Faculty

Institution

Unit

Venue

Mayra Shanley

The University of Texas MD Anderson Cancer Center

Affiliations

Institute for Cell Therapy Discovery & Innovation

Mayra Shanley is a Senior Professor at The University of Texas MD Anderson Cancer Center. Her research focuses on cancer immunotherapy, cellular therapy, and cell biology, with a particular emphasis on engineering natural killer (NK) cells for adoptive cell therapy. Her latest work explores mitochondrial fitness and metabolic supercharging of NK cells via IL-21 and adenoviral E4ORF-1, universal multi-receptor NK cell platforms for synergy with antibody and T-cell engager therapies, CD5-directed CAR5/IL-15 NK cells for T-cell malignancies, and agent-based modeling of cellular dynamics in adoptive cell therapy. She also investigates oncolytic virus-induced AP-1 and IRF signaling to sustain anti-tumor NK activity, with publications in Communications Biology and Cancer Research.

Honors

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Experiences

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Education

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Mayra Shanley

The University of Texas MD Anderson Cancer Center

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immunology cellular therapy cell biology cancer immunotherapy immune responses cancer cells cellular immune responses medicinal research tumor biology cancer research cell therapy cancer biology hematology oncology cell transplantation nk cells adaptive immune system medicine dermatology stem cell research cell death leukemia immune checkpoint inhibitors therapeutic targets gene therapy brain tumor research oncogenes cord blood cancer immunosurveillance vascular biology tumor targeting novel therapies anti-cancer agents hematological malignancies clinical immunology pharmacotherapy bone marrow transplantation cancer care cancer treatment innate immune system therapeutic efficacy tumor heterogeneity brain-immune interaction biological therapies t-regulatory cell cancer genetics crispr gene editing immunological memory regulatory checkpoint adoptive cell therapy clinical investigation cell metabolism science advance cytokines science studies viral persistence immunopathology immunogenetics metabolic profiling mesenchymal stem cells stem-cell therapy lymphoid neoplasia cytokine checkpoint glioblastoma stem cells cytokine engineering car-nk cell therapy antitumor activity gmp-compliant universal antigen metabolic fitness metabolic competition genome-wide crispr screens critical targets major driver cbti mscs metabolic reprogramming

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 142: A Universal Multi-Receptor Nk Cell Platform Engineered for Synergistic Combination With Antibody and T-Cell Engager Therapies.. Cancer Research (2026)

immunologycell engineeringabstract 142cell therapysynthetic immunologycellular immune responsessynergistic combinationbiomolecular engineeringimmune responsescell transplantationimmunomodulationcellular therapyt-cell engager therapiesimmunotherapycell biology

Abstract 5187: Il-21-Enhanced Nk Cells: A Mitochondrial Fitness Enhancement for Targeting Glioblastoma Stem Cells. Cancer Research (2026)

immunologystem cell researchcell therapycellular immune responsesimmunologic mechanismsbrain tumor researchcancer immunotherapycellular therapymitochondrial fitness enhancementstem cellsil-21-enhanced nk cellscancer cellsabstract 5187tumor biologyimmunotherapycell biology

Abstract 5194: Oncolytic Virus Infected Tumors Drive Ap-1 and Irf Signaling in Nk Cells to Sustain Anti Tumor Activity. Cancer Research (2026)

immunologyabstract 5194cell deathoncolytic viruscell signalingimmune checkpoint inhibitorsnk cellsoncogenescancer cellstumor biologyviral oncologyimmunotherapycell biology

Abstract 5197: Metabolically Supercharged Nk Cells Engineered With Adenoviral E4Orf-1. Cancer Research (2026)

antiviral researchcell engineeringbiomolecular engineeringantiviral responsesnk cellscellular therapysynthetic biologyviral oncologycell biology

Abstract 5204: Cd5-Directed Car5/Il-15 Nk Cells as a Therapeutic Platform for T-Cell Malignancies. Cancer Research (2026)

immunologytherapeutic platformcellular immune responsest-cell malignanciescancer immunotherapyimmune responsescancer cellsimmunomodulationcellular therapyabstract 5204immunotherapycell biology

Abstract 5206: Mitochondrial Remodeling Sustains Car-Nk Stemness for Superior Tumor Control. Cancer Research (2026)

immunologymitochondrial dynamicsabstract 5206stem cell researchsustains car-nk stemnessmitochondrial functioncellular therapysuperior tumor controlstem cellscancer cellstumor microenvironmentcancer biologytumor biologycell biology

Agent-Based Modeling of Cellular Dynamics in Adoptive Cell Therapy. Communications Biology (2026)

biomedical modelingcell engineeringadoptive cell therapycell transplantationtheoretical biologycellular therapycell biology

Abstract 6396: Crem is a Regulatory Checkpoint of Car and Il-15 Signaling in Nk Cells. Cancer Research (2025)

