Faculty

Institution

Unit

Venue

Mary J. Kelley

Associate Professor of Ophthalmology

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Department Of Ophthalmology

Institute Of Casey Eye

Oregon Health & Science University

Mary J. Kelley is an Associate Professor of Ophthalmology at Oregon Health & Science University. Her research integrates biomedical engineering, biomechanics, and cell biology to investigate the mechanobiology of the trabecular meshwork and its role in glaucoma pathogenesis. Her recent work employs advanced techniques such as 3D traction force microscopy to characterize segmental mechanobiology, flow-dependent traction, and matrix stiffness effects on cytoskeletal dynamics and collagen reorganization in normal and glaucomatous tissues. She has also explored actin-microtubule synergy in force transmission and ROCK/YAP-TAZ inhibition pathways, alongside genetic studies of VEGF polymorphisms in diabetic retinopathy.

Honors

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Experiences

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Education

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Mary J. Kelley

Oregon Health & Science University

Associate Professor of Ophthalmology

You can click a keyword to filter the displayed items

cell biology ophthalmology trabecular meshwork cellular physiology matrix biology biomedical engineering biomechanics mechanobiology glaucoma extracellular matrix molecular cell biology trabecular meshwork cells cell research cell biomechanics cell-matrix interactions biophysics visual science tissue (biology) ocular surface ophthalmology retina stem cell research signaling pathways mechanotransduction experimental ophthalmology cytoskeleton ocular disease ocular tissues medical optical imaging vascular biology biomedical imaging vision research ocular pathology aqueous humour adult stem cells cell regulation outflow facility cellular biology stem-cell therapy cell physiology mechanical stretching hypertension circulatory physiology cardiovascular research biomedical modeling biomedical flows anatomical model retina induced pluripotent stem cells metalloproteins biofluid dynamics intraocular pressure regulation traction forces biofabrication hearing research craniofacial research enzyme inhibition eye health blood pressure soft tissue reconstruction tissue imaging in vivo systems treatment and prevention vascular adaptation clinical medicine feedback loop extracellular matrix turnover outflow resistance intraocular pressure homeostasis glaucomatous outflow regulation open-angle glaucoma calpain ii selenite cataract alpha-crystallin chaperone activity glycosaminoglycan biosynthesis perfusion culture ocular hypertension

Notable Scholarly Works

Notable Federal Grants

Collaborators

Flow-Dependent Traction in High- and Low-Flow Normal Trabecular Meshwork Cells. Acta Biomaterialia (2026)

biophysicscellular physiologybiomedical engineeringcell biomechanicsmatrix biologymechanotransductionmechanobiologybiomechanicsflow-dependent traction

Segmental Mechanobiology of Normal and Glaucomatous Human Trabecular Meshwork Cells. ACS Measurement Science Au (2026)

glaucomasegmental mechanobiologyophthalmologybiomedical engineeringocular surfacematrix biologymechanobiologyocular tissuestrabecular meshworkbiomechanicsocular surface physiology

3D Traction Force Microscopy in Human Trabecular Meshwork Tissues: Effects of Rock and Yap/Taz Inhibition in Normal and Glaucomatous Tissues. Tissue and Cell (2025)

glaucomabiophysicsophthalmologybiomedical engineeringtraction force microscopyocular surfacecell biomechanicsmatrix biologytissue physiologymechanobiologyocular tissuesophthalmology retinatrabecular meshworktissue (biology)yap/taz inhibitionglaucomatous tissues

A Case-Control Study of Promoter and 5'Utr Vegf Polymorphisms in Diabetic Retinopathy. Biomedical Papers (2025)

human polymorphismsgene expressiondiabetesophthalmologyophthalmology retinadiabetic retinopathyretinavegf polymorphismsgeneticscase-control studydiabetic medicinegenetic determinantspathologyhuman geneticsdiabetes researchocular diseasegenetic epidemiology

Actin-Microtubule Synergy Dominates Force Transmission and Collagen Strain in Human Trabecular Meshwork. Acta Biomaterialia (2025)

human trabecular meshworkcellular structuremolecular motorsbiophysicsactin-microtubule synergy dominatesbiomedical engineeringcytoskeletoncellular physiologycell motilitycollagen straincell biomechanicsmatrix biologymechanotransductionmechanobiologybiomechanicscell biology

Matrix Stiffness Regulates Traction Forces, Cytoskeletal Dynamics, and Collagen Reorganization in Trabecular Meshwork Cells in Glaucoma. Matter (2025)

ophthalmologycellular physiologycytoskeletonmatrix stiffnesscell biomechanicsmatrix biologymechanotransductioncell-matrix interactionsmechanobiologytraction forcestrabecular meshworkbiomechanicscollagen reorganizationcell biology

Protocols for Tm Cell Replacement Using Differentiated Tm-Like Induced Pluripotent Stem Cells (Ipsc). BENTHAM SCIENCE PUBLISHERS eBooks (2025)

cell engineeringstem cell researchbiomedical engineeringregenerative medicinetissue engineeringstem-cell therapystem cellscellular differentiationcellular therapyinduced pluripotent stem cellscell biology

Response to “Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway”. Investigative Ophthalmology & Visual Science (2025)

biofluid dynamicsbiophysicsfluid dynamicssystems biologyfluid-solid interactionsscientific concernsfluid mechanicsfluid sciencefluid flow

