Faculty

Institution

Unit

Venue

Martin McMahon

Senior Director for Preclinical Translation Efim Guzik Distinguished Professor of Cancer Biology Cumming-Presidential Professor of Cancer Biology

University of Utah

Affiliations

Spencer Fox Eccles School of Medicine

Oncological Sciences

Martin Mcmahon is currently serving as an Oncological Sciences Senior Director for Preclinical Translation Efim Guzik Distinguished Professor of Cancer Biology Cumming-Presidential Professor of Cancer Biology at University of Utah.

Honors

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Experiences

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Education

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Martin McMahon

University of Utah

Senior Director for Preclinical Translation Efim Guzik Distinguished Professor of Cancer Biology Cumming-Presidential Professor of Cancer Biology

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oncology cancer research tumor biology cancer biology pharmacology medicinal research genetics molecular biology oncogenes cancer genetics molecular cancer cell biology cancer treatment melanoma gene expression cancer genomics cell signaling leukemia skin cancer clinical research cancer care signal transduction cell regulation cancer growth mammalian biology enzyme inhibition cancer cells anti-cancer agents molecular and cellular biology tumor targeting thoracic oncology cellular therapy molecular cell biology protein science signaling pathways cancer management cellular biology molecular regulation molecular physiology cellular physiology cell research cytokines drug targeting genome biology gene function oncogenic agent medical genetics pancreatic cancer hematological malignancies apoptosis gene regulation cytokine dependency cell proliferation hematopoietic cells functional modification liver cancer cytogenetics pathway analysis cell cycle clinical medicine lung tumors malignant progression tumor suppressors cellular senescence pten loss epithelial cells biochemical properties induced expression extracellular signal-regulated kinase melanoma cells murine hematopoietic cells pancreatic cancer tumorigenesis metastatic melanoma differential activation human fibroblasts oncogenic raf metastasis radiation oncology lung cancer pathology

Notable Scholarly Works

Notable Federal Grants

Collaborators

CORRIGENDUM: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse. Cold Spring Harbor Perspectives in Medicine (2024)

Aria VaishnaviConan G. KinseyMartin McMahon

pathway-targeted therapymedicinehuman lung cancerpreclinical modelingcancer treatmentlung cancer

Figure S2 From Genetic Silencing of Akt Induces Melanoma Cell Death via Mtor Suppression. (2024)

Gennie L. ParkmanTursun TurapovDavid A. KircherWilliam J. BurnettChristopher M. StehnKayla O'TooleKatie M. CulverAshley T. ChadwickRiley C. ElmerRyan FlahertyKarly A. StanleyMona FothDavid H. LumRobert L. Judson-TorresJohn E. FriendMatthew W. VanBrocklinMartin McMahonSheri L. Holmen

dermatologycell deathleukemiamelanomacancer geneticsgenetic silencingcancer researchmtor suppressiongeneticsoncologyskin cancertumor biology

Inhibition of Ulk1/2 and Krasg12C Controls Tumor Growth in Preclinical Models of Lung Cancer. eLife (2024)

Phaedra C GhaziKayla T O'TooleSanjana Srinivas BoggaramMichael T ScherzerMark R SilvisYun ZhangMadhumita BogdanBryan D SmithGuillermina LozanoDaniel L FlynnEric L SnyderConan G KinseyMartin McMahon

cell growthpreclinical modelscancer managementcancer biologybladder cancercancer researchsurgical oncologycancer growthcancer treatmentlung cancertumor biologyimmunologypharmacologythoracic oncologyradiation oncologycancer imagingoncologyoncogenesmedicinal research

Spatial Sequencing Reveals Transcriptional Variation Between Amelanotic and Pigmented Acral Melanoma. British Journal of Dermatology (2024)

Martin McMahonDekker C Deacon

genomicsgenome biologydermatologycancer geneticspigmented acral melanomageneticscancer genomicsgenome analysismolecular biologymolecular geneticssequence analysis