Hind RafeiRafet BasarSunil AcharyaYu-Sung HsuPinghua LiuDeqiang ZhangQingnan LiangVakul MohantyRanjan UpadhyayPing LiPravin PhadatareMerve DedeDonghai XiongCorry JonesMay DaherAna Karen Nunez CortesMayra ShanleyBin LiuSadie M. MoseleyPatrick ZhangDexing FangPinaki BanerjeeNadima UpretyYe LiRejeena ShresthaXinhai WanHong ShenVernikka WoodsApril GilbertSeema RawalJinzhuang DouYukun TanJeong-Min ParkFrancia Reyes SilvaAlexander BiederstädtMecit KaplanXin Ru JiangInci BiederstädtSilvia TibertiMadison MooreJingling JinLuis Muniz-FelicianoPaul LinGary M. DeyterNatalie W. FowlkesAbhinav JainDavid MarinKen ChenElizabeth ShpallKatayoun Rezvani

cancer researchnk cellsregulatory checkpointcancer biology

Crem is a Regulatory Checkpoint of Car and Il-15 Signalling in Nk Cells. Nature (2025)

Hind RafeiRafet BasarSunil AcharyaYu-Sung HsuPinghua LiuDeqiang ZhangToszka BohnQingnan LiangVakul MohantyRanjan UpadhyayPing LiPravin PhadatareMerve DedeDonghai XiongHuihui FanCorry Mathew JonesSebastian KunzMay DaherAna Karen Nunez CortesMayra ShanleyBin LiuSadie Mae MoseleyChenyu ZhangDexing FangPinaki BanerjeeNadima UpretyYe LiRejeena ShresthaXinhai WanHong ShenVernikka WoodsApril Lamour GilbertSeema RawalJinzhuang DouYukun TanJeong-Min ParkFrancia Reyes SilvaAlexander BiederstädtMecit KaplanXin Ru JiangInci BiederstädtBijender KumarSilvia TibertiMadison MooreJingling JinRyan Z YangLuis Muniz-FelicianoSamuel RosemorePaul LinGary M DeyterNatalie Wall FowlkesAbhinav K JainDavid MarinAnirban MaitraKen ChenTobias BoppElizabeth J ShpallKatayoun Rezvani

novel therapiesregulatory checkpointtumor heterogeneitytherapeutic efficacypathologyliver physiologystem cell researchvascular biologycancer biologyinflammationdermatologyleukemiatherapeutic targetstumor biologygene expressionpharmacologyviral persistencegliomasmedicinal researchnk cells

Genome-Wide Crispr Screens Identify Critical Targets to Enhance Car-Nk Cell Antitumor Potency. Cancer Cell (2025)

immunologycritical targetsgene editinggenome editingnovel therapiescancer immunotherapycancer cellsgenome-wide crispr screenscellular therapycrisprcell biology

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Mayra Shanley

The University of Texas MD Anderson Cancer Center

Affiliations

Institute for Cell Therapy Discovery & Innovation

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Mayra Shanley

The University of Texas MD Anderson Cancer Center

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Abstract 142: A Universal Multi-Receptor Nk Cell Platform Engineered for Synergistic Combination With Antibody and T-Cell Engager Therapies.. Cancer Research (2026)

Abstract 5187: Il-21-Enhanced Nk Cells: A Mitochondrial Fitness Enhancement for Targeting Glioblastoma Stem Cells. Cancer Research (2026)

Abstract 5194: Oncolytic Virus Infected Tumors Drive Ap-1 and Irf Signaling in Nk Cells to Sustain Anti Tumor Activity. Cancer Research (2026)

immunologyabstract 5194cell deathoncolytic viruscell signalingimmune checkpoint inhibitorsnk cellsoncogenescancer cellstumor biologyviral oncologyimmunotherapycell biology

Abstract 5197: Metabolically Supercharged Nk Cells Engineered With Adenoviral E4Orf-1. Cancer Research (2026)

antiviral researchcell engineeringbiomolecular engineeringantiviral responsesnk cellscellular therapysynthetic biologyviral oncologycell biology

Abstract 5204: Cd5-Directed Car5/Il-15 Nk Cells as a Therapeutic Platform for T-Cell Malignancies. Cancer Research (2026)

immunologytherapeutic platformcellular immune responsest-cell malignanciescancer immunotherapyimmune responsescancer cellsimmunomodulationcellular therapyabstract 5204immunotherapycell biology

Abstract 5206: Mitochondrial Remodeling Sustains Car-Nk Stemness for Superior Tumor Control. Cancer Research (2026)

Agent-Based Modeling of Cellular Dynamics in Adoptive Cell Therapy. Communications Biology (2026)

biomedical modelingcell engineeringadoptive cell therapycell transplantationtheoretical biologycellular therapycell biology

Abstract 6396: Crem is a Regulatory Checkpoint of Car and Il-15 Signaling in Nk Cells. Cancer Research (2025)

cancer researchnk cellsregulatory checkpointcancer biology

Crem is a Regulatory Checkpoint of Car and Il-15 Signalling in Nk Cells. Nature (2025)

Genome-Wide Crispr Screens Identify Critical Targets to Enhance Car-Nk Cell Antitumor Potency. Cancer Cell (2025)

immunologycritical targetsgene editinggenome editingnovel therapiescancer immunotherapycancer cellsgenome-wide crispr screenscellular therapycrisprcell biology

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