Comparative Analysis of Traction Forces in Normal and Glaucomatous Trabecular Meshwork Cells Within a 3D, Active Fluid-Structure Interaction Culture Environment. Acta Biomaterialia (2024)

Alireza KarimiMini AgaTaaha KhanSiddharth Daniel D'costaOmkar ThawareElizabeth WhiteMary J. KelleyHaiyan GongTed S. Acott

materials sciencebiomedical engineeringmechanical engineeringtissue engineeringcell biomechanicsbiomaterialstraction forcesbiomechanicsmechanical science

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Investigative Ophthalmology & Visual Science (2024)

Ted S. AcottMichael P. FautschWeiming MaoC. Ross EthierAlex S. HuangMary J. KelleyMini AgaSanjoy K. BhattacharyaTerete BorrasDiane BovenkampUttio Roy ChowdhuryAbbot F. ClarkMohammed I. DibasYiqin DuMichael H. ElliottJennifer A. FaralliHaiyan GongSamuel HerbergMurray A. JohnstonePaul L. KaufmanKate E. KellerRuth A. KellyDavid KrizajMarkus H. KuehnHoi Lam LiRaquel LiebermanShan C. LinYutao LiuFiona S. McDonnellColleen M. McDowellGillian J. McLellanPhilip MzykKayarat Saidas NairDarryl R. OverbyDonna M. PetersVijayKrishna RaghunathanPonugoti Vasantha RaoGavin W. RoddyNajam A. SharifMyoung Sup ShimYang SunBenjamin R. ThomsonCarol B. TorisColin E. WilloughbyHao F. ZhangThomas F. FreddoRudolf FuchshoferKamisha R. HillAlireza KarimiKrishnakumar KizhatilCasey C. KopcyznskiPaloma LitonGaurang PatelMichael PengPadmanabhan P. PattabiramanGanesh PrasannaEster Reina-TorresE. Griffen SamplesJohn R. SamplesCynthia L. SteelClemens A. StrohmaierPreeti SubramanianChenna Kesavulu SugaliJoseph van Batenburg-SherwoodCydney WongHannah YoungbloodGulab S. ZodeElizabeth WhiteW. Daniel Stamer

medical optical imagingvisual scienceophthalmologyvision researchocular surfaceoutflow facilityocular tissuesintraocular pressure regulationexperimental ophthalmologyocular surface physiology

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Mary J. Kelley

Associate Professor of Ophthalmology

Oregon Health & Science University

Affiliations

OHSU School of Medicine

Department Of Ophthalmology

Institute Of Casey Eye

Oregon Health & Science University

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Mary J. Kelley

Oregon Health & Science University

Associate Professor of Ophthalmology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Flow-Dependent Traction in High- and Low-Flow Normal Trabecular Meshwork Cells. Acta Biomaterialia (2026)

biophysicscellular physiologybiomedical engineeringcell biomechanicsmatrix biologymechanotransductionmechanobiologybiomechanicsflow-dependent traction

Segmental Mechanobiology of Normal and Glaucomatous Human Trabecular Meshwork Cells. ACS Measurement Science Au (2026)

glaucomasegmental mechanobiologyophthalmologybiomedical engineeringocular surfacematrix biologymechanobiologyocular tissuestrabecular meshworkbiomechanicsocular surface physiology

3D Traction Force Microscopy in Human Trabecular Meshwork Tissues: Effects of Rock and Yap/Taz Inhibition in Normal and Glaucomatous Tissues. Tissue and Cell (2025)

A Case-Control Study of Promoter and 5'Utr Vegf Polymorphisms in Diabetic Retinopathy. Biomedical Papers (2025)

Actin-Microtubule Synergy Dominates Force Transmission and Collagen Strain in Human Trabecular Meshwork. Acta Biomaterialia (2025)

Matrix Stiffness Regulates Traction Forces, Cytoskeletal Dynamics, and Collagen Reorganization in Trabecular Meshwork Cells in Glaucoma. Matter (2025)

Protocols for Tm Cell Replacement Using Differentiated Tm-Like Induced Pluripotent Stem Cells (Ipsc). BENTHAM SCIENCE PUBLISHERS eBooks (2025)

Response to “Scientific Concerns About Recent Fluid-Structure Interaction Models of the Aqueous Humor Outflow Pathway”. Investigative Ophthalmology & Visual Science (2025)

biofluid dynamicsbiophysicsfluid dynamicssystems biologyfluid-solid interactionsscientific concernsfluid mechanicsfluid sciencefluid flow

Comparative Analysis of Traction Forces in Normal and Glaucomatous Trabecular Meshwork Cells Within a 3D, Active Fluid-Structure Interaction Culture Environment. Acta Biomaterialia (2024)

Alireza KarimiMini AgaTaaha KhanSiddharth Daniel D'costaOmkar ThawareElizabeth WhiteMary J. KelleyHaiyan GongTed S. Acott

materials sciencebiomedical engineeringmechanical engineeringtissue engineeringcell biomechanicsbiomaterialstraction forcesbiomechanicsmechanical science

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches. Investigative Ophthalmology & Visual Science (2024)

medical optical imagingvisual scienceophthalmologyvision researchocular surfaceoutflow facilityocular tissuesintraocular pressure regulationexperimental ophthalmologyocular surface physiology

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10 / page