmovement disorderscancer-associated cachexia declinekinesiologycancer researchpathological gaitmovement analysisapplied physiologyrehabilitationoncology

Increased Cxcl10 is Seen at 1-Year After Autologous Hematopoietic Cell Transplantation in Multiple Myeloma Patients on Maintenance Lenalidomide Therapy. Front Immunol (2023)

radiation oncologyimmunologycell transplantationhematological malignancieshematologybone marrow transplantationmaintenance lenalidomide therapymultiple myeloma patientsoncologymalignant blood disorders

Physiology of Chemokines in the Cancer Microenvironment.. Bone Marrow Transplant (2023)

cancer microenvironmentradiation oncologybiological microenvironmentscancer researchtumor microenvironmentcancer cellsoncology

Synthesis of Fluorinated Triphenylphosphonium Analogs That Improve Cancer Cell Selectivity and in Vivo Detection.. STAR Protoc (2023)

radiation oncologytumor targetingvivo detectionfluorous synthesisdrug targetinganti-cancer agentsmedicinal chemistrycancer imagingcancer cell selectivitycancer discoveryfluorinated triphenylphosphonium analogspharmacologydrug discoverycancer cellsfluorescence

The C-Terminal Peptide of Ccl21 Drastically Augments Ccl21 Activity Through the Dendritic Cell Lymph Node Homing Receptor Ccr7 by Interaction With the Receptor N-Terminus. Cell Mol Life Sci (2023)

immunologyc-terminal peptidecellular immune responsesccl21 activityadaptive immune systemcell researchcell signalingcell biologypeptidesimmunity (medicine)receptorsreceptor ccr7immunologic mechanismsmolecular immunologyreceptor (biochemistry)molecular physiologymolecular cell biologyimmune responsessignal transduction

Dna Methylation in Circulating Leukocytes is a Novel Biomarker in Multiple Myeloma. Bone Marrow Transplantation (2022)

Anita D’SouzaRuta BrazauskasBi Qing TengGrant YunHannah UttleyJing DongMichael B. DwinellMarcelo C. PasquiniSergio GiraltHeather LandauEdward StadtmauerAmrita KrishnanSiegfried Janz

biomarker discoveryimmunologydermatologybone marrow transplantationpharmacologydna methylationmultiple myelomatransplantation medicinenovel therapieshematologycancer researchbiomarkersbiomarker (medicine)medicinal researchcellular therapyregenerative medicinenovel biomarkercell transplantationclinical transplantationoncologynucleic acid biomarkers

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Michael B. Dwinell

Professor; Founding Director Center for Immunology; Director Bobbie Nick Voss Laboratory for Colon Cancer Research; Hanis-Stepka-Rettig Endowed Chair in Cancer Research

Medical College of Wisconsin

Affiliations

Biochemistry Department

Center for Infectious Disease Research

Graduate School

Microbiology & Immunology

Pancreatic Cancer Program

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Michael B. Dwinell

Medical College of Wisconsin

Professor; Founding Director Center for Immunology; Director Bobbie Nick Voss Laboratory for Colon Cancer Research; Hanis-Stepka-Rettig Endowed Chair in Cancer Research

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Cxcl12 Chemokine Dimer Signaling Modulates Acute Myelogenous Leukemia Cell Migration Through Altered Receptor Internalization. bioRxiv (Cold Spring Harbor Laboratory) (2024)

Donovan DrouillardMichael HalykoElizabeth CinquegraniDonna McAllisterFrancis C. PetersonAdriano MarcheseMichael B. Dwinell

cell signalingcell biologyhematological malignanciessignaling pathwaysleukemiareceptor internalizationmolecular biologysystems biologyreceptorscancer biologycytokines

Low-Dose Orthotopic Cancer Implantation Permits Measurement of Longitudinal Functional Changes Associated With Cachexia.. J Appl Physiol (1985) (2024)

radiation oncologylongitudinal functional changesradiologycancer researchcancer managementcancer treatmentcancer lettercancer careoncology

A Modified Elisa Assay Differentiates Ccl20 Locked Dimers From Wild-Type Monomers. Journal of Immunological Methods (2023)

Xuesong WuWilliam R. ClarkeChad A. KoplinskiFrancis C. PetersonMichael B. DwinellGrace WeiEllen ChaoMindy HuynhDaisuke YamadaBrian F. VolkmanSamuel T. Hwang

immunologylaboratory immunology

Fragment-Based Drug Discovery of Small Molecule Ligands for the Human Chemokine Ccl28. SLAS Discov (2023)

Gait Speed is a Biomarker of Cancer-Associated Cachexia Decline and Recovery.. bioRxiv (2023)

Increased Cxcl10 is Seen at 1-Year After Autologous Hematopoietic Cell Transplantation in Multiple Myeloma Patients on Maintenance Lenalidomide Therapy. Front Immunol (2023)

Physiology of Chemokines in the Cancer Microenvironment.. Bone Marrow Transplant (2023)

cancer microenvironmentradiation oncologybiological microenvironmentscancer researchtumor microenvironmentcancer cellsoncology

Synthesis of Fluorinated Triphenylphosphonium Analogs That Improve Cancer Cell Selectivity and in Vivo Detection.. STAR Protoc (2023)

The C-Terminal Peptide of Ccl21 Drastically Augments Ccl21 Activity Through the Dendritic Cell Lymph Node Homing Receptor Ccr7 by Interaction With the Receptor N-Terminus. Cell Mol Life Sci (2023)

Dna Methylation in Circulating Leukocytes is a Novel Biomarker in Multiple Myeloma. Bone Marrow Transplantation (2022)

Anita D’SouzaRuta BrazauskasBi Qing TengGrant YunHannah UttleyJing DongMichael B. DwinellMarcelo C. PasquiniSergio GiraltHeather LandauEdward StadtmauerAmrita KrishnanSiegfried Janz

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