Abstract 3861: C-Myc Mediated Resistance to Trametinib Plus Hydroxychloroquine in Pancreatic Cancer is Overcome by Cdk4/6 and Lysosomal Inhibition. Cancer Research (2023)

Mark SilvisDilru SilvaRohweder RileySophia SchumanSwapna GudipatyAmanda TruongJeffery YapKajsa AffolterMartin McMahonConan Kinsey

enzyme inhibitionpharmacologycancer carecancer managementradiation oncologycancer researchpancreatic cancercancer immunotherapyanti-cancer agentsoncologybreast cancerclinical researchmedicinal researchcancer treatmentlysosomal inhibitioncancer biologyhealth sciences

Abstract 427: Newer Generation Mtor Inhibition Represents Effective Therapeutic Strategy for Braf-Mutant Melanoma. Cancer Research (2023)

Gennie L. ParkmanTursun TurapovDavid KircherWilliam BurnettChristopher StehnKayla O'TooleKatie CulverAshley ChadwickRiley ElmerRyan FlahertyMona FothKarly StanleyRobert AndtbackaDavid LumRobert Judson-TorresMartin McMahonSheri Holmen

melanomacell researchcancer screeningcancer registrationcancer caremolecular cancerbreast cancereffective therapeutic strategyhealth sciencescancer researchbraf-mutant melanomaradiation therapyimmunotherapypharmacologyradiation oncologyclinical radiation oncologydrug resistanceoncologyoncogenesmedicinal research

Abstract Pr03: Cooperative Anti-Tumor Effects of Combined Inhibition of Krasg12C Plus Autophagy in Preclinical Models of Krasg12C-Driven Lung Cancer. Molecular Cancer Research (2023)

Phaedra C. GhaziConan KinseyMadhumita BogdanBryan D. SmithDaniel L. FlynnMartin McMahon

molecular researchcooperative anti-tumor effectscell researchpreclinical modelspathologycell biologyreceptor tyrosine kinasescancer genomicsmolecular cell biologyanti-cancer agentsmolecular diagnosticstumor microenvironmentmolecular evidencecombined inhibitionmolecular and cellular biologycarcinogenesispharmacologycancer discoverydrug resistanceoncogenesmolecular medicine

CORRECTION: Activation of Nfat by Hgf and Igf-1 via Arf6 and Its Effector Asap1 Promotes Uveal Melanoma Metastasis. Oncogene (2023)

Jackson R. RichardsDonghan ShinRob PryorLise K. SorensenZhonglou SunWon Mi SoGaram ParkRoger WolffAmanda TruongMartin McMahonAllie H. GrossmannJ. William HarbourWeiquan ZhuShannon J. OdelbergJae Hyuk Yoo

gene therapymetastasismelanomacancer geneticsmolecular cancercancer genomicscancer biologyleukemiauveal melanoma metastasistumor biologycarcinogenesispharmacologygeneticsmolecular biologyoncogenesmedicinal researchepigeneticsskin cancercellular therapy

Data From Pi3′-Kinase Inhibition Forestalls the Onset of Mek1/2 Inhibitor Resistance in I Braf /I -Mutated Melanoma. (2023)

Marian M. DeukerVictoria Marsh DurbanWayne A. PhillipsMartin McMahon

hematological malignanciesdermatologyleukemiapharmacologymelanomacancer geneticscancer researchmolecular cancergeneticscancer immunotherapydrug resistanceoncologyoncogenesmedicinal researchcancer biologyskin cancertumor biology

Data From Transposon Mutagenesis Reveals Rbms3 Silencing as a Promoter of Malignant Progression of Braf Sup V600E /Sup -Driven Lung Tumorigenesis. (2023)

