Manu M. Sebastian, DVM, PhD

Professor Adjunct Assistant Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Pathology And Translational Molecular Pathology

Department Of Veterinary Medicine And Surgery

The University of Texas MD Anderson Cancer Center

Manu M. Sebastian, Dvm, Phd is currently serving as a Pathology And Translational Molecular Pathology Professor Adjunct Assistant Professor at The University of Texas Md Anderson Cancer Center.

Honors

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Education

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Manu M. Sebastian, DVM, PhD

The University of Texas MD Anderson Cancer Center

Professor Adjunct Assistant Professor

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cell biology tumor biology pharmacology cancer research cancer cells oncogenes therapeutic targets cancer biology pathology oncology carcinogenesis molecular cancer immunology cancer discovery toxicology cancer imaging digestive diseases colorectal cancer anti-cancer agents oncogenic agent diagnosis health informatics biomedical informatics digital medicine lymphoid neoplasia cancer genetics gastrointestinal oncology tumor suppressors novel therapies immune checkpoint inhibitors tumor targeting duodenal-jejunal bypass sleeve gastrectomy b-cell performance polyp reduction vascular biology medical image computing histopathology forensic medicine forensic toxicology arthroplasty thoracic surgery vascular surgery breast oncology computational medicine intermediate host digital pathology general surgery digestive system surgery upper gastrointestinal surgery bariatric surgery early detection dysbiosis protein assembly ulcerative colitis drug targeting knockout mice hepatocellular carcinoma liver cancer adaptive immune system positron emission tomography cancer management cancer treatment immunomodulation computational assessment gastric progenitor cells interferon gamma mouse models arginine methyltransferases sensitive spectrophotometric method equine blood antibiotic-induced dysbiosis streptozotocin-induced hyperglycemia cecal metabolome mouse model colorectal cancer development parasitology cancer letter medicine gynecologic cancers anatomical pathology surgical pathology mammalian biology anatomy oral radiology metastasis clinical investigation sarcoma animal biotechnology clinical research avian medicine radiation oncology in vitro toxicology infectious diseases veterinary medicine ovarian cancer laboratory medicine animal bioscience animal physiology tropical animal health pathogens breast cancer oral pathology livestock science thyroid dermatology veterinary science animal science infectious diseases (medical specialty) mesothelioma regulatory toxicology translational research veterinary parasitology zooarchaeology

Notable Scholarly Works

Notable Federal Grants

Collaborators

Anti-Cancer Immune Priming With β-Radioligand Therapy Using a Novel High Affinity Antibody Selectively Targeting the 4Ig-Isoform of B7-H3. Theranostics (2026)

β-radioligand therapytumor targetingcancer immunotherapyimmunologyimmunotherapycellular therapyantibody engineeringimmunomodulationimmune responsespharmacologytherapeutic targetsexperimental medicineanti-cancer immunecancer cells

Applications and Challenges of Utilizing Digital Pathology and AI-Enabled Workflows in Clinical Trials. Journal of Pathology Informatics (2026)

informaticspathologybiomedical informaticshealth informaticsdigital healthindividualized medicinetranslational researchdiagnosisclinical laboratoryradiologyhealth information sciencehealth technologycancer imagingmedicineinternal medicinedigital medicinepersonalized medicine

Potential Role of Agentic Artificial Intelligence in Toxicologic Pathology. Open MIND (2026)

The Critical Role of Standards for AI in Digital Pathology. Journal of Pathology Informatics (2026)

Abstract 271: Bmh-21, an Rna Polymerase I Inhibitor Provides a Novel Mechanism to Target ΔP53 and R248Wp53 Driven Pancreatic Cancers. Cancer Research (2025)

oncogenestumor biologymolecular medicinecell biologynucleic acidsmolecular cancercarcinogenesiscancer researchcancer discoverytranscription (biology)molecular cell biologytherapeutic targetsmolecular biologysystems biologycancer cellscancer lettertumor microenvironment

An Inducible Foxl2-Dependent Mouse Model of Ovarian Adult Type Granulosa Cell Tumor. Gynecologic Oncology (2025)

pathologycancer cellstumor biologycell biologycarcinogenesisgynecologic cancersovarian cancer

Discovery of Novel, Potent, and Orally Bioavailable Smarca2 Proteolysis-Targeting Chimeras With Synergistic Antitumor Activity in Combination With Kirsten Rat Sarcoma Viral Oncogene Homologue G12C Inhibitors. Journal of Medicinal Chemistry (2025)

oncogenesdrug targetinganti-cancer agentsmedicinal researchnovel therapiessynergistic antitumor activitycancer discoveryoncogenic agentpharmacologytherapeutic targetsdrug discoveryenzyme inhibitionbiomolecular engineering

Exth-33. the Oncolytic Adenovirus Rgdox Sensitizes the Anti-Tumor Efficacy of Immune Checkpoint Blockades in Murine Melanoma Brain Metastases Models. Neuro-Oncology (2025)

metastasisoncolytic adenovirus rgdoxcancer immunotherapyimmunologycell biologymelanomaimmunotherapybrain tumor researchcellular therapyviral oncologyanti-tumor efficacyimmune checkpoint inhibitorsimmune checkpoint blockades

Loss of Atg5 Expression in a Subset of Human Prostate Cancers Promotes Tumor Growth Through Accumulation of P62. bioRxiv (Cold Spring Harbor Laboratory) (2025)

oncogenescancer cellstumor biologyhuman prostate cancerscell deathcell biologyprostate cancercarcinogenesisprostatic diseasemolecular cell biologytumor suppressorsoncogenic agenttumor growththerapeutic targetsurologytumor microenvironmentcancer biology

Repurposing of the Macrolide Antibiotic Clarithromycin for the Prevention of Lung Cancer. Molecular Cancer Therapeutics (2025)

antimicrobial agentsinfectious diseasespharmaceuticsantibiotic resistancelung cancermacrolide antibiotic clarithromycinantimicrobial compoundsmedicinepharmacologytherapeutic targetsantibioticsantibacterial agentsdrug discovery

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Manu M. Sebastian, DVM, PhD

Professor Adjunct Assistant Professor

The University of Texas MD Anderson Cancer Center

Affiliations

Department Of Pathology And Translational Molecular Pathology

Department Of Veterinary Medicine And Surgery

The University of Texas MD Anderson Cancer Center

Manu M. Sebastian, Dvm, Phd is currently serving as a Pathology And Translational Molecular Pathology Professor Adjunct Assistant Professor at The University of Texas Md Anderson Cancer Center.

Honors