Faculty

Institution

Unit

Venue

Mark Andrew McLean

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Mark Andrew Mclean is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

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Experiences

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Education

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Mark Andrew McLean

UIUC

Research Scientist

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biochemistry biophysics biophysical chemistry molecular biology membrane proteins protein science membrane biology biological chemistry proteinlipid interaction molecular metabolism biological macromolecules cellular biochemistry enzymes chemical biology protein structure membranes membrane science drug metabolism biomolecular structure lipid chemistry biomolecular engineering biochemical sciences molecular cell biology nanodisc membrane systems molecular structure structural molecular biology pharmacological research redox biology transition metal chemistry enzyme inhibition molecular physiology molecular complexes structure-function enzyme kinetics lipid movement membrane structure cytochrome p450 mechanotransduction cell adhesion protein phosphorylation biomolecular interactions biochemical interaction cellular enzymology heme degradation heme signaling bioelectrochemistry drug targets biocatalysis carbonyl metabolism conformational studies cell-matrix interactions protein phase separation polypyridine complexes altmetric attention score cytochrome b5 md simulations cell biomechanics g protein-coupled receptor biochemical taxonomy microbial physiology microbial proteomics biochemical genetics toxicological mechanism heme homeostasis heme transport focal adhesion dynamics mechanical tension vinculin reveals regulation physiological integrin activation mechanical force native disc membrane higher order oligomers arrestin-1 binding thermotropic phase transition scaffold protein lipid domain size

Notable Scholarly Works

Notable Federal Grants

Collaborators

Kras4B–Calmodulin Interaction With Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics. Biochemistry (2024)

Shweta ShreeMark A. McLeanAndrew G. StephenStephen G. Sligar

biophysicsmembrane transportdissociation kineticsprotein transportbiological macromoleculesprotein scienceproteinlipid interactionkras4b dissociationmembrane proteinsbiochemistrymembrane biologylipid movementintracellular traffickingsignal transductionchain lengthbiophysical chemistrymolecular physiologycellular biochemistry

Selective α-Hydroxyketone Formation and Subsequent C–C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes. ACS Catalysis (2024)

Joel H. Z. LeeTom ColemanMark A. McleanMatthew N. PodgorskiEva F. HayballIsobella S. J. StoneJohn B. BruningFiona WhelanJames J. De VossStephen G. SligarStephen G. Bell

enzymesmolecular metabolismbiomolecular engineeringbiocatalysisbenzoic acidenzyme catalysisbiosynthesisbiochemistryprocess biochemistrymd simulationsenzyme inhibitioncytochrome p450

Engineering C–C Bond Cleavage Activity Into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society (2023)

Justin C. MillerJoel H. Z. LeeMark A. McleanRebecca R. ChaoIsobella S. J. StoneTara L. PukalaJohn B. BruningJames J. De VossMary A. SchulerStephen G. SligarStephen G. Bell

biochemical sciencesenzymesmolecular metabolismbiomolecular engineeringbiocatalysisalcohol dehydrogenasesbiosynthesisbiochemistrycarbonyl metabolismprocess biochemistryp450 monooxygenase enzymemolecular biologymetabolic engineeringcytochrome p450human p450 cyp17a1

Revealing Kras4B Topology on the Membrane Surface. Biochemical and Biophysical Research Communications (2023)

Shweta ShreeMark A. McLeanAndrew G. StephenStephen G. Sligar

biophysicsinterface (matter)membrane systemstopologybiomolecular structuremembrane proteinsinterface sciencemembranesmembrane biologygeometric topologymembrane sciencekras4b topologymembrane structure

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

pharmaceutical sciencesdrug metabolismpharmacological researchlipid nanodiscsnew drug candidatesdrug targetsbiochemistrypharmacologyapplied pharmacologytherapeutic targetspharmacokineticsmolecular pharmacologymd simulationsdrug discoverypharmacotherapy

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

drug metabolismmembrane surfacepharmacological researchmechanisms of actionfirst mdz moleculedrug targetsbiochemistrypharmacologyproductive sitemolecular pharmacologyenzyme inhibitiondrug discovery

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for Membrane Protein Investigations. Analytical Biochemistry (2020)

Mark A. McLeanIlia G. DenisovYelena V. GrinkovaStephen G. Sligar

biophysicsmembrane protein investigationsnanodiscprotein sciencemembrane proteinsmembrane biology

Pip2 Influences the Conformational Dynamics of Membrane-Bound Kras4b. Biochemistry (2019)

Mark A. McLeanAndrew G. StephenStephen G. Sligar

protein sciencecell signalingproteinlipid interactionmembrane proteinslipidsbilayer surfacemembrane-bound kras4bconformational dynamicsmembrane biologyprotein phosphorylationbiological macromoleculesbiochemistrybiophysicsmembrane systemslipid chemistrymembraneslipid movementsignal transductioncellular biochemistry