Aria VaishnaviJoseph JuanMaebh JacobChristopher StehnEric E. GardnerMichael T. ScherzerSophia SchumanJ. Edward Van VeenBrandon MurphyChristopher S. HackettAdam J. DupuySteven A. ChmuraLouise van der WeydenJustin Y. NewbergAnnie LiuKaren MannAlistair G. RustWilliam A. WeissConan G. KinseyDavid J. AdamsAllie GrossmannMichael B. MannMartin McMahon

cancer geneticstumor targetingmolecular cancercancer genomicscancer biologycancer researchcancer growthlung cancertumor biologygene expressionthoracic oncologyradiation oncologygeneticscancer imagingmolecular biologyoncologymedicinal researchcancer cellsmalignant progression

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Martin McMahon

Senior Director for Preclinical Translation Efim Guzik Distinguished Professor of Cancer Biology Cumming-Presidential Professor of Cancer Biology

University of Utah

Affiliations

Spencer Fox Eccles School of Medicine

Oncological Sciences

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Martin McMahon

University of Utah

Senior Director for Preclinical Translation Efim Guzik Distinguished Professor of Cancer Biology Cumming-Presidential Professor of Cancer Biology

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

CORRIGENDUM: Preclinical Modeling of Pathway-Targeted Therapy of Human Lung Cancer in the Mouse. Cold Spring Harbor Perspectives in Medicine (2024)

Aria VaishnaviConan G. KinseyMartin McMahon

pathway-targeted therapymedicinehuman lung cancerpreclinical modelingcancer treatmentlung cancer

Figure S2 From Genetic Silencing of Akt Induces Melanoma Cell Death via Mtor Suppression. (2024)

dermatologycell deathleukemiamelanomacancer geneticsgenetic silencingcancer researchmtor suppressiongeneticsoncologyskin cancertumor biology

Inhibition of Ulk1/2 and Krasg12C Controls Tumor Growth in Preclinical Models of Lung Cancer. eLife (2024)

Phaedra C GhaziKayla T O'TooleSanjana Srinivas BoggaramMichael T ScherzerMark R SilvisYun ZhangMadhumita BogdanBryan D SmithGuillermina LozanoDaniel L FlynnEric L SnyderConan G KinseyMartin McMahon

Spatial Sequencing Reveals Transcriptional Variation Between Amelanotic and Pigmented Acral Melanoma. British Journal of Dermatology (2024)

Martin McMahonDekker C Deacon

genomicsgenome biologydermatologycancer geneticspigmented acral melanomageneticscancer genomicsgenome analysismolecular biologymolecular geneticssequence analysis

Abstract 3861: C-Myc Mediated Resistance to Trametinib Plus Hydroxychloroquine in Pancreatic Cancer is Overcome by Cdk4/6 and Lysosomal Inhibition. Cancer Research (2023)

Mark SilvisDilru SilvaRohweder RileySophia SchumanSwapna GudipatyAmanda TruongJeffery YapKajsa AffolterMartin McMahonConan Kinsey

Abstract 427: Newer Generation Mtor Inhibition Represents Effective Therapeutic Strategy for Braf-Mutant Melanoma. Cancer Research (2023)

Abstract Pr03: Cooperative Anti-Tumor Effects of Combined Inhibition of Krasg12C Plus Autophagy in Preclinical Models of Krasg12C-Driven Lung Cancer. Molecular Cancer Research (2023)

Phaedra C. GhaziConan KinseyMadhumita BogdanBryan D. SmithDaniel L. FlynnMartin McMahon

CORRECTION: Activation of Nfat by Hgf and Igf-1 via Arf6 and Its Effector Asap1 Promotes Uveal Melanoma Metastasis. Oncogene (2023)

Data From Pi3′-Kinase Inhibition Forestalls the Onset of Mek1/2 Inhibitor Resistance in I Braf /I -Mutated Melanoma. (2023)

Marian M. DeukerVictoria Marsh DurbanWayne A. PhillipsMartin McMahon

Data From Transposon Mutagenesis Reveals Rbms3 Silencing as a Promoter of Malignant Progression of Braf Sup V600E /Sup -Driven Lung Tumorigenesis. (2023)

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