The Hydrodynamic Motion of Nanodiscs. Chemistry and Physics of Lipids (2019)

Tyler CampMark McLeanMallory KatoLionel CheruzelStephen Sligar

fluid dynamicshydrodynamic motionfluid mechanicsfluid flowactive fluidsapplied physicsphysicsnanofluidicsnanotechnology

Understanding the Role of Anionic Lipids in the Interaction of Kras4B With the Membrane Surface. Biophysical Journal (2019)

Mark A. McLeanMichael C. GregoryTyler CampStephen G. Sligar

biophysicsbiochemical sciencesmembrane systemsmembrane surfaceanionic lipidslipid chemistryproteinlipid interactionbiomoleculesbiochemistrymembrane biologymembraneslipidsmembrane sciencebiophysical chemistrymembrane structure

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Mark Andrew McLean

Research Scientist

UIUC

Affiliations

College of Liberal Arts & Sciences

Department of Biochemistry

School of Molecular & Cellular Biology

Department of Biochemistry

Mark Andrew Mclean is currently serving as a College Of Liberal Arts & Sciences Research Scientist at Uiuc.

Honors

Create free account to unlock more features

Experiences

Create free account to unlock more features

Education

Create free account to unlock more features

Mark Andrew McLean

UIUC

Research Scientist

You can click a keyword to filter the displayed items

Notable Scholarly Works

Notable Federal Grants

Collaborators

Kras4B–Calmodulin Interaction With Membrane Surfaces: Role of Headgroup, Acyl Chain, and Electrostatics. Biochemistry (2024)

Shweta ShreeMark A. McLeanAndrew G. StephenStephen G. Sligar

Selective α-Hydroxyketone Formation and Subsequent C–C Bond Cleavage by Cytochrome P450 Monooxygenase Enzymes. ACS Catalysis (2024)

Joel H. Z. LeeTom ColemanMark A. McleanMatthew N. PodgorskiEva F. HayballIsobella S. J. StoneJohn B. BruningFiona WhelanJames J. De VossStephen G. SligarStephen G. Bell

enzymesmolecular metabolismbiomolecular engineeringbiocatalysisbenzoic acidenzyme catalysisbiosynthesisbiochemistryprocess biochemistrymd simulationsenzyme inhibitioncytochrome p450

Engineering C–C Bond Cleavage Activity Into a P450 Monooxygenase Enzyme. Journal of the American Chemical Society (2023)

Justin C. MillerJoel H. Z. LeeMark A. McleanRebecca R. ChaoIsobella S. J. StoneTara L. PukalaJohn B. BruningJames J. De VossMary A. SchulerStephen G. SligarStephen G. Bell

Revealing Kras4B Topology on the Membrane Surface. Biochemical and Biophysical Research Communications (2023)

Shweta ShreeMark A. McLeanAndrew G. StephenStephen G. Sligar

Midazolam as a Probe for Heterotropic Drug-Drug Interactions Mediated by Cyp3a4. Biomolecules (2022)

Ilia G. DenisovYelena V. GrinkovaMark A. McLeanTyler CampStephen G. Sligar

Midazolam as a Probe for Drug–Drug Interactions Mediated by Cyp3A4: Homotropic Allosteric Mechanism of Site-Specific Hydroxylation. Biochemistry (2021)

Ilia G. DenisovYelena V. GrinkovaTyler CampMark A. McLeanStephen G. Sligar

drug metabolismmembrane surfacepharmacological researchmechanisms of actionfirst mdz moleculedrug targetsbiochemistrypharmacologyproductive sitemolecular pharmacologyenzyme inhibitiondrug discovery

Dark, Ultra-Dark and Ultra-Bright Nanodiscs for Membrane Protein Investigations. Analytical Biochemistry (2020)

Mark A. McLeanIlia G. DenisovYelena V. GrinkovaStephen G. Sligar

biophysicsmembrane protein investigationsnanodiscprotein sciencemembrane proteinsmembrane biology

Pip2 Influences the Conformational Dynamics of Membrane-Bound Kras4b. Biochemistry (2019)

Mark A. McLeanAndrew G. StephenStephen G. Sligar

The Hydrodynamic Motion of Nanodiscs. Chemistry and Physics of Lipids (2019)

Tyler CampMark McLeanMallory KatoLionel CheruzelStephen Sligar

fluid dynamicshydrodynamic motionfluid mechanicsfluid flowactive fluidsapplied physicsphysicsnanofluidicsnanotechnology

Understanding the Role of Anionic Lipids in the Interaction of Kras4B With the Membrane Surface. Biophysical Journal (2019)

Mark A. McLeanMichael C. GregoryTyler CampStephen G. Sligar

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5
10